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SCO1977 SCO1977 SCO2025 SCO2025 SCO2026 SCO2026 SCO2198 SCO2198 SCO2210 SCO2210 SCO2234 SCO2234 SCO2241 SCO2241 SCO2999 SCO2999 SCO4683 SCO4683 SCO5583 SCO5583 SCO5584 SCO5584 SCO5585 SCO5585
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO1977SC3C9.12c, possible glutamate synthase small subunit, len: 496 aa; similar to C-terminal part of SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa glutamate synthase [NADH], chloroplast precursor (EC 1.4.1.14) (NADH-GOGAT) GlsN, 2194 aa; fasta scores: opt: 1473 Z-score: 1543.9 bits: 297.3 E(): 2.2e-78; 47.551% identity in 490 aa overlap and to TR:Q9S2Z0 (EMBL:AL109849) Streptomyces coelicolor putative glutamate synthase small subunit SC3A3.03c, 487 aa; fasta scores: opt: 2145 Z-score: 2259.1 bits: 427.5 E(): 3.2e-118; 66.398% identity in 497 aa overlap. Contains Pfam match to entry PF00070 p [...] (496 aa)
SCO2025SC3A3.03c, gltD, probable glutamate synthase small subunit, len: 487 aa; similar to bacterial glutamate synthases e.g. TR:Q51584 (EMBL:D85230), gltD, Plectonema boryanum small subunit of NADH-dependent glutamate synthase (492 aa), fasta scores; opt: 1295 z-score: 1405.0 E(): 0, 51.2% identity in 500 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.1% identity in 489 aa overlap). Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulf [...] (487 aa)
SCO2026SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap). (1514 aa)
SCO2198Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
SCO2210SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
SCO2234Glutamate-ammonia-ligase adenylyltransferase; Adenylation and deadenylation of glutamate--ammonia ligase. (999 aa)
SCO2241SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa)
SCO2999SCE33.01c, hypothetical protein (fragment), len: >187 aa; similar to TR:Q9X7B2 (EMBL:AL049913) Mycobacterium leprae hypothetical 177.9 kD protein MCLB1610.10, 1622 aa; fasta scores: opt: 154 z-score: 172.5 E(): 0.038; 29.7% identity in 155 aa overlap; SCE99.06c, conserved hypothetical protein (fragment), len: >1515 aa; similar to TR:AAG06456 (EMBL:AE004731) Pseudomonas aeruginosa conserved hypothetical protein PA3068, 1620 aa; fasta scores: opt: 4170 z-score: 4589.7 E(): 0; 46.3% identity in 1521 aa overlap. (1653 aa)
SCO4683SCD31.08, gdhA, NADP-specific glutamate dehydrogenase, len: 461 aa; similar to TR:O87403 (EMBL:AF056335) Bacillus licheniformis NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 460 aa; fasta scores: opt: 1759 z-score: 1940.3 E(): 0; 59.1% identity in 435 aa overlap and to SW:DHE4_ECOLI (EMBL:J01615) Escherichia coli NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 447 aa; fasta scores: opt: 1683 z-score: 1856.8 E(): 0; 58.7% identity in 446 aa overlap. Contains Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase and match to P [...] (461 aa)
SCO5583SC7A1.27, amt, ammonium transporter, len: 448 aa; similar to many eg. TR:O67997 (EMBL:AF005275) (438 aa) fasta scores; opt: 1224, z-score: 1126.9, E(): 0, (47.1% identity in 414 aa overlap). Contains PS01219 Ammonium transporters signature and Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family, score 537.00, E-value 1.3e-157. (448 aa)
SCO5584SC2E1.01, glnB, nitrogen regulatory protein P-II, partial CDS, len: >54 aa; highly similar to many e.g. GLNB_AZOBR (112 aa), fasta scores; opt: 198 z-score: 381.9 E(): 4.9e-14, 50.0% identity in 54 aa overlap; SC7A1.28, partial CDS, glnB, nitrogen regulatory protein P-II, len: 92aa; similar to many eg. SW:GLNB_RHIME nitrogen regulatory protein P-II from Rhizobium meliloti (112 aa) fasta scores; opt: 402, z-score: 776.2, E(): 0, (58.7% identity in 92 aa overlap). Contains PS00496 P-II protein urydylation site and Pfam match to entry PF00543 P-II, Nitrogen regulatory protein P-II, score [...] (112 aa)
SCO5585Putative protein pII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (835 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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