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Adamts19 Adamts19 Fcer1g Fcer1g Akt3 Akt3 Cers5 Cers5 Ppp2r5c Ppp2r5c Gna12 Gna12 S1pr3 S1pr3 Akt2 Akt2 Sgpl1 Sgpl1 Bdkrb2 Bdkrb2 S1pr5 S1pr5 Adora1 Adora1 Sphk2 Sphk2 Mapk8 Mapk8 Hras Hras Ppp2r2c Ppp2r2c Plcb2 Plcb2 ENSDORP00000024608 ENSDORP00000024608 Mapk14 Mapk14 Tmigd3 Tmigd3 Trp53 Trp53 Aadacl2 Aadacl2 ENSDORP00000023479 ENSDORP00000023479 Ppp2r5e Ppp2r5e ENSDORP00000023068 ENSDORP00000023068 Acer2 Acer2 Nos3 Nos3 ENSDORP00000022835 ENSDORP00000022835 Fcer1a Fcer1a Nras Nras Smpd1 Smpd1 Asah1 Asah1 LOC106000559 LOC106000559 Kras Kras Plcb1 Plcb1 S1pr1 S1pr1 Pld1 Pld1 Ppp2ca Ppp2ca Aadac Aadac Abcc1 Abcc1 Pik3r1 Pik3r1 Kng1 Kng1 Adamts17 Adamts17 Sphk1 Sphk1 LOC105998610 LOC105998610 Rhoa Rhoa Pld2 Pld2 Cers1 Cers1 Ppp2r3a Ppp2r3a S1pr4 S1pr4 Gnai1 Gnai1 Mapk1 Mapk1 Ppp2r2b Ppp2r2b LOC105991955 LOC105991955 Pik3r3 Pik3r3 Ppp2r2a Ppp2r2a Gna13 Gna13 Sgms1 Sgms1 Degs2 Degs2 Prkcb Prkcb Asah2 Asah2 Bax Bax Plcb4 Plcb4 Tradd Tradd Gnai3 Gnai3 Mapk13 Mapk13 Ppp2r1a Ppp2r1a Rac1 Rac1 Ifitm10 Ifitm10 Acer1 Acer1 S1pr2 S1pr2 Rela Rela Ppp2r2d Ppp2r2d Tnf Tnf Pik3cd Pik3cd ENSDORP00000011621 ENSDORP00000011621 Cers4 Cers4 Ppp2r5d Ppp2r5d Pdpk1 Pdpk1 Ppp2r5b Ppp2r5b Csde1 Csde1 Kras-2 Kras-2 Sgpp2 Sgpp2 Prkce Prkce Prkca Prkca Sptlc3 Sptlc3 Sgms2 Sgms2 Mapk10 Mapk10 Rock1 Rock1 Gab2 Gab2 Pik3ca Pik3ca Rac2 Rac2 Ppp2r1b Ppp2r1b Pten Pten Ms4a2 Ms4a2 Sptlc2 Sptlc2 Cers3 Cers3 Rock2 Rock2 Ppp2cb Ppp2cb Ppp2r5a Ppp2r5a Nfkb1 Nfkb1 Cers2 Cers2 Nsmaf Nsmaf Smpd2 Smpd2 Gnai2 Gnai2 Pik3cb Pik3cb Akt1 Akt1 Cers6 Cers6 Ptk6 Ptk6 Degs1 Degs1 Mast3 Mast3 Traf2 Traf2 Bid Bid Prkcg Prkcg Mapk9 Mapk9 Rhoc Rhoc Mapk3 Mapk3 Sptlc1 Sptlc1 Bcl2 Bcl2 Mapk12 Mapk12 Plcb3 Plcb3 Map3k5 Map3k5 Map2k1 Map2k1 Map2k2 Map2k2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Adamts19A disintegrin and metalloproteinase with thrombospondin motifs 19. (1178 aa)
Fcer1gHigh affinity immunoglobulin epsilon receptor subunit gamma. (69 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Cers5Ceramide synthase 5. (128 aa)
Ppp2r5cSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
S1pr3Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Sgpl1Sphingosine-1-phosphate lyase 1. (568 aa)
Bdkrb2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
S1pr5LOW QUALITY PROTEIN: sphingosine 1-phosphate receptor 5; Belongs to the G-protein coupled receptor 1 family. (114 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (327 aa)
Sphk2Sphingosine kinase 2. (619 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
HrasGTPase HRas isoform X1. (192 aa)
Ppp2r2cSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (474 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSDORP00000024608annotation not available (540 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Tmigd3Transmembrane domain-containing protein TMIGD3-like isoform X3. (209 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Aadacl2Arylacetamide deacetylase-like 2. (354 aa)
ENSDORP00000023479annotation not available (101 aa)
Ppp2r5eSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (428 aa)
ENSDORP00000023068annotation not available (544 aa)
Acer2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1201 aa)
ENSDORP00000022835annotation not available (193 aa)
Fcer1aHigh affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (250 aa)
NrasGTPase NRas. (189 aa)
Smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
Asah1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Pld1Phospholipase. (968 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
AadacArylacetamide deacetylase. (399 aa)
Abcc1Multidrug resistance-associated protein 1. (1502 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Kng1Kininogen-1 isoform X3. (643 aa)
Adamts17A disintegrin and metalloproteinase with thrombospondin motifs 17. (1067 aa)
Sphk1Sphingosine kinase 1. (372 aa)
LOC105998610Interferon-induced transmembrane protein 1-like. (118 aa)
RhoaTransforming protein RhoA. (193 aa)
Pld2Phospholipase. (934 aa)
Cers1Ceramide synthase 1. (288 aa)
Ppp2r3aSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1096 aa)
S1pr4Sphingosine 1-phosphate receptor 4. (388 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Ppp2r2bSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
LOC105991955Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ppp2r2aSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (431 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (372 aa)
Sgms1Phosphatidylcholine:ceramide cholinephosphotransferase 1. (420 aa)
Degs2Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2. (309 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Asah2Neutral ceramidase. (605 aa)
BaxApoptosis regulator BAX. (143 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein. (309 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Ifitm10Interferon-induced transmembrane protein 10. (198 aa)
Acer1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (272 aa)
S1pr2Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Ppp2r2dSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ENSDORP00000011621annotation not available (186 aa)
Cers4Ceramide synthase 4. (282 aa)
Ppp2r5dSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (592 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Ppp2r5bSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform. (256 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Sgpp2Sphingosine-1-phosphate phosphatase 2. (340 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (548 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Sptlc3Serine palmitoyltransferase 3. (559 aa)
Sgms2Phosphatidylcholine:ceramide cholinephosphotransferase 2. (365 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
Gab2GRB2-associated-binding protein 2. (608 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (184 aa)
Ppp2r1bProtein phosphatase 2 scaffold subunit Abeta. (584 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Ms4a2High affinity immunoglobulin epsilon receptor subunit beta. (243 aa)
Sptlc2Serine palmitoyltransferase 2. (557 aa)
Cers3Ceramide synthase 3. (382 aa)
Rock2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1114 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Ppp2r5aSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (416 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Cers2Ceramide synthase 2. (380 aa)
NsmafProtein FAN. (920 aa)
Smpd2Sphingomyelin phosphodiesterase 2. (422 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Cers6Ceramide synthase 6 isoform X1. (392 aa)
Ptk6Tyrosine-protein kinase. (451 aa)
Degs1Sphingolipid delta(4)-desaturase DES1. (311 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Traf2TNF receptor-associated factor. (484 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Sptlc1Serine palmitoyltransferase 1 isoform X1. (473 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5. (144 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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