STRINGSTRING
Socs3 Socs3 Ikbkg Ikbkg Grb2 Grb2 Akt3 Akt3 Ppp3ca Ppp3ca Cyld Cyld Map2k6 Map2k6 Tnfsf11 Tnfsf11 Il1r1 Il1r1 Akt2 Akt2 Fos Fos Ppp3cb Ppp3cb Ncf2 Ncf2 Fosl2 Fosl2 Mapk8 Mapk8 Btk Btk Tnfrsf11b Tnfrsf11b Relch Relch LOC105996454 LOC105996454 Mapk14 Mapk14 Nox1 Nox1 Trem2 Trem2 Ppp3cc Ppp3cc Oscar Oscar Socs1 Socs1 Tab1 Tab1 LOC106000559 LOC106000559 Ifngr2 Ifngr2 Ncf1 Ncf1 Nfatc1 Nfatc1 Pik3r1 Pik3r1 Nfatc2 Nfatc2 Cyba Cyba Ppp3r1 Ppp3r1 Ctsk Ctsk LOC106001529 LOC106001529 Tgfbr1 Tgfbr1 Il1a Il1a Mapk1 Mapk1 Noxa1 Noxa1 Spi1 Spi1 Pik3r3 Pik3r3 Traf6 Traf6 Tec Tec Itgb3 Itgb3 Fcgr1 Fcgr1 Plcg2 Plcg2 Map3k14 Map3k14 Csf1 Csf1 Tgfbr2 Tgfbr2 Sqstm1 Sqstm1 Mapk13 Mapk13 Rac1 Rac1 Spib Spib Jak1 Jak1 Nfkb2 Nfkb2 Map3k7 Map3k7 Stat2 Stat2 Nfkbia Nfkbia Ncf4 Ncf4 Ikbkb Ikbkb Acp5 Acp5 Rela Rela Tnfrsf11a Tnfrsf11a Creb1 Creb1 Tnf Tnf Pik3cd Pik3cd Chuk Chuk Stat1 Stat1 Tyk2 Tyk2 Mapk10 Mapk10 Fosl1 Fosl1 Gab2 Gab2 Il1b Il1b Csf1r Csf1r Pik3ca Pik3ca Map2k7 Map2k7 Fcgr4 Fcgr4 Fosb Fosb Nfkb1 Nfkb1 Sirpa Sirpa Pik3cb Pik3cb Akt1 Akt1 Fhl2 Fhl2 Ptk6 Ptk6 Calcr Calcr Mast3 Mast3 Traf2 Traf2 Tgfb2 Tgfb2 Mapk9 Mapk9 Ifngr1 Ifngr1 Tgfb1 Tgfb1 Relb Relb Pparg Pparg Mapk3 Mapk3 Mitf Mitf Tyrobp Tyrobp Mapk12 Mapk12 Map2k1 Map2k1 Tab2 Tab2 Syk Syk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Socs3Suppressor of cytokine signaling 3. (228 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Ppp3caSerine/threonine-protein phosphatase. (479 aa)
CyldUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (957 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
Il1r1Interleukin-1 receptor type 1 isoform X1. (574 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FosProto-oncogene c-Fos. (380 aa)
Ppp3cbSerine/threonine-protein phosphatase. (492 aa)
Ncf2Neutrophil cytosol factor 2 isoform X1. (526 aa)
Fosl2Fos-related antigen 2. (327 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
BtkTyrosine-protein kinase. (659 aa)
Tnfrsf11bTumor necrosis factor receptor superfamily member 11B isoform X1. (386 aa)
RelchlisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1221 aa)
LOC105996454Low affinity immunoglobulin gamma Fc region receptor II-like. (311 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Nox1NADPH oxidase 1 isoform X1. (567 aa)
Trem2Triggering receptor expressed on myeloid cells 2. (251 aa)
Ppp3ccSerine/threonine-protein phosphatase. (478 aa)
OscarOsteoclast-associated immunoglobulin-like receptor isoform X1. (271 aa)
Socs1Suppressor of cytokine signaling 1. (177 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (460 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Ifngr2Interferon gamma receptor 2. (297 aa)
Ncf1Neutrophil cytosol factor 1 isoform X4. (396 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (690 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (728 aa)
CybaCytochrome b-245 light chain. (176 aa)
Ppp3r1Calcineurin subunit B type 1. (169 aa)
CtskCathepsin K; Belongs to the peptidase C1 family. (329 aa)
LOC106001529Mitogen-activated protein kinase kinase kinase 7-like. (538 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (270 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Noxa1NADPH oxidase activator 1 isoform X1. (418 aa)
Spi1Transcription factor PU.1. (293 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
TecTyrosine-protein kinase. (631 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (766 aa)
Fcgr1High affinity immunoglobulin gamma Fc receptor I-like isoform X2. (387 aa)
Plcg2Phosphoinositide phospholipase C. (1065 aa)
Map3k14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (933 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Sqstm1Sequestosome-1. (433 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
SpibTranscription factor Spi-B. (262 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Nfkb2Nuclear factor NF-kappa-B p100 subunit. (895 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (596 aa)
Stat2Signal transducer and activator of transcription. (752 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
Ncf4Neutrophil cytosol factor 4. (341 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Acp5Tartrate-resistant acid phosphatase type 5. (365 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Tnfrsf11aTumor necrosis factor receptor superfamily member 11A. (556 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Tyk2Tyrosine-protein kinase. (1053 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Fosl1Fos-related antigen 1 isoform X1. (278 aa)
Gab2GRB2-associated-binding protein 2. (608 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Csf1rMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor III-A isoform X2. (243 aa)
FosbProtein fosB isoform X1. (332 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
SirpaTyrosine-protein phosphatase non-receptor type substrate 1. (216 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Fhl2Four and a half LIM domains protein 2. (279 aa)
Ptk6Tyrosine-protein kinase. (451 aa)
CalcrCalcitonin receptor isoform X2; Belongs to the G-protein coupled receptor 2 family. (485 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Traf2TNF receptor-associated factor. (484 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Ifngr1Interferon gamma receptor 1. (469 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
RelbTranscription factor RelB. (556 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
MitfMicrophthalmia-associated transcription factor isoform X1. (526 aa)
TyrobpTYRO protein tyrosine kinase-binding protein. (114 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
SykTyrosine-protein kinase. (633 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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