STRINGSTRING
Irs1 Irs1 Akt3 Akt3 Bcl2l1 Bcl2l1 Mlst8 Mlst8 Rragd Rragd Akt2 Akt2 Wdr41 Wdr41 Ambra1 Ambra1 Pik3r4-2 Pik3r4-2 Mtmr14 Mtmr14 Rasl11b Rasl11b Rab1a Rab1a Rragb Rragb Rab43 Rab43 Rab39a Rab39a Mapk8 Mapk8 Hras Hras ENSDORP00000025450 ENSDORP00000025450 ENSDORP00000025100 ENSDORP00000025100 Itpr1 Itpr1 Hif3a Hif3a Kcnk1 Kcnk1 Prkcq Prkcq Atg14 Atg14 Hmgb1 Hmgb1 Smcr8 Smcr8 Atg12 Atg12 Rab33b Rab33b Insr Insr Tssk1b Tssk1b Prkaa2 Prkaa2 Atg10 Atg10 Mapk10 Mapk10 Rragc Rragc Rheb Rheb Wipi1 Wipi1 Vamp8 Vamp8 Hmgb3 Hmgb3 Supt20h Supt20h Kras-2 Kras-2 LOC106001479 LOC106001479 Csde1 Csde1 Atg2a Atg2a Atg16l2 Atg16l2 Pdpk1 Pdpk1 Wipi2 Wipi2 Dapk3 Dapk3 Tsc1 Tsc1 Pik3cd Pik3cd Ctsb Ctsb Bnip3 Bnip3 Atg4a Atg4a Irs4 Irs4 Atg2b Atg2b Ulk2 Ulk2 Map3k7 Map3k7 Rptor Rptor Tbk1 Tbk1 Atg4d Atg4d Rrad Rrad Tsc2 Tsc2 Ifitm10 Ifitm10 Igbp1 Igbp1 Prkaa1 Prkaa1 Lamp1 Lamp1 Rit1 Rit1 Rubcnl Rubcnl Pik3c3 Pik3c3 Sqstm1 Sqstm1 Rras Rras Prkaca Prkaca Akt1s1 Akt1s1 Tank Tank Zfyve1 Zfyve1 Rasef Rasef Uvrag Uvrag Rraga Rraga ENSDORP00000015115 ENSDORP00000015115 Atg4b Atg4b Deptor Deptor Traf6 Traf6 Gsap Gsap Rubcn Rubcn Pik3r3 Pik3r3 ENSDORP00000016478 ENSDORP00000016478 Vmp1 Vmp1 Rem1 Rem1 Pdik1l Pdik1l LOC106000842 LOC106000842 Mapk1 Mapk1 Rras2 Rras2 ENSDORP00000017463 ENSDORP00000017463 ENSDORP00000017544 ENSDORP00000017544 ENSDORP00000017661 ENSDORP00000017661 Crygn Crygn Sh3glb1 Sh3glb1 LOC105984988 LOC105984988 Stx17 Stx17 Hmgb2 Hmgb2 Atg4b-2 Atg4b-2 Ddit4 Ddit4 LOC105998610 LOC105998610 Rab7a Rab7a Prkcd Prkcd Becn1 Becn1 Nol4l Nol4l LOC106001529 LOC106001529 Gabarapl2 Gabarapl2 Ern2 Ern2 Ulk1 Ulk1 Dapk2 Dapk2 Tp53inp2 Tp53inp2 Gabarap Gabarap Prkacb Prkacb Rab39b Rab39b Atg3 Atg3 Pik3r1 Pik3r1 ENSDORP00000020340 ENSDORP00000020340 Ppp2ca Ppp2ca Rps6kb2 Rps6kb2 ENSDORP00000021099 ENSDORP00000021099 Kras Kras Ins Ins Atg4c Atg4c LOC106000559 LOC106000559 Mras Mras LOC105993563 LOC105993563 Stk35 Stk35 Nrbf2 Nrbf2 Rb1cc1-2 Rb1cc1-2 Rab7b Rab7b Gabarapl1 Gabarapl1 Rab33a Rab33a Nras Nras LOC106002845 LOC106002845 Lmln Lmln Atg5 Atg5 Tp53inp1 Tp53inp1 ENSDORP00000023223 ENSDORP00000023223 Eif2ak3 Eif2ak3 Crybb3 Crybb3 Prap1 Prap1 Atg7 Atg7 Tssk5 Tssk5 Atg9a Atg9a Atg16l1 Atg16l1 Atg101 Atg101 Atg13 Atg13 Stk11 Stk11 Npas3 Npas3 Eif2ak4 Eif2ak4 Tssk4 Tssk4 Map2k2 Map2k2 Map2k1 Map2k1 Ern1 Ern1 Ppp1r14bl Ppp1r14bl Bad Bad Dus2 Dus2 Ddit4l Ddit4l Mtmr4 Mtmr4 Bcl2 Bcl2 Arid4a Arid4a Npas1 Npas1 Ttc14 Ttc14 Dapk1 Dapk1 Mtmr3 Mtmr3 Mapk3 Mapk3 Camkk2 Camkk2 Mtor Mtor Tssk2 Tssk2 Gem Gem Mapk9 Mapk9 Atg9b Atg9b Mast3 Mast3 Hif1a Hif1a Igf1r Igf1r Pik3r4 Pik3r4 Rem2 Rem2 Snap29 Snap29 Rb1cc1 Rb1cc1 Akt1 Akt1 Pik3cb Pik3cb Lamp2 Lamp2 Rhebl1 Rhebl1 C9orf72 C9orf72 Rab19 Rab19 Ppp2cb Ppp2cb Tssk6 Tssk6 Pten Pten Rit2 Rit2 Pik3ca Pik3ca Tssk3 Tssk3 Zfyve28 Zfyve28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Irs1Insulin receptor substrate 1. (1239 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Mlst8Target of rapamycin complex subunit LST8. (326 aa)
RragdRas-related GTP-binding protein D. (366 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Wdr41WD repeat-containing protein 41. (451 aa)
Ambra1Activating molecule in BECN1-regulated autophagy protein 1. (1243 aa)
Pik3r4-2Phosphoinositide 3-kinase regulatory subunit 4. (296 aa)
Mtmr14Myotubularin-related protein 14 isoform X1. (649 aa)
Rasl11bRas-like protein family member 11B. (219 aa)
Rab1aRas-related protein Rab-1A. (205 aa)
RragbRas-related GTP-binding protein B isoform X2. (374 aa)
Rab43Ras-related protein Rab-43. (183 aa)
Rab39aRas-related protein Rab-39A. (217 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
HrasGTPase HRas isoform X1. (192 aa)
ENSDORP00000025450annotation not available (102 aa)
ENSDORP00000025100annotation not available (204 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2702 aa)
Hif3aHypoxia-inducible factor 3-alpha. (673 aa)
Kcnk1Potassium channel subfamily K member. (336 aa)
PrkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
Atg14Beclin 1-associated autophagy-related key regulator. (492 aa)
Hmgb1High mobility group protein B1 isoform X2. (215 aa)
Smcr8Smith-Magenis syndrome chromosomal region candidate gene 8 protein. (934 aa)
Atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (85 aa)
Rab33bRas-related protein Rab-33B. (229 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Tssk1bTestis-specific serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (362 aa)
Prkaa2Non-specific serine/threonine protein kinase. (549 aa)
Atg10Ubiquitin-like-conjugating enzyme ATG10. (216 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
RragcRas-related GTP-binding protein C. (399 aa)
RhebGTP-binding protein Rheb. (112 aa)
Wipi1WD repeat domain phosphoinositide-interacting protein 1 isoform X2. (453 aa)
Vamp8Vesicle-associated membrane protein 8. (103 aa)
Hmgb3High mobility group protein B3. (200 aa)
Supt20hTranscription factor SPT20 homolog isoform X3. (181 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Atg2aAutophagy-related protein 2 homolog A isoform X3. (1918 aa)
Atg16l2Autophagy-related protein 16-2 isoform X1. (618 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Wipi2WD repeat domain phosphoinositide-interacting protein 2 isoform X2. (445 aa)
Dapk3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (276 aa)
Tsc1Hamartin isoform X1. (1121 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (202 aa)
Atg4aCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (390 aa)
Irs4Insulin receptor substrate 4. (1262 aa)
Atg2bAutophagy-related protein 2 homolog B. (2077 aa)
Ulk2Serine/threonine-protein kinase ULK2 isoform X1. (1036 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (596 aa)
RptorRegulatory-associated protein of mTOR. (1310 aa)
Tbk1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
Atg4dCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (411 aa)
RradGTP-binding protein RAD. (296 aa)
Tsc2Tuberin isoform X1. (1809 aa)
Ifitm10Interferon-induced transmembrane protein 10. (198 aa)
Igbp1Immunoglobulin-binding protein 1. (340 aa)
Prkaa1Non-specific serine/threonine protein kinase. (538 aa)
Lamp1Lysosome-associated membrane glycoprotein 1. (388 aa)
Rit1GTP-binding protein Rit1 isoform X1. (183 aa)
RubcnlUncharacterized protein KIAA0226-like homolog isoform X1. (653 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
Sqstm1Sequestosome-1. (433 aa)
RrasRas-related protein R-Ras. (218 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Akt1s1Proline-rich AKT1 substrate 1 isoform X2. (282 aa)
TankTRAF family member-associated NF-kappa-B activator isoform X2. (425 aa)
Zfyve1LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 1. (756 aa)
RasefRas and EF-hand domain-containing protein. (594 aa)
UvragUV radiation resistance-associated gene protein. (693 aa)
RragaRas-related GTP-binding protein A. (313 aa)
ENSDORP00000015115annotation not available (144 aa)
Atg4bAutophagy related 4B cysteine peptidase. (143 aa)
DeptorDEP domain-containing mTOR-interacting protein. (410 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
GsapGamma-secretase-activating protein. (97 aa)
RubcnRun domain Beclin-1 interacting and cysteine-rich containing protein. (949 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ENSDORP00000016478annotation not available (212 aa)
Vmp1Vacuole membrane protein 1. (410 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Pdik1lSerine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily. (341 aa)
LOC106000842Autophagy protein 5 pseudogene. (184 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Rras2Ras-related protein R-Ras2 isoform X1. (171 aa)
ENSDORP00000017463annotation not available (188 aa)
ENSDORP00000017544annotation not available (179 aa)
ENSDORP00000017661annotation not available (180 aa)
CrygnGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (183 aa)
Sh3glb1endophilin-B1 isoform X3. (392 aa)
LOC105984988High mobility group protein B1 pseudogene. (207 aa)
Stx17Syntaxin-17 isoform X2; Belongs to the syntaxin family. (288 aa)
Hmgb2High mobility group protein B2. (210 aa)
Atg4b-2Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (221 aa)
Ddit4DNA damage-inducible transcript 4 protein. (228 aa)
LOC105998610Interferon-induced transmembrane protein 1-like. (118 aa)
Rab7aRas-related protein Rab-7a isoform X1. (207 aa)
PrkcdProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
Becn1Beclin-1. (448 aa)
Nol4lNucleolar protein 4-like. (679 aa)
LOC106001529Mitogen-activated protein kinase kinase kinase 7-like. (538 aa)
Gabarapl2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
Ern2Serine/threonine-protein kinase/endoribonuclease IRE2. (981 aa)
Ulk1Serine/threonine-protein kinase ULK1. (1012 aa)
Dapk2Death-associated protein kinase 2-like. (302 aa)
Tp53inp2Tumor protein p53-inducible nuclear protein 2 isoform X1. (221 aa)
GabarapGamma-aminobutyric acid receptor-associated protein. (117 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Rab39bRas-related protein Rab-39B. (213 aa)
Atg3Autophagy-related protein 3. (314 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ENSDORP00000020340annotation not available (258 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
ENSDORP00000021099annotation not available (270 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
Atg4cCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
MrasRas-related protein M-Ras. (208 aa)
LOC105993563High mobility group protein B1-like. (194 aa)
Stk35Serine/threonine-protein kinase 35; Belongs to the protein kinase superfamily. (496 aa)
Nrbf2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
Rb1cc1-2RB1-inducible coiled-coil protein 1 isoform X2. (229 aa)
Rab7bRas-related protein Rab-7b. (199 aa)
Gabarapl1Gamma-aminobutyric acid receptor-associated protein-like 1. (87 aa)
Rab33aRas-related protein Rab-33A. (237 aa)
NrasGTPase NRas. (189 aa)
LOC106002845Target of rapamycin complex subunit LST8-like. (149 aa)
LmlnLeishmanolysin-like peptidase. (671 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
Tp53inp1Tumor protein p53-inducible nuclear protein 1 isoform X1. (240 aa)
ENSDORP00000023223annotation not available (74 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1025 aa)
Crybb3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (212 aa)
Prap1Proline-rich acidic protein 1. (80 aa)
Atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
Tssk5Testis-specific serine/threonine-protein kinase 5-like. (342 aa)
Atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
Atg16l1Autophagy-related protein 16-1 isoform X1. (615 aa)
Atg101Autophagy-related protein 101. (218 aa)
Atg13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (480 aa)
Stk11Serine/threonine-protein kinase STK11 isoform X1; Belongs to the protein kinase superfamily. (310 aa)
Npas3Neuronal PAS domain-containing protein 3 isoform X2. (803 aa)
Eif2ak4Eukaryotic translation initiation factor 2-alpha kinase 4. (1599 aa)
Tssk4Testis-specific serine/threonine-protein kinase 4 isoform X2; Belongs to the protein kinase superfamily. (321 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Ern1Serine/threonine-protein kinase/endoribonuclease IRE1. (406 aa)
Ppp1r14blProtein phosphatase 1 regulatory subunit 14B. (141 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Dus2tRNA-dihydrouridine(20) synthase [NAD(P)+]-like. (403 aa)
Ddit4lDNA damage-inducible transcript 4-like protein. (192 aa)
Mtmr4Myotubularin-related protein 4 isoform X1. (204 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Arid4aAT-rich interactive domain-containing protein 4A. (1214 aa)
Npas1Neuronal PAS domain-containing protein 1. (597 aa)
Ttc14Tetratricopeptide repeat protein 14. (766 aa)
Dapk1Death-associated protein kinase 1. (1430 aa)
Mtmr3Myotubularin-related protein 3 isoform X1. (565 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Camkk2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X5. (577 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Tssk2Testis-specific serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Atg9bAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (848 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Hif1aHypoxia-inducible factor 1-alpha. (246 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Pik3r4Phosphoinositide-3-kinase regulatory subunit 4. (208 aa)
Rem2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
Snap29Synaptosomal-associated protein 29. (224 aa)
Rb1cc1RB1 inducible coiled-coil 1. (164 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Lamp2Lysosome-associated membrane glycoprotein 2. (430 aa)
Rhebl1GTPase RhebL1. (176 aa)
C9orf72Protein C9orf72 homolog. (481 aa)
Rab19Ras-related protein Rab-19 isoform X1. (217 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Tssk6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Rit2GTP-binding protein Rit2. (217 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Tssk3Testis-specific serine/threonine-protein kinase 3. (268 aa)
Zfyve28Lateral signaling target protein 2 homolog isoform X1. (191 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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