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| | SCO0209 | Hypothetical protein SCJ12.21; SCJ12.21, unknown, len: 134 aa. (134 aa) |
| | SCO0436 | SCF51A.14, possible 50S ribosomal protein L32, len: 56 aa. Similar to many including: Helicobacter pylori J99 SW:RL32_HELPY (EMBL; AE000540) 50S ribosomal protein L32 (48 aa), fasta scores opt: 85 z-score: 146.1 E(): 0.89 30.2% identity in 43 aa overlap and highly similar to the N-terminus of Streptomyces coelicolor TR:Q9ZBQ8 (EMBL; AL034447) 50S ribosomal protein L32 SC7A1.15 (57 aa), fasta scores opt: 165 z-score: 258.9 E(): 4.6e-07 82.1% identity in 28 aa overlap. (56 aa) |
| | SCO0504 | SCF34.23, probable DEAD-box RNA-helicase, len: 439 aa; similar to many e.g. to TR:O64430 (EMBL:AB010259), Drh1, Arabidopsis thaliana DEAD box ATPase/RNA helicase protein (619 aa), except where the A.thaliana protein is longer at the N-terminus, fasta scores; opt: 806 z-score: 892.9 E(): 0, 35.3% identity in 447 aa overlap. Also similar to many putative RNA-helicases e.g. SW:RHLE_ECOLI (EMBL:L02123), RhlE, Escherichia coli putative ATP-dependent RNA helicase (454 aa) (36.4% identity in 451 aa overlap) and to TR:O54116 (EMBL:AL021529) Streptomyces coelicolor probable DEAD-box RNA-helicas [...] (439 aa) |
| | SCO0569 | SC5G5.01c, possible 50S ribosomal protein L36 (fragment), len: >28 aa; similar to N-terminal region of SW:RL36_RICPR (EMBL:AJ235271) Rickettsia prowazekii 50S ribosomal protein L36 RpmJ or RP456, 41 aa; fasta scores: opt: 77 Z-score: 156.1 bits: 30.6 E(): 0.44; 48.276% identity in 29 aa overlap; St8B3.03c, possible ribosomal protein L36, len: 40aa: similar to many eg. TR:Q9A383 (EMBL:AE005994) from Caulobacter crescentus (41 aa) fasta scores; opt: 164, Z-score: 272.8, 60.976% identity (62.500% ungapped) in 41 aa overlap and SW:P28528 (RK36_GUITH) from Guillardia theta (Cryptomonas phi) [...] (40 aa) |
| | SCO0570 | SC5G5.02c, rpmG2, 50S ribosomal protein L33, len: 54 aa; highly similar to SW:R331_STRCO (EMBL:AL049841) Streptomyces coelicolor 50S ribosomal protein L33 RpmG1 or SCE9.35c, 54 aa; fasta scores: opt: 294 Z-score: 436.0 bits: 83.8 E(): 1.1e-16; 81.481% identity in 54 aa overlap. Contains Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | SCO0718 | Hypothetical protein SCF42.28; SCF42.28, unknown, len: 73 aa. (73 aa) |
| | SCO0783 | 3SCF60.15, tetM, tetracycline resistance protein, len: 635 aa; identical to SW:TETM_STRLI (EMBL:M74049) Streptomyces lividans tetracycline resistance protein TetM, 639 aa. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family and PF00679 EFG_C, Elongation factor G C-terminus and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (635 aa) |
| | SCO0999 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (215 aa) |
| | SCO1150 | SCG8A.04, rpmE2, 50S ribosomal protein L31, len: 90 aa; strongly similar to many eg. SW:O34967 (YTIA_BACSU) hypothetical ribosomal protein in dps-menE intergenic region from Bacillus subtilis (82 aa) fasta scores; opt: 297, z-score: 406.7, E(): 3.3e-15, 47.6% identity in 82 aa overlap and TR:Q9X8K6 (EMBL:AL049841) 50S ribosomal protein L31 from Streptomyces coelicolor (84 aa) fasta scores; opt: 399, z-score: 539.3, E(): 1.4e-22, 67.5% identity in 83 aa overlap. Contains Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31, Prosite match to PS00030 Eukaryotic putative RNA-bi [...] (90 aa) |
| | SCO1321 | Elongation factor TU-3; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (392 aa) |
| | SCO1480 | SC9C5.04c, conserved hypothetical protein, len: 107 aa; highly similar to TR:P96802 (EMBL:U75344) Mycobacterium smegmatis integration host factor MihF, 105 aa; fasta scores: opt: 378 z-score: 470.3 E(): 1e-1; 58.1% identity in 105 aa overlap. (107 aa) |
| | SCO1490 | Putative NusB-family protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (142 aa) |
| | SCO1491 | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (188 aa) |
| | SCO1505 | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa) |
| | SCO1508 | SC9C5.32c, hisS, histidyl tRNA synthetase, len: 425 aa; similar to SW:SYH_ECOLI (EMBL:M11843) Escherichia coli histidyl tRNA synthetase (EC 6.1.1.21) HisS, 423 aa; fasta scores: opt: 1054 z-score: 1173.7 E(): 0; 42.3% identity in 421 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). (425 aa) |
| | SCO1510 | SC9C5.34, possible peptidyl-prolyl cis-trans isomerase, len: 277 aa; similar to SW:CYPB_MYCLE (EMBL:U00011) Mycobacterium leprae probable peptidyl-prolyl cis-trans isomerase PpiB or MLCB1259.10c, 295 aa; fasta scores: opt: 514 z-score: 573.6 E(): 1.8e-24; 40.0% identity in 295 aa overlap and to SW:CYPB_BACSU (EMBL:L09228) Bacillus subtilis peptidyl-prolyl cis-trans isomerase PpiB, 143 aa; fasta scores: opt: 240 z-score: 276.9 E(): 5.9e-08; 37.0% identity in 127 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Contains [...] (277 aa) |
| | SCO1528 | SCL2.18, possible elongation factor, len: 732 aa; similar to TR:O07170 (EMBL:Z96071) Mycobacterium tuberculosis FusA2, 714 aa; fasta scores: opt: 2328 z-score: 2349.0 E(): 0; 61.4% identity in 731 aa overlap, to SW:EFG (EMBL:X00415) Escherichia coli elongation factor G (EF-G) FusA, 703 aa; fasta scores: opt: 853 z-score: 862.2 E(): 0; 30.1% identity in 722 aa overlap and to SW:EFG2_STRCO (EMBL:AL031013) Streptomyces coelicolor elongation factor G 2 (EF-G 2), FusB, 686 aa; fasta scores: opt: 937 z-score: 947.0 E(): 0; 35.5% identity in 710 aa overlap. Contains Pfam matches to entries PF [...] (732 aa) |
| | SCO1531 | threonine-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (658 aa) |
| | SCO1594 | SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding. (840 aa) |
| | SCO1595 | SCI35.17c, pheS, probable phenylalanyl-tRNA synthetase alpha chain, len: 373 aa; similar to many e.g. SYFA_ECOLI phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) (327 aa), fasta scores; opt: 682 z-score: 1248.8 E(): 0, 43.1% identity in 343 aa overlap. Contains PS00179 and PS00339 Aminoacyl-transfer RNA synthetases class-II signatures 1 and 2. (373 aa) |
| | SCO1598 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (127 aa) |
| | SCO1599 | SCI35.21c, rpmI, 50S ribosomal protein L35, len: 64 aa; similar to many e.g. RL35_BACSU 50S ribosomal protein L35 (65 aa), fasta scores; opt: 179 z-score: 355.6 E(): 1.5e-12, 45.9% identity in 61 aa overlap; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | SCO1600 | Putative translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (217 aa) |
| | SCO1794 | SCI5.02, conserved hypothetical protein, len: 179 aa; similar to many eg. TR:O06235 (EMBL:Z95388) hypothetical protein from Mycobacterium tuberculosis (176 aa) fasta scores; opt: 581, z-score: 658.0, E(): 2.6e-29, (52.9% identity in 172 aa overlap); Belongs to the UPF0098 family. (179 aa) |
| | SCO1818 | tyrosyl-tRNA synthetase (EC 6.1.1.1); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa) |
| | SCO1998 | SC7H2.12c, rpsA, 30S ribosomal protein S1, len: 502aa; similar to many eg. SW:RS1_ECOLI rpsA, 30S ribosomal protein S1 from Escherichia coli (557 aa) fasta scores; opt: 1016, z-score: 1019.6, E(): 0, (39.8% identity in 452 aa overlap). Also similar to TR:O06147 (EMBL:Z95554) 30S ribosomal protein S1 from Mycobacterium tuberculosis (481 aa) fasta scores; opt: 2420, z-score: 2422.2, E(): 0, (79.1% identity in 492 aa overlap). Contains four Pfam matches to entry PF00575 S1, S1 RNA binding domain. Also contains possible coiled-coil region around 400-410aa. (502 aa) |
| | SCO2000 | SC7H2.14, possible ATP-binding RNA helicase, len: 998 aa; similar to many proposed helicases eg. SW:HRPB_ECOLI ATP-dependent helicase from Escherichia coli (809 aa) fasta scores; opt: 889, z-score: 783.0, E(): 0, (33.6% identity in 998 aa overlap). Contains a repeat region which does not appear in homologues: 8 x GDDRR(R/G)QRATVES. Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00037 Myb DNA-binding domain repeat signature 1. (998 aa) |
| | SCO2002 | Hypothetical protein; SC7H2.16c, unknown, len: 118aa. (118 aa) |
| | SCO2073 | Putative ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (314 aa) |
| | SCO2076 | Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1047 aa) |
| | SCO2211 | Hypothetical protein SC10B7.06; SC10B7.06, unknown, len: 309 aa. (309 aa) |
| | SCO2362 | Hypothetical protein; SCC8A.20c, unknown, len: 839 aa; regions similar to others of undefined function e.g. TR:AAF11767 (EMBL:AE002054) hypothetical protein from Deinococcus radiodurans (353 aa) fasta scores; opt: 463, z-score: 489.2, E(): 8.7e-20, 40.3% identity in 355 aa overlap. (839 aa) |
| | SCO2562 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (622 aa) |
| | SCO2563 | 30s ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa) |
| | SCO2571 | SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). (966 aa) |
| | SCO2577 | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (148 aa) |
| | SCO2595 | GTP-binding protein; Plays an unknown essential role and a regulatory role in sporulation. Overexpression suppresses sporulation although cell growth rate was not reduced. Impaired differentiation was eliminated by addition of decoyinine, an inhibitor of GMP synthesis. Overexpression has no effect on undecylprodigiosin production, but decreases actinorhodin production. (478 aa) |
| | SCO2596 | SCC88.07c, rpmA, 50S ribosomal protein L27, len: 84 aa; identical to SW:RL27_STRGR (EMBL:D87916) Streptomyces griseus 50S ribosomal protein L27 RpmA, 85 aa. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 proteinand match to Prosite entry PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family. (84 aa) |
| | SCO2597 | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (106 aa) |
| | SCO2615 | Valyl tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (874 aa) |
| | SCO2620 | Putative cell division trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (468 aa) |
| | SCO2633 | Superoxide dismutase [Fe-Zn] (EC 1.15.1.1); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (213 aa) |
| | SCO2966 | Small protein B homologue; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switch [...] (159 aa) |
| | SCO2972 | Chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (368 aa) |
| | SCO3009 | Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (254 aa) |
| | SCO3124 | Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (198 aa) |
| | SCO3125 | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (200 aa) |
| | SCO3304 | SCE68.02, argS, probable arginyl-tRNA synthetase, len: 586 aa; similar to many e.g. SW:SYR_ECOLI (EMBL:X15320), argS, Escherichia coli arginyl-tRNA synthetase (577 aa), fasta scores; opt: 1415 z-score: 1562.9 E(): 0, 43.8% identity in 587 aa overlap. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R) and PS00178 Aminoacyl-transfer RNA synthetases class-I signature. (586 aa) |
| | SCO3334 | Tryptophanyl tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (336 aa) |
| | SCO3409 | Putative inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (163 aa) |
| | SCO3425 | Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa) |
| | SCO3427 | SCE9.34c, rpmE, probable 50S ribosomal protein L31, len: 84 aa; similar to many e.g. SW:RK31_GUITH (EMBL:U81044) Guillardia theta chloroplast 50S ribosomal protein L31 (72 aa), fasta scores; opt: 149 z-score: 220.0 E(): 6.2e-05, 48.8% identity in 43 aa overlap. Contains Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31, score 59.20, E-value 8.7e-14 and PS01143 Ribosomal protein L31 signature. (84 aa) |
| | SCO3428 | SCE9.35c, rpmG, probable 50S ribosomal protein L33, len: 54 aa; similar to many e.g. SW:RL33_ECOLI (EMBL:J01677), rpmG, Escherichia coli 50S ribosomal protein L33 (54 aa), fasta scores; opt: 162 z-score: 270.5 E(): 9.5e-08, 46.9% identity in 49 aa overlap. Contains Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 37.80, E-value 2e-08; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | SCO3429 | SCE9.36, rpmB, probable 50S ribosomal protein L28, len: 73 aa; similar to many e.g. SW:RL28_ECOLI (EMBL:J01677), rpmB, Escherichia coli 50S ribosomal protein L28 (77 aa), fasta scores; opt: 235 z-score: 344.6 E(): 7.1e-12, 47.8% identity in 69 aa overlap. Contains Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 88.70, E-value 1.2e-22; Belongs to the bacterial ribosomal protein bL28 family. (73 aa) |
| | SCO3430 | Putative 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | SCO3676 | SCH35.48c, possible integral membrane protein, len: 350aa; Contains possible membrane spanning hydrophobic regions in the C-terminal half and a hydrophobic N-terminal half. (350 aa) |
| | SCO3732 | SCH22A.10, probable DEAD-box RNA helicase, len: 528 aa; similar to TR:O54116 (EMBL:AL021529) Streptomyces coelicolor DEAD-box RNA helicase SC10A5.25c, 498 aa; fasta scores: opt: 2348 z-score: 2252.6 E(): 0; 74.9% identity in 506 aa overlap and to SW:RHLE_ECOLI (EMBL:L02123) Escherichia coli putative ATP-dependent RNA helicase RhlE, 454 aa; fasta scores: opt: 874 z-score: 843.8 E(): 0; 36.6% identity in 470 aa overlap. Contains two Pfam matches to entries PF00270 DEAD, DEAD/DEAH box helicase and PF00271 helicase_C, Helicases conserved C-terminal domain, and two matches to Prosite entry [...] (528 aa) |
| | SCO3778 | SCH63.25, possible threonyl tRNA synthetase, len: 430 aa; highly similar to C-terminal region of many threonyl tRNA synthetases, e.g. SW:SYT1_BACSU (EMBL:M36594) Bacillus subtilis threonyl tRNA synthetase 1 (EC 6.1.1.3) ThrS, 643 aa; fasta scores: opt: 1274 z-score: 1489.5 E(): 0; 50.9% identity in 379 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). (430 aa) |
| | SCO3792 | Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (538 aa) |
| | SCO3795 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (587 aa) |
| | SCO3856 | Putative peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa) |
| | SCO3857 | SCH69.27, possible regulatory protein, len: 232aa; similar to SW:NHSR_STRAS proposed regulator of the nosiheptide-resistance genes from Streptomyces actuosus (233 aa) fasta scores; opt: 1231, z-score: 1330.5, E(): 0, (83.2% identity in 226 aa overlap). (232 aa) |
| | SCO3906 | Putative 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa) |
| | SCO3908 | Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa) |
| | SCO3909 | 50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa) |
| | SCO3961 | seryl-tRNA synthase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | SCO4018 | 2SC10A7.22c, conserved hypothetical protein, len: 177 aa; highly similar to SW:YL40_MYCTU (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 18.6 kDa protein MTCY270.28, 176 aa; fasta scores: opt: 672 z-score: 724.7 E(): 7.4e-33; 57.7% identity in 175 aa overlap. Contains Pfam match to entry PF01161 PBP, Phosphatidylethanolamine-binding protein. (177 aa) |
| | SCO4092 | SCD25.28c, ATP-dependent helicase, len: 1327 aa. Highly similar to Escherichia coli SW:HRPA_ECOLI (EMBL; D42105) ATP-dependent helicase (1281 aa), fasta scores opt: 1818 z-score: 1967.4 E(): 0 61.9% identity in 1306 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). (1327 aa) |
| | SCO4096 | SCD25.32, ATP-dependent RNA helicase, 839 aa. Highly similar to many including: Streptomyces coelicolor TR:O54116 (EMBL; AL021529) DEAD-box RNA helicase SC10A5.25C (498 aa), fasta scores opt: 1467 z-score: 1347.1 E(): 0 50.0% identity in 486 aa overlap. Contains Pfam matches to entry PF00270 DEAD, DEAD/DEAH box helicase and Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, as well as a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a degenerate direct repeat region: containing several different repeats: 6.5x RRDDRGDRGGRSF(D/E) 2 [...] (740 aa) |
| | SCO4235 | SCD8A.08, probable cysteinyl-tRNA synthetase, len: 613 aa; C-terminal region highly similar to SW:SYC_ECOLI (EMBL:X56234) Escherichia coli cysteinyl-tRNA synthetase (EC 6.1.1.16) CysS, 461 aa; fasta scores: opt: 1267 z-score: 1248.2 E(): 0; 43.7% identity in 469 aa overlap. Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C) and a N-terminal region degenerate 6x repeat; Belongs to the class-I aminoacyl-tRNA synthetase family. (613 aa) |
| | SCO4236 | SCD8A.09, possible tRNA/rRNA methyltransferase, len: 314 aa; similar to TR:P96861 (EMBL:Z92774) Mycobacterium tuberculosis hypothetical 34.0 kD protein MTCY06G11.26c, 322 aa; fasta scores: opt: 937 z-score: 1001.6 E(): 0; 56.7% identity in 319 aa overlap and to SW:YJFH_ECOLI (EMBL:U14003) Escherichia coli hypothetical tRNA/rRNA methyltransferase YjfH (EC 2.1.1.-), 243 aa; fasta scores: opt: 519 z-score: 560.7 E(): 8.5e-24; 38.6% identity in 249 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; Belongs to the class IV-like SAM-binding methyltra [...] (314 aa) |
| | SCO4278 | SCD95A.11, hypothetical protein, len: 145 aa; similar to SW:YAEJ_ECOLI (EMBL:L38619) Escherichia coli hypothetical 15.6 kD protein in MesJ-CutF intergenic region (ORF140) YaeJ, 140 aa; fasta scores: opt: 338 z-score: 405.8 E(): 3.8e-15; 45.7% identity in 138 aa overlap. Contains Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain and match to Prosite entry PS00745 Prokaryotic-type class I peptide chain release factors signature. (145 aa) |
| | SCO4489 | SCD69.09c, putative membrane protein, len: 100 aa. Contains possible hydrophobic membrane spanning regions. (100 aa) |
| | SCO4560 | Putative polypetide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). (208 aa) |
| | SCO4635 | SCD82.06, rpmG3, 50S ribosomal protein L33, len: 54 aa; highly similar to SW:R331_BACSU (EMBL:D84432) Bacillus subtilis 50S ribosomal protein L33 type 1, RpmG1, 49 aa; fasta scores: opt: 235 z-score: 376.8 E(): 1.4e-13; 65.3% identity in 49 aa overlap. Contains Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | SCO4647 | Transcription antitermination protein; Participates in transcription elongation, termination and antitermination. (300 aa) |
| | SCO4648 | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa) |
| | SCO4649 | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (241 aa) |
| | SCO4652 | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (176 aa) |
| | SCO4653 | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa) |
| | SCO4654 | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1161 aa) |
| | SCO4659 | 30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS12 family. (123 aa) |
| | SCO4660 | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | SCO4661 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (708 aa) |
| | SCO4662 | Elongation factor TU-1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa) |
| | SCO4701 | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | SCO4702 | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (214 aa) |
| | SCO4703 | 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (219 aa) |
| | SCO4704 | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (139 aa) |
| | SCO4705 | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa) |
| | SCO4706 | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | SCO4707 | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (125 aa) |
| | SCO4708 | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (277 aa) |
| | SCO4709 | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa) |
| | SCO4710 | SCD31.35, rpmC, 50S ribosomal protein L29, len: 74 aa; highly similar to SW:RL29_BACST (PIR:A02825) Bacillus stearothermophilus 50S ribosomal protein L29 RpmC, 66 aa; fasta scores: opt: 244 z-score: 361.6 E(): 1e-12; 63.9% identity in 61 aa overlap. Contains Pfam match to entry PF00831 Ribosomal_L29, Ribosomal L29 protein and match to Prosite entry PS00323 Ribosomal protein S19 signature. (74 aa) |
| | SCO4711 | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (95 aa) |
| | SCO4712 | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | SCO4713 | 50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (107 aa) |
| | SCO4714 | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa) |
| | SCO4715 | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | SCO4716 | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | SCO4717 | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa) |
| | SCO4718 | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (127 aa) |
| | SCO4719 | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (201 aa) |
| | SCO4720 | SCD31.45, rpmD, 50S ribosomal protein L30, len: 60 aa; identical to previously sequenced SW:RL30_STRCO (EMBL:X83011) Streptomyces coelicolor 50S ribosomal protein L30 RpmD, 60 aa. Contains Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e and match to Prosite entry PS00634 Ribosomal protein L30 signature. (60 aa) |
| | SCO4721 | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (151 aa) |
| | SCO4725 | Translational initiation factor IF1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa) |
| | SCO4726 | SC6G4.04, rpmJ, 50S ribosomal protein L36, len: 37 aa; highly similar to many e.g. RL36_BACST 50S ribosomal protein L36 (37 aa), fasta scores; opt: 225 z-score: 380.1 E() : 6.6e-14, 78.4% identity in 37 aa overlap. Contains PS0082 8 Ribosomal protein L36 signature and Pfam match to entry PF00444 L36, Ribosomal protein L36, score 70.40, E-value 3.1 e-22; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | SCO4727 | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa) |
| | SCO4728 | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa) |
| | SCO4729 | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa) |
| | SCO4730 | SC6G4.08, rplQ, 50S ribosomal protein L17, len: 168 aa; highly similar to many e.g. RL17_BACST 50S ribosomal protein L17 (119 aa), fasta scores; opt: 339 z-score: 597.2 E (): 5.3e-26, 47.4% identity in 116 aa overlap. Contains approx 50 aa C-terminal extension, not present in other RplQ. (168 aa) |
| | SCO4734 | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | SCO4735 | SC6G4.13, rpsI, 30S ribosomal protein S9, len: 170 a a; identical to RS9_STRCO 30S ribosomal protein S9 (170 aa) and highly similar to many e.g.RS9_ECOLI (129 aa), fasta s cores; opt: 408 z-score: 663.5 E(): 1.1e-29, 49.2% identity in 124 aa overlap. Contains PS00360 Ribosomal protein S9 s ignature and Pfam match to entry PF00380 S9, Ribosomal prot ein S9, score 162.60, E-value 1e-49; Belongs to the universal ribosomal protein uS9 family. (170 aa) |
| | SCO4839 | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (339 aa) |
| | SCO4965 | Putative transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (165 aa) |
| | SCO4980 | Hypothetical protein 2SCK36.03c; 2SCK36.03c, unknown, len: 316 aa. (316 aa) |
| | SCO5061 | Putative ATP/GTP binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (362 aa) |
| | SCO5111 | SCBAC31E11.07, possible GTP-binding protein, len: 635 aa; similar to SW:TYPA_ECOLI (EMBL:L19201) Escherichia coli GTP-binding protein TypA/BipA (tyrosine phosphorylated protein A) TypA or BipA or B3871, 591 aa; fasta scores: opt: 915 Z-score: 968.6 bits: 189.3 E(): 2.5e-46; 48.039% identity in 612 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature. (635 aa) |
| | SCO5352 | SCBAC5H2.21, possible arginyl tRNA synthetase, len: 347 aa; similar to SW:SYR_BRELA (EMBL:Z21501) Brevibacterium lactofermentum arginyl tRNA synthetase (EC 6.1.1.19) ArgS, 550 aa; fasta scores (to C-terminal region): opt: 234 z-score: 260.2 E(): 6.4e-07; 36.0% identity in 161 aa overlap and blastp scores (to N-terminal region): Score = 182 (64.1 bits), Expect = 1.2e-28, Sum P(2) = 1.2e-28; Identities = 45/116 (38%), Positives = 65/116 (56%) and similar to SW:SYR_MYCTU (EMBL:Z73419) Mycobacterium tuberculosis arginyl t-RNA synthetase (EC 6.1.1.19) ArgS or MTCY373.12, 550 aa; fasta score [...] (347 aa) |
| | SCO5357 | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (694 aa) |
| | SCO5359 | 50S ribosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (74 aa) |
| | SCO5360 | Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (358 aa) |
| | SCO5361 | Putative methylase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (281 aa) |
| | SCO5362 | 2SC6G5.06, conserved hypothetical protein, len: 281aa; similar to many eg. SW:Q10618 (YD01_MYCTU) hypothetical protein from Mycobacterium tuberculosis (217 aa) fasta scores; opt: 777, z-score: 892.2, E(): 0, 56.7% identity in 208 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family and Prosite match to PS01147 SUA5/yciO/yrdC family signature. (215 aa) |
| | SCO5367 | ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (273 aa) |
| | SCO5368 | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (76 aa) |
| | SCO5369 | ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (184 aa) |
| | SCO5370 | ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (274 aa) |
| | SCO5371 | ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (529 aa) |
| | SCO5372 | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa) |
| | SCO5373 | ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (478 aa) |
| | SCO5374 | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa) |
| | SCO5547 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (494 aa) |
| | SCO5564 | SC7A1.08c, rpmB, 50S ribosomal protein L28, len: 61aa; similar to many including SW:RL28_BACSU RpmB 50S ribosomal protein L28 from Bacillus subtilis (62 aa) fasta scores; opt: 171, z-score: 301.8, E(): 1.6e-09, (41.0% identity in 61 aa overlap). Contains Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 74.50, E-value 2.2e-18; Belongs to the bacterial ribosomal protein bL28 family. (61 aa) |
| | SCO5569 | Hypothetical protein SC7A1.13; SC7A1.13, unknown, len: 379 aa; similar to TR:O69467 (EMBL:AL023635) hypothetical protein from Mycobacterium tuberculosis (245 aa) fasta scores; opt: 254, z-score: 388.8, E(): 2.3e-14, (29.5% identity in 234 aa overlap). Contains probable coiled-coil from 82 to 124 (43 residues) Max score: 1.615 (probability 1.00). (379 aa) |
| | SCO5570 | Hypothetical protein; SC7A1.14, unknown, len: 217 aa; similar to Y06F_MYCTU hypothetical protein from Mycobacterium tuberculosis (207 aa) fasta scores; opt: 244, z-score: 699.9, E(): 1.1e-31, (45.5% identity in 189 aa overlap). (217 aa) |
| | SCO5571 | SC7A1.15, rpmF, 50S ribosomal protein L32, len: 57 aa; similar to many eg. SW:RL32_BACST 50S PrmF, ribosomal protein L32 from Bacillus stearothermophilus (56 aa) fasta scores; opt: 180, z-score: 341.1, E(): 1.1e-11, (48.1% identity in 54 aa overlap). (57 aa) |
| | SCO5572 | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. May modulate key aspects of gene expression as its absence has extensive effects on the abundance of about 200 different transcripts. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. Belongs to the ribonuclease III family. (272 aa) |
| | SCO5591 | SC2E1.08, rpsP, 30S ribosomal protein S16, highly similar to many e.g. RS16_MYCTU (162 aa), fatsa scores; opt:480 z-score: 771.3 E(): 0, 56.3% identity in 144 aa overlap. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family. (139 aa) |
| | SCO5593 | Putative 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (188 aa) |
| | SCO5594 | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (277 aa) |
| | SCO5595 | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa) |
| | SCO5624 | SC2E1.41, rpsB, 30S ribosomal protein S2, len: 310 aa; almost identical to RS2_STRCO 30S ribosomal protein S2 (242 aa), E(): 0, 96.7% identity in 242 aa overlap and also highly similar to many others e.g. RS2_ECOLI 30S ribosomal protein S2 (240 aa), fasta scores; opt: 744 z-score: 950.7 E(): 0, 50.4% identity in 224 aa overlap. Contains PS00962 Ribosomal protein S2 signature 1 and PS00211 ABC transporters family signature (probably a false positive). Also contains Pfam matches to entry S2 PF00318, Ribosomal protein S2, score 304.89 and to entry 60s_ribosomal PF00428, 60s Acidic ribosom [...] (310 aa) |
| | SCO5625 | Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family. (278 aa) |
| | SCO5626 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (253 aa) |
| | SCO5627 | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | SCO5699 | Prolyl tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (567 aa) |
| | SCO5704 | Putative transcriptional termination/antitermination factor; Participates in both transcription termination and antitermination. (340 aa) |
| | SCO5736 | 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (95 aa) |
| | SCO5796 | Conserved hypothetical protein SC4H2.17; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (497 aa) |
| | SCO5939 | Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (157 aa) |
| | SCO6028 | SC1C3.16c, possible ribonuclease, len: 394 aa; similar to hypothetical proteins e.g. M. tuberculosis TR:O07183 (EMBL:Z96072) MTCY05A6.02 (438 aa), fasta scores; opt: 1338 z-score: 1167.9 E(): 0, 51.9% identity in 405 aa overlap. (394 aa) |
| | SCO6409 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (258 aa) |
| | SCO6436 | SC9B5.03, probable tRNA synthetase, len: 506 aa; similar to many eg. SW:SYM_METTH methionyl-tRNA synthetase from Methanobacterium thermoautotrophicum (651 aa) fasta scores; opt: 610, z-score: 560.9, E(): 5.9e-24, (28.9% identity in 402 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. (506 aa) |
| | SCO6589 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (686 aa) |
| | SCO6807 | Hypothetical protein SC1A2.16c; SC1A2.16c, unknown, len: 597 aa. (597 aa) |
| | SCO6821 | Putative transferase; SC1A2.30c, possible transferase, len: 240 aa. Weakly similar to the C-terminal glutamine amide transferase domain of several CTP synthases e.g. Escherichia coli SW:PYRG_ECOLI(EMBL:M12843) CTP synthase (EC 6.3.4.2) (544 aa), fasta scores opt: 184 z-score: 227.2 E(): 3e-05 24.4% identity in 225 aa overlap. (240 aa) |
| | SCO7051 | Putative transcription terminator factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (415 aa) |
| | SCO7510 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | SCO7600 | SC7H9.12c, possible alanyl tRNA synthetase, len: 404 aa; similar to N-terminal region of SW:SYA_THIFE (EMBL:X95571) Thiobacillus ferrooxidans alanyl-tRNA-synthetase (EC 6.1.1.7) AlaS, 877 aa; fasta scores: opt: 728 z-score: 825.4 E(): 0; 37.4% identity in 425 aa overlap. Contains Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A) and matches to Prosite entries PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 and PS00017 ATP/GTP-binding site motif A (P-loop). (404 aa) |
| | SCP1.205c | Hypothetical protein; SCP1.205c, unknown, len: 841aa; weak but full length similarity to TR:O87242 (EMBL:AE001272) hypothetical protein from plasmid pMRC01 of Lactococcus lactis blastp scores; Identities = 223/824 (27%), Positives = 406/824 (49%). (841 aa) |
