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SCO1554 SCO1554 SCO1555 SCO1555 SCO1847 SCO1847 SCO1848 SCO1848 SCO1849 SCO1849 SCO1851 SCO1851 SCO1852 SCO1852 SCO1855 SCO1855 SCO1856 SCO1856 SCO1857 SCO1857 SCO2173 SCO2173 SCO2175 SCO2175 SCO2177 SCO2177 SCO3282 SCO3282 SCO3283 SCO3283 SCO5381 SCO5381 SCO6971 SCO6971
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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SCO1554Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1212 aa)
SCO1555SCL11.11c, probable methyltransferase, len: 408 aa; similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE, 425 aa; fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15; 29.9% identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE, 201 aa; fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08; 33.3% identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (408 aa)
SCO1847Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (327 aa)
SCO1848Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
SCO1849Cobalamin biosynthesis protein; SCI8.34, cobN, CobN protein, len: 1217 aa. Highly similar to many e.g. Mycobacterium tuberculosis TR: O53498 (EMBL: AL021922) CobN (1194 aa), fasta scores opt: 2277 z-score: 2513.8 E(): 0 62.2% identity in 1224 aa overlap and Pseudomonas denitrificans SW:COBN_PSEDE (EMBL: M62866) CobN protein (1275 aa), fasta scores opt: 2437 z-score: 2690.5 E(): 0 41.6% identity in 1258 aa overlap. Also similar to metal chelatases e.g. Heliobacillus mobilis TR:Q9ZGE5 (EMBL: AF080002) Mg chelatase subunit H (1292 aa), fasta scores opt: 1647 z-score: 1815.7 E(): 0 31.4% i [...] (1217 aa)
SCO1851SCI8.36, cobO, cob(I)alamin adenosyltransferase (EC 2.5.1.17), len: 199 aa. Highly similar to many including: Pseudomonas denitrificans SW:COBO_PSEDE (EMBL: M62866) cob(I)alamin adenosyltransferase (EC 2.5.1.17) (corrinoid adenosyltransferase) (213 aa), fasta scores opt: 418 z-score: 517.2 E(): 1.9e-21 37.0% identity in 200 aa overlap and Mycobacterium tuberculosis TR:O05810 (EMBL: Z95207) cob(I)alamin adenosyltransferase CobA (207 aa), fasta scores opt: 918 z-score: 1124.4 E(): 0 64.7% identity in 207 aa overlap. (199 aa)
SCO1852Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
SCO1855SCI39.02, probable precorrin-4 C11-methyltransferase, len: 281 aa; similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF, 258 aa; fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35; 41.502% identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM, 253 aa; fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34; 43.145% identity in 248 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (281 aa)
SCO1856SCI39.03, probable precorrin-6Y C5,15-methyltransferase, len: 410 aa; similar to SW:COBL_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CobL, 413 aa; fasta scores: opt: 614 Z-score: 634.0 bits: 126.3 E(): 1e-27; 37.500% identity in 408 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (410 aa)
SCO1857SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...] (583 aa)
SCO2173SC5F7.28, putative adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase, len: 397 aa; regions similar to different proteins. 1-220aa similar to TR:O05479 (EMBL:M86351) triacylglycerol acylhydrolase from Streptomyces sp. (481 aa) fasta scores; opt: 146, z-score: 158.6, E(): 0.17, (30.4% identity in 207 aa overlap). 220-397aa similar to many bifunctional adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase proteins in the biosynthesis of cobalamin (vitamin B12) eg. SW:COBU_SALTY adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltra [...] (397 aa)
SCO2175Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (357 aa)
SCO2177Putative cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
SCO3282SCE39.32, possible precorrin-8X methylmutase, len: 218 aa; similar to many e.g. SW:COBH_PSEDE Precorrin-8X methylmutase from Pseudomonas denitrificans (210 aa) fasta scores; opt: 868, z-score: 1000.1, E(): 0, (64.2% identity in 204 aa overlap) and SW:COBH_MYCTU precorrin-8X methylmutase from Mycobacterium tuberculosis (208 aa) fasta scores; opt: 852, z-score: 982.0, E(): 0, (64.1% identity in 206 aa overlap). (218 aa)
SCO3283SCE39.33c, possible precorrin-6X reductase, len: 255 aa; similar to many e.g. SW:COBK_RHOSO precorrin-6X reductase from Rhodococcus sp. (248 aa) fasta scores; opt: 873, z-score: 978.5, E(): 0, (55.1% identity in 247 aa overlap) and SW:COBK_MYCTU precorrin-6X reductase from Mycobacterium tuberculosis (244 aa) fasta scores; opt: 690, z-score: 775.5, E(): 0, (50.4% identity in 244 aa overlap). (255 aa)
SCO53812SC6G5.25c, conserved hypothetical protein, len: 190aa; similar to many eg. SW:Q10622 (Y02Y_MYCTU) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores; opt: 800, z-score: 984.0, E(): 0, 65.6% identity in 189 aa overlap. Contains Pfam match to entry PF01923 DUF80, Protein of unknown function; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
SCO6971SC6F7.24c, possible methylase, len: 257 aa. Highly similar to Pseudomonas denitrificans SW:COBF_PSEDE(EMBL:M59301) cobalamin biosynthesis protein, CobF (261 aa), fasta scores opt: 869 z-score: 1009.4 E():0 53.6% identity in 252 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (257 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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