STRINGSTRING
Cox6c Cox6c Ndufa9 Ndufa9 Ndufab1 Ndufab1 Ndufa12 Ndufa12 Ern1 Ern1 Map3k5 Map3k5 Ndufs2 Ndufs2 Ndufs4 Ndufs4 Ndufb6 Ndufb6 Ndufa11 Ndufa11 Ppara Ppara Ndufs8 Ndufs8 Tgfb1 Tgfb1 Mapk9 Mapk9 Bid Bid Cyct Cyct 4921507P07Rik 4921507P07Rik Uqcrfs1 Uqcrfs1 Traf2 Traf2 Lep Lep Mast3 Mast3 Uqcr11 Uqcr11 Xbp1 Xbp1 Atf4 Atf4 Ndufc1 Ndufc1 Akt1 Akt1 Mlxip Mlxip Pik3cb Pik3cb Mlx Mlx Ndufa2 Ndufa2 Adipor1 Adipor1 Ddit3 Ddit3 Ndufb10 Ndufb10 Nfkb1 Nfkb1 Ndufb5 Ndufb5 Nr1h3 Nr1h3 Ndufa3 Ndufa3 Prkag2 Prkag2 Cyc1 Cyc1 Ndufb9 Ndufb9 Ndufa6 Ndufa6 Uqcrc1 Uqcrc1 Pik3ca Pik3ca Prkaa2 Prkaa2 ENSDORP00000009146 ENSDORP00000009146 Rxra Rxra LOC105985285 LOC105985285 Akt3 Akt3 Ndufa1 Ndufa1 Ndufb11 Ndufb11 Socs3 Socs3 Il1b Il1b Ndufv1 Ndufv1 Mapk10 Mapk10 Kiaa1958 Kiaa1958 Faslg Faslg Mlxipl Mlxipl Irs1 Irs1 Pik3cd Pik3cd Tnf Tnf Map3k11 Map3k11 Rela Rela Ikbkb Ikbkb LOC105999527 LOC105999527 Adipoq Adipoq Prkaa1 Prkaa1 Ndufa10 Ndufa10 Casp7 Casp7 Rac1 Rac1 Ndufb4 Ndufb4 Sdhb Sdhb Ndufs5 Ndufs5 Il6r Il6r Cox5a Cox5a LOC105988216 LOC105988216 Ndufb7 Ndufb7 LOC105999165 LOC105999165 Bax Bax Ndufs3 Ndufs3 Cox4i2 Cox4i2 Ndufa8 Ndufa8 Cyp2e1 Cyp2e1 Cox4i1 Cox4i1 Bcl2l11 Bcl2l11 Pik3r3 Pik3r3 Sdha Sdha Sdhc Sdhc Uqcr10 Uqcr10 Uqcrh Uqcrh Gm10053 Gm10053 Prkag3 Prkag3 Cox7b Cox7b Il1a Il1a ENSDORP00000018243 ENSDORP00000018243 Ndufa5 Ndufa5 LOC105982750 LOC105982750 Cox6a2 Cox6a2 Itch Itch ENSDORP00000019320 ENSDORP00000019320 Ndufs7 Ndufs7 Ndufb8 Ndufb8 ENSDORP00000019550 ENSDORP00000019550 Uqcrq Uqcrq Casp3 Casp3 ENSDORP00000020083 ENSDORP00000020083 Pik3r1 Pik3r1 Cox8a Cox8a ENSDORP00000020846 ENSDORP00000020846 ENSDORP00000021143 ENSDORP00000021143 Gsk3a Gsk3a Pklr Pklr Prkab1 Prkab1 LOC106000559 LOC106000559 Cebpa Cebpa Cox7a2l Cox7a2l ENSDORP00000022450 ENSDORP00000022450 Ndufa4 Ndufa4 Ndufs6 Ndufs6 LOC105989352 LOC105989352 ENSDORP00000023006 ENSDORP00000023006 Ndufa4l2 Ndufa4l2 Eif2ak3 Eif2ak3 Gsk3b Gsk3b Prkag1 Prkag1 Srebf1 Srebf1 Sdhd Sdhd LOC105985350 LOC105985350 Ndufs1 Ndufs1 Cox6b1 Cox6b1 Uqcrc2 Uqcrc2 Ndufa7 Ndufa7 Mapk8 Mapk8 ENSDORP00000025725 ENSDORP00000025725 ENSDORP00000026425 ENSDORP00000026425 Fos Fos Akt2 Akt2 Prkab2 Prkab2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cox6cCytochrome c oxidase subunit 6C. (75 aa)
Ndufa9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (358 aa)
Ndufab1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (100 aa)
Ndufa12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (149 aa)
Ern1Serine/threonine-protein kinase/endoribonuclease IRE1. (406 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5. (144 aa)
Ndufs2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Belongs to the complex I 49 kDa subunit family. (457 aa)
Ndufs4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. (175 aa)
Ndufb6NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6. (97 aa)
Ndufa11NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11. (143 aa)
PparaPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
Ndufs8NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial. (64 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
4921507P07RikUncharacterized protein C7orf31 homolog. (560 aa)
Uqcrfs1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
Traf2TNF receptor-associated factor. (484 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Uqcr11Cytochrome b-c1 complex subunit 10. (56 aa)
Xbp1LOW QUALITY PROTEIN: X-box-binding protein 1. (275 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (345 aa)
Ndufc1NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. (76 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
MlxipMLX-interacting protein. (848 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
MlxMax-like protein X isoform X1. (244 aa)
Ndufa2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
Adipor1Adiponectin receptor protein 1. (375 aa)
Ddit3DNA damage-inducible transcript 3 protein. (166 aa)
Ndufb10NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10. (126 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Ndufb5LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial. (149 aa)
Nr1h3Oxysterols receptor LXR-alpha isoform X2. (336 aa)
Ndufa3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3. (84 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2. (191 aa)
Cyc1WD repeat-containing protein KIAA1875. (321 aa)
Ndufb9NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Belongs to the complex I LYR family. (179 aa)
Ndufa6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (131 aa)
Uqcrc1Cytochrome b-c1 complex subunit 1, mitochondrial. (480 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Prkaa2Non-specific serine/threonine protein kinase. (549 aa)
ENSDORP00000009146annotation not available (56 aa)
RxraRetinoic acid receptor RXR-alpha. (457 aa)
LOC105985285NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like. (94 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Ndufa1NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. (70 aa)
Ndufb11NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial. (154 aa)
Socs3Suppressor of cytokine signaling 3. (228 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Ndufv1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Kiaa1958Uncharacterized protein KIAA1958 homolog isoform X1. (737 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (276 aa)
MlxiplCarbohydrate-responsive element-binding protein isoform X1. (851 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Map3k11Mitogen-activated protein kinase kinase kinase. (847 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
LOC105999527Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
AdipoqAdiponectin. (251 aa)
Prkaa1Non-specific serine/threonine protein kinase. (538 aa)
Ndufa10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (89 aa)
Casp7Caspase-7; Belongs to the peptidase C14A family. (305 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Ndufb4NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4. (129 aa)
SdhbSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (281 aa)
Ndufs5NADH dehydrogenase [ubiquinone] iron-sulfur protein 5. (106 aa)
Il6rInterleukin-6 receptor subunit alpha. (445 aa)
Cox5aCytochrome c oxidase subunit 5A, mitochondrial. (77 aa)
LOC105988216Cytochrome c oxidase subunit 5B, mitochondrial. (125 aa)
Ndufb7NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7. (137 aa)
LOC105999165Cytochrome c oxidase subunit 7A2, mitochondrial. (83 aa)
BaxApoptosis regulator BAX. (143 aa)
Ndufs3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (164 aa)
Cox4i2Cytochrome c oxidase subunit 4 isoform 2, mitochondrial. (171 aa)
Ndufa8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
Cyp2e1Cytochrome P450 2E1; Belongs to the cytochrome P450 family. (495 aa)
Cox4i1Cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1. (169 aa)
Bcl2l11Bcl-2-like protein 11 isoform X1. (200 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (657 aa)
SdhcSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial. (169 aa)
Uqcr10Cytochrome b-c1 complex subunit 9. (64 aa)
UqcrhCytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
Gm10053Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
Prkag35'-AMP-activated protein kinase subunit gamma-3. (490 aa)
Cox7bCytochrome c oxidase subunit 7B, mitochondrial. (80 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (270 aa)
ENSDORP00000018243annotation not available (251 aa)
Ndufa5NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1. (116 aa)
LOC105982750Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (124 aa)
Cox6a2Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa)
ItchE3 ubiquitin-protein ligase. (857 aa)
ENSDORP00000019320annotation not available (203 aa)
Ndufs7NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1; Belongs to the complex I 20 kDa subunit family. (215 aa)
Ndufb8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
ENSDORP00000019550annotation not available (99 aa)
UqcrqCytochrome b-c1 complex subunit 8. (82 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
ENSDORP00000020083annotation not available (83 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Cox8aCytochrome c oxidase subunit 8A, mitochondrial. (69 aa)
ENSDORP00000020846annotation not available (90 aa)
ENSDORP00000021143annotation not available (105 aa)
Gsk3aGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
Prkab15'-AMP-activated protein kinase subunit beta-1. (270 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
CebpaCCAAT/enhancer-binding protein alpha. (369 aa)
Cox7a2lCytochrome c oxidase subunit 7A-related protein, mitochondrial. (114 aa)
ENSDORP00000022450annotation not available (211 aa)
Ndufa4Cytochrome c oxidase subunit NDUFA4. (82 aa)
Ndufs6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (116 aa)
LOC105989352Cell division control protein 42 homolog. (243 aa)
ENSDORP00000023006annotation not available (100 aa)
Ndufa4l2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2. (87 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1025 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Prkag15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
Srebf1Sterol regulatory element-binding protein 1 isoform X1. (1126 aa)
SdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
LOC105985350LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like. (215 aa)
Ndufs1LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family. (243 aa)
Cox6b1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (87 aa)
Uqcrc2Cytochrome b-c1 complex subunit 2, mitochondrial. (453 aa)
Ndufa7NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X2. (113 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
ENSDORP00000025725annotation not available (105 aa)
ENSDORP00000026425annotation not available (105 aa)
FosProto-oncogene c-Fos. (380 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Prkab25'-AMP-activated protein kinase subunit beta-2. (268 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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