STRINGSTRING
Atr Atr Chek1 Chek1 Akt3 Akt3 ENSDORP00000027329 ENSDORP00000027329 Ppp3ca Ppp3ca Map2k6 Map2k6 Lin37 Lin37 Akt2 Akt2 LOC105998647 LOC105998647 Hipk1 Hipk1 Ppp3cb Ppp3cb Myc Myc Hras Hras Vdac2 Vdac2 Gata6 Gata6 Capn1 Capn1 Itpr1 Itpr1 Cdk6 Cdk6 Mapk14 Mapk14 Trp53 Trp53 E2f3 E2f3 ENSDORP00000023508 ENSDORP00000023508 Ccnd3 Ccnd3 Gata5 Gata5 Crybb3 Crybb3 Smad3 Smad3 Rbl2 Rbl2 ENSDORP00000022665 ENSDORP00000022665 Ppp3cc Ppp3cc Itpr2 Itpr2 Nras Nras Zfp36l2 Zfp36l2 Mras Mras LOC106000559 LOC106000559 ENSDORP00000021644 ENSDORP00000021644 Cdkn2b Cdkn2b Capn8 Capn8 LOC105998920 LOC105998920 Ccnd2 Ccnd2 Calm3 Calm3 Kras Kras Nfatc1 Nfatc1 LOC105997103 LOC105997103 Sirt1 Sirt1 Pik3r1 Pik3r1 Nfatc4 Nfatc4 LOC105998647-2 LOC105998647-2 Nfatc3 Nfatc3 Nfatc2 Nfatc2 Lin52 Lin52 Rb1 Rb1 Lin54 Lin54 Gadd45b Gadd45b Ppp3r1 Ppp3r1 ENSDORP00000018543 ENSDORP00000018543 Calml4 Calml4 Ets1 Ets1 Tgfbr1 Tgfbr1 LOC105996339 LOC105996339 Il1a Il1a Smad2 Smad2 Crygn Crygn Rbbp4 Rbbp4 Rras2 Rras2 Calm1 Calm1 Capn11 Capn11 Mapkapk2 Mapkapk2 Mapk1 Mapk1 Ccnb2 Ccnb2 Rbl1 Rbl1 Eif4ebp1 Eif4ebp1 Rem1 Rem1 Foxo3 Foxo3 Cdk2 Cdk2 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Zfp36l1 Zfp36l1 LOC106001397 LOC106001397 Calml3 Calml3 ENSDORP00000015336 ENSDORP00000015336 Slc25a5 Slc25a5 ENSDORP00000014998 ENSDORP00000014998 Foxo1 Foxo1 LOC105996972 LOC105996972 Foxm1 Foxm1 E2f4 E2f4 Tgfbr2 Tgfbr2 Ccne2 Ccne2 Rras Rras Sqstm1 Sqstm1 Mapk13 Mapk13 Btrc Btrc Ppp1cb Ppp1cb Capn2 Capn2 Tesmin Tesmin Efcab3 Efcab3 E2f1 E2f1 Slc25a4 Slc25a4 Tsc2 Tsc2 Atm Atm Rrad Rrad Mcub Mcub Rassf5 Rassf5 Tgfb3 Tgfb3 Rela Rela Map2k3 Map2k3 Pik3cd Pik3cd Ppp1ca Ppp1ca Rad9a Rad9a Tsc1 Tsc1 Gadd45g Gadd45g LOC105988993 LOC105988993 Lin9 Lin9 Gadd45a Gadd45a Csde1 Csde1 Kras-2 Kras-2 Hipk4 Hipk4 E2f5 E2f5 Serpine1 Serpine1 Ppp1cc Ppp1cc Rheb Rheb Calm2 Calm2 Fbxw11 Fbxw11 Pik3ca Pik3ca Rad1 Rad1 Chek2 Chek2 Pten Pten Hipk3 Hipk3 Ccne1 Ccne1 Tprg1 Tprg1 Ccna2 Ccna2 Capn3 Capn3 Nfkb1 Nfkb1 Cdk4 Cdk4 Mdm2 Mdm2 Azgp1 Azgp1 LOC105996958 LOC105996958 Capn12 Capn12 Mybl2 Mybl2 Hus1 Hus1 Tprgl Tprgl Rhebl1 Rhebl1 Pik3cb Pik3cb Trpv4 Trpv4 Akt1 Akt1 ENSDORP00000005529 ENSDORP00000005529 Cacna1d Cacna1d Mre11 Mre11 Cdk3 Cdk3 Igfbp3 Igfbp3 Rassf3 Rassf3 Mast3 Mast3 Tgfb2 Tgfb2 Gem Gem Gata4 Gata4 Mtor Mtor Capn9 Capn9 Tgfb1 Tgfb1 E2f2 E2f2 Mapk3 Mapk3 LOC105996964 LOC105996964 Vdac3 Vdac3 Mcu Mcu Ppid Ppid Mapk12 Mapk12 Itpr3 Itpr3 Pkd1l1 Pkd1l1 Map2k1 Map2k1 Map2k2 Map2k2 Ccna1 Ccna1 Rbbp7 Rbbp7 Trpm7 Trpm7 Vdac1 Vdac1 Hipk2 Hipk2 Slc25a31 Slc25a31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AtrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2592 aa)
Chek1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSDORP00000027329annotation not available (278 aa)
Ppp3caSerine/threonine-protein phosphatase. (479 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
Lin37Protein lin-37 homolog. (246 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC105998647G2/mitotic-specific cyclin-B1-like. (332 aa)
Hipk1Homeodomain-interacting protein kinase 1. (1139 aa)
Ppp3cbSerine/threonine-protein phosphatase. (492 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
HrasGTPase HRas isoform X1. (192 aa)
Vdac2Voltage-dependent anion-selective channel protein 2. (294 aa)
Gata6Transcription factor GATA-6. (585 aa)
Capn1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (714 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2702 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
ENSDORP00000023508annotation not available (156 aa)
Ccnd3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
Gata5Transcription factor GATA-5. (222 aa)
Crybb3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (212 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Rbl2Retinoblastoma-like protein 2. (1051 aa)
ENSDORP00000022665annotation not available (680 aa)
Ppp3ccSerine/threonine-protein phosphatase. (478 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2678 aa)
NrasGTPase NRas. (189 aa)
Zfp36l2Zinc finger protein 36, C3H1 type-like 2. (289 aa)
MrasRas-related protein M-Ras. (208 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
ENSDORP00000021644annotation not available (241 aa)
Cdkn2bCyclin-dependent kinase 4 inhibitor B-like. (139 aa)
Capn8Calpain-8; Belongs to the peptidase C2 family. (713 aa)
LOC105998920DNA repair protein RAD50-like. (122 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (224 aa)
Calm3Calmodulin 3. (149 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (690 aa)
LOC105997103Serine/threonine-protein phosphatase PP1-alpha catalytic subunit pseudogene. (308 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (646 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Nfatc4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (899 aa)
LOC105998647-2LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like; Belongs to the cyclin family. (396 aa)
Nfatc3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1077 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (728 aa)
Lin52Protein lin-52 homolog. (116 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Lin54Protein lin-54 homolog. (706 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Ppp3r1Calcineurin subunit B type 1. (169 aa)
ENSDORP00000018543annotation not available (129 aa)
Calml4Calmodulin-like protein 4 isoform X1. (153 aa)
Ets1Protein C-ets-1. (441 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
LOC105996339Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (270 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
CrygnGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (183 aa)
Rbbp4Histone-binding protein RBBP4. (425 aa)
Rras2Ras-related protein R-Ras2 isoform X1. (171 aa)
Calm1Calmodulin 1. (149 aa)
Capn11Calpain-11; Belongs to the peptidase C2 family. (706 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (353 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Ccnb2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (380 aa)
Rbl1Retinoblastoma-like protein 1. (1063 aa)
Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Foxo3Forkhead box protein O3. (672 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Zfp36l1Zinc finger protein 36, C3H1 type-like 1. (338 aa)
LOC106001397Patr class I histocompatibility antigen, B-1 alpha chain-like; Belongs to the MHC class I family. (273 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
ENSDORP00000015336annotation not available (189 aa)
Slc25a5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ENSDORP00000014998annotation not available (169 aa)
Foxo1Forkhead box protein O1. (537 aa)
LOC105996972HLA class I histocompatibility antigen, B-46 alpha chain-like; Belongs to the MHC class I family. (220 aa)
Foxm1Forkhead box protein M1. (717 aa)
E2f4Transcription factor E2F4 isoform X3. (121 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
RrasRas-related protein R-Ras. (218 aa)
Sqstm1Sequestosome-1. (433 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
BtrcF-box/WD repeat-containing protein 1A. (594 aa)
Ppp1cbSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
Capn2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
TesminTesmin. (300 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (433 aa)
E2f1Transcription factor E2F1. (436 aa)
Slc25a4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
Tsc2Tuberin isoform X1. (1809 aa)
AtmSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RradGTP-binding protein RAD. (296 aa)
McubCalcium uniporter regulatory subunit MCUb, mitochondrial. (295 aa)
Rassf5Ras association domain-containing protein 5. (313 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3. (202 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Ppp1caSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
Rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
Tsc1Hamartin isoform X1. (1121 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC105988993Cyclin-dependent kinase inhibitor 2A-like. (90 aa)
Lin9Protein lin-9 homolog. (536 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Hipk4Homeodomain-interacting protein kinase 4. (409 aa)
E2f5Transcription factor E2F5 isoform X1. (352 aa)
Serpine1Plasminogen activator inhibitor 1 isoform X2; Belongs to the serpin family. (401 aa)
Ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
RhebGTP-binding protein Rheb. (112 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (149 aa)
Fbxw11F-box/WD repeat-containing protein 11 isoform X1. (541 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Rad1Cell cycle checkpoint protein RAD1 isoform X2. (281 aa)
Chek2Serine/threonine-protein kinase Chk2. (467 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Hipk3Homeodomain-interacting protein kinase 3. (1093 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (413 aa)
Tprg1Tumor protein p63-regulated gene 1 protein. (280 aa)
Ccna2cyclin-A2; Belongs to the cyclin family. (425 aa)
Capn3Calpain-3 isoform X2; Belongs to the peptidase C2 family. (815 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
Azgp1Zinc-alpha-2-glycoprotein; Belongs to the MHC class I family. (179 aa)
LOC105996958LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like; Belongs to the MHC class I family. (322 aa)
Capn12Calpain-12; Belongs to the peptidase C2 family. (676 aa)
Mybl2Myb-related protein B. (695 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (267 aa)
TprglTumor protein p63-regulated gene 1-like protein. (237 aa)
Rhebl1GTPase RhebL1. (176 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Trpv4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (869 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
ENSDORP00000005529annotation not available (297 aa)
Cacna1dVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2039 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (203 aa)
Cdk3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (172 aa)
Rassf3Ras association domain-containing protein 3. (229 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
Gata4Transcription factor GATA-4. (235 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Capn9Calpain-9 isoform X1; Belongs to the peptidase C2 family. (701 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
E2f2Transcription factor E2F2. (308 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
LOC105996964HLA class I histocompatibility antigen, A-11 alpha chain-like; Belongs to the MHC class I family. (345 aa)
Vdac3Voltage-dependent anion-selective channel protein 3. (283 aa)
McuCalcium uniporter protein, mitochondrial. (283 aa)
PpidPeptidyl-prolyl cis-trans isomerase D. (370 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3 isoform X3. (2668 aa)
Pkd1l1Polycystic kidney disease protein 1-like 1. (1981 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Ccna1cyclin-A1; Belongs to the cyclin family. (420 aa)
Rbbp7Histone-binding protein RBBP7. (416 aa)
Trpm7Transient receptor potential cation channel subfamily M member 7. (1863 aa)
Vdac1Voltage-dependent anion-selective channel protein 1. (296 aa)
Hipk2Homeodomain-interacting protein kinase 2 isoform X1. (1196 aa)
Slc25a31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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