STRINGSTRING
ENSDORP00000018543 ENSDORP00000018543 Fgf16 Fgf16 Akt3 Akt3 Fgf4 Fgf4 Akt2 Akt2 Hras Hras Cdk6 Cdk6 Pdgfrb Pdgfrb Fgf8 Fgf8 Insr Insr Bak1 Bak1 Fgfr1 Fgfr1 Trp53 Trp53 E2f3 E2f3 Nras Nras Fgf18 Fgf18 LOC106000559 LOC106000559 Fgf9 Fgf9 Pdgfb Pdgfb Kras Kras Pik3r1 Pik3r1 Pdgfra Pdgfra Met Met Araf Araf Rb1 Rb1 Gadd45b Gadd45b Hgf Hgf Fgf2 Fgf2 Fgf6 Fgf6 Fgf1 Fgf1 Fgf7 Fgf7 Braf Braf Mapk1 Mapk1 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Raf1 Raf1 Bax Bax Igf1 Igf1 Egf Egf Fgf21 Fgf21 Map2k2 Map2k2 Map2k1 Map2k1 Bad Bad Cdh1 Cdh1 Mitf Mitf Mapk3 Mapk3 Pdgfa Pdgfa E2f2 E2f2 Fgf22 Fgf22 Mast3 Mast3 Igf1r Igf1r Akt1 Akt1 Pik3cb Pik3cb Fgf20 Fgf20 Mdm2 Mdm2 Cdk4 Cdk4 Fgf10 Fgf10 Ddb2 Ddb2 Polk Polk Pten Pten Pik3ca Pik3ca Pdgfc Pdgfc Kras-2 Kras-2 Csde1 Csde1 Galk2 Galk2 Gadd45a Gadd45a Gadd45g Gadd45g Fgf17 Fgf17 Pik3cd Pik3cd Egfr Egfr Fgf5 Fgf5 E2f1 E2f1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSDORP00000018543annotation not available (129 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HrasGTPase HRas isoform X1. (192 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
NrasGTPase NRas. (189 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MetHepatocyte growth factor receptor. (1382 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
MitfMicrophthalmia-associated transcription factor isoform X1. (526 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (210 aa)
E2f2Transcription factor E2F2. (308 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
PolkDNA polymerase kappa isoform X1. (546 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PdgfcPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Galk2N-acetylgalactosamine kinase. (392 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
E2f1Transcription factor E2F1. (436 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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