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SCO0194 SCO0194 SCO0195 SCO0195 SCO0196 SCO0196 SCO0864 SCO0864 SCO0866 SCO0866 SCO0941 SCO0941 SCO0942 SCO0942 SCO0943 SCO0943 SCO0944 SCO0944 SCO2638 SCO2638 SCO2639 SCO2639 SCO2953 SCO2953 SCO2954 SCO2954 SCO2955 SCO2955 SCO3323 SCO3323 SCO3324 SCO3324 SCO4005 SCO4005 SCO4146 SCO4146 SCO4147 SCO4147 SCO4148 SCO4148 SCO4149 SCO4149 SCO4150 SCO4150 SCO4769 SCO4769 SCO4861 SCO4861 SCO4862 SCO4862 SCO4863 SCO4863 SCO4864 SCO4864 SCO4865 SCO4865 SCO4866 SCO4866 SCO4867 SCO4867 SCO4908 SCO4908 SCO4938 SCO4938 SCO5147 SCO5147 SCO5148 SCO5148 SCO5151 SCO5151 SCO5213 SCO5213 SCO5214 SCO5214 SCO5215 SCO5215 SCO5216 SCO5216 SCO5217 SCO5217 SCO5218 SCO5218 SCO5219 SCO5219 SCO5220 SCO5220 SCO5221 SCO5221 SCO5934 SCO5934 SCO6239 SCO6239 SCP1.161c SCP1.161c
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO0194SCJ12.06, possible sigma factor, len: 202 aa. Similar to many including: Rhodobacter sphaeroide TR:O33546 (EMBL; U11283) RpoE homologue (168 aa), fasta scores opt: 291 z-score: 373.4 E(): 1.9e-13 35.4% identity in 161 aa overlap and Streptomyces coelicolor TR:O54163 (EMBL; AL021411) putative sigma factor SC7H1.04 (200 aa), fasta scores opt: 255 z-score: 327.4 E(): 7.1e-11 33.7% identity in 184 aa overlap. Contains a PS01063 Sigma-70 factors ECF subfamily signature and a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains a possible helix-turn-helix motif [...] (202 aa)
SCO0195SCJ12.07, possible lipoprotein, len: 228 aa. Contains an N-terminal signal sequence and a PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (228 aa)
SCO0196Hypothetical protein SCJ12.08; SCJ12.08, unknown, len:134 aa. Shares a low level of similarity with Mycobacterium tuberculosis TR:O53597 (EMBL; AL021426) hypothetical 24.0 KD protein MTV028.10C (224 aa), fasta scores opt: 119 z-score: 159.2 E(): 0.1 32.8% identity in 116 aa overlap. (134 aa)
SCO0864SCM2.17c, probable ECF-family sigma factor, len: 198 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 268 z-score: 337.2 E(): 2.1e-11 34.3% identity in 181 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU (EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 517 z-score: 643.3 E(): 1.9e-28 50.8% identity in 177 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the downstream gene, [...] (198 aa)
SCO0866SCM2.19c, probable ECF-family sigma factor, len: 213 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 292 z-score: 354.1 E(): 2.4e-12 35.7% identity in 185 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU(EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 530 z-score: 636.2 E(): 4.6e-28 51.7% identity in 178 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the upstream gene, SCM [...] (213 aa)
SCO0941SCM10.29c, possible lipoprotein, len: 384 aa; weakly similar to SW:CAPA_BACAN (EMBL:M24150) Bacillus anthracis CapA protein, 411 aa; fasta scores: opt: 270 z-score: 296.6 E(): 4e-09; 24.0% identity in 338 aa overlap. Contains match correctly situated to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence. (384 aa)
SCO0942SCM10.30, possible RNA polymerase sigma factor, len: 184 aa; similar to various sigma factors, e.g. TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis, and Mycobacterium bovis RNA polymerase sigma factor SigJ, 177 aa; fasta scores: opt: 364 z-score: 454.2 E(): 6.6e-18; 42.0% identity in 174 aa overlap, to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor SigT, 236 aa; fasta scores: opt: 235 z-score: 295.6 E(): 4.5e-09; 35.4% identity in 161 aa overlap, to SW:RPSC_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC, 185 aa; fasta sco [...] (184 aa)
SCO0943Hypothetical protein SCM10.31; SCM10.31, unknown, len: 171 aa. (171 aa)
SCO0944SCM1032, possible membrane protein, len: 216 aa; similar to TR:O53799 (EMBL:AL021958) Mycobacterium tuberculosis, and Mycobacterium bovis hypothetical 25.9 kD protein MTV041.10, 250 aa; fasta scores: opt: 180 z-score: 217.2 E(): 0.0001; 34.3% identity in 216 aa overlap and to S. coelicolor StF56.17, 250 aa; fasta scores: opt: 137 z-score: 133.5 E(): 0.05; 31.2% identity in 247 aa overlap. (216 aa)
SCO2638SC8E4A.08c, putative membrane protein, len: 249 aa. Contains possible hydrophobic membrane spanning regions. (249 aa)
SCO2639SC8E4A.09c, possible RNA polymerase sigma factor, len: 208 aa; similar to TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis RNA polymerase sigma factor SigJ, 177 aa; fasta scores: opt: 221 z-score: 269.6 E(): 1.3e-07; 34.9% identity in 146 aa overlap and to SW:SIGV_BACSU (EMBL:U93874) Bacillus subtilis RNA polymerase sigma factor SigV, 166 aa; fasta scores: opt: 177 z-score: 218.8 E(): 8.9e-05; 28.2% identity in 142 aa overlap. Contains possible helix-turn-helix motif at residues 171..192 (+2.79 SD); Belongs to the sigma-70 factor family. ECF subfamily. (208 aa)
SCO2953SCE59.12c, possible membrane protein, len: 262 aa; similar to TR:CAB63193 (EMBL:AL133469) Streptomyces coelicolor putative membrane protein SCM10.32, 216 aa; fasta scores: opt: 204 z-score: 218.0 E(): 9.9e-05; 37.2% identity in 253 aa overlap. Contains possible hydrophobic membrane spanning region. (262 aa)
SCO2954SCE59.13c, probable RNA polymerase sigma factor, len: 194 aa; similar to TR:CAB63191 (EMBL:AL133469) Streptomyces coelicolor putative RNA polymerase sigma factor SCM10.30, 184 aa; fasta scores: opt: 522 z-score: 641.7 E(): 2.5e-28; 54.7% identity in 161 aa overlap and to SW:SIGY_BACSU (EMBL:D83026) Bacillus subtilis RNA polymerase sigma factor SigY, 178 aa; fasta scores: opt: 211 z-score: 266.1 E(): 2.1e-07; 27.2% identity in 169 aa overlap Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) PS01063 Sigma-70 factors ECF subfamily signature. (194 aa)
SCO2955SCE59.14c, hypothetical protein, len: 196 aa; similar to various hypothetical proteins, e.g. TR:CAB56723 (EMBL:AL121600) Streptomyces coelicolor hypothetical 22.2kD protein SCF76.03, 204 aa; fasta scores: opt: 357 z-score: 403.5 E(): 4.6e-15; 37.4% identity in 187 aa overlap. (196 aa)
SCO3323SCE68.21, probable RNA polymerase sigma factor, len: 177 aa; similar to many members of the extracytoplasmic function sigma factor family e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 237 z-score: 281.3 E(): 2.4e-08, 32.0% identity in 169 aa overlap. Similar to others from S. coelicolor e.g. TR:O54163 (EMBL:AL021411), SC7H1.04, possible sigma factor (200 aa) (30.8% identity in 172 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (177 aa)
SCO3324SCE68.22, hypothetical protein, len: 419 aa; unknown function, probable serine-rich CDS suggested by positional base preference, GC frame analysis and amino acid composition. An alternative start codon is present at codon 4. (419 aa)
SCO40052SC10A7.09, probable RNA polymerase sigma factor, len: 157 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 451 z-score: 556.7 E(): 1.7e-23; 48.7% identity in 150 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 120..141 (+3.36 SD). (157 aa)
SCO4146SCD84.13, probable ECF subfamily sigma factor, len: 180 aa; similar to TR:Q9WWP4 (EMBL:AF121850) Synechococcus sp. SigH, 199 aa; fasta scores: opt: 273 z-score: 333.6 E(): 4e-11; 37.4% identity in 163 aa overlap and to TR:O05767 (EMBL:U87307) Mycobacterium smegmatis extracytoplasmic function alternative sigma factor, SigE, 204 aa; fasta scores: opt: 261 z-score: 319.3 E(): 2.5e-10; 33.5% identity in 188 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (180 aa)
SCO4147SCD84.14, possible integral membrane protein, len: 287 aa. Contains possible hydrophobic membrane spanning regions. (287 aa)
SCO4148SCD84.15, probable ABC transport system ATP-binding protein, len: 289 aa; similar to TR:AAF23811 (EMBL:AF213822) Zymomonas mobilis ABC binding protein, 298 aa; fasta scores: opt: 607 z-score: 650.5 E(): 8.9e-29; 38.6% identity in 285 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. (289 aa)
SCO4149SCD84.16, possible ABC transport system transmembrane protein, len: 509 aa; N-terminal region similar to TR:CAB50958 (EMBL:AL096849) Streptomyces coelicolor putative ABC-transporter transmembrane protein SCI11.32, 239 aa; fasta scores: opt: 142 z-score: 168.1 E(): 0.066; 27.9% identity in 244 aa overlap. Contains possible hydrophobic membrane spanning regions in N-terminal region. (509 aa)
SCO4150SCD84.17, possible ABC transport system transmembrane protein, len: 206 aa; similar to TR:O69958 (EMBL:AL022268) Streptomyces coelicolor putative transmembrane transport protein SC4H2.03c, 411 aa; fasta scores: opt: 136 z-score: 161.5 E(): 0.16; 30.8% identity in 185 aa overlap. Contains possible hydrophobic membrane sapnning regions. (206 aa)
SCO4769SCD63.01, ECF sigma factor, len: 195 aa; identical to previously sequenced TR:O86843 (EMBL:AJ010601) Streptomyces coelicolor ECF sigma factor, 195 aa; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SCO4861Hypothetical protein SCK20.02; SCK20.02, unknown, len: 181 aa. (181 aa)
SCO4862Hypothetical protein SCK20.03; SCK20.03, unknown, len: 189 aa. (189 aa)
SCO4863Hypothetical protein SCK20.04; SCK20.04, unknown, len: 140 aa. (140 aa)
SCO4864SCK20.05, possible ECF sigma factor, len: 225 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11; 34.0% identity in 212 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.07, 220 aa; fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (225 aa)
SCO4865Hypothetical protein SCK20.06; SCK20.06, unknown, len: 306 aa. High G+C content (82.13%). (306 aa)
SCO4866SCK20.07, possible ECF sigma factor, len: 220 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11; 31.9% identity in 182 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.05, 225 aa; fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (220 aa)
SCO4867SCK20.08, possible membrane protein, len: 393 aa. Contains possible hydrophobic membrane spanning regions and 2x degenerate repeat at C-terminal region: PHHP(A/D)R. (393 aa)
SCO49082SCK8.34, probable RNA polymerase sigma factor (fragment), len: 196 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma factor SigE, 176 aa; fasta scores: opt: 377 z-score: 396.4 E(): 1.7e-14; 44.6% identity in 148 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 148..169 (+3.34 SD). (196 aa)
SCO4938SCK13.30, possible ECF-sigma factor, len: 304 aa; similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor putative RNA polymerase sigma factor SCF51.13c, 298 aa; fasta scores: opt: 1110 z-score: 1299.2 E(): 0; 58.4% identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD). (304 aa)
SCO5147SCP8.10, probable ECF-subfamily sigma factor, len: 223 aa; similar to TR:O05735 (EMBL:U87308) Mycobacterium avium extracytoplasmic function alternative sigma factor SigE, 251 aa; fasta scores: opt: 852 z-score: 1013.1 E(): 0; 62.5% identity in 216 aa overlap and to SW:CARQ_MYXXA (EMBL:X71062) Myxococcus xanthus RNA polymerase sigma factor CarQ, 174 aa; fasta scores: opt: 285 z-score: 347.6 E(): 6.8e-12; 36.5% identity in 159 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Also contains a possible helix-turn-helix motif at residues 164..185 [...] (223 aa)
SCO5148SCP8.11, possible membrane protein, len: 329 aa. Contains possible hydrophobic membrane spanning region. (329 aa)
SCO5151Hypothetical protein SCP8.14; SCP8.14, unknown, len: 248 aa. (248 aa)
SCO5213SC7E4.10c, possible integral membrane protein, len: 240 aa; similar to TR:CAB89063 (EMBL:AL353872) Streptomyces coelicolor putative integral membrane protein SC5G8.12, 322 aa; fasta scores: opt: 126 z-score: 158.5 E(): 0.23; 25.6% identity in 160 aa overlap. Contains possible hydrophobic membrane spanning regions. (240 aa)
SCO5214SC7E4.11, hypothetical protein, len: 271 aa; similar to TR:O05872 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 27.6 kD protein MTCY20B11.01c, 252 aa; fasta scores: opt: 383 z-score: 460.8 E(): 3.4e-18; 39.6% identity in 283 aa overlap; Belongs to the SOS response-associated peptidase family. (271 aa)
SCO5215SC7E4.12, hypothetical protein, len: 211 aa; similar to TR:P96267 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 21.7 kD protein MTCY22G10.18c, 209 aa; fasta scores: opt: 255 z-score: 287.1 E(): 1.6e-08; 29.8% identity in 205 aa overlap. (211 aa)
SCO5216RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-s [...] (227 aa)
SCO5217Anti-sigma factor; A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress. (105 aa)
SCO5218SC7E4.15, possible integral membrane protein, len: 441 aa; similar to TR:Q9X1H8 (EMBL:AE001797) Thermotoga maritima conserved hypothetical protein TM1467, 426 aa; fasta scores: opt: 471 z-score: 536.1 E(): 2.2e-22; 29.0% identity in 352 aa overlap. Contains possible N-terminal signal peptide sequence and possible hydrophobic membrane spanning regions. (441 aa)
SCO5219SC7E4.16, possible lipoprotein, len: 418 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site, possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions. (418 aa)
SCO5220Hypothetical protein SC7E4.17; SC7E4.17, unknown, len: 326 aa. (326 aa)
SCO5221Putative polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (216 aa)
SCO5934SC7H1.04, possible sigma factor, len: 200 aa; some similarity to sigma factors (ECF subfamily) from diverse organisms e.g. Alcaligenes eutrophus CNRH_ALCEU P37978 rna polymerase sigma factor cnrh (191 aa), fasta scores; opt: 230 z-score: 337.3 E(): 1.4e-11, 29.5% identity in 183 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)
SCO6239SCAH10.04c, possible sigma factor, len: 322 aa; similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor putative sigma factor, SCH10.04c, 294 aa; fasta scores: opt: 379 z-score: 438.7 E(): 4.6e-17; 34.7% identity in 291 aa overlap and to (EMBL:AL132707) Streptomyces coelicolor SCF51.13c, 298 aa; fasta scores: opt: 833 z-score: 802.7 E(): 0; 44.9% identity in 305 aa overlap; Belongs to the sigma-70 factor family. (322 aa)
SCP1.161cPutative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. Belongs to the sigma-70 factor family. ECF subfamily. (268 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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