STRINGSTRING
Akt3 Akt3 Ankra2 Ankra2 LOC105999836 LOC105999836 Fcer1g Fcer1g Ciita Ciita Bcl2 Bcl2 Lsp1 Lsp1 Mapk12 Mapk12 Bad Bad Ppp1r14bl Ppp1r14bl Cd74 Cd74 Rfxank Rfxank Nfya Nfya Lbp Lbp Rab5c Rab5c Nfkb1 Nfkb1 Tlr4 Tlr4 Nos2 Nos2 Syk Syk Camk2b Camk2b Calml3 Calml3 Traf6 Traf6 Arhgef12 Arhgef12 ENSDORP00000016454 ENSDORP00000016454 Mapk1 Mapk1 Gm10053 Gm10053 Calm1 Calm1 Vdr Vdr ENSDORP00000017709 ENSDORP00000017709 Camk2a Camk2a LOC105991094 LOC105991094 Il1a Il1a Rhoa Rhoa LOC105998610 LOC105998610 Irak1 Irak1 Rab7a Rab7a Calml4 Calml4 ENSDORP00000018707 ENSDORP00000018707 Sphk1 Sphk1 Ppp3r1 Ppp3r1 Clec7a Clec7a Jak2 Jak2 Atp6v1h Atp6v1h ENSDORP00000019550 ENSDORP00000019550 LOC105999877 LOC105999877 Cyp27b1 Cyp27b1 Casp3 Casp3 Nod2 Nod2 Atp6ap1 Atp6ap1 Plk5 Plk5 Atp6v0a2 Atp6v0a2 ENSDORP00000020304 ENSDORP00000020304 Nfyb Nfyb Itgam Itgam LOC105999837 LOC105999837 Camk2d Camk2d ENSDORP00000021143 ENSDORP00000021143 Calm3 Calm3 Ifngr2 Ifngr2 LOC105998778 LOC105998778 Bcl10 Bcl10 Coro1a Coro1a Crebbp Crebbp Ppp3cc Ppp3cc Rab5a Rab5a ENSDORP00000022835 ENSDORP00000022835 ENSDORP00000023006 ENSDORP00000023006 Mrc2 Mrc2 ENSDORP00000023508 ENSDORP00000023508 Il12b Il12b Fcgr4 Fcgr4 Eea1 Eea1 Arsi Arsi Apaf1 Apaf1 Atp6v0c Atp6v0c Rab17 Rab17 ENSDORP00000024097 ENSDORP00000024097 Mapk14 Mapk14 LOC105996454 LOC105996454 Rab5b Rab5b Mapk8 Mapk8 ENSDORP00000025725 ENSDORP00000025725 Sphk2 Sphk2 Ppp3cb Ppp3cb ENSDORP00000026390 ENSDORP00000026390 ENSDORP00000026425 ENSDORP00000026425 LOC105999835 LOC105999835 LOC106001046 LOC106001046 Akt2 Akt2 Nfyc Nfyc Il1b Il1b Calm2 Calm2 Mapk10 Mapk10 Mrc1 Mrc1 Cebpg Cebpg Ep300 Ep300 Card9 Card9 Ppp3ca Ppp3ca Atp6v0b Atp6v0b Cr1l Cr1l Malt1 Malt1 Camp Camp Ctss Ctss Hspd1 Hspd1 Stat1 Stat1 Il10 Il10 LOC105999834 LOC105999834 Irak2 Irak2 ENSDORP00000011621 ENSDORP00000011621 Pla2r1 Pla2r1 Tnf Tnf Tcirg1 Tcirg1 Creb1 Creb1 Rela Rela Il18 Il18 Ksr1 Ksr1 Tlr9 Tlr9 Tgfb3 Tgfb3 Il23a Il23a Coro1c Coro1c Atp6v0a1 Atp6v0a1 Jak1 Jak1 Ifitm10 Ifitm10 Efcab3 Efcab3 Atp6v0d1 Atp6v0d1 Coro6 Coro6 Hspa9 Hspa9 Mapk13 Mapk13 Coro1b Coro1b Lamp1 Lamp1 H2-Ea-ps H2-Ea-ps Pik3c3 Pik3c3 ENSDORP00000004839 ENSDORP00000004839 LOC105999888 LOC105999888 Myd88 Myd88 Irak4 Irak4 Tradd Tradd Bax Bax Atp6v0d2 Atp6v0d2 ENSDORP00000015115 ENSDORP00000015115 Fcgr1 Fcgr1 Clec4e Clec4e H2-Oa H2-Oa Atp6v0a4 Atp6v0a4 4921507P07Rik 4921507P07Rik Cyct Cyct Tgfb2 Tgfb2 Bid Bid Mapk9 Mapk9 Ifngr1 Ifngr1 Camk2g Camk2g Plk3 Plk3 Akt1 Akt1 Itgax Itgax Lamp2 Lamp2 Tgfb1 Tgfb1 Rhoc Rhoc Mapk3 Mapk3 Ripk2 Ripk2 Rfxap Rfxap
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Ankra2Ankyrin repeat family A protein 2. (283 aa)
LOC105999836H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1. (176 aa)
Fcer1gHigh affinity immunoglobulin epsilon receptor subunit gamma. (69 aa)
CiitaMHC class II transactivator isoform X1. (1079 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Lsp1Lymphocyte-specific protein 1 isoform X1. (82 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Ppp1r14blProtein phosphatase 1 regulatory subunit 14B. (141 aa)
Cd74HLA class II histocompatibility antigen gamma chain. (259 aa)
RfxankDNA-binding protein RFXANK. (256 aa)
NfyaNuclear transcription factor Y subunit alpha isoform X3. (347 aa)
LbpLipopolysaccharide-binding protein-like. (407 aa)
Rab5cRas-related protein Rab-5C. (216 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Tlr4Toll-like receptor 4 isoform X2; Belongs to the Toll-like receptor family. (842 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
SykTyrosine-protein kinase. (633 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
Arhgef12Rho guanine nucleotide exchange factor 12. (1511 aa)
ENSDORP00000016454annotation not available (81 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Gm10053Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
Calm1Calmodulin 1. (149 aa)
VdrVitamin D3 receptor. (75 aa)
ENSDORP00000017709annotation not available (94 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (488 aa)
LOC105991094C-type lectin domain family 4 member A-like isoform X1. (209 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (270 aa)
RhoaTransforming protein RhoA. (193 aa)
LOC105998610Interferon-induced transmembrane protein 1-like. (118 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
Rab7aRas-related protein Rab-7a isoform X1. (207 aa)
Calml4Calmodulin-like protein 4 isoform X1. (153 aa)
ENSDORP00000018707annotation not available (208 aa)
Sphk1Sphingosine kinase 1. (372 aa)
Ppp3r1Calcineurin subunit B type 1. (169 aa)
Clec7aC-type lectin domain family 7 member A. (131 aa)
Jak2Tyrosine-protein kinase. (1037 aa)
Atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
ENSDORP00000019550annotation not available (99 aa)
LOC105999877HLA class II histocompatibility antigen, DP beta 1 chain isoform X1. (220 aa)
Cyp27b125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (508 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1012 aa)
Atp6ap1V-type proton ATPase subunit S1. (467 aa)
Plk5Serine/threonine-protein kinase PLK. (458 aa)
Atp6v0a2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ENSDORP00000020304annotation not available (160 aa)
NfybNuclear transcription factor Y subunit beta. (207 aa)
ItgamIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1143 aa)
LOC105999837HLA class II histocompatibility antigen, DRB1-10 beta chain-like. (203 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (533 aa)
ENSDORP00000021143annotation not available (105 aa)
Calm3Calmodulin 3. (149 aa)
Ifngr2Interferon gamma receptor 2. (297 aa)
LOC105998778CD209 antigen-like protein E isoform X1. (230 aa)
Bcl10B-cell lymphoma/leukemia 10. (117 aa)
Coro1aCoronin; Belongs to the WD repeat coronin family. (461 aa)
CrebbpCREB-binding protein. (2432 aa)
Ppp3ccSerine/threonine-protein phosphatase. (478 aa)
Rab5aRas-related protein Rab-5A. (215 aa)
ENSDORP00000022835annotation not available (193 aa)
ENSDORP00000023006annotation not available (100 aa)
Mrc2C-type mannose receptor 2. (1476 aa)
ENSDORP00000023508annotation not available (156 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor III-A isoform X2. (243 aa)
Eea1Early endosome antigen 1. (1411 aa)
ArsiArylsulfatase I. (573 aa)
Apaf1Apoptotic protease-activating factor 1. (1107 aa)
Atp6v0cV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (112 aa)
Rab17Ras-related protein Rab-17 isoform X1. (212 aa)
ENSDORP00000024097annotation not available (150 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
LOC105996454Low affinity immunoglobulin gamma Fc region receptor II-like. (311 aa)
Rab5bRas-related protein Rab-5B. (215 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
ENSDORP00000025725annotation not available (105 aa)
Sphk2Sphingosine kinase 2. (619 aa)
Ppp3cbSerine/threonine-protein phosphatase. (492 aa)
ENSDORP00000026390annotation not available (153 aa)
ENSDORP00000026425annotation not available (105 aa)
LOC105999835HLA class II histocompatibility antigen, DRB1-12 beta chain-like. (262 aa)
LOC106001046Stress-70 protein, mitochondrial pseudogene. (567 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NfycNuclear transcription factor Y subunit gamma isoform X1. (335 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (149 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Mrc1Macrophage mannose receptor 1. (1454 aa)
CebpgCCAAT/enhancer-binding protein gamma. (150 aa)
Ep300Histone acetyltransferase p300. (2345 aa)
Card9Caspase recruitment domain-containing protein 9 isoform X1. (534 aa)
Ppp3caSerine/threonine-protein phosphatase. (479 aa)
Atp6v0bV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
Cr1lComplement receptor type 1-like isoform X2. (439 aa)
Malt1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (823 aa)
CampCathelicidin antimicrobial peptide. (171 aa)
CtssLOW QUALITY PROTEIN: cathepsin S; Belongs to the peptidase C1 family. (305 aa)
Hspd160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Il10Interleukin-10. (178 aa)
LOC105999834HLA class II histocompatibility antigen, DR beta 4 chain-like isoform X4. (275 aa)
Irak2Interleukin-1 receptor-associated kinase-like 2. (541 aa)
ENSDORP00000011621annotation not available (186 aa)
Pla2r1Secretory phospholipase A2 receptor. (1441 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (514 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (183 aa)
Ksr1Kinase suppressor of Ras 1 isoform X2. (896 aa)
Tlr9Toll-like receptor 9 isoform X3. (1029 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Il23aInterleukin-23 subunit alpha. (191 aa)
Coro1ccoronin-1C. (451 aa)
Atp6v0a1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (740 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Ifitm10Interferon-induced transmembrane protein 10. (198 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (433 aa)
Atp6v0d1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
Coro6Coronin; Belongs to the WD repeat coronin family. (471 aa)
Hspa9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Coro1bCoronin; Belongs to the WD repeat coronin family. (173 aa)
Lamp1Lysosome-associated membrane glycoprotein 1. (388 aa)
H2-Ea-psHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
ENSDORP00000004839annotation not available (167 aa)
LOC105999888HLA class II histocompatibility antigen, DM beta chain. (244 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein. (309 aa)
BaxApoptosis regulator BAX. (143 aa)
Atp6v0d2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ENSDORP00000015115annotation not available (144 aa)
Fcgr1High affinity immunoglobulin gamma Fc receptor I-like isoform X2. (387 aa)
Clec4eC-type lectin domain family 4 member E isoform X2. (170 aa)
H2-OaHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
Atp6v0a4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (808 aa)
4921507P07RikUncharacterized protein C7orf31 homolog. (560 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Ifngr1Interferon gamma receptor 1. (469 aa)
Camk2gCalcium/calmodulin-dependent protein kinase type II subunit gamma. (515 aa)
Plk3Serine/threonine-protein kinase PLK. (647 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
ItgaxIntegrin alpha-X; Belongs to the integrin alpha chain family. (1145 aa)
Lamp2Lysosome-associated membrane glycoprotein 2. (430 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
RfxapRegulatory factor X-associated protein. (196 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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