STRINGSTRING
Shc1 Shc1 Smarcd1 Smarcd1 Tgfb1 Tgfb1 E2f2 E2f2 Mapk3 Mapk3 Lrp6 Lrp6 Smarcb1 Smarcb1 Smarca4 Smarca4 Arid1a Arid1a Sos1 Sos1 Actl6b Actl6b LOC105997419 LOC105997419 LOC105989276 LOC105989276 Bad Bad Shc2 Shc2 Map2k1 Map2k1 Map2k2 Map2k2 Smarcc2 Smarcc2 Elk1 Elk1 Nqo1 Nqo1 Wnt8b Wnt8b Gstm3 Gstm3 Smarcc1 Smarcc1 ENSDORP00000025740 ENSDORP00000025740 Myc Myc LOC105997442 LOC105997442 Dpf1 Dpf1 Akt2 Akt2 Gstp3 Gstp3 LOC106002396 LOC106002396 Actl11 Actl11 Bcl2l1 Bcl2l1 Akt3 Akt3 Grb2 Grb2 Txnrd2 Txnrd2 Hras Hras Arid1b Arid1b Mgst1 Mgst1 Cdk6 Cdk6 Fzd3 Fzd3 Insr Insr Bak1 Bak1 Wnt7b Wnt7b Trp53 Trp53 E2f3 E2f3 LOC105997857 LOC105997857 Gsk3b Gsk3b ENSDORP00000023223 ENSDORP00000023223 Smad3 Smad3 Fzd4 Fzd4 LOC105997443 LOC105997443 Frat2 Frat2 Nras Nras Wnt5a Wnt5a Actb Actb Nfe2l2 Nfe2l2 LOC106000559 LOC106000559 Tgfa Tgfa Axin2 Axin2 Gsta4 Gsta4 Txnrd1 Txnrd1 ENSDORP00000021275 ENSDORP00000021275 Kras Kras Rps6kb2 Rps6kb2 Sos2 Sos2 Fzd2 Fzd2 Igf2 Igf2 LOC105993205 LOC105993205 ENSDORP00000020585 ENSDORP00000020585 Gstt4 Gstt4 Axin1 Axin1 Pik3r1 Pik3r1 Wnt7a Wnt7a Fzd9 Fzd9 Met Met Gstt3 Gstt3 LOC105987815 LOC105987815 Araf Araf Rb1 Rb1 Gadd45b Gadd45b Hgf Hgf LOC105997437 LOC105997437 Wnt2b Wnt2b Tgfbr1 Tgfbr1 Fzd8 Fzd8 Gstm7 Gstm7 Smad2 Smad2 Apc2 Apc2 Lrp5 Lrp5 Pbrm1 Pbrm1 Braf Braf Wnt3 Wnt3 Mapk1 Mapk1 Fzd5 Fzd5 Txnrd3 Txnrd3 Pik3r3 Pik3r3 Apc Apc Ccnd1 Ccnd1 Wnt4 Wnt4 Wnt2 Wnt2 Plcg2 Plcg2 Smarce1 Smarce1 Prkcb Prkcb Gab1 Gab1 Raf1 Raf1 Bax Bax Tgfbr2 Tgfbr2 Smarca2 Smarca2 Wnt16 Wnt16 LOC105987814 LOC105987814 LOC105997418 LOC105997418 Fzd7 Fzd7 Hmox1 Hmox1 E2f1 E2f1 Tcf7l1 Tcf7l1 Keap1 Keap1 Phf10 Phf10 Egfr Egfr Tgfb3 Tgfb3 Smarcd3 Smarcd3 Pik3cd Pik3cd Arid2 Arid2 Gadd45g Gadd45g Plcg1 Plcg1 Csnk1a1 Csnk1a1 Gadd45a Gadd45a Csde1 Csde1 LOC106001479 LOC106001479 Kras-2 Kras-2 Tcf7l2 Tcf7l2 Shc4 Shc4 Cep152 Cep152 Brd7 Brd7 LOC105997438 LOC105997438 Wnt10b Wnt10b Prkca Prkca Pik3ca Pik3ca Mgst2 Mgst2 Smad4 Smad4 Gsto2 Gsto2 Gsto1 Gsto1 Pten Pten Actl7a Actl7a Actl7b Actl7b Dpf3 Dpf3 Polk Polk Ddb2 Ddb2 Wnt1 Wnt1 Lef1 Lef1 Actl6a Actl6a Wnt8a Wnt8a Cdk4 Cdk4 Gstt1 Gstt1 Wnt9b Wnt9b Pik3cb Pik3cb Fzd1 Fzd1 Akt1 Akt1 Wnt11 Wnt11 Wnt10a Wnt10a Wnt6 Wnt6 Fzd6 Fzd6 Shc3 Shc3 Wnt9a Wnt9a Mgst3 Mgst3 Dvl2 Dvl2 Tcf7 Tcf7 Dvl3 Dvl3 Igf1r Igf1r Mast3 Mast3 Smarcd2 Smarcd2 Tgfb2 Tgfb2 Prkcg Prkcg Actrt2 Actrt2 Mtor Mtor LOC106002055 LOC106002055
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
E2f2Transcription factor E2F2. (308 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (1602 aa)
Smarcb1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
Smarca4Transcription activator BRG1. (1513 aa)
Arid1aAT-rich interactive domain-containing protein 1A isoform X2. (1862 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Actl6bActin-like protein 6B; Belongs to the actin family. (426 aa)
LOC105997419Glutathione S-transferase. (189 aa)
LOC105989276Glutathione S-transferase P; Belongs to the GST superfamily. (210 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Shc2SHC-transforming protein 2. (513 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Smarcc2SWI/SNF complex subunit SMARCC2. (1178 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (277 aa)
Wnt8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Gstm3Glutathione S-transferase Mu 3; Belongs to the GST superfamily. (226 aa)
Smarcc1SWI/SNF complex subunit SMARCC1. (1061 aa)
ENSDORP00000025740annotation not available (331 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
LOC105997442Glutathione S-transferase. (218 aa)
Dpf1Zinc finger protein neuro-d4 isoform X1. (396 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Gstp3Glutathione S-transferase P-like. (209 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Actl11Uncharacterized protein LOC105994564; Belongs to the actin family. (1215 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Txnrd2Thioredoxin reductase 2, mitochondrial isoform X1. (531 aa)
HrasGTPase HRas isoform X1. (192 aa)
Arid1bAT-rich interactive domain-containing protein 1B. (1934 aa)
Mgst1Microsomal glutathione S-transferase 1. (47 aa)
Cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Fzd3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Bak1Bcl-2 homologous antagonist/killer. (211 aa)
Wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
LOC105997857Casein kinase I isoform alpha-like isoform X2; Belongs to the protein kinase superfamily. (336 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ENSDORP00000023223annotation not available (74 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Fzd4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
LOC105997443Glutathione S-transferase Mu 1-like. (148 aa)
Frat2GSK-3-binding protein FRAT2. (138 aa)
NrasGTPase NRas. (189 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ActbActin, cytoplasmic 1. (375 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (592 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
TgfaProtransforming growth factor alpha. (156 aa)
Axin2Axin-2. (837 aa)
Gsta4Glutathione S-transferase A4-like. (204 aa)
Txnrd1Thioredoxin reductase 1, cytoplasmic isoform X2. (497 aa)
ENSDORP00000021275annotation not available (206 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Fzd2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
Igf2Insulin-like growth factor II. (176 aa)
LOC105993205Casein kinase I isoform alpha isoform X5. (325 aa)
ENSDORP00000020585annotation not available (80 aa)
Gstt4Glutathione S-transferase theta-4. (216 aa)
Axin1Axin-1. (868 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
Fzd9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
MetHepatocyte growth factor receptor. (1382 aa)
Gstt3Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
LOC105987815Glutathione S-transferase A1; Belongs to the GST superfamily. (221 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
LOC105997437Glutathione S-transferase. (218 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
Fzd8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (418 aa)
Gstm7Glutathione S-transferase Mu 2; Belongs to the GST superfamily. (218 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Apc2Adenomatous polyposis coli protein 2. (2138 aa)
Lrp5Low-density lipoprotein receptor-related protein 5. (1616 aa)
Pbrm1Protein polybromo-1 isoform X1. (1704 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Txnrd3Thioredoxin reductase 3. (601 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ApcAdenomatous polyposis coli protein isoform X2. (2842 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
Plcg2Phosphoinositide phospholipase C. (1065 aa)
Smarce1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1. (394 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Smarca2Probable global transcription activator SNF2L2 isoform X1. (1589 aa)
Wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC105987814Glutathione S-transferase A3-like. (170 aa)
LOC105997418Glutathione S-transferase. (196 aa)
Fzd7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (285 aa)
E2f1Transcription factor E2F1. (436 aa)
Tcf7l1Transcription factor 7-like 1. (524 aa)
Keap1Kelch-like ECH-associated protein 1. (619 aa)
Phf10PHD finger protein 10 isoform X1. (451 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Smarcd3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (456 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Arid2AT-rich interactive domain-containing protein 2. (1725 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Csnk1a1Casein kinase I isoform alpha isoform X1. (275 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
Brd7Bromodomain-containing protein 7. (652 aa)
LOC105997438Glutathione S-transferase. (213 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Mgst2Microsomal glutathione S-transferase 2. (123 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
Gsto2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (245 aa)
Gsto1Glutathione S-transferase omega-1. (241 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Actl7aActin-like protein 7A; Belongs to the actin family. (439 aa)
Actl7bActin-like protein 7B; Belongs to the actin family. (418 aa)
Dpf3Zinc finger protein DPF3 isoform X1. (373 aa)
PolkDNA polymerase kappa isoform X1. (546 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (428 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Lef1Lymphoid enhancer-binding factor 1. (370 aa)
Actl6aActin-like protein 6A; Belongs to the actin family. (429 aa)
Wnt8aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Gstt1Glutathione S-transferase theta-1-like isoform X1; Belongs to the GST superfamily. (240 aa)
Wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Fzd1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (656 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Wnt10aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
Wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Fzd6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
Shc3SHC-transforming protein 3. (598 aa)
Wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
Mgst3Microsomal glutathione S-transferase 3. (164 aa)
Dvl2Segment polarity protein dishevelled homolog DVL-2 isoform X3. (736 aa)
Tcf7Transcription factor 7 isoform X10. (344 aa)
Dvl3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Smarcd2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
Actrt2Actin-related protein T2; Belongs to the actin family. (377 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
LOC106002055Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (160 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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