STRINGSTRING
Itgb1 Itgb1 Rps6ka2 Rps6ka2 Nfkb1 Nfkb1 Wasf2 Wasf2 Rps6ka1 Rps6ka1 Zap70 Zap70 Pik3cb Pik3cb Akt1 Akt1 Myd88 Myd88 Mast3 Mast3 Traf2 Traf2 Wipf3 Wipf3 Mapk9 Mapk9 Actrt2 Actrt2 Dock1 Dock1 Rhoc Rhoc Mapk3 Mapk3 Vav3 Vav3 Actr3b Actr3b Mapk12 Mapk12 Actr2 Actr2 Map2k1 Map2k1 Tlr4 Tlr4 Map2k2 Map2k2 Tab2 Tab2 Limk1 Limk1 LOC106000559 LOC106000559 Wipf1 Wipf1 Crkl Crkl Nfatc1 Nfatc1 Vav1 Vav1 ENSDORP00000020304 ENSDORP00000020304 Wipf2 Wipf2 Pik3r1 Pik3r1 Ptk2 Ptk2 Nfatc3 Nfatc3 Nfatc2 Nfatc2 Rps6ka6 Rps6ka6 Skap2 Skap2 Itga4 Itga4 LOC106001529 LOC106001529 Rhog Rhog Arhgef1 Arhgef1 Pip5k1c Pip5k1c Irak1 Irak1 Ikbkg Ikbkg Akt3 Akt3 Actl11 Actl11 Map2k6 Map2k6 Bcar1 Bcar1 Akt2 Akt2 Fos Fos ENSDORP00000026390 ENSDORP00000026390 ENSDORP00000026359 ENSDORP00000026359 Was Was Rhoa Rhoa Arhgef7 Arhgef7 Mapk8 Mapk8 Fn1 Fn1 Mapk14 Mapk14 Baiap2 Baiap2 Arf6 Arf6 Pxn Pxn Gsk3b Gsk3b LOC105989352 LOC105989352 Pip5k1a Pip5k1a ENSDORP00000022835 ENSDORP00000022835 Pycard Pycard Crk Crk Actb Actb Tab1 Tab1 Pkn1 Pkn1 ENSDORP00000017709 ENSDORP00000017709 Lpxn Lpxn Mapk1 Mapk1 Pip5k1b Pip5k1b Pik3r3 Pik3r3 Arhgef12 Arhgef12 Traf6 Traf6 Lat Lat Fyb Fyb Irak4 Irak4 Il2 Il2 Irf3 Irf3 Mapk13 Mapk13 Rac1 Rac1 Tbk1 Tbk1 Map3k7 Map3k7 Nfkbia Nfkbia Ikbkb Ikbkb Il18 Il18 Rela Rela Tnf Tnf Map2k3 Map2k3 Pik3cd Pik3cd ENSDORP00000011621 ENSDORP00000011621 Plcg1 Plcg1 Actr3 Actr3 Chuk Chuk Vav2 Vav2 Rps6ka3 Rps6ka3 Wasl Wasl Il10 Il10 Elmo2 Elmo2 Nlrp3 Nlrp3 Arhgef28 Arhgef28 Ptk2b Ptk2b Nlrc4 Nlrc4 Mapk10 Mapk10 Rock1 Rock1 Il1b Il1b Pik3ca Pik3ca Rac2 Rac2 Map2k7 Map2k7 Git2 Git2 Actl7a Actl7a Actl7b Actl7b Itga5 Itga5 Rock2 Rock2 Pkn2 Pkn2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Rps6ka2Non-specific serine/threonine protein kinase. (705 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Wasf2wiskott-Aldrich syndrome protein family member 2. (496 aa)
Rps6ka1Non-specific serine/threonine protein kinase. (644 aa)
Zap70Tyrosine-protein kinase. (618 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Traf2TNF receptor-associated factor. (484 aa)
Wipf3WAS/WASL-interacting protein family member 3. (508 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Actrt2Actin-related protein T2; Belongs to the actin family. (377 aa)
Dock1Dedicator of cytokinesis protein 1 isoform X2; Belongs to the DOCK family. (1870 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Vav3Guanine nucleotide exchange factor VAV3. (847 aa)
Actr3bActin-related protein 3B; Belongs to the actin family. (407 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Tlr4Toll-like receptor 4 isoform X2; Belongs to the Toll-like receptor family. (842 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
Limk1LIM domain kinase 1. (635 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Wipf1WAS/WASL-interacting protein family member 1. (227 aa)
CrklCrk-like protein. (303 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (690 aa)
Vav1Proto-oncogene vav. (845 aa)
ENSDORP00000020304annotation not available (160 aa)
Wipf2WAS/WASL-interacting protein family member 2. (107 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
Nfatc3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1077 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (728 aa)
Rps6ka6Ribosomal protein S6 kinase. (836 aa)
Skap2Src kinase-associated phosphoprotein 2 isoform X1. (358 aa)
Itga4Integrin alpha-4; Belongs to the integrin alpha chain family. (1032 aa)
LOC106001529Mitogen-activated protein kinase kinase kinase 7-like. (538 aa)
RhogRho-related GTP-binding protein RhoG. (191 aa)
Arhgef1Rho guanine nucleotide exchange factor 1 isoform X3. (913 aa)
Pip5k1cLOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (976 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Actl11Uncharacterized protein LOC105994564; Belongs to the actin family. (1215 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
Bcar1Breast cancer anti-estrogen resistance protein 1 isoform X1. (931 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FosProto-oncogene c-Fos. (380 aa)
ENSDORP00000026390annotation not available (153 aa)
ENSDORP00000026359annotation not available (202 aa)
Waswiskott-Aldrich syndrome protein. (503 aa)
RhoaTransforming protein RhoA. (193 aa)
Arhgef7Rho guanine nucleotide exchange factor 7. (820 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Fn1Fibronectin. (321 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Baiap2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (517 aa)
Arf6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PxnPaxillin isoform X3; Belongs to the paxillin family. (547 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC105989352Cell division control protein 42 homolog. (243 aa)
Pip5k1aPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha. (569 aa)
ENSDORP00000022835annotation not available (193 aa)
PycardApoptosis-associated speck-like protein containing a CARD. (190 aa)
CrkAdapter molecule crk. (304 aa)
ActbActin, cytoplasmic 1. (375 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (460 aa)
Pkn1Serine/threonine-protein kinase N1 isoform X1. (944 aa)
ENSDORP00000017709annotation not available (94 aa)
LpxnLeupaxin; Belongs to the paxillin family. (386 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pip5k1bPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3. (540 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Arhgef12Rho guanine nucleotide exchange factor 12. (1511 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
LatLinker for activation of T-cells family member 1 isoform X1. (234 aa)
FybFYN-binding protein isoform X1. (806 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
Il2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
Irf3Interferon regulatory factor 3. (424 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Tbk1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (596 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (183 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3. (202 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ENSDORP00000011621annotation not available (186 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Actr3Actin-related protein 3; Belongs to the actin family. (403 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Vav2Guanine nucleotide exchange factor VAV2. (766 aa)
Rps6ka3Ribosomal protein S6 kinase alpha-3. (654 aa)
WaslNeural Wiskott-Aldrich syndrome protein. (506 aa)
Il10Interleukin-10. (178 aa)
Elmo2Engulfment and cell motility protein 2 isoform X1. (732 aa)
Nlrp3NACHT, LRR and PYD domains-containing protein 3. (1027 aa)
Arhgef28Rho guanine nucleotide exchange factor 28 isoform X2. (1676 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
Nlrc4NLR family CARD domain-containing protein 4 isoform X1. (1019 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (184 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
Git2ARF GTPase-activating protein GIT2 isoform X1. (757 aa)
Actl7aActin-like protein 7A; Belongs to the actin family. (439 aa)
Actl7bActin-like protein 7B; Belongs to the actin family. (418 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (1057 aa)
Rock2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1114 aa)
Pkn2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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