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Ifih1 Ifih1 Ikbkg Ikbkg Ddx58 Ddx58 Akt3 Akt3 Pik3r3 Pik3r3 Cd3g Cd3g Ccnd1 Ccnd1 Traf6 Traf6 Msn Msn Hspa1l Hspa1l Bax Bax Hspa8 Hspa8 Tradd Tradd Irak4 Irak4 Il2 Il2 Ccne2 Ccne2 Irf3 Irf3 Tp73 Tp73 Csnk2b Csnk2b Irf7 Irf7 Traf3 Traf3 Jak1 Jak1 Cd28 Cd28 Tbk1 Tbk1 Map3k7 Map3k7 Stat2 Stat2 Ikbke Ikbke Nfkbia Nfkbia Tlr9 Tlr9 Jak3 Jak3 Ikbkb Ikbkb Rela Rela Pik3cd Pik3cd Chuk Chuk Faslg Faslg Stat1 Stat1 Rack1 Rack1 Cblb Cblb Tyk2 Tyk2 Mapk10 Mapk10 Il1b Il1b Pik3ca Pik3ca Eif2ak2 Eif2ak2 Rab9a Rab9a Apaf1 Apaf1 Ccne1 Ccne1 Il12b Il12b Adar Adar Slamf1 Slamf1 Nfkb1 Nfkb1 Cdk4 Cdk4 Pik3cb Pik3cb Il2ra Il2ra Eif3h Eif3h Akt1 Akt1 Myd88 Myd88 Mast3 Mast3 4921507P07Rik 4921507P07Rik Cyct Cyct Bid Bid Rchy1 Rchy1 Mapk9 Mapk9 Mavs Mavs Cd3d Cd3d Cd3e Cd3e LOC105993986 LOC105993986 Tnfaip3 Tnfaip3 ENSDORP00000002235 ENSDORP00000002235 Bcl2 Bcl2 Csnk2a2 Csnk2a2 Bad Bad Nfkbib Nfkbib Tlr4 Tlr4 Eif2ak4 Eif2ak4 Cdkn1b Cdkn1b Tab2 Tab2 Stat5a Stat5a Bcl2l1 Bcl2l1 Akt2 Akt2 Fos Fos ENSDORP00000026425 ENSDORP00000026425 ENSDORP00000025725 ENSDORP00000025725 Mapk8 Mapk8 Cdk6 Cdk6 LOC105996454 LOC105996454 Stat3 Stat3 Bak1 Bak1 Eif2ak1 Eif2ak1 Trp53 Trp53 Ccnd3 Ccnd3 Gsk3b Gsk3b Eif2ak3 Eif2ak3 ENSDORP00000023006 ENSDORP00000023006 LOC105984826 LOC105984826 LOC105998778 LOC105998778 LOC106000559 LOC106000559 ENSDORP00000021272 ENSDORP00000021272 Ccnd2 Ccnd2 ENSDORP00000021143 ENSDORP00000021143 Pik3r1 Pik3r1 Casp3 Casp3 ENSDORP00000019550 ENSDORP00000019550 Hspa1b Hspa1b Csnk2a1 Csnk2a1 Il2rg Il2rg LOC106001529 LOC106001529 LOC105999841 LOC105999841 Irak1 Irak1 Il1a Il1a Hspa2 Hspa2 Gm10053 Gm10053 Cdk2 Cdk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ifih1Interferon-induced helicase C domain-containing protein 1. (1013 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Ddx58Probable ATP-dependent RNA helicase DDX58. (924 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Cd3gT-cell surface glycoprotein CD3 gamma chain. (180 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
MsnMoesin. (583 aa)
Hspa1lHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
BaxApoptosis regulator BAX. (143 aa)
Hspa8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (646 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein. (309 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
Il2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
Irf3Interferon regulatory factor 3. (424 aa)
Tp73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (638 aa)
Csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
Irf7Interferon regulatory factor 7 isoform X2. (432 aa)
Traf3TNF receptor-associated factor. (549 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Cd28T-cell-specific surface glycoprotein CD28. (219 aa)
Tbk1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (596 aa)
Stat2Signal transducer and activator of transcription. (752 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (725 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
Tlr9Toll-like receptor 9 isoform X3. (1029 aa)
Jak3Tyrosine-protein kinase JAK3. (999 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (276 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Rack1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
CblbE3 ubiquitin-protein ligase CBL-B isoform X2. (939 aa)
Tyk2Tyrosine-protein kinase. (1053 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase isoform X2. (476 aa)
Rab9aRas-related protein Rab-9A. (201 aa)
Apaf1Apoptotic protease-activating factor 1. (1107 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (413 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
AdarDouble-stranded RNA-specific adenosine deaminase isoform X4. (920 aa)
Slamf1Signaling lymphocytic activation molecule. (338 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Il2raInterleukin-2 receptor subunit alpha. (269 aa)
Eif3hEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
4921507P07RikUncharacterized protein C7orf31 homolog. (560 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
Rchy1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
MavsMitochondrial antiviral-signaling protein. (476 aa)
Cd3dT-cell surface glycoprotein CD3 delta chain. (167 aa)
Cd3eT-cell surface glycoprotein CD3 epsilon chain. (190 aa)
LOC105993986Interferon-induced GTP-binding protein Mx2-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (616 aa)
Tnfaip3Tumor necrosis factor alpha-induced protein 3. (329 aa)
ENSDORP00000002235annotation not available (390 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Csnk2a2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
NfkbibNF-kappa-B inhibitor beta. (344 aa)
Tlr4Toll-like receptor 4 isoform X2; Belongs to the Toll-like receptor family. (842 aa)
Eif2ak4Eukaryotic translation initiation factor 2-alpha kinase 4. (1599 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
Stat5aSignal transducer and activator of transcription. (793 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FosProto-oncogene c-Fos. (380 aa)
ENSDORP00000026425annotation not available (105 aa)
ENSDORP00000025725annotation not available (105 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
LOC105996454Low affinity immunoglobulin gamma Fc region receptor II-like. (311 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Eif2ak1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3. (619 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Ccnd3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1025 aa)
ENSDORP00000023006annotation not available (100 aa)
LOC105984826Guanine nucleotide-binding protein subunit beta-2-like 1 pseudogene. (259 aa)
LOC105998778CD209 antigen-like protein E isoform X1. (230 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
ENSDORP00000021272annotation not available (382 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (224 aa)
ENSDORP00000021143annotation not available (105 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
ENSDORP00000019550annotation not available (99 aa)
Hspa1bHeat shock protein family A (Hsp70) member 1B. (635 aa)
Csnk2a1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
Il2rgCytokine receptor common subunit gamma. (94 aa)
LOC106001529Mitogen-activated protein kinase kinase kinase 7-like. (538 aa)
LOC105999841Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (270 aa)
Hspa2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (634 aa)
Gm10053Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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