STRINGSTRING
Gnai2 Gnai2 Wnt9b Wnt9b Adcy8 Adcy8 Cyp17a1 Cyp17a1 Kmt2a Kmt2a Cdk4 Cdk4 Wnt8a Wnt8a Lef1 Lef1 Wnt1 Wnt1 Ahr Ahr Adcy3 Adcy3 Ccne1 Ccne1 Atf2 Atf2 LOC105991916 LOC105991916 LOC106002066 LOC106002066 Cacna1g Cacna1g Arsi Arsi Cyp11a1 Cyp11a1 Wnt10b Wnt10b Atf6b Atf6b Nr4a1 Nr4a1 Adcy5 Adcy5 Wnt8b Wnt8b Adcy1 Adcy1 Cdkn1b Cdkn1b Map2k2 Map2k2 Map2k1 Map2k1 Itpr3 Itpr3 Plcb3 Plcb3 Gnas Gnas Creb3l2 Creb3l2 Wdr5b Wdr5b Creb3l3 Creb3l3 Mapk3 Mapk3 Fh1 Fh1 E2f2 E2f2 LOC106002055 LOC106002055 Kcna3 Kcna3 Kcna2 Kcna2 Dvl3 Dvl3 Atf4 Atf4 Cacna1i Cacna1i Tcf7 Tcf7 Cacna1d Cacna1d Adcy6 Adcy6 Dvl2 Dvl2 Wnt9a Wnt9a Fzd6 Fzd6 Camk2g Camk2g Pomc Pomc Wnt6 Wnt6 Wnt10a Wnt10a Wnt11 Wnt11 Creb5 Creb5 Fzd1 Fzd1 Pde8b Pde8b Agtr1 Agtr1 Kcna10 Kcna10 LOC106002396 LOC106002396 Men1 Men1 Orai1 Orai1 ENSDORP00000026363 ENSDORP00000026363 Cdkn2c Cdkn2c Creb3l1 Creb3l1 Pde8a Pde8a Gna11 Gna11 Mrap Mrap Itpr1 Itpr1 Cdk6 Cdk6 Fzd3 Fzd3 Plcb2 Plcb2 Cacna1f Cacna1f Wnt7b Wnt7b E2f3 E2f3 Gsk3b Gsk3b Fzd4 Fzd4 Itpr2 Itpr2 Kmt2d Kmt2d Wnt5a Wnt5a Cacna1h Cacna1h Rasd1 Rasd1 Cdkn2b Cdkn2b Axin2 Axin2 Gnaq Gnaq Camk2d Camk2d Fzd2 Fzd2 Nceh1 Nceh1 Plcb1 Plcb1 ENSDORP00000020585 ENSDORP00000020585 Kcnk2 Kcnk2 Cacna1c Cacna1c Axin1 Axin1 Ash2l Ash2l Prkacb Prkacb Wnt7a Wnt7a Fzd9 Fzd9 Crhr1 Crhr1 Rb1 Rb1 Aipl1 Aipl1 Nr5a1 Nr5a1 Rap1b Rap1b Usp8 Usp8 Wnt2b Wnt2b Fzd8 Fzd8 ENSDORP00000018236 ENSDORP00000018236 Kcna4 Kcna4 Camk2a Camk2a Apc2 Apc2 Ptrhd1 Ptrhd1 Creb3 Creb3 Crhr2 Crhr2 Braf Braf Wnt3 Wnt3 Adcy9 Adcy9 Gnai1 Gnai1 Mapk1 Mapk1 Fzd5 Fzd5 Mc2r Mc2r Cdk2 Cdk2 Apc Apc Ccnd1 Ccnd1 Sp1 Sp1 Camk2b Camk2b Wnt4 Wnt4 Wnt2 Wnt2 Cacna1s Cacna1s Plcb4 Plcb4 Wdr5 Wdr5 Ccne2 Ccne2 Prkaca Prkaca Gnai3 Gnai3 Aip Aip Wnt16 Wnt16 Fzd7 Fzd7 Rbbp5 Rbbp5 Scarb1 Scarb1 E2f1 E2f1 Tcf7l1 Tcf7l1 Crh Crh Egfr Egfr Kcna1 Kcna1 Creb1 Creb1 Adcy4 Adcy4 Pbx1 Pbx1 LOC105988993 LOC105988993 Creb3l4 Creb3l4 Rap1a Rap1a Armc5 Armc5 Tcf7l2 Tcf7l2 Agt Agt Adcy2 Adcy2 Kcnk3 Kcnk3 Adcy7 Adcy7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3886 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Wnt8aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Lef1Lymphoid enhancer-binding factor 1. (370 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
AhrAryl hydrocarbon receptor. (807 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (413 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
LOC1059919163 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4-like isoform X1; Belongs to the 3-beta-HSD family. (373 aa)
LOC106002066Cytochrome P450 11B2, mitochondrial-like; Belongs to the cytochrome P450 family. (420 aa)
Cacna1gVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2385 aa)
ArsiArylsulfatase I. (573 aa)
Cyp11a1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (518 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta. (604 aa)
Nr4a1Nuclear receptor subfamily 4 group A member 1. (596 aa)
Adcy5Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1186 aa)
Wnt8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (937 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3 isoform X3. (2668 aa)
Plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
GnasGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (394 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
Wdr5bWD repeat-containing protein 5B. (330 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3. (464 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Fh1Fumarate hydratase, mitochondrial. (466 aa)
E2f2Transcription factor E2F2. (308 aa)
LOC106002055Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (160 aa)
Kcna3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (509 aa)
Kcna2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
Dvl3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (345 aa)
Cacna1iVoltage-dependent T-type calcium channel subunit alpha-1I. (2201 aa)
Tcf7Transcription factor 7 isoform X10. (344 aa)
Cacna1dVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2039 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Dvl2Segment polarity protein dishevelled homolog DVL-2 isoform X3. (736 aa)
Wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
Fzd6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
Camk2gCalcium/calmodulin-dependent protein kinase type II subunit gamma. (515 aa)
PomcPro-opiomelanocortin isoform X1. (261 aa)
Wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Wnt10aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
Fzd1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (656 aa)
Pde8bPhosphodiesterase. (783 aa)
Agtr1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Kcna10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (509 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Men1Menin isoform X2. (610 aa)
Orai1Calcium release-activated calcium channel protein 1. (300 aa)
ENSDORP00000026363annotation not available (164 aa)
Cdkn2cCyclin-dependent kinase 4 inhibitor C. (168 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (524 aa)
Pde8aPhosphodiesterase. (698 aa)
Gna11Guanine nucleotide-binding protein subunit alpha-11. (313 aa)
MrapMelanocortin-2 receptor accessory protein. (129 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2702 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Fzd3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
Cacna1fVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (247 aa)
Wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Fzd4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2678 aa)
Kmt2dHistone-lysine N-methyltransferase 2D. (774 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Cacna1hVoltage-dependent T-type calcium channel subunit alpha-1H. (2166 aa)
Rasd1Dexamethasone-induced Ras-related protein 1 isoform X1. (282 aa)
Cdkn2bCyclin-dependent kinase 4 inhibitor B-like. (139 aa)
Axin2Axin-2. (837 aa)
GnaqGuanine nucleotide-binding protein G(Q) subunit alpha. (333 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (533 aa)
Fzd2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
Nceh1Neutral cholesterol ester hydrolase 1. (408 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ENSDORP00000020585annotation not available (80 aa)
Kcnk2Potassium channel subfamily K member 2 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
Cacna1cVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1179 aa)
Axin1Axin-1. (868 aa)
Ash2lset1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2. (628 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
Fzd9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
Crhr1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (415 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Aipl1Aryl-hydrocarbon-interacting protein-like 1. (374 aa)
Nr5a1Steroidogenic factor 1. (468 aa)
Rap1bRas-related protein Rap-1b. (184 aa)
Usp8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1018 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
Fzd8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (418 aa)
ENSDORP00000018236annotation not available (218 aa)
Kcna4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (653 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (488 aa)
Apc2Adenomatous polyposis coli protein 2. (2138 aa)
Ptrhd1Putative peptidyl-tRNA hydrolase PTRHD1. (146 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (372 aa)
Crhr2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
Adcy9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1330 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Mc2rAdrenocorticotropic hormone receptor. (297 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ApcAdenomatous polyposis coli protein isoform X2. (2842 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Sp1Transcription factor Sp1. (786 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
Cacna1sVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
Wdr5WD repeat-containing protein 5. (334 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
AipAH receptor-interacting protein. (330 aa)
Wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Fzd7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
Rbbp5Retinoblastoma-binding protein 5 isoform X1. (545 aa)
Scarb1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (472 aa)
E2f1Transcription factor E2F1. (436 aa)
Tcf7l1Transcription factor 7-like 1. (524 aa)
CrhCorticoliberin. (188 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Kcna1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (496 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
Pbx1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
LOC105988993Cyclin-dependent kinase inhibitor 2A-like. (90 aa)
Creb3l4Cyclic AMP-responsive element-binding protein 3-like protein 4. (378 aa)
Rap1aRas-related protein Rap-1A. (178 aa)
Armc5Armadillo repeat-containing protein 5. (700 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
AgtAngiotensinogen; Belongs to the serpin family. (473 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (854 aa)
Kcnk3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (416 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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