STRINGSTRING
Ddb1 Ddb1 Stat5a Stat5a Tab2 Tab2 Egr3 Egr3 Elk1 Elk1 Ccna1 Ccna1 Map2k2 Map2k2 Tlr4 Tlr4 Map2k1 Map2k1 Bad Bad Mapk12 Mapk12 Bcl2 Bcl2 Sos1 Sos1 ENSDORP00000002235 ENSDORP00000002235 Vdac3 Vdac3 Creb3l2 Creb3l2 Creb3l3 Creb3l3 Mapk3 Mapk3 E2f2 E2f2 Tgfb1 Tgfb1 Atf2 Atf2 Mavs Mavs Mapk9 Mapk9 Prkcg Prkcg Bid Bid Tgfb2 Tgfb2 Cyct Cyct 4921507P07Rik 4921507P07Rik Atf6b Atf6b Mast3 Mast3 Birc5 Birc5 Atf4 Atf4 Myd88 Myd88 Akt1 Akt1 Pik3cb Pik3cb Nfkb1 Nfkb1 Ccna2 Ccna2 Ddb2 Ddb2 Ccne1 Ccne1 Map3k1 Map3k1 Smad4 Smad4 Map2k7 Map2k7 Apaf1 Apaf1 Pik3ca Pik3ca Mapk10 Mapk10 Tyk2 Tyk2 Ptk2b Ptk2b Prkca Prkca Ep300 Ep300 Creb5 Creb5 Stat1 Stat1 Ywhaz Ywhaz Kras-2 Kras-2 Csde1 Csde1 Creb3l4 Creb3l4 Faslg Faslg Chuk Chuk Pik3cd Pik3cd Map2k3 Map2k3 Tnf Tnf Creb1 Creb1 Stat6 Stat6 Rela Rela Ikbkb Ikbkb Jak3 Jak3 Nfkbia Nfkbia Tgfb3 Tgfb3 Ikbke Ikbke Stat2 Stat2 Hspg2 Hspg2 Map3k7 Map3k7 Tbk1 Tbk1 Jak1 Jak1 Traf3 Traf3 E2f1 E2f1 Irf7 Irf7 Mapk13 Mapk13 Irf3 Irf3 Ccne2 Ccne2 Tgfbr2 Tgfbr2 Irak4 Irak4 Bax Bax Raf1 Raf1 Prkcb Prkcb Traf6 Traf6 Pik3r3 Pik3r3 Cdk2 Cdk2 Mapk1 Mapk1 Gm10053 Gm10053 Braf Braf Creb3 Creb3 LOC105985511 LOC105985511 Irak1 Irak1 Tgfbr1 Tgfbr1 LOC106001529 LOC106001529 Ddx3x Ddx3x Ifih1 Ifih1 Rb1 Rb1 Jak2 Jak2 Araf Araf Ywhaq Ywhaq ENSDORP00000019550 ENSDORP00000019550 Nfatc2 Nfatc2 Tmed7 Tmed7 Nfatc3 Nfatc3 Casp3 Casp3 Nfatc4 Nfatc4 Pik3r1 Pik3r1 Atp6ap1 Atp6ap1 Stat4 Stat4 Sos2 Sos2 Nfatc1 Nfatc1 Kras Kras ENSDORP00000021143 ENSDORP00000021143 LOC106000559 LOC106000559 Tab1 Tab1 Pcna Pcna Crebbp Crebbp Nras Nras ENSDORP00000023006 ENSDORP00000023006 Smad3 Smad3 E2f3 E2f3 Trp53 Trp53 Stat3 Stat3 Mapk14 Mapk14 Hras Hras Mapk8 Mapk8 Myc Myc ENSDORP00000025725 ENSDORP00000025725 Creb3l1 Creb3l1 Tlr3 Tlr3 ENSDORP00000026425 ENSDORP00000026425 Fos Fos Akt2 Akt2 Map2k6 Map2k6 Ywhab Ywhab Akt3 Akt3 Ddx58 Ddx58 LOC105996819 LOC105996819 Grb2 Grb2 Ikbkg Ikbkg Egr2 Egr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ddb1DNA damage-binding protein 1. (1025 aa)
Stat5aSignal transducer and activator of transcription. (793 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
Egr3Early growth response protein 3 isoform X1. (387 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Ccna1cyclin-A1; Belongs to the cyclin family. (420 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Tlr4Toll-like receptor 4 isoform X2; Belongs to the Toll-like receptor family. (842 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
ENSDORP00000002235annotation not available (390 aa)
Vdac3Voltage-dependent anion-selective channel protein 3. (283 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3. (464 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
E2f2Transcription factor E2F2. (308 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
MavsMitochondrial antiviral-signaling protein. (476 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
4921507P07RikUncharacterized protein C7orf31 homolog. (560 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta. (604 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Birc5Baculoviral IAP repeat-containing protein 5. (142 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (345 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Ccna2cyclin-A2; Belongs to the cyclin family. (425 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (413 aa)
Map3k1Mitogen-activated protein kinase kinase kinase 1. (1468 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
Apaf1Apoptotic protease-activating factor 1. (1107 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Tyk2Tyrosine-protein kinase. (1053 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Ep300Histone acetyltransferase p300. (2345 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Creb3l4Cyclic AMP-responsive element-binding protein 3-like protein 4. (378 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (276 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3. (202 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Stat6Signal transducer and activator of transcription. (834 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Jak3Tyrosine-protein kinase JAK3. (999 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (725 aa)
Stat2Signal transducer and activator of transcription. (752 aa)
Hspg2Basement membrane-specific heparan sulfate proteoglycan core protein. (4318 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (596 aa)
Tbk1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Traf3TNF receptor-associated factor. (549 aa)
E2f1Transcription factor E2F1. (436 aa)
Irf7Interferon regulatory factor 7 isoform X2. (432 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Irf3Interferon regulatory factor 3. (424 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
BaxApoptosis regulator BAX. (143 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Gm10053Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (372 aa)
LOC105985511TIR domain-containing adapter molecule 2-like. (233 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
LOC106001529Mitogen-activated protein kinase kinase kinase 7-like. (538 aa)
Ddx3xATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (662 aa)
Ifih1Interferon-induced helicase C domain-containing protein 1. (1013 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Jak2Tyrosine-protein kinase. (1037 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Ywhaq14-3-3 protein theta; Belongs to the 14-3-3 family. (125 aa)
ENSDORP00000019550annotation not available (99 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (728 aa)
Tmed7Transmembrane emp24 domain-containing protein 7-like. (203 aa)
Nfatc3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1077 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
Nfatc4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (899 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Atp6ap1V-type proton ATPase subunit S1. (467 aa)
Stat4Signal transducer and activator of transcription. (748 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (690 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
ENSDORP00000021143annotation not available (105 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (460 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CrebbpCREB-binding protein. (2432 aa)
NrasGTPase NRas. (189 aa)
ENSDORP00000023006annotation not available (100 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
HrasGTPase HRas isoform X1. (192 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
ENSDORP00000025725annotation not available (105 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (524 aa)
Tlr3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (914 aa)
ENSDORP00000026425annotation not available (105 aa)
FosProto-oncogene c-Fos. (380 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
Ywhab14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Ddx58Probable ATP-dependent RNA helicase DDX58. (924 aa)
LOC10599681914-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Egr2E3 SUMO-protein ligase EGR2. (72 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (18%) [HD]