STRINGSTRING
Egfr Egfr Pfkm Pfkm Map2k2 Map2k2 Map2k1 Map2k1 Gls2 Gls2 Sirt6 Sirt6 Mapk3 Mapk3 LOC105988035 LOC105988035 Mtor Mtor Mast3 Mast3 Slc2a2 Slc2a2 Hif1a Hif1a Ntrk1 Ntrk1 Idh1 Idh1 Akt1 Akt1 Hk3 Hk3 Pik3cb Pik3cb Hk2 Hk2 Pfkl Pfkl Kit Kit Pkm Pkm Pten Pten Pik3ca Pik3ca Fgfr3 Fgfr3 Slc16a3 Slc16a3 Flt3 Flt3 Kras-2 Kras-2 Csde1 Csde1 Pdha1 Pdha1 Slc2a1 Slc2a1 Parp8 Parp8 Pik3cd Pik3cd G6pd G6pd Sco1 Sco1 Slc7a5 Slc7a5 Idh2 Idh2 Erbb2 Erbb2 Hkdc1 Hkdc1 Tnik Tnik Pfkp Pfkp Pik3r3 Pik3r3 Fgfr2 Fgfr2 Ntrk3 Ntrk3 Mapk1 Mapk1 Ldhc Ldhc Sirt3 Sirt3 Pgam2 Pgam2 LOC105995863 LOC105995863 Met Met Pdgfra Pdgfra Ldhb Ldhb Pik3r1 Pik3r1 LOC105981059 LOC105981059 Kras Kras LOC106000559 LOC106000559 LOC105993236 LOC105993236 Nras Nras Fgfr3-2 Fgfr3-2 Trp53 Trp53 Fgfr1 Fgfr1 Ret Ret Pgam1 Pgam1 Gls Gls Pdgfrb Pdgfrb Pdk1 Pdk1 Hras Hras Myc Myc Parp6 Parp6 Gck Gck Akt2 Akt2 Tigar Tigar Pdhb Pdhb Akt3 Akt3 Hk1 Hk1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EgfrReceptor protein-tyrosine kinase. (1215 aa)
PfkmATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Gls2Glutaminase liver isoform, mitochondrial. (323 aa)
Sirt6NAD-dependent protein deacetylase sirtuin-6. (328 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
LOC105988035L-lactate dehydrogenase A chain-like; Belongs to the LDH/MDH superfamily. (335 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Slc2a2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa)
Hif1aHypoxia-inducible factor 1-alpha. (246 aa)
Ntrk1Tyrosine-protein kinase receptor. (799 aa)
Idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Hk3Hexokinase-3. (894 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Hk2Hexokinase-2. (917 aa)
PfklATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (770 aa)
KitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PkmPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
Slc16a3Monocarboxylate transporter 4. (461 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
Slc2a1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
Parp8Poly [ADP-ribose] polymerase. (483 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
G6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (535 aa)
Sco1Protein SCO1 homolog, mitochondrial. (247 aa)
Slc7a5Large neutral amino acids transporter small subunit 1. (241 aa)
Idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (449 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
Hkdc1Putative hexokinase HKDC1. (896 aa)
TnikTRAF2 and NCK-interacting protein kinase. (1315 aa)
PfkpATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (793 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Ntrk3Tyrosine-protein kinase receptor. (864 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LdhcL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (329 aa)
Sirt3NAD-dependent protein deacetylase sirtuin-3, mitochondrial. (257 aa)
Pgam2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
LOC105995863Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like. (109 aa)
MetHepatocyte growth factor receptor. (1382 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LdhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC105981059Pyruvate dehydrogenase E1 component subunit beta, mitochondrial pseudogene. (319 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
LOC105993236L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
NrasGTPase NRas. (189 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
RetProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1115 aa)
Pgam1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
GlsGlutaminase kidney isoform, mitochondrial. (491 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
Pdk1Protein-serine/threonine kinase. (406 aa)
HrasGTPase HRas isoform X1. (192 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
Parp6Poly [ADP-ribose] polymerase. (630 aa)
GckPhosphotransferase. (466 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TigarFructose-2,6-bisphosphatase TIGAR. (244 aa)
PdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Hk1Hexokinase-1. (974 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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