STRINGSTRING
Pik3cb Pik3cb Akt1 Akt1 Mast3 Mast3 Tgfb2 Tgfb2 Mapk9 Mapk9 Mtor Mtor Tgfb1 Tgfb1 E2f2 E2f2 Mapk3 Mapk3 Bad Bad Map2k1 Map2k1 Ikbkg Ikbkg Akt3 Akt3 Bcl2l1 Bcl2l1 Rad51 Rad51 Akt2 Akt2 Ralgds Ralgds Mapk8 Mapk8 Cdk6 Cdk6 LOC105987731 LOC105987731 Stat3 Stat3 Bak1 Bak1 Trp53 Trp53 E2f3 E2f3 ENSDORP00000023223 ENSDORP00000023223 Smad3 Smad3 Rala Rala LOC105989352 LOC105989352 LOC105987800 LOC105987800 Ralbp1 Ralbp1 LOC106000559 LOC106000559 Tgfa Tgfa Egf Egf Rps6kb2 Rps6kb2 Pld1 Pld1 Pik3r1 Pik3r1 Araf Araf Rb1 Rb1 Gadd45b Gadd45b Tgfbr1 Tgfbr1 Pld2 Pld2 Smad2 Smad2 Braf Braf Mapk1 Mapk1 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Raf1 Raf1 Bax Bax Tgfbr2 Tgfbr2 Erbb2 Erbb2 Rac1 Rac1 E2f1 E2f1 Jak1 Jak1 Egfr Egfr Ralb Ralb Tgfb3 Tgfb3 Ikbkb Ikbkb Rela Rela Pik3cd Pik3cd Gadd45g Gadd45g Chuk Chuk Gadd45a Gadd45a LOC106001479 LOC106001479 Stat1 Stat1 Mapk10 Mapk10 Pik3ca Pik3ca Rac2 Rac2 Smad4 Smad4 Polk Polk Ddb2 Ddb2 Nfkb1 Nfkb1 Cdk4 Cdk4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
E2f2Transcription factor E2F2. (308 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RalgdsRal guanine nucleotide dissociation stimulator isoform X2. (855 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
LOC105987731Uncharacterized protein LOC105987731. (169 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
ENSDORP00000023223annotation not available (74 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
RalaRas-related protein Ral-A. (206 aa)
LOC105989352Cell division control protein 42 homolog. (243 aa)
LOC105987800Vascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (185 aa)
Ralbp1ralA-binding protein 1. (654 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
TgfaProtransforming growth factor alpha. (156 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Pld1Phospholipase. (968 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
Pld2Phospholipase. (934 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
E2f1Transcription factor E2F1. (436 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
RalbRas-related protein Ral-B. (206 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (184 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
PolkDNA polymerase kappa isoform X1. (546 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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