STRINGSTRING
Rela Rela Ifit1b Ifit1b Ifit3 Ifit3 Ppp2r2d Ppp2r2d Tnf Tnf Pik3cd Pik3cd Chuk Chuk Faslg Faslg Cldn10 Cldn10 Csde1 Csde1 Kras-2 Kras-2 Cldn19 Cldn19 Ywhaz Ywhaz Stat1 Stat1 Ripk1 Ripk1 Tyk2 Tyk2 Rxra Rxra Pik3ca Pik3ca Eif2ak2 Eif2ak2 Apaf1 Apaf1 Ppp2r1b Ppp2r1b Cldn16 Cldn16 Ppp2cb Ppp2cb Nr1h3 Nr1h3 Nfkb1 Nfkb1 Cdk4 Cdk4 Pik3cb Pik3cb Akt1 Akt1 Rnasel Rnasel Cldn6 Cldn6 Cldn7 Cldn7 Mast3 Mast3 Traf2 Traf2 4921507P07Rik 4921507P07Rik Cyct Cyct Bid Bid Mavs Mavs E2f2 E2f2 Ppara Ppara Mapk3 Mapk3 LOC105993986 LOC105993986 Ifit5 Ifit5 Pias1 Pias1 Sos1 Sos1 Cldn15 Cldn15 Bad Bad Cd81 Cd81 Cldn8 Cldn8 Map2k1 Map2k1 Map2k2 Map2k2 Eif2ak4 Eif2ak4 Ywhae Ywhae ENSDORP00000020585 ENSDORP00000020585 Cldn1 Cldn1 ENSDORP00000019550 ENSDORP00000019550 Ywhaq Ywhaq Araf Araf Rb1 Rb1 ENSDORP00000019192 ENSDORP00000019192 Rsad2 Rsad2 Cldn18 Cldn18 Braf Braf Ywhah Ywhah Gm10053 Gm10053 Mapk1 Mapk1 Ppp2r2b Ppp2r2b Cdk2 Cdk2 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Traf6 Traf6 Ppp2r2a Ppp2r2a Raf1 Raf1 Bax Bax Cldn11 Cldn11 Tradd Tradd Irf3 Irf3 Ppp2r1a Ppp2r1a Eif3e Eif3e Irf7 Irf7 Cldn3 Cldn3 Pik3r1 Pik3r1 Casp3 Casp3 Egf Egf Socs3 Socs3 Ikbkg Ikbkg Grb2 Grb2 LOC105996819 LOC105996819 Ddx58 Ddx58 Cldn9 Cldn9 Akt3 Akt3 Ifit2 Ifit2 Ywhab Ywhab Ifit1 Ifit1 Psme3 Psme3 Akt2 Akt2 ENSDORP00000026425 ENSDORP00000026425 Tlr3 Tlr3 Ocln Ocln ENSDORP00000025725 ENSDORP00000025725 Myc Myc Hras Hras Ppp2r2c Ppp2r2c Cdk6 Cdk6 ENSDORP00000024608 ENSDORP00000024608 Stat3 Stat3 Cldn23 Cldn23 Bak1 Bak1 Eif2ak1 Eif2ak1 Cldn5 Cldn5 Trp53 Trp53 E2f3 E2f3 Gsk3b Gsk3b Eif2ak3 Eif2ak3 Cldn4 Cldn4 ENSDORP00000023068 ENSDORP00000023068 ENSDORP00000023006 ENSDORP00000023006 Nras Nras Ywhag Ywhag Cldn14 Cldn14 Cldn17 Cldn17 LOC106000559 LOC106000559 ENSDORP00000021272 ENSDORP00000021272 ENSDORP00000021143 ENSDORP00000021143 Kras Kras Sos2 Sos2 Ppp2ca Ppp2ca Scarb1 Scarb1 E2f1 E2f1 Traf3 Traf3 Jak1 Jak1 Tbk1 Tbk1 Egfr Egfr Stat2 Stat2 Ikbke Ikbke Nfkbia Nfkbia Ikbkb Ikbkb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RelaTranscription factor p65 isoform X1. (236 aa)
Ifit1bInterferon-induced protein with tetratricopeptide repeats 1B isoform X2. (461 aa)
Ifit3Interferon-induced protein with tetratricopeptide repeats 3. (401 aa)
Ppp2r2dSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (276 aa)
Cldn10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Cldn19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (662 aa)
Tyk2Tyrosine-protein kinase. (1053 aa)
RxraRetinoic acid receptor RXR-alpha. (457 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase isoform X2. (476 aa)
Apaf1Apoptotic protease-activating factor 1. (1107 aa)
Ppp2r1bProtein phosphatase 2 scaffold subunit Abeta. (584 aa)
Cldn16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (289 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Nr1h3Oxysterols receptor LXR-alpha isoform X2. (336 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Rnasel2-5A-dependent ribonuclease isoform X2. (701 aa)
Cldn6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
Cldn7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Traf2TNF receptor-associated factor. (484 aa)
4921507P07RikUncharacterized protein C7orf31 homolog. (560 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
MavsMitochondrial antiviral-signaling protein. (476 aa)
E2f2Transcription factor E2F2. (308 aa)
PparaPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
LOC105993986Interferon-induced GTP-binding protein Mx2-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (616 aa)
Ifit5Interferon-induced protein with tetratricopeptide repeats 5. (482 aa)
Pias1E3 SUMO-protein ligase PIAS1. (647 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Cldn15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Cd81Tetraspanin. (68 aa)
Cldn8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Eif2ak4Eukaryotic translation initiation factor 2-alpha kinase 4. (1599 aa)
Ywhae14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ENSDORP00000020585annotation not available (80 aa)
Cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ENSDORP00000019550annotation not available (99 aa)
Ywhaq14-3-3 protein theta; Belongs to the 14-3-3 family. (125 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
ENSDORP00000019192annotation not available (133 aa)
Rsad2Radical S-adenosyl methionine domain-containing protein 2. (366 aa)
Cldn18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (264 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Ywhah14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
Gm10053Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Ppp2r2bSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
Ppp2r2aSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (431 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
Cldn11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein. (309 aa)
Irf3Interferon regulatory factor 3. (424 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Eif3eEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
Irf7Interferon regulatory factor 7 isoform X2. (432 aa)
Cldn3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Socs3Suppressor of cytokine signaling 3. (228 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
LOC10599681914-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
Ddx58Probable ATP-dependent RNA helicase DDX58. (924 aa)
Cldn9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Ifit2Interferon-induced protein with tetratricopeptide repeats 2. (462 aa)
Ywhab14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
Ifit1Interferon-induced protein with tetratricopeptide repeats 1. (475 aa)
Psme3Proteasome activator complex subunit 3 isoform X2. (254 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSDORP00000026425annotation not available (105 aa)
Tlr3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (914 aa)
OclnOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (523 aa)
ENSDORP00000025725annotation not available (105 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
HrasGTPase HRas isoform X1. (192 aa)
Ppp2r2cSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (474 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ENSDORP00000024608annotation not available (540 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Cldn23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (294 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Eif2ak1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3. (619 aa)
Cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1025 aa)
Cldn4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
ENSDORP00000023068annotation not available (544 aa)
ENSDORP00000023006annotation not available (100 aa)
NrasGTPase NRas. (189 aa)
Ywhag14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
Cldn14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
Cldn17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
ENSDORP00000021272annotation not available (382 aa)
ENSDORP00000021143annotation not available (105 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Scarb1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (472 aa)
E2f1Transcription factor E2F1. (436 aa)
Traf3TNF receptor-associated factor. (549 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Tbk1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Stat2Signal transducer and activator of transcription. (752 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (725 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (18%) [HD]