(53 nodes) Taste transduction network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Scnn1g	Amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
	Chrm3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
	Adcy4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	Htr1e	5-hydroxytryptamine receptor 1E. (365 aa)
	Htr3a	5-hydroxytryptamine receptor 3A isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
	Htr3b	5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (437 aa)
	Hcn4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (712 aa)
	Itpr3	Inositol 1,4,5-trisphosphate receptor type 3 isoform X3. (2668 aa)
	P2ry1	p2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	Gabra2	Gamma-aminobutyric acid receptor subunit alpha-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
	Htr1a	5-hydroxytryptamine receptor 1A. (422 aa)
	ENSDORP00000016518	annotation not available (92 aa)
	P2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	Gnb3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
	Kcnk5	Potassium channel subfamily K member 5 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (505 aa)
	Asic2	Acid-sensing ion channel 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa)
	Gabra6	Gamma-aminobutyric acid receptor subunit alpha-6 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
	Plcb4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
	Prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	Scn9a	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
	Trpm5	Transient receptor potential cation channel subfamily M member 5. (1148 aa)
	Plcb3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	Gabbr2	Gamma-aminobutyric acid type B receptor subunit 2. (954 aa)
	Pde1b	Phosphodiesterase. (535 aa)
	Scnn1a	Amiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (653 aa)
	Gabra3	Gamma-aminobutyric acid receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)
	Entpd2	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (399 aa)
	Gnat3	Guanine nucleotide-binding protein G(T) subunit alpha-3. (354 aa)
	Tas1r3	Taste receptor type 1 member 3-like. (858 aa)
	Adcy6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	Pkd2l1	Polycystic kidney disease 2-like 1 protein. (792 aa)
	Scn3a	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1985 aa)
	Adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	Tas1r1	Taste receptor type 1 member 1. (841 aa)
	Htr1f	5-hydroxytryptamine receptor 1F. (366 aa)
	Gabra4	Gamma-aminobutyric acid receptor subunit alpha-4 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (576 aa)
	Gabra1	Gamma-aminobutyric acid receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	Scnn1b	Amiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (543 aa)
	Gabra5	Gamma-aminobutyric acid receptor subunit alpha-5; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
	Plcb2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
	Gng13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	P2ry4	p2Y purinoceptor 4; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	Pde1c	Phosphodiesterase. (633 aa)
	Tas2r139	Taste receptor type 2. (318 aa)
	Htr1d	5-hydroxytryptamine receptor 1D. (377 aa)
	Cacna1a	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (2254 aa)
	Plcb1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	Htr1b	5-hydroxytryptamine receptor 1B. (394 aa)
	Tas1r2	Taste receptor type 1 member 2. (803 aa)
	Cacna1c	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1179 aa)
	Pde1a	Phosphodiesterase. (545 aa)
	Prkacb	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
	Gabbr1	Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (961 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcy4	Adcy6	ENSDORP00000011554	ENSDORP00000004840	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.957
Adcy4	Adcy8	ENSDORP00000011554	ENSDORP00000006075	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.869
Adcy4	Entpd2	ENSDORP00000011554	ENSDORP00000003207	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family.	0.855
Adcy4	Gnat3	ENSDORP00000011554	ENSDORP00000003716	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(T) subunit alpha-3.	0.724
Adcy4	Gnb3	ENSDORP00000011554	ENSDORP00000015536	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1.	0.866
Adcy4	Gng13	ENSDORP00000011554	ENSDORP00000024033	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.861
Adcy4	Pde1a	ENSDORP00000011554	ENSDORP00000020093	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.859
Adcy4	Pde1b	ENSDORP00000011554	ENSDORP00000001990	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.859
Adcy4	Pde1c	ENSDORP00000011554	ENSDORP00000023302	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.859
Adcy4	Prkaca	ENSDORP00000011554	ENSDORP00000014055	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.908
Adcy4	Prkacb	ENSDORP00000011554	ENSDORP00000019868	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily.	0.910
Adcy6	Adcy4	ENSDORP00000004840	ENSDORP00000011554	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.957
Adcy6	Adcy8	ENSDORP00000004840	ENSDORP00000006075	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.859
Adcy6	Gnat3	ENSDORP00000004840	ENSDORP00000003716	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(T) subunit alpha-3.	0.626
Adcy6	Gnb3	ENSDORP00000004840	ENSDORP00000015536	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1.	0.866
Adcy6	Gng13	ENSDORP00000004840	ENSDORP00000024033	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.859
Adcy6	Pde1a	ENSDORP00000004840	ENSDORP00000020093	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.866
Adcy6	Pde1b	ENSDORP00000004840	ENSDORP00000001990	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.904
Adcy6	Pde1c	ENSDORP00000004840	ENSDORP00000023302	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.866
Adcy6	Prkaca	ENSDORP00000004840	ENSDORP00000014055	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.940