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SCO1553 SCO1553 SCO1554 SCO1554 SCO1555 SCO1555 SCO1847 SCO1847 SCO1848 SCO1848 SCO1849 SCO1849 SCO1851 SCO1851 SCO1852 SCO1852 SCO1853 SCO1853 SCO1855 SCO1855 SCO1856 SCO1856 SCO1857 SCO1857 SCO1858 SCO1858 SCO2173 SCO2173 SCO2175 SCO2175 SCO2177 SCO2177 SCO3159 SCO3159 SCO3160 SCO3160 SCO3161 SCO3161 SCO3162 SCO3162 SCO3282 SCO3282 SCO3283 SCO3283 SCO5381 SCO5381 SCO5958 SCO5958 SCO5959 SCO5959 SCO5960 SCO5960 SCO5961 SCO5961 SCO6971 SCO6971
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO1553SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...] (410 aa)
SCO1554Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1212 aa)
SCO1555SCL11.11c, probable methyltransferase, len: 408 aa; similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE, 425 aa; fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15; 29.9% identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE, 201 aa; fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08; 33.3% identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (408 aa)
SCO1847Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (327 aa)
SCO1848Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
SCO1849Cobalamin biosynthesis protein; SCI8.34, cobN, CobN protein, len: 1217 aa. Highly similar to many e.g. Mycobacterium tuberculosis TR: O53498 (EMBL: AL021922) CobN (1194 aa), fasta scores opt: 2277 z-score: 2513.8 E(): 0 62.2% identity in 1224 aa overlap and Pseudomonas denitrificans SW:COBN_PSEDE (EMBL: M62866) CobN protein (1275 aa), fasta scores opt: 2437 z-score: 2690.5 E(): 0 41.6% identity in 1258 aa overlap. Also similar to metal chelatases e.g. Heliobacillus mobilis TR:Q9ZGE5 (EMBL: AF080002) Mg chelatase subunit H (1292 aa), fasta scores opt: 1647 z-score: 1815.7 E(): 0 31.4% i [...] (1217 aa)
SCO1851SCI8.36, cobO, cob(I)alamin adenosyltransferase (EC 2.5.1.17), len: 199 aa. Highly similar to many including: Pseudomonas denitrificans SW:COBO_PSEDE (EMBL: M62866) cob(I)alamin adenosyltransferase (EC 2.5.1.17) (corrinoid adenosyltransferase) (213 aa), fasta scores opt: 418 z-score: 517.2 E(): 1.9e-21 37.0% identity in 200 aa overlap and Mycobacterium tuberculosis TR:O05810 (EMBL: Z95207) cob(I)alamin adenosyltransferase CobA (207 aa), fasta scores opt: 918 z-score: 1124.4 E(): 0 64.7% identity in 207 aa overlap. (199 aa)
SCO1852Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
SCO1853SCI8.38, cobI, precorrin-2 C20-methyltransferase (EC 2.1.1.130), len: 243 aa. Similar to many including: Pseudomonas denitrificans SW:COBI_PSEDE (EMBL: M59301) precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine-precorrin-2 methyltransferase) (SP2MT) (244 aa), fasta scores opt: 322 z-score: 369.3 E(): 3.3e-13 30.0% identity in 240 aa overlap and to the N-terminus of the CobI/J fusion protein from Mycobacterium tuberculosis SW:COBI_MYCTU (EMBL: Z73966) cobalamin biosynthesis protein CobIJ [includes: precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-met [...] (243 aa)
SCO1855SCI39.02, probable precorrin-4 C11-methyltransferase, len: 281 aa; similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF, 258 aa; fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35; 41.502% identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM, 253 aa; fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34; 43.145% identity in 248 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (281 aa)
SCO1856SCI39.03, probable precorrin-6Y C5,15-methyltransferase, len: 410 aa; similar to SW:COBL_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CobL, 413 aa; fasta scores: opt: 614 Z-score: 634.0 bits: 126.3 E(): 1e-27; 37.500% identity in 408 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (410 aa)
SCO1857SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...] (583 aa)
SCO1858SCI39.05, conserved hypothetical protein, len: 305 aa; similar to TR:O87690 (EMBL:AJ000758) Bacillus megaterium Cbi protein CbiX, 306 aa; fasta scores: opt: 791 Z-score: 870.2 bits: 169.1 E(): 7e-41; 39.000% identity in 300 aa overlap. Contains Pfam match to entry PF01903 CbiX, CbiX. (305 aa)
SCO2173SC5F7.28, putative adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase, len: 397 aa; regions similar to different proteins. 1-220aa similar to TR:O05479 (EMBL:M86351) triacylglycerol acylhydrolase from Streptomyces sp. (481 aa) fasta scores; opt: 146, z-score: 158.6, E(): 0.17, (30.4% identity in 207 aa overlap). 220-397aa similar to many bifunctional adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase proteins in the biosynthesis of cobalamin (vitamin B12) eg. SW:COBU_SALTY adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltra [...] (397 aa)
SCO2175Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (357 aa)
SCO2177Putative cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
SCO3159SCE87.10, possible membrane protein, len: 353 aa. Weakly similar to Salmonella typhimurium SW:CBIM_SALTY (EMBL:L12006) cobalamin biosynthesis protein CbiM (245 aa), fasta scores opt: 224 z-score: 251.7 E(): 1.2e-06 32.8% identity in 180 aa overlap. Also similar to Methanobacterium thermoautotrophicum TR: O27742 (EMBL:AE000928) cobalamin biosynthesis protein M (217 aa), fasta scores opt: 495 z-score: 544.6 E(): 5.9e-23 41.4% identity in 220 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. (353 aa)
SCO3160SCE87.11, possible integral membrane transport protein, len: 253 aa. Similar to many proteins thought to be involved in the transport of cobalt e.g. Streptomyces coelicolor TR:O54188(EMBL:AL021411) cobalt transport integral membrane protein SC7H1.29c (CbiQ) (249 aa), fasta scores opt: 196 z-score: 249.6 E(): 1.6e-06 25.5% identity in 251 aa overlap and Methanobacterium thermoautotrophicum TR:O27740(EMBL:AE000928) cobalt transport membrane protein (261 aa), fasta scores opt: 332 z-score: 417.0 E(): 7.5e-16 30.2% identity in 212 aa overlap. Contains multiple possible membrane spanning hy [...] (253 aa)
SCO3161Putative ABC transport protein, ATP-binding subunit; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (260 aa)
SCO3162SCE87.13, possible esterase, len: 420 aa. Similar to several including: Streptomyces chrysomallus TR:O87861(EMBL:Z15137) esterase A (389 aa), fasta scores opt: 684 z-score: 729.1 E():0 44.9% identity in 405 aa overlap and Pseudomonas fluorescens TR:Q53403 (EMBL:S69066) esterase III (382 aa), fasta scores opt: 597 z-score: 637.2 E(): 4e-28 41.8% identity in 397 aa overlap. (420 aa)
SCO3282SCE39.32, possible precorrin-8X methylmutase, len: 218 aa; similar to many e.g. SW:COBH_PSEDE Precorrin-8X methylmutase from Pseudomonas denitrificans (210 aa) fasta scores; opt: 868, z-score: 1000.1, E(): 0, (64.2% identity in 204 aa overlap) and SW:COBH_MYCTU precorrin-8X methylmutase from Mycobacterium tuberculosis (208 aa) fasta scores; opt: 852, z-score: 982.0, E(): 0, (64.1% identity in 206 aa overlap). (218 aa)
SCO3283SCE39.33c, possible precorrin-6X reductase, len: 255 aa; similar to many e.g. SW:COBK_RHOSO precorrin-6X reductase from Rhodococcus sp. (248 aa) fasta scores; opt: 873, z-score: 978.5, E(): 0, (55.1% identity in 247 aa overlap) and SW:COBK_MYCTU precorrin-6X reductase from Mycobacterium tuberculosis (244 aa) fasta scores; opt: 690, z-score: 775.5, E(): 0, (50.4% identity in 244 aa overlap). (255 aa)
SCO53812SC6G5.25c, conserved hypothetical protein, len: 190aa; similar to many eg. SW:Q10622 (Y02Y_MYCTU) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores; opt: 800, z-score: 984.0, E(): 0, 65.6% identity in 189 aa overlap. Contains Pfam match to entry PF01923 DUF80, Protein of unknown function; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
SCO5958Cobalt transport system ATP binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (284 aa)
SCO5959SC7H1.29c, cbiQ, probable cobalt transport integral membrane protein, len: 249 aa; similar to eg. CBIQ_SALTY Q05598 cobalt transport protein cbiq (225 aa), fasta scores; opt: 182 z-score: 241.4 E(): 3e-06, 28.1% identity in 228 aa overlap. (249 aa)
SCO5960Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (118 aa)
SCO5961Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (257 aa)
SCO6971SC6F7.24c, possible methylase, len: 257 aa. Highly similar to Pseudomonas denitrificans SW:COBF_PSEDE(EMBL:M59301) cobalamin biosynthesis protein, CobF (261 aa), fasta scores opt: 869 z-score: 1009.4 E():0 53.6% identity in 252 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (257 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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