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SCO3452 SCO3452 SCO3453 SCO3453 SCO3454 SCO3454 SCO3455 SCO3455 SCO3456 SCO3456 SCO3457 SCO3457 SCO3913 SCO3913 SCO3914 SCO3914 SCO3915 SCO3915 SCO3916 SCO3916 SCO5545 SCO5545 SCO5546 SCO5546 SCO5548 SCO5548 SCO5549 SCO5549 SCO5550 SCO5550 SCO5551 SCO5551 SCO5638 SCO5638 SCO5639 SCO5639 SCO5640 SCO5640 SCO5641 SCO5641 SCO5642 SCO5642 SCO5643 SCO5643 SCO5644 SCO5644 SCO5646 SCO5646 SCO5647 SCO5647 SCO5648 SCO5648 SCO5649 SCO5649 SCO5650 SCO5650 SCO5651 SCO5651 SCO5652 SCO5652 SCO5653 SCO5653 SCO5654 SCO5654 SCO5655 SCO5655 SCO5656 SCO5656 SCO5658 SCO5658 SCO5667 SCO5667 SCO5668 SCO5668 SCO5669 SCO5669 SCO5670 SCO5670 SCO5671 SCO5671 SCO5672 SCO5672 SCO5923 SCO5923 SCO5924 SCO5924 SCO5925 SCO5925 SCO5927 SCO5927 SCO5928 SCO5928
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3452SCE46.09c, probable methyltransferase, len: 359 aa; similar to TR:AAF00618 (EMBL:AF166383) Mus musculus methyltransferase, 336 aa; fasta scores: opt: 868 z-score: 1022.0 E(): 0; 44.7% identity in 320 aa overlap and to SW:GRC2_LACLA (EMBL:L14679) Lactococcus lactis probable menaquinone biosynthesis methyltransferase (EC 2.1.1.-), 252 aa; fasta scores: opt: 221 z-score: 265.2 E(): 2e-07; 38.7% identity in 111 aa overlap. Contains Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. (359 aa)
SCO3453SCE46.10c, probable ABC-transporter ATP binding protein, len: 354 aa; similar to TR:CAB49712 (EMBL:AJ248285) Pyrococcus abyssi ABC-transporter ATP binding protein, 329 aa; fasta scores opt: 708 z-score: 742.4 E(): 0; 43.9% identity in 280 aa overlap and to SW:CYSA_ECOLI (EMBL:M32101) Escherichia coli sulfate transport ATP-binding protein CysA, 365 aa; fasta scores: opt: 668 z-score: 700.3 E(): 1.2e-31; 38.6% identity in 332 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and two matches to Prosite entries PS00211 ABC transporters family signature and PS00017 [...] (354 aa)
SCO3454SCE46.11c, possible ABC-transporter membrane protein, len: 280 aa; similar to TR:Q44381 (EMBL:U60011) Agrobacterium tumefaciens inner membrane protein MotD, 273 aa; fasta scores: opt: 360 z-score: 418.0 E(): 6.1e-16; 29.3% identity in 256 aa overlap and to SW:POTC_ECOLI (EMBL:M64519) Escherichia coli spermidine/putrescine transport system permease protein PotC, 264 aa; fasta scores: opt: 309 z-score: 360.4 E(): 1e-12; 25.8% identity in 260 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and Prosite match [...] (280 aa)
SCO3455SCE46.12c, possible ABC-transporter transport protein, len: 285 aa; similar to TR:O57756 (EMBL:AP000001) Pyrococcus horikoshii 284 aa long hypothetical sugar transport membrane protein, 284 aa; fasta scores: opt: 281 z-score: 329.5 E(): 5.2e-11; 26.6% identity in 278 aa overlap and to SW:UGPA_ECOLI (EMBL:X13141) Escherichia coli SN-glycerol-3-phosphate transport system permease protein UgpA, 295 aa; fasta scores: opt: 233 z-score: 274.6 E(): 6e-08; 28.7% identity in 279 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membra [...] (285 aa)
SCO3456SCE46.13c, possible secreted protein, len: 135 aa; similar to TR:CAC41457 (EMBL:AL591782) Rhizobium meliloti conserved hypothetical protein SMC02589, 408 aa; fasta scores: opt: 927 Z-score: 1029.9 E(): 9.8e-50; 37.198% identity in 414 aa overlap. Contains possible N-terminal region signal peptide sequence. (417 aa)
SCO3457SCE46.14, possible transmembrane protein, len: 205 aa; similar to TR:P76226 (EMBL:AE000270) Escherichia coli from bases 1830199 to 1840304, 208 aa; fasta scores: opt: 402 z-score: 471.0 E(): 6.9e-19; 37.4% identity in 206 aa overlap and to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi predicted CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PgsA, 185 aa; fasta scores: opt: 216 z-score: 259.1 E(): 4.4e-07; 31.2% identity in 205 aa overlap. (205 aa)
SCO3913SCH24.35c, hypothetical protein, len: 150 aa; similar to TR:Q54244 (EMBL:D29961) Streptomyces griseus phnO-like regulator for C-P lyase (150 aa), fasta scores; opt: 797 z-score: 972.8 E(): 0, 79.3% identity in 150 aa overlap and to SW:PHNO_ECOLI (EMBL:D90227), phnO, in Escherichia coli alkylphosphonate utilization operon (144 aa) (32.2% identity in 146 aa overlap). Weakly similar to TR:O86792 (EMBL:AL031317) S.coelicolor probable acetyltransferase (177 aa) (32.7% identity in 150 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 80.70 [...] (150 aa)
SCO3914SCH24.36c, probable transcriptional regulator, len: 154 aa; weakly similar to SW:PECS_ERWCH (EMBL:X74409) PecS, Erwinia chrysanthemi regulator of pectinase, cellulase, and blue pigment production (166 aa), fasta scores; opt: 136 z-score: 183.2 E(): 0.0068, 30.5% identity in 95 aa overlap. Also similar to other putative regulatory proteins. Contains Pfam match to entry PF01047 MarR, MarR family, score 52.20, E-value 1.1e-11. (154 aa)
SCO3915SCH24.37, probable transmembrane efflux protein, len: 404 aa; similar to many e.g. TR:Q56147 (EMBL:U09991), cmlV, Streptomyces violaceus chloramphenicol efflux pump (436 aa), fasta scores; opt: 1012 z-score: 1048.2 E(): 0, 40.5% identity in 395 aa overlap. Similar to other putative efflux proteins from S.coelicolor e.g. SCE94.17c (EMBL:AL049628) possible exporter (531 aa) (26.8% identity in 395 aa overlap). Contains several hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -61.60, E-value 0.00088. (404 aa)
SCO3916SCH24.38, conserved hypothetical protein, len: 139 aa; similar to many e.g. SW:YDHY_CITFR (EMBL:U09771) Citrobacter freundii hypothetical protein (142 aa), fasta scores; opt: 257 z-score: 321.3 E(): 1.4e-10, 35.4% identity in 130 aa overlap. (139 aa)
SCO5545Hypothetical protein SC1C2.26; SC1C2.26, unknown, len: 58 aa. (58 aa)
SCO5546SC1C2.27, unknown, len: 261 aa; similar to hypothetical proteins e.g. E. coli TR:P76004 (EMBL:AE000216) O219 (219 aa), fasta scores; opt: 555 z-score: 764.8 E(): 0, 45.7% identity in 208 aa overlap and to e.g. HPCE_ECOLI 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (405 aa), fasta scores; opt: 389 z-score: 507.2 E(): 5.3e-21, 33.9% identity in 218 aa overlap. (261 aa)
SCO5548Hypothetical protein SC1C2.29; SC1C2.29, unknown, len: 131 aa; similar to M. tuberculosis hypothetical protein TR:O07205 (EMBL:Z96072) MTCY05A6.25 (142 aa), fasta scores; opt: 149 z-score: 314.1 E(): 3e-10, 34.7% identity in 121 aa overlap. (131 aa)
SCO5549SC1C2.30, probable hydrolase, len: 244 aa; similar to hypothetical proteins from many organisms and to HAD1_PSESP 2-haloalkanoic acid dehalogenase I (EC 3.8. (227 aa), fasta scores; opt: 201 z-score: 261.1 E(): 2.7e-07, 30.4% identity in 237 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 43.50, E-value 4.8e-09. (244 aa)
SCO5550SC1C2.31c, probable transcriptional regulator, len: 214 aa; N-terminus is similar to the N-terminus of members of the MerR family, e.g. MERR_THIFE mercuric resistance operon regulatory protein (122 aa), fasta scores; opt: 111 z-score: 189.7 E(): 0.0026, 30.3% identity in 66 aa overlap. Contains probable helix-turn-helix motif at aa 2-23 (1799, +5.31 SD). (214 aa)
SCO5551Hypothetical protein SC1C2.32; SC1C2.32, unknown, len: 190 aa. (190 aa)
SCO5638SC6A9.29, probable integral membrane protein, len: 295 aa; this ORF has atypically low GC bias in FramePlot. (295 aa)
SCO5639Hypothetical protein SC6A9.28; SC6A9.28, unknown, len: 176 aa; this ORF has atypically low GC bias in FramePlot. (176 aa)
SCO5640Hypothetical protein SC6A9.27; SC6A9.27, unknown, len: 155 aa; this ORF has atypically low GC bias in FramePlot. (155 aa)
SCO5641Transposase; SC6A9.26, probable transposase for IS1649, len: 318 aa; similar to many e.g. Corynebacterium striatum TR:O30997 (EMBL:AF024666) transposase TNP5564 (329 aa), fasta scores; opt: 589 z-score: 1572.9 E(): 0, 50.0% identity in 330 aa overlap. Contains probable helix-turn-helix motif at aa 26-47 (Score 1176, +3.19 SD). (318 aa)
SCO5642Hypothetical protein SC6A9.25; SC6A9.25, unknown, len: 254 aa; this ORF has atypically low GC bias in FramePlot. (254 aa)
SCO5643Hypothetical protein SC6A9.24; SC6A9.24, questionable ORF, len: 175 aa; this ORF has atypically low GC bias in FramePlot. (175 aa)
SCO5644Hypothetical protein SC6A9.23c; SC6A9.23c, unknown, len: 208 aa; this ORF has atypically low GC bias in FramePlot. (208 aa)
SCO5646SC6A9.21c, probable solute binding lipoprotein, len: 373 aa; similar to e.g. TBPA_ECOLI thiamin-binding periplasmic protein (327 aa), fasta scores; opt: 220 z-score: 423.3 E(): 2.4e-16, 28.4% identity in 327 aa overlap. Contains N-terminla signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (373 aa)
SCO5647SC6A9.20c, probable ABC transporter integral membrane protein, len: 553 aa; similar to many e.g. Y4FN_RHISN probable ABC transporter permease protein (569 aa), fasta scores; opt: 296 z-score: 555.5 E(): 1e-23, 25.4% identity in 563 aa overlap. Contains 2x Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, scores 40.70, E-value 3.2e-08 and 46.50, E-value 6.1e-10. (553 aa)
SCO5648ABC transporter ATP binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (348 aa)
SCO5649Conserved hypothetical protein; SC6A9.18c, unknown, len: 266 aa; similar to M. tuberculosis hypothetical protein TR:O07256 (EMBL:Z96800) MTCY63.37 (261 aa), fasta scores; opt: 508 z-score: 606.3 E(): 1.6e-26, 36.7% identity in 251 aa overlap. (266 aa)
SCO5650SC6A9.17, possible membrane protein, len: 234 aa. Contains possible hydrpphobic membrane spanning regions. (234 aa)
SCO5651Hypothetical protein SC6A9.16; SC6A9.16, unknown, len: 394 aa. (394 aa)
SCO5652SC6A9.15, conserved hypothetical protein, len: 135 aa; similar to TR:Q98D71 (EMBL:AP003005) hypothetical protein from Rhizobium loti (134 aa) fasta scores; opt: 401, Z-score: 482.3, E(): 3.1e-19, 46.212% identity (46.565% ungapped) in 132 aa overlap. (135 aa)
SCO5653SC6A9.14, probable integral membrane protein, len: 486 aa; contains Pro- Ala- rich central region. (486 aa)
SCO5654SC6A9.13, probable ABC transporter ATP-binding protein, len: 258 aa; similar to many e.g. YBBA_ECOLI hypothetical ABC transporter ATP-binding protein (228 aa), fasta scores; opt: 462 z-score: 578.7 E(): 5.3e-25, 40.4% identity in 198 aa overlap. Contains PS00017 ATP. (258 aa)
SCO5655SC6A9.12, probable aminotransferase, len: 457 aa; similar to many e.g. BIOA_BACSU adenosylmethionine-8-amino-7-oxononanoate aminotransferase (448 aa), fasta scores; opt: 895 z-score: 881.6 E(): 0, 35.6% identity in 449 aa overlap. Also highly similar to M. tuberculosis putative aminotransferase TR:O53379 (EMBL:AL021841) MTV016.29; 70.3% identity in 438 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate, score 355.70, E-value 3.5e-123; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SCO5656SC6A9.11, probable transcriptional regulatory protein, len: 166 aa; similar to many members of the asnC family e.g. LRP_ECOLI leucine-responsive regulatory protein (164 aa), fasta scores; opt: 190 z-score: 294.3 E(): 3.7e-09, 27.6% identity in 156 aa overlap. Contains PS00519 Bacterial regulatory proteins, asnC family signature and probable helix-turn-helix motif at aa 39-60 (Score 1545, +4.45 SD). (166 aa)
SCO5658SC6A9.09c, possible polyamine-binding lipoprotein, len: 399 aa; some similarity to several spermidine. (399 aa)
SCO5667SC8B7.11c, probable ABC-transporter polyamine-binding lipoprotein, len: 399 aa; similar to e.g. POTF_ECOLI putrescine-binding periplasmic protein precursor (370 aa), fasta scores; opt: 327 z-score: 259.5 E(): 3.4e-07, 28.5% identity in 365 aa overlap. Also similar to upstream gene SC6A9.09c (E(): 0, 46.8% identity in 391 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible N-terminal region signal sequence peptide. (399 aa)
SCO5668Putative polyamine ABC-transporter ATP-binding p rotein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (397 aa)
SCO5669SC8B7.09c, probable polyamine ABC-transporter integr al membrane protein, len: 309 aa; similar to many e.g. POTB _ECOLI spermidine/putrescine transport system permease (275 aa), fasta scores; opt: 548 z-score: 685.1 E(): 6.6e-31, 3 6.9% identity in 274 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 38.20, E-value 1.8e -07. (309 aa)
SCO5670SC8B7.08c, probable polyamine ABC-transporter integr al membrane protein, len: 266 aa; similar to many e.g. POTC _ECOLI spermidine/putrescine transport system permease (264 aa), fasta scores; opt: 579 z-score: 718.8 E(): 8.8e-33, 3 5.5% identity in 251 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 23.00, E-value 0.00 7. (266 aa)
SCO5671SC8B7.07c, possible oxidoreductase, len: 475 aa; some similarity to e.g. ORDL_ECOLI probable oxidoreductase ord L (426 aa), fasta scores; opt: 413 z-score: 280.3 E(): 2.4 e-08, 32.1% identity in 436 aa overlap. (475 aa)
SCO5672Hypothetical protein; SC8B7.06c, unknown, len: 152 aa. (152 aa)
SCO5923SC10A5.28c, ABC-transporter ATP-binding protein, len : 361 aa; similar to many eg. Streptomyces reticuli TR:P964 83 (EMBL:Y08921) MSIK PROTEIN involved in in cellobiose and maltose transport(377 aa), opt: 809 z-score: 1069.1 E(): 0, 40.4% identity in 381 aa overlap. Contains PS00017 ATP/GT P-binding site motif A (P-loop). PS00211 ABC transporters f amily signature and Pfam match to entry ABC_tran PF00005, A BC transporters, score 35.90. (361 aa)
SCO5924SC10A5.29c, probable integral membrane protein, len: 589 aa; similar to many permeases eg. TR:Q44123 (EMBL:U050 42) iron utilisation protein AFUB from Actinobacillus pleur opneumoniae (687 aa), fasta scores; opt: 564 z-score: 426.3 E(): 1.5e-16, 25.0% identity in 547 aa overlap. (589 aa)
SCO5925Hypothetical protein; SC10A5.30c, unknown, len: 83 aa. (83 aa)
SCO5927Hypothetical protein; SC10A5.32c, unknown, len: 73. (73 aa)
SCO5928Hypothetical protein; SC10A5.33c, unknown, len: 234 aa. (234 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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