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Phkg1 Phkg1 Map2k2 Map2k2 Crygn Crygn Prkag3 Prkag3 Calm1 Calm1 Braf Braf Ppp1r3a Ppp1r3a Mapk1 Mapk1 Eif4ebp1 Eif4ebp1 Rem1 Rem1 Prkar1a Prkar1a Ppp1r3c Ppp1r3c Pik3r3 Pik3r3 Calml3 Calml3 Pygm Pygm Ppargc1a Ppargc1a Eif4e1b Eif4e1b Raf1 Raf1 Foxo1 Foxo1 Hkdc1 Hkdc1 Prkcz Prkcz Prkaca Prkaca G6pc G6pc Myo9b Myo9b Prkaa1 Prkaa1 Ppp1cb Ppp1cb Efcab3 Efcab3 Socs3 Socs3 Hk1 Hk1 Grb2 Grb2 G6pc3 G6pc3 Myo9a Myo9a Akt3 Akt3 Inpp5a Inpp5a Prkab2 Prkab2 Gys2 Gys2 Akt2 Akt2 Elk3 Elk3 Gck Gck Bmt2 Bmt2 ENSDORP00000026265 ENSDORP00000026265 Gys1 Gys1 Mapk8 Mapk8 Hras Hras Sorbs1 Sorbs1 Ptpn1 Ptpn1 Srebf1 Srebf1 Acacb Acacb Ppp1r3f Ppp1r3f Tmem145 Tmem145 ENSDORP00000023508 ENSDORP00000023508 Prkag1 Prkag1 Gsk3b Gsk3b Crybb3 Crybb3 Socs2 Socs2 ENSDORP00000023223 ENSDORP00000023223 Prkci Prkci Eif4e Eif4e Tbca Tbca Nras Nras Tsc2 Tsc2 Phka1 Phka1 Rrad Rrad Rptor Rptor Ikbkb Ikbkb Irs4 Irs4 Pik3cd Pik3cd Irs1 Irs1 Ppp1ca Ppp1ca Tsc1 Tsc1 Rps6 Rps6 Pdpk1 Pdpk1 Csde1 Csde1 LOC106001479 LOC106001479 Kras-2 Kras-2 Inppl1 Inppl1 Pck1 Pck1 Slc2a4 Slc2a4 Shc4 Shc4 Cep152 Cep152 Cblb Cblb Ppp1cc Ppp1cc Flot2 Flot2 Rheb Rheb Mapk10 Mapk10 Calm2 Calm2 Phkg2 Phkg2 Prkaa2 Prkaa2 Pik3ca Pik3ca Trip10 Trip10 Pygl Pygl Prkag2 Prkag2 Lipe Lipe Mknk1 Mknk1 Acaca Acaca Fbp2 Fbp2 Rhebl1 Rhebl1 Hk2 Hk2 Crk Crk Prkar2b Prkar2b Socs1 Socs1 LOC106000559 LOC106000559 Pygb Pygb Prkab1 Prkab1 Ptprd Ptprd Pklr Pklr Calm3 Calm3 Kras Kras Crkl Crkl Rps6kb2 Rps6kb2 Sos2 Sos2 Eif4e2 Eif4e2 LOC105997103 LOC105997103 Pde3b Pde3b Cbl Cbl Pik3r1 Pik3r1 Rhoq Rhoq Prkacb Prkacb Ppp1r3b Ppp1r3b Araf Araf LOC106002348 LOC106002348 Mknk2 Mknk2 Calml4 Calml4 ENSDORP00000018243 ENSDORP00000018243 Bud23 Bud23 Pik3cb Pik3cb Ptprs Ptprs Hk3 Hk3 Akt1 Akt1 Alkbh4 Alkbh4 Sh2b2 Sh2b2 Ptprf Ptprf Shc3 Shc3 G6pc2 G6pc2 Fbp1 Fbp1 Sorbs2 Sorbs2 Prkar2a Prkar2a Exoc7 Exoc7 Mast3 Mast3 Phkb Phkb Mapk9 Mapk9 Gem Gem Mtor Mtor Shc1 Shc1 Rapgef1 Rapgef1 Mapk3 Mapk3 Prkar1b Prkar1b Flot1 Flot1 Ppp1r3e Ppp1r3e Sos1 Sos1 Sorbs3 Sorbs3 Bad Bad Ppp1r14bl Ppp1r14bl Shc2 Shc2 Pck2 Pck2 Map2k1 Map2k1 Socs4 Socs4 Srebf2 Srebf2 Elk1 Elk1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Phkg1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (388 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CrygnGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (183 aa)
Prkag35'-AMP-activated protein kinase subunit gamma-3. (490 aa)
Calm1Calmodulin 1. (149 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Ppp1r3aProtein phosphatase 1 regulatory subunit 3A. (1051 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Prkar1acAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
Ppp1r3cProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
PygmAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (797 aa)
Eif4e1bEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (231 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Foxo1Forkhead box protein O1. (537 aa)
Hkdc1Putative hexokinase HKDC1. (896 aa)
PrkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (518 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
G6pcGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
Myo9bUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
Prkaa1Non-specific serine/threonine protein kinase. (538 aa)
Ppp1cbSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (433 aa)
Socs3Suppressor of cytokine signaling 3. (228 aa)
Hk1Hexokinase-1. (974 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
G6pc3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
Myo9aUnconventional myosin-IXa isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2627 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Inpp5aType I inositol 1,4,5-trisphosphate 5-phosphatase. (395 aa)
Prkab25'-AMP-activated protein kinase subunit beta-2. (268 aa)
Gys2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (551 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Elk3ETS domain-containing protein Elk-3. (407 aa)
GckPhosphotransferase. (466 aa)
Bmt2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
ENSDORP00000026265annotation not available (58 aa)
Gys1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
HrasGTPase HRas isoform X1. (192 aa)
Sorbs1Sorbin and SH3 domain containing 1. (1290 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type. (436 aa)
Srebf1Sterol regulatory element-binding protein 1 isoform X1. (1126 aa)
Acacbacetyl-CoA carboxylase 2. (2446 aa)
Ppp1r3fProtein phosphatase 1 regulatory subunit 3F. (741 aa)
Tmem145Transmembrane protein 145. (695 aa)
ENSDORP00000023508annotation not available (156 aa)
Prkag15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Crybb3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (212 aa)
Socs2Suppressor of cytokine signaling 2. (198 aa)
ENSDORP00000023223annotation not available (74 aa)
PrkciProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
Eif4eEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
TbcaTubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
NrasGTPase NRas. (189 aa)
Tsc2Tuberin isoform X1. (1809 aa)
Phka1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1205 aa)
RradGTP-binding protein RAD. (296 aa)
RptorRegulatory-associated protein of mTOR. (1310 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Irs4Insulin receptor substrate 4. (1262 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Ppp1caSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
Tsc1Hamartin isoform X1. (1121 aa)
Rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Inppl1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1240 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
Slc2a4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
CblbE3 ubiquitin-protein ligase CBL-B isoform X2. (939 aa)
Ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
Flot2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
RhebGTP-binding protein Rheb. (112 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (149 aa)
Phkg2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Belongs to the protein kinase superfamily. (406 aa)
Prkaa2Non-specific serine/threonine protein kinase. (549 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Trip10Cdc42-interacting protein 4 isoform X2. (597 aa)
PyglAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (760 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2. (191 aa)
LipeHormone-sensitive lipase isoform X3. (758 aa)
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (422 aa)
Acacaacetyl-CoA carboxylase 1 isoform X1. (2346 aa)
Fbp2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
Rhebl1GTPase RhebL1. (176 aa)
Hk2Hexokinase-2. (917 aa)
CrkAdapter molecule crk. (304 aa)
Prkar2bcAMP-dependent protein kinase type II-beta regulatory subunit. (258 aa)
Socs1Suppressor of cytokine signaling 1. (177 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
PygbAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
Prkab15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PtprdReceptor-type tyrosine-protein phosphatase delta isoform X3. (1912 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
Calm3Calmodulin 3. (149 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
CrklCrk-like protein. (303 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Eif4e2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (208 aa)
LOC105997103Serine/threonine-protein phosphatase PP1-alpha catalytic subunit pseudogene. (308 aa)
Pde3bPhosphodiesterase. (1011 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RhoqRho-related GTP-binding protein RhoQ. (205 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Ppp1r3bProtein phosphatase 1 regulatory subunit. (284 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
LOC106002348Glucose-6-phosphatase 2-like. (109 aa)
Mknk2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (464 aa)
Calml4Calmodulin-like protein 4 isoform X1. (153 aa)
ENSDORP00000018243annotation not available (251 aa)
Bud23Probable 18S rRNA (Guanine-N(7))-methyltransferase isoform X1. (281 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
PtprsReceptor-type tyrosine-protein phosphatase S. (1430 aa)
Hk3Hexokinase-3. (894 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Alkbh4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X1. (301 aa)
Sh2b2SH2B adapter protein 2. (436 aa)
PtprfReceptor-type tyrosine-protein phosphatase F isoform X1. (1901 aa)
Shc3SHC-transforming protein 3. (598 aa)
G6pc2Glucose-6-phosphatase 2. (245 aa)
Fbp1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (350 aa)
Sorbs2Sorbin and SH3 domain-containing protein 2 isoform X1. (1136 aa)
Prkar2acAMP-dependent protein kinase type II-alpha regulatory subunit. (358 aa)
Exoc7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (697 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
PhkbPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (607 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Rapgef1Rap guanine nucleotide exchange factor 1 isoform X1. (1198 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Prkar1bcAMP-dependent protein kinase type I-beta regulatory subunit. (381 aa)
Flot1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (241 aa)
Ppp1r3eProtein phosphatase 1 regulatory subunit 3E. (279 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Sorbs3Vinexin. (702 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Ppp1r14blProtein phosphatase 1 regulatory subunit 14B. (141 aa)
Shc2SHC-transforming protein 2. (513 aa)
Pck2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (643 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Socs4Suppressor of cytokine signaling 4. (441 aa)
Srebf2Sterol regulatory element-binding protein 2. (1144 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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