STRINGSTRING
SCO2018 SCO2018 SCO2179 SCO2179 SCO2635 SCO2635 SCO2643 SCO2643 SCO3416 SCO3416 SCO3622 SCO3622 SCO5945 SCO5945 SCO6407 SCO6407 SCO6444 SCO6444 SCO7331 SCO7331 SCO7507 SCO7507
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO2018SC7H2.32c, possible aminopeptidase, len: 835aa; similar to many eg. SW:AMPN_LACDL lysyl aminopeptidase from Lactobacillus delbruckii ssp. lactis (842 aa) fasta scores; opt: 705, z-score: 805.5, E(): 0, (27.7% identity in 622 aa overlap). Also similar to TR:O53194 (EMBL:AL021246) aminopeptidase from Mycobacterium tuberculosis (861 aa) fasta scores; opt: 1490, z-score: 1707.1, E(): 0, (39.6% identity in 867 aa overlap). Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1 and Prosite match to PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. (835 aa)
SCO2179Putative aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (517 aa)
SCO2635SC8E4A.05, probable aminopeptidase, len: 833 aa; similar to SW:AMPN_STRLI (EMBL:L23172) Streptomyces lividans aminopeptidase N (EC 3.4.11.2) PepN, 857 aa; fasta scores: opt: 3002 z-score: 3413.5 E(): 0; 56.5% identity in 832 aa overlap, to TR:O53194 (EMBL:AL021246) Mycobacterium tuberculosis aminopeptidase MTV008.23, 861 aa; fasta scores: opt: 2215 z-score: 2517.8 E(): 0; 50.8% identity in 837 aa overlap and to S. coelicolor St8E4A.13, pepN, 857 aa; fasta scores: opt: 2998 z-score: 2999.1 E(): 0; 55.8% identity in 842 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Pepti [...] (833 aa)
SCO2643SC8E4A.13, pepN, aminopeptidase N, len: 857 aa; identical to SW:AMPN_STRLI (EMBL:L23172) Streptomyces lividans aminopeptidase N (EC 3.4.11.2) PepN, 857 aa and similar to SW:AMPN_LACLA (EMBL:D38040) Lactococcus lactis aminopeptidase N (EC 3.4.11.2) PepN, 848 aa; fasta scores: opt: 738 z-score: 846.7 E(): 0; 33.4% identity in 440 aa overlap and to S. coelicolor SC8E4A.05, 833 aa; fasta scores: opt: 2998 z-score: 2943.4 E(): 0; 55.8% identity in 842 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1 and match ot Prosite entry PS00142 Neutral zinc metallopep [...] (857 aa)
SCO3416SCE9.23, gad, probable glutamate decarboxylase, len: 475 aa; similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024), gadA, Escherichia coli glutamate decarboxylase alpha (466 aa), fasta scores; opt: 1433 z-score: 1665.2 E(): 0, 50.0% identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain, score 276.70, E-value 1.1e-79; Belongs to the group II decarboxylase family. (475 aa)
SCO3622SC66T3.33, probable aminotransferase, len: 451 aa; similar to many e.g. SW:GABT_ECOLI (EMBL:M88334), gabT, Escherichia coli 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 706 z-score: 815.4 E(): 0, 32.3% identity in 427 aa overlap. Also similar to TR:O86744 (EMBL:AL031035) S.coelicolor probable aminotransferase (457 aa) (37.3% identity in 362 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate [...] (451 aa)
SCO5945SC7H1.15, probable transferase, len: 606 aa; similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa), fasta scores; opt: 921 z-score: 1470.0 E(): 0, 45.8% identity in 600 aa overlap and to other gamma-glutamyl transferases. (606 aa)
SCO6407SC3C8.26, possible gamma-glutamyltranspeptidase (putative secreted protein), len: 603 aa; similar to many e.g. GGT_BACSU gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa), fasta scores; opt: 705 z-score: 863.9 E(): 0, 36.9% identity in 591 aa overlap, and to PAC1_PSESV cephalosporin acylase I (EC 3.5.1.-) (557 aa), fasta scores; opt: 377 z-score: 819.8 E(): 0, 34.1% identity in 569 aa overlap. Contains probable N-terminal signal sequence. (603 aa)
SCO6444SC9B5.11, probable gamma-glutamyl transferase, len: 647 aa; similar to many gamma-glutamyl transferases eg. TR:Q54353 (EMBL:X79146) LmbA, gamma-glutamyl transferase involved in lincomycin production in Streptomyces lincolnensis 78-11 (601 aa) fasta scores; opt: 871, z-score: 1756.8, E(): 0, (48.1% identity in 619 aa overlap). Also similar to TR:O54174 (EMBL:AL021411) probable transferase (606aa) from Streptomyces coelicolor fasta scores: opt: 953, z-score: 1203.1, E(): 0, (53.7% identity in 635 aa overlap). Contains Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase. (647 aa)
SCO7331Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (363 aa)
SCO7507SCBAC17A6.40c, possible dioxygenase, len: 315 aa; similar to many eg. SW:P37610 (TAUD_ECOLI) alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli (282 aa) fasta scores: opt: 786, Z-score: 906.3, 44.245% identity (45.556% ungapped) in 278 aa overlap. Contains Pfam match to entry PF02668 TauD, Taurine catabolism dioxygenase TauD, TfdA family. (315 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.