STRINGSTRING
Shc4 Shc4 Cep152 Cep152 Prkca Prkca Calm2 Calm2 Pik3ca Pik3ca Arsi Arsi Pten Pten Polk Polk Ddb2 Ddb2 Cdk4 Cdk4 Mdm2 Mdm2 Pik3cb Pik3cb Akt1 Akt1 Camk2g Camk2g Shc3 Shc3 Igf1r Igf1r Mast3 Mast3 Camk1g Camk1g Prkcg Prkcg Mtor Mtor Shc1 Shc1 E2f2 E2f2 Pdgfa Pdgfa Mapk3 Mapk3 Sos1 Sos1 Shc2 Shc2 Map2k1 Map2k1 Map2k2 Map2k2 Egf Egf Igf1 Igf1 Akt3 Akt3 Akt2 Akt2 Hras Hras Cdk6 Cdk6 Pdgfrb Pdgfrb Insr Insr Bak1 Bak1 Trp53 Trp53 E2f3 E2f3 Nras Nras LOC106000559 LOC106000559 Tgfa Tgfa Pdgfb Pdgfb Calm3 Calm3 Kras Kras Sos2 Sos2 Camk2d Camk2d Pik3r1 Pik3r1 Pdgfra Pdgfra Araf Araf Rb1 Rb1 Gadd45b Gadd45b ENSDORP00000018543 ENSDORP00000018543 Calml4 Calml4 Camk2a Camk2a Calm1 Calm1 Braf Braf Mapk1 Mapk1 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Calml3 Calml3 Camk2b Camk2b Plcg2 Plcg2 Prkcb Prkcb Raf1 Raf1 Bax Bax E2f1 E2f1 Egfr Egfr Pik3cd Pik3cd Grb2 Grb2 Gadd45g Gadd45g Plcg1 Plcg1 Gadd45a Gadd45a Csde1 Csde1 Kras-2 Kras-2 Camk1d Camk1d Camk1 Camk1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (149 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ArsiArylsulfatase I. (573 aa)
PtenPhosphatase and tensin homolog. (396 aa)
PolkDNA polymerase kappa isoform X1. (546 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Camk2gCalcium/calmodulin-dependent protein kinase type II subunit gamma. (515 aa)
Shc3SHC-transforming protein 3. (598 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Camk1gCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (476 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
E2f2Transcription factor E2F2. (308 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (210 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Shc2SHC-transforming protein 2. (513 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HrasGTPase HRas isoform X1. (192 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
NrasGTPase NRas. (189 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
TgfaProtransforming growth factor alpha. (156 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
Calm3Calmodulin 3. (149 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (533 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
ENSDORP00000018543annotation not available (129 aa)
Calml4Calmodulin-like protein 4 isoform X1. (153 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (488 aa)
Calm1Calmodulin 1. (149 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
Plcg2Phosphoinositide phospholipase C. (1065 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
E2f1Transcription factor E2F1. (436 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Camk1dCalcium/calmodulin-dependent protein kinase type 1D. (375 aa)
Camk1Calcium/calmodulin-dependent protein kinase type 1 isoform X2; Belongs to the protein kinase superfamily. (370 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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