STRINGSTRING
LOC105989276 LOC105989276 Bad Bad Il1r2 Il1r2 Map2k1 Map2k1 Map2k2 Map2k2 Cdkn1b Cdkn1b Egf Egf Igf1 Igf1 Plat Plat Ikbkg Ikbkg Grb2 Grb2 Akt3 Akt3 LOC106002396 LOC106002396 Gstp3 Gstp3 Akt2 Akt2 Creb3l1 Creb3l1 Hras Hras Pdgfrb Pdgfrb Insr Insr Fgfr1 Fgfr1 Trp53 Trp53 E2f3 E2f3 Gsk3b Gsk3b Etv5 Etv5 Nras Nras Crebbp Crebbp Erg Erg LOC106000559 LOC106000559 Ar Ar Tgfa Tgfa Pdgfb Pdgfb Kras Kras Sos2 Sos2 ENSDORP00000020585 ENSDORP00000020585 Pik3r1 Pik3r1 Zeb1 Zeb1 Pdgfra Pdgfra Plau Plau Araf Araf Rb1 Rb1 Nkx3-1 Nkx3-1 ENSDORP00000018543 ENSDORP00000018543 Creb3 Creb3 Braf Braf Mapk1 Mapk1 Fgfr2 Fgfr2 Cdk2 Cdk2 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Raf1 Raf1 Foxo1 Foxo1 Mmp3 Mmp3 Mmp10 Mmp10 Ccne2 Ccne2 Erbb2 Erbb2 E2f1 E2f1 Tcf7l1 Tcf7l1 Egfr Egfr Nfkbia Nfkbia Ikbkb Ikbkb Rela Rela Creb1 Creb1 Pik3cd Pik3cd Chuk Chuk Pdpk1 Pdpk1 Creb3l4 Creb3l4 Csde1 Csde1 Kras-2 Kras-2 Tcf7l2 Tcf7l2 Srd5a2 Srd5a2 Hsp90ab1 Hsp90ab1 Creb5 Creb5 Pdgfc Pdgfc Ep300 Ep300 Ar-2 Ar-2 Pik3ca Pik3ca Pten Pten Ccne1 Ccne1 Lef1 Lef1 Insrr Insrr Nfkb1 Nfkb1 Mdm2 Mdm2 Pik3cb Pik3cb Akt1 Akt1 Hsp90aa1 Hsp90aa1 Hsp90b1 Hsp90b1 Tcf7 Tcf7 Atf4 Atf4 Igf1r Igf1r Mast3 Mast3 Mtor Mtor Nkx2-3 Nkx2-3 E2f2 E2f2 Pdgfa Pdgfa Mapk3 Mapk3 Tmprss2 Tmprss2 Creb3l3 Creb3l3 Creb3l2 Creb3l2 Sos1 Sos1 Bcl2 Bcl2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105989276Glutathione S-transferase P; Belongs to the GST superfamily. (210 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Il1r2Interleukin-1 receptor type 2 isoform X1. (390 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
PlatPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
IkbkgNF-kappa-B essential modulator isoform X3. (410 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Gstp3Glutathione S-transferase P-like. (209 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (524 aa)
HrasGTPase HRas isoform X1. (192 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Etv5ETS translocation variant 5. (510 aa)
NrasGTPase NRas. (189 aa)
CrebbpCREB-binding protein. (2432 aa)
ErgTranscriptional regulator ERG isoform X1. (473 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
ArAndrogen receptor. (397 aa)
TgfaProtransforming growth factor alpha. (156 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
ENSDORP00000020585annotation not available (80 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Zeb1Zinc finger E-box-binding homeobox 1 isoform X2. (1105 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PlauUrokinase-type plasminogen activator. (425 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Nkx3-1Homeobox protein Nkx-3.1. (138 aa)
ENSDORP00000018543annotation not available (129 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (372 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Foxo1Forkhead box protein O1. (537 aa)
Mmp3Stromelysin-1-like. (474 aa)
Mmp10Stromelysin-2. (479 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
E2f1Transcription factor E2F1. (436 aa)
Tcf7l1Transcription factor 7-like 1. (524 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
NfkbiaNF-kappa-B inhibitor alpha. (224 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
RelaTranscription factor p65 isoform X1. (236 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Creb3l4Cyclic AMP-responsive element-binding protein 3-like protein 4. (378 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
Srd5a23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
Hsp90ab1Heat shock protein HSP 90-beta. (723 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
PdgfcPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
Ep300Histone acetyltransferase p300. (2345 aa)
Ar-2Androgen receptor. (495 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (413 aa)
Lef1Lymphoid enhancer-binding factor 1. (370 aa)
InsrrTyrosine-protein kinase receptor. (1300 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Hsp90aa1Heat shock protein HSP 90-alpha. (733 aa)
Hsp90b1Endoplasmin. (804 aa)
Tcf7Transcription factor 7 isoform X10. (344 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (345 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Nkx2-3LOW QUALITY PROTEIN: homeobox protein Nkx-2.3. (363 aa)
E2f2Transcription factor E2F2. (308 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (210 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Tmprss2Transmembrane protease serine 2 isoform X1; Belongs to the peptidase S1 family. (490 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3. (464 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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