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SCO2117 SCO2117 SCO3211 SCO3211 SCO3212 SCO3212 SCO3213 SCO3213 SCO3214 SCO3214
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO2117SC6E10.11, trpE1, probable anthranilate synthase, len: 634 aa; highly similar to many anthranilate synthases e.g. TR:O30589 (EMBL:AF012627), TrpE, Streptomyces venezuelae anthranilate synthase (623 aa), fasta scores; opt: 3108 z-score: 3257.7 E(): 0, 80.0% identity in 620 aa overlap. Anthranilate synthases may have one or two components. This protein is similar at the C-terminus to TR:Q9Z4W8 (EMBL:AL035654), TrpG, S.coelicolor probable anthranilate synthase component II (200 aa) (32.7% identity in 202 aa overlap) and centrally to TR:Q9Z4W7 (EMBL:AL035654), trpE2, S.coelicolor probable [...] (634 aa)
SCO3211Putative indoleglycerol phosphate synthase; The function of the second trp operon in S.coelicolor is to produce tryptophane for the biosynthesis of calcium-dependent antibiotic (CDA). (258 aa)
SCO3212Probable anthranilate phosphoribotransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa)
SCO3213SCE8.06c, trpG, anthranilate synthase component II, len: 200aa; similar to many eg. TR:G4185545 (EMBL:AF108766) TrpG, anthranilate synthase component II, from Rhodobacter sphaeroides (195 aa) fasta scores; opt: 728, z-score: 825.0, E(): 0, (60.2% identity in 186 aa overlap). Contains matches to Pfam entry PF00117 GATase, Glutamine amidotransferases class-I, score 332.60, E-value 4.3e-96 and Prosite PS00442 Glutamine amidotransferases class-I active site. (200 aa)
SCO3214Probable anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (511 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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