STRINGSTRING
Axin2 Axin2 Egf Egf Ilk Ilk Elk1 Elk1 Map2k2 Map2k2 Map2k1 Map2k1 Bad Bad Cdh1 Cdh1 Sos1 Sos1 Mapk3 Mapk3 Mast3 Mast3 Tcf7 Tcf7 Akt1 Akt1 Pik3cb Pik3cb Lef1 Lef1 Ddb2 Ddb2 Polk Polk Pten Pten Pik3ca Pik3ca Ctnna3 Ctnna3 Ctnna1 Ctnna1 Tcf7l2 Tcf7l2 Kras-2 Kras-2 Csde1 Csde1 Gadd45a Gadd45a Pdpk1 Pdpk1 Gadd45g Gadd45g Pik3cd Pik3cd Egfr Egfr Tcf7l1 Tcf7l1 Erbb2 Erbb2 Bax Bax Raf1 Raf1 Ctnna2 Ctnna2 Ccnd1 Ccnd1 Apc Apc Pik3r3 Pik3r3 Foxo3 Foxo3 Mapk1 Mapk1 Braf Braf Apc2 Apc2 Gadd45b Gadd45b Araf Araf Pik3r1 Pik3r1 Axin1 Axin1 ENSDORP00000020585 ENSDORP00000020585 Sos2 Sos2 Grb2 Grb2 Akt3 Akt3 LOC106002396 LOC106002396 Akt2 Akt2 Myc Myc Hras Hras Bak1 Bak1 Trp53 Trp53 Mlh1 Mlh1 Gsk3b Gsk3b Nras Nras LOC106000559 LOC106000559 Kras Kras
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Axin2Axin-2. (837 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
IlkIntegrin-linked protein kinase isoform X1. (452 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Tcf7Transcription factor 7 isoform X10. (344 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Lef1Lymphoid enhancer-binding factor 1. (370 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
PolkDNA polymerase kappa isoform X1. (546 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Ctnna3Catenin alpha-3. (896 aa)
Ctnna1LOW QUALITY PROTEIN: catenin alpha-1. (896 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Tcf7l1Transcription factor 7-like 1. (524 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
BaxApoptosis regulator BAX. (143 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Ctnna2Catenin alpha-2 isoform X1. (954 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
ApcAdenomatous polyposis coli protein isoform X2. (2842 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Foxo3Forkhead box protein O3. (672 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Apc2Adenomatous polyposis coli protein 2. (2138 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Axin1Axin-1. (868 aa)
ENSDORP00000020585annotation not available (80 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
HrasGTPase HRas isoform X1. (192 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Mlh1DNA mismatch repair protein Mlh1 isoform X2. (762 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NrasGTPase NRas. (189 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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