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SCO0182 SCO0182 SCO0183 SCO0183 SCO0184 SCO0184 SCO0185 SCO0185 SCO0186 SCO0186 SCO0187 SCO0187 SCO0188 SCO0188 SCO0189 SCO0189 SCO0190 SCO0190 SCO0191 SCO0191 SCO0192 SCO0192 SCO0565 SCO0565 SCO0568 SCO0568 SCO1019 SCO1019 SCO2509 SCO2509 SCO3148 SCO3148 SCO3391 SCO3391 SCO3858 SCO3858 SCO4233 SCO4233 SCO4234 SCO4234 SCO4583 SCO4583 SCO5058 SCO5058 SCO5222 SCO5222 SCO5223 SCO5223 SCO5250 SCO5250 SCO5694 SCO5694 SCO5696 SCO5696 SCO6013 SCO6013 SCO6073 SCO6073 SCO6485 SCO6485 SCO6750 SCO6750 SCO6752 SCO6752 SCO6753 SCO6753 SCO6754 SCO6754 SCO6755 SCO6755 SCO6756 SCO6756 SCO6759 SCO6759 SCO6760 SCO6760 SCO6762 SCO6762 SCO6763 SCO6763 SCO6764 SCO6764 SCO6765 SCO6765 SCO6766 SCO6766 SCO6767 SCO6767 SCO6768 SCO6768 SCO6769 SCO6769 SCO6770 SCO6770 SCO6771 SCO6771 SCP1.212 SCP1.212 23.ORF1 23.ORF1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
SCO0182Hypothetical protein; SCJ1.31c, doubtful CDS, len: 74 aa. Contains a TTA/leucine codon, possible target for bldA regulation. (74 aa)
SCO0183Deoxiribopirymidine photolyase; SCJ1.32, unknown,len: 415 aa. Likely to have arisen as a result of a duplication of SCF43A.31/32, followed by a deletion event generating a possible CDS with the 5' coding sequence of SCF43A.31 and the 3' coding sequence of SCF43A.32. Similarity scores are as follows: to Streptomyces coelicolor TR:CAB48918 (EMBL; AL096837) putative oxidoreductase SCF43A.31 (520 aa), fasta scores opt: 1191 z-score: 1365.3 E(): 0 64.2% identity in 307 aa overlap and to Streptomyces coelicolor TR:CAB48919(EMBL; AL096837) putative deoxyribodipyrimidine photolyase SCF43A.32 ( [...] (415 aa)
SCO0184Conserved hypothetical protein SCJ1.33; SCJ1.33 unknown, len: 604 aa. Highly similar to Synechocystis sp. (strain PCC6803) TR:P74080 (EMBL;D90912) hypothetical 58.1 KD protein (504 aa), fasta scores opt: 931 z-score: 996.4 E(): 0 38.8% identity in 479 aa overlap and Methanobacterium thermoautotrophicum TR:O27804 (EMBL;AE000932) conserved protein MTH1776 (491 aa), fasta scores opt: 572 z-score: 613.5 E(): 8.1e-27 31.7% identity in 483 aa overlap. Also shares a low level of similarity with Streptomyces coelicolor TR:CAB48919 (EMBL;AL096837) putative deoxyribodipyrimidine photolyase SCF43 [...] (604 aa)
SCO0185SCJ1.34, crtB, possible geranylgeranyl pyrophosphate synthase, len: 392 aa. Shares a high level of similarity with Streptomyces griseus TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase (425 aa), fasta scores: opt: 964 z-score: 1076.9 E(): 0 48.0% identity in 381 aa overlap and Mycobacterium tuberculosis TR:O53507 (EMBL:AL021957) geranylgeranyl pyrophosphate synthase (352 aa), fasta scores opt: 742 z-score: 831.2 E(): 0 43.0% identity in 328 aa overlap. Contains a PS00723 Polyprenyl synthetases signature 1. (392 aa)
SCO0186SCJ1.35, crtE, probable phytoene dehydrogenase (phytoene desaturase) (putative secreted protein), len: 523 aa. High level of similarity to Streptomyces griseus SW:CRTI_STRGR (EMBL; L37405) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (507 aa), fasta scores opt: 2459 z-score: 2615.3 E(): 0; 74.5% identity in 501 aa overlap and Streptomyces setonii SW:CRTI_STRSE (EMBL; D55723) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (508 aa), fasta scores opt: 2455 z-score: 2611.0 E(): 0; 74.3% identity in 498 aa overlap. Contains a PS00982 Bacterial-type phytoene dehydroge [...] (523 aa)
SCO0187SCJ1.36, crtI, probable phytoene synthase, len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL; L37405) phytoene synthase (342 aa), fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6% identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL; U92075) phytoene synthase (319 aa), fasta scores opt: 996 z-score: 1191.5 E():0 52.2% identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases. (331 aa)
SCO0188SCJ1.37, crtV, probable methylesterase, len: 336 aa. Highly similar to Streptomyces griseus TR:P72448 (EMBL; X95596) methylesterase (338 aa), fasta scores opt: 1315 z-score: 1538.7 E(): 0 60.5% identity in 337 aa overlap. (336 aa)
SCO0189SCJ1.38c, crtU, probable dehydrogenase, a partial CDS, len: >336 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa), fasta scores opt: 1277 z-score: 1459.8 E():0 69.0% identity in 281 aa overlap and Synechocystis sp SW:CRTI_SYNY3 (EMBL; X62574) phytoene dehydrogenase (427 aa), fasta scores opt: 133 z-score: 155.8 E():0.25 24.6% identity in 260 aa overlap; SCJ12.01c, crtU, probable dehydrogenase, partial CDS, len: >278 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa), fasta scores opt: 1311 z-score: 1471.3 E [...] (522 aa)
SCO0190SCJ12.02c, crtT, probable methyltransferase, len: 246 aa. Shares a high level of sequence similarity with Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores opt: 984 z-score: 1164.2 E(): 0 65.0% identity in 234 aa overlap. Contains a Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. (246 aa)
SCO0191SCJ12.03c, crtY, probable lycopene cyclase, len: 405 aa. Highly similar to Streptomyces griseus TR:P72451 (EMBL:X95596) lycopene cyclase (418 aa), fasta scores opt: 1426 z-score: 1602.7 E(): 0 56.3% identity in 396 aa overlap. (405 aa)
SCO0192SCJ12.04c, possible oxidoreductase, len: 416 aa. Similar to many protoporphyrinogen oxidases including: Propionibacterium freudenreichii shermanii SW:PPOX_PROFR (EMBL:D85417) HemY (527 aa), fasta scores opt: 228 z-score: 249.0 E(): 1.6e-06 26.8% identity in 504 aa overlap and Bacillus subtilis SW:PPOX_BACSU (EMBL; M97208) HemY (470 aa), fasta scores opt: 209 z-score: 229.3 E(): 2.1e-05 25.7% identity in 311 aa overlap. Contains a Pfam match to entry PF01593 Amino_oxidase. (416 aa)
SCO0565SCF73.12c, probable polyprenyl synthetase, len: 352 aa; similar to members of the FPP/GGPP synthetases family e.g. GGPP_MYCTU probable geranylgeranyl pyrophosphate synthetase (359 aa), fasta scores; opt: 253 z-score: 299.8 E(): 2.5e-09 30.1% identity in 346 aa overlap, and ISPB_ECOLI octaprenyl-diphosphate synthase (323 aa), fasta scores; opt: 222 z-score: 264.3 E(): 2.4e-07, 30.0% identity in 337 aa overlap. Contains PS00444 Polyprenyl synthetases signature 2, and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases. (352 aa)
SCO0568St8B3.02c, possible polyprenyl synthetase, len: 279 aa: similar to many e.g. TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa) fasta scores; opt: 479, Z-score: 544.9, 36.242% identity (38.710% ungapped) in 298 aa overlap and SW:P22939 (ISPA_ECOLI) geranyltransferase from Escherichia coli (299 aa) fasta scores; opt: 350, Z-score: 401.9, 31.939% identity (34.855% ungapped) in 263 aa overlap. Contains Prosite match to PS00723 Polyprenyl synthetases signature 1 and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase. (357 aa)
SCO10192SCG2.33, possible integral membrane protein, len: 411 aa; similar to TR:P74597 (EMBL:D90916) Synechocystis sp. hypothetical 43.6 kDa protein SLR1566, 395 aa; fasta scores: opt: 1119 z-score: 1282.3 E(): 0; 46.3% identity in 402 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase and a cleavable N-terminal signal sequence. (411 aa)
SCO2509Undecaprenyl phosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (277 aa)
SCO3148Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (299 aa)
SCO3391Hypothetical protein; SCE126.09, unknown,len: 362aa; similar to TR:O25492 (EMBL:AE000593) hypothetical protein from Helicobacter pylori (336 aa) fasta scores; opt: 143, z-score: 161.4, E(): 0.11, (31.5% identity in 111 aa overlap). (362 aa)
SCO3858Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (258 aa)
SCO42334-diphodphocytidyl-2C-methyl-D-erythriol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (270 aa)
SCO42342C-methyl-D-erythriol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (170 aa)
SCO4583SCD20.01, putative polyprenyl diphosphate synthase, len: 336 aa; similar to SW:HEP2_BACSU (EMBL:M80245) Bacillus subtilis heptaprenyl diphosphate synthase component II (EC 2.5.1.30) HepT, 348 aa; fasta scores: opt: 586 z-score: 674.6 E(): 4.2e-30; 33.0% identity in 309 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00444 Polyprenyl synthetases signature 2. (336 aa)
SCO5058Hypothetical protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
SCO5222Putative lyase; Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene. (361 aa)
SCO5223Putative cytochrome P450; Involved in the biosynthesis of the sesquiterpenoid antibiotic albaflavenone. Catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone. First carries out a non-stereo- specific oxidation of epi-isozizaene to give a mixture of the albaflavenol epimers ((5R)-albaflavenol and (5S)-albaflavenol), each of which can serve as substrate for the second oxidation to yield albaflavenone. This is quite different from most other P450s which catalyze regio- and stereospecific oxidation. Displays also a farnesene synthase activity with farnesyl diphosphate [...] (461 aa)
SCO52502SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa; previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1; Belongs to the FPP/GGPP synthase family. (386 aa)
SCO56941-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (418 aa)
SCO5696Hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
SCO6013Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
SCO6073Putative cyclase; Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species. (726 aa)
SCO6485Hypothetical protein SC9C7.21; SC9C7.21, unknown, len: 240 aa. (240 aa)
SCO6750Putative IPP isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (197 aa)
SCO6752SC6A5.01, partial CDS, possible integral membrane transferase, len: >490aa; similar to TR:O67379 (EMBL:AE000737) glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 215, z-score: 245.5, E(): 2.2e-06, (26.2% identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature and possible membrane spanning hydrophobic regions; SC5F2A.35, partial CDS, possible transferase, len: >148aa; C-terminal region lies on cosmid 6A5 (EMBL:AL049485). Similar over a defined region to many proposed/hypothetical proteins e [...] (605 aa)
SCO6753SC6A5.02, probable nucleotide sugar-1-phosphate transferase, len: 250aa; similar to many eg. TR:O05171 (EMBL:Y11985) dNDP-glucose synthase from the avilamycin biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 (355 aa) fasta scores; opt: 192, z-score: 226.4, E(): 2.6e-05. (26.9% identity in 242 aa overlap). Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. (250 aa)
SCO6754SC6A5.03, possible glycerol dehydrogenase, len: 340aa; similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase, GldA, from Pseudomonas putida (365 aa) fasta scores; opt: 261, z-score: 303.7, E(): 1.3e-09, (27.9% identity in 308 aa overlap). (340 aa)
SCO6755Putative transferase; SC6A5.04, possible integral membrane transferase, len: 227aa; similar to many eg. TR:O67379 (EMBL:AE000737) glucose-1-phophate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 206, z-score: 257.3, E(): 5e-07, (28.1% identity in 199 aa overlap). Contains possible membrane spanning hydrophobic region. (227 aa)
SCO6756SC6A5.05, possible glycosyltransferase, len: 290aa; similar to many eg. TR:E1388141 (EMBL:AL035478) putative transferase from Streptomyces coelicolor (344 aa) fasta scores; opt: 202, z-score: 235.1, E(): 8.6e-06, (28.1% identity in 317 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Contains possible membrane spanning hydrophobic regions. (290 aa)
SCO6759SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08. (303 aa)
SCO6760SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...] (312 aa)
SCO6762SC6A5.11, possible phytoene dehydrogenase, len: 478aa; similar to many from eukaryotes eg. SW:CRTI_CAPAN phytoene dehydrogenase precursor from Capsicum annuum (bell pepper) (582 aa) fasta scores; opt: 276, z-score: 302.1, E(): 1.6e-09, (24.0% identity in 459 aa overlap). Also similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed dehydrogenase from a cryptic carotenoid biosynthesis cluster in Streptomyces griseus (517 aa) fasta scores; opt: 206, z-score: 226.8, E(): 2.5e-05, (29.7% identity in 512 aa overlap). (478 aa)
SCO6763SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...] (378 aa)
SCO6764SC6A5.13, probable squalene-hopene cyclase, len: 680 aa; similar to many e.g. SW:SQHC_ALIAC squalene-hopene cyclase A key enzyme in triterpenoid metabolism in Bacillus acidocaldarius (630 aa) fasta scores; opt: 2153, z-score: 2386.3, E(): 0, (51.8% identity in 620 aa overlap). Contains two Pfam matches to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats and a Prosite match to PS01074 Terpene synthases signature. (680 aa)
SCO6765SC6A5.14, possible lipoprotein, len: 213 aa; similar to SW:TYRT_STRLN proposed tyrosinase co-factor from the melanin biosynthesis in Streptomyces lincolnensis (140 aa) fasta scores; opt: 115, z-score: 142.8, E(): 1.2, (29.2% identity in 120 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (213 aa)
SCO6766Conserved hypothetical protein; SC6A5.15, unknown, len: 340 aa; similar to many of undefined function e.g. TR:P95416 (EMBL:D84475) NirJ, from a locus for heme D1 biosynthesis in Pseudomonas aeruginosa (387 aa) fasta scores; opt: 222, z-score: 264.2, E(): 2.1e-07, (24.2% identity in 207 aa overlap). (340 aa)
SCO6767GcpE protein homolog, conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
SCO6768Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (656 aa)
SCO6769SC6A5.18, probable aminotransferase, len: 461 aa; similar to many e.g. SW:ARGD_BACSU acetylornithine aminotransferase from Bacillus subtilis (385 aa) fasta scores; opt: 663, z-score: 757.6, E(): 0, (37.8% identity in 341 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and Prosite match to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
SCO6770SC6A5.19, probable DNA-binding protein, len: 204 aa; similar to several of undefined function eg. TR:O86784 (EMBL:AL031317) hypothetical protein from Streptomyces coelicolor (201 aa) fasta scores; opt: 297, z-score: 356.2, E(): 1.5e-12, (34.9% identity in 212 aa overlap). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (204 aa)
SCO6771SC6A5.20, possible small hydrophobic secreted protein, len: 39 aa; contains possible N-terminal signal sequence. (39 aa)
SCP1.212Putative bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase; Catalyzes the reaction from prephytoene diphosphate to phytoene; In the N-terminal section; belongs to the phytoene/squalene synthase family. (564 aa)
23.ORF1Hypothetical protein; SCP1.227c, unknown, len: 233aa; previously sequenced and annotated as TR:Q9JN74 (EMBL:AJ276673). Similar to TR:Q9KZ23 (EMBL:AL355752) putative reductase from Streptomyces coelicolor (366 aa) fasta scores; opt: 496, z-score: 569.0, E(): 3.2e-24, 38.2% identity in 212 aa overlap. (233 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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