STRINGSTRING
Serpine1 Serpine1 Adcy5 Adcy5 Mylk4 Mylk4 Nos2 Nos2 ENSDORP00000000566 ENSDORP00000000566 Adcy1 Adcy1 Map2k2 Map2k2 Map2k1 Map2k1 Itpr3 Itpr3 Plcb3 Plcb3 Gng7 Gng7 Ucp1 Ucp1 Cdh1 Cdh1 Mylk Mylk Mapk3 Mapk3 Ucp3 Ucp3 Mtor Mtor Gem Gem Gnb5 Gnb5 Pik3r4 Pik3r4 Pik3r6 Pik3r6 Ryr2 Ryr2 Adcy6 Adcy6 Jag1 Jag1 Gng8 Gng8 Akt1 Akt1 Myl4 Myl4 Gnai2 Gnai2 Adcy8 Adcy8 Mef2d Mef2d Apln Apln Adcy3 Adcy3 Lipe Lipe Snapin Snapin Prkag2 Prkag2 Gng4 Gng4 Smad4 Smad4 Fbxo21 Fbxo21 Nos1 Nos1 Prkaa2 Prkaa2 Gngt1 Gngt1 Slc8a2 Slc8a2 Calm2 Calm2 Ucp2 Ucp2 Prkce Prkce Adcy7 Adcy7 Pik3cg Pik3cg Adcy2 Adcy2 Kras-2 Kras-2 LOC106001479 LOC106001479 Csde1 Csde1 Rps6 Rps6 Slc9a1 Slc9a1 Adcy4 Adcy4 Rrad Rrad Plin1 Plin1 Efcab3 Efcab3 Tfam Tfam Prkaa1 Prkaa1 Pik3c3 Pik3c3 Gnai3 Gnai3 Rras Rras Prkaca Prkaca Mef2a Mef2a Plcb4 Plcb4 Gnb4 Gnb4 Adcy10 Adcy10 Ppargc1a Ppargc1a Hdac5 Hdac5 Calml3 Calml3 Gnb3 Gnb3 Plat Plat Agtr1 Agtr1 Myl3 Myl3 Akt3 Akt3 Gng10 Gng10 Prkab2 Prkab2 Akt2 Akt2 Pik3r4-2 Pik3r4-2 Gnb1 Gnb1 Sphk2 Sphk2 Aplnr Aplnr Egr1 Egr1 Hras Hras ENSDORP00000025450 ENSDORP00000025450 Itpr1 Itpr1 Plcb2 Plcb2 Slc8a1 Slc8a1 LOC105994685 LOC105994685 Gng13 Gng13 Myl2 Myl2 Tmem145 Tmem145 ENSDORP00000023508 ENSDORP00000023508 Gng3 Gng3 Prkag1 Prkag1 Gm5741 Gm5741 Ryr3 Ryr3 ENSDORP00000023223 ENSDORP00000023223 Smad3 Smad3 Gng2 Gng2 Gng5 Gng5 Nos3 Nos3 LOC105983978 LOC105983978 Itpr2 Itpr2 Gnb2 Gnb2 Ryr1 Ryr1 Nras Nras Slc8a3 Slc8a3 Gabarapl1 Gabarapl1 ENSDORP00000022081 ENSDORP00000022081 Hdac4 Hdac4 Pik3r5 Pik3r5 Mras Mras LOC105981033 LOC105981033 Prkab1 Prkab1 Gng12 Gng12 Calm3 Calm3 Kras Kras Rps6kb2 Rps6kb2 Plcb1 Plcb1 Pde3b Pde3b Prkacb Prkacb Ccn2 Ccn2 Gabarap Gabarap Gngt2 Gngt2 Gabarapl2 Gabarapl2 Mylk2 Mylk2 Nrf1 Nrf1 Sphk1 Sphk1 Becn1 Becn1 Notch3 Notch3 Calml4 Calml4 Mef2c Mef2c Tgfbr1 Tgfbr1 Ttn Ttn ENSDORP00000018243 ENSDORP00000018243 Smad2 Smad2 Ptrhd1 Ptrhd1 Prkag3 Prkag3 Rras2 Rras2 Calm1 Calm1 Adcy9 Adcy9 Gnai1 Gnai1 Mapk1 Mapk1 Rem1 Rem1 Ccnd1 Ccnd1 Gng11 Gng11 Acta2 Acta2 Gna13 Gna13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Serpine1Plasminogen activator inhibitor 1 isoform X2; Belongs to the serpin family. (401 aa)
Adcy5Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1186 aa)
Mylk4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (387 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
ENSDORP00000000566annotation not available (65 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (937 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3 isoform X3. (2668 aa)
Plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
Gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Ucp1Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
MylkMyosin light chain kinase, smooth muscle isoform X2. (1904 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Ucp3Mitochondrial uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
Gnb5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
Pik3r4Phosphoinositide-3-kinase regulatory subunit 4. (208 aa)
Pik3r6LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6. (682 aa)
Ryr2Ryanodine receptor 2. (4946 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
Gng8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Myl4Myosin light chain 4. (195 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
Mef2dMyocyte-specific enhancer factor 2D. (513 aa)
AplnApelin. (77 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
LipeHormone-sensitive lipase isoform X3. (758 aa)
SnapinSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2. (191 aa)
Gng4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
Fbxo21F-box only protein 21 isoform X1. (628 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1423 aa)
Prkaa2Non-specific serine/threonine protein kinase. (549 aa)
Gngt1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Slc8a2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (776 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (149 aa)
Ucp2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (548 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
Pik3cgPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (264 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (854 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
Slc9a1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (802 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RradGTP-binding protein RAD. (296 aa)
Plin1Perilipin; Belongs to the perilipin family. (161 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (433 aa)
TfamTranscription factor A, mitochondrial. (245 aa)
Prkaa1Non-specific serine/threonine protein kinase. (538 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
RrasRas-related protein R-Ras. (218 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Mef2aMyocyte-specific enhancer factor 2A isoform X2. (496 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
Gnb4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
Adcy10Adenylate cyclase type 10 isoform X1. (1611 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (797 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1119 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
Gnb3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
PlatPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
Agtr1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Myl3Myosin light chain 3. (197 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Prkab25'-AMP-activated protein kinase subunit beta-2. (268 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r4-2Phosphoinositide 3-kinase regulatory subunit 4. (296 aa)
Gnb1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
Sphk2Sphingosine kinase 2. (619 aa)
AplnrApelin receptor; Belongs to the G-protein coupled receptor 1 family. (379 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
HrasGTPase HRas isoform X1. (192 aa)
ENSDORP00000025450annotation not available (102 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2702 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
Slc8a1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
LOC105994685Myocyte-specific enhancer factor 2B-like. (241 aa)
Gng13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
Myl2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (144 aa)
Tmem145Transmembrane protein 145. (695 aa)
ENSDORP00000023508annotation not available (156 aa)
Gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
Prkag15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
Gm5741Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Ryr3Ryanodine receptor 3. (4767 aa)
ENSDORP00000023223annotation not available (74 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
Gng5G protein subunit gamma 5. (64 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1201 aa)
LOC105983978Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2678 aa)
Gnb2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
Ryr1Ryanodine receptor 1. (4894 aa)
NrasGTPase NRas. (189 aa)
Slc8a3Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
Gabarapl1Gamma-aminobutyric acid receptor-associated protein-like 1. (87 aa)
ENSDORP00000022081annotation not available (68 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
Pik3r5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (872 aa)
MrasRas-related protein M-Ras. (208 aa)
LOC105981033Actin, muscle. (257 aa)
Prkab15'-AMP-activated protein kinase subunit beta-1. (270 aa)
Gng12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Calm3Calmodulin 3. (149 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
Pde3bPhosphodiesterase. (1011 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Ccn2Connective tissue growth factor. (349 aa)
GabarapGamma-aminobutyric acid receptor-associated protein. (117 aa)
Gngt2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Gabarapl2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
Mylk2Myosin light chain kinase 2, skeletal/cardiac muscle. (607 aa)
Nrf1Nuclear respiratory factor 1. (534 aa)
Sphk1Sphingosine kinase 1. (372 aa)
Becn1Beclin-1. (448 aa)
Notch3Neurogenic locus notch homolog protein 3. (2133 aa)
Calml4Calmodulin-like protein 4 isoform X1. (153 aa)
Mef2cMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
TtnTitin. (519 aa)
ENSDORP00000018243annotation not available (251 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Ptrhd1Putative peptidyl-tRNA hydrolase PTRHD1. (146 aa)
Prkag35'-AMP-activated protein kinase subunit gamma-3. (490 aa)
Rras2Ras-related protein R-Ras2 isoform X1. (171 aa)
Calm1Calmodulin 1. (149 aa)
Adcy9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1330 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Gng11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
Acta2Actin, aortic smooth muscle. (377 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (372 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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