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Gng3 Gng3 Gm5741 Gm5741 Gng2 Gng2 Gng5 Gng5 LOC105987800 LOC105987800 Nos3 Nos3 LOC105983978 LOC105983978 Gnb2 Gnb2 Nras Nras Arrb2 Arrb2 ENSDORP00000022081 ENSDORP00000022081 Rxfp1 Rxfp1 Col4a1 Col4a1 LOC106000559 LOC106000559 Gng12 Gng12 Kras Kras Sos2 Sos2 Plcb1 Plcb1 Pik3r1 Pik3r1 Prkacb Prkacb Arrb1 Arrb1 Gngt2 Gngt2 Vegfc Vegfc Tgfbr1 Tgfbr1 Smad2 Smad2 Ptrhd1 Ptrhd1 Creb3 Creb3 Adcy9 Adcy9 Gnai1 Gnai1 Mapk1 Mapk1 Pik3r3 Pik3r3 Col3a1 Col3a1 Gng11 Gng11 Acta2 Acta2 Gnb3 Gnb3 Gnb4 Gnb4 Plcb4 Plcb4 Mmp1 Mmp1 Tgfbr2 Tgfbr2 Prkaca Prkaca Gnai3 Gnai3 Mapk13 Mapk13 Mff Mff Mmp13 Mmp13 Rxfp2 Rxfp2 Col1a1 Col1a1 Rln3 Rln3 Mmp2 Mmp2 Egfr Egfr Nfkbia Nfkbia Col4a6 Col4a6 Rela Rela Creb1 Creb1 Pik3cd Pik3cd Col4a4 Col4a4 Adcy4 Adcy4 Rxfp4 Rxfp4 Creb3l4 Creb3l4 Csde1 Csde1 Kras-2 Kras-2 Adcy2 Adcy2 Shc4 Shc4 Cep152 Cep152 Adcy7 Adcy7 Creb5 Creb5 Col4a2 Col4a2 Mapk10 Mapk10 Gngt1 Gngt1 Pik3ca Pik3ca Nos1 Nos1 Fbxo21 Fbxo21 Map2k7 Map2k7 Ednrb Ednrb Gng4 Gng4 Gna15 Gna15 Vegfd Vegfd Adcy3 Adcy3 Nfkb1 Nfkb1 Adcy8 Adcy8 Gnai2 Gnai2 Pik3cb Pik3cb Akt1 Akt1 Shc3 Shc3 Gng8 Gng8 Adcy6 Adcy6 Atf4 Atf4 Gnas Gnas Mast3 Mast3 Atf6b Atf6b Gnb5 Gnb5 Mapk9 Mapk9 Atf2 Atf2 Shc1 Shc1 Tgfb1 Tgfb1 Mapk3 Mapk3 Creb3l3 Creb3l3 Col1a2 Col1a2 Creb3l2 Creb3l2 Rxfp3 Rxfp3 Sos1 Sos1 Mapk12 Mapk12 Gng7 Gng7 Plcb3 Plcb3 Vegfb Vegfb Shc2 Shc2 Map2k1 Map2k1 Map2k2 Map2k2 Adcy1 Adcy1 ENSDORP00000000566 ENSDORP00000000566 Nos2 Nos2 Adcy5 Adcy5 Plcb2 Plcb2 LOC105987731 LOC105987731 Edn1 Edn1 Hras Hras Mapk8 Mapk8 Creb3l1 Creb3l1 Gnb1 Gnb1 Gnao1 Gnao1 Fos Fos Akt2 Akt2 Gng10 Gng10 Akt3 Akt3 Grb2 Grb2 Mapk14 Mapk14 Gng13 Gng13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
Gm5741Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
Gng5G protein subunit gamma 5. (64 aa)
LOC105987800Vascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (185 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1201 aa)
LOC105983978Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Gnb2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
NrasGTPase NRas. (189 aa)
Arrb2Beta-arrestin-2 isoform X1. (420 aa)
ENSDORP00000022081annotation not available (68 aa)
Rxfp1Relaxin receptor 1 isoform X2. (759 aa)
Col4a1Collagen alpha-1(IV) chain. (1669 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Gng12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Arrb1Beta-arrestin-1 isoform X1. (411 aa)
Gngt2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Ptrhd1Putative peptidyl-tRNA hydrolase PTRHD1. (146 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (372 aa)
Adcy9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1330 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Col3a1Collagen alpha-1(III) chain. (1437 aa)
Gng11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
Acta2Actin, aortic smooth muscle. (377 aa)
Gnb3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
Gnb4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
Mmp1Interstitial collagenase. (468 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
MffMitochondrial fission factor isoform X4. (291 aa)
Mmp13Collagenase 3. (471 aa)
Rxfp2Relaxin receptor 2 isoform X3. (740 aa)
Col1a1Collagen alpha-1(I) chain. (1285 aa)
Rln3Relaxin-3. (140 aa)
Mmp272 kDa type IV collagenase. (126 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
Col4a6Collagen alpha-6(IV) chain. (1663 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Col4a4Collagen alpha-4(IV) chain. (1683 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
Rxfp4Relaxin-3 receptor 2. (374 aa)
Creb3l4Cyclic AMP-responsive element-binding protein 3-like protein 4. (378 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (854 aa)
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
Col4a2Collagen alpha-2(IV) chain. (1643 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Gngt1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1423 aa)
Fbxo21F-box only protein 21 isoform X1. (628 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
EdnrbEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Gng4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Gna15Guanine nucleotide-binding protein subunit alpha-15. (342 aa)
VegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (351 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Shc3SHC-transforming protein 3. (598 aa)
Gng8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (345 aa)
GnasGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (394 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta. (604 aa)
Gnb5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3. (464 aa)
Col1a2Collagen alpha-2(I) chain. (1364 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
Rxfp3Relaxin-3 receptor 1. (469 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (204 aa)
Shc2SHC-transforming protein 2. (513 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (937 aa)
ENSDORP00000000566annotation not available (65 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
Adcy5Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1186 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
LOC105987731Uncharacterized protein LOC105987731. (169 aa)
Edn1Endothelin-1-like isoform X1. (202 aa)
HrasGTPase HRas isoform X1. (192 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (524 aa)
Gnb1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
Gnao1Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa)
FosProto-oncogene c-Fos. (380 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Gng13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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