STRINGSTRING
SCO0405 SCO0405 SCO0703 SCO0703 SCO1242 SCO1242 SCO1978 SCO1978 SCO1979 SCO1979 SCO3365 SCO3365 SCO3421 SCO3421 SCO3424 SCO3424 SCO4301 SCO4301 SCO6606 SCO6606 SCO6607 SCO6607 SCO7715 SCO7715
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0405SCF51.04, conserved hypothetical protein, len: 272 aa; similar to TR:O86540 (EMBL:AL031350) Streptomyces coelicolor hypothetical 32.8 kD protein, 300 aa; fasta scores: opt: 656 z-score: 793.0 E(): 0; 43.1% identity in 246 aa overlap. (272 aa)
SCO0703SCF42.13, possible regulator, len: 75 aa. Identical to the previously published Streptomyces coelicolor TR:Q53896 (EMBL:X60316) pleiotropic antibiotic regulatory locus AbaA, OrfD (75 aa), fasta scores opt: 507 z-score: 699.1 E(): 1.5e-31 98.7% identity in 75 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X8K3 (EMBL:AL049841) putative regulator SCE9.31c (83 aa), fasta scores opt: 308 z-score: 431.8 E(): 1.2e-16 63.6% identity in 77 aa overlap. (75 aa)
SCO12422SCG1.17, probable DNA-binding protein, len: 286 aa; similar to TR:CAB8844 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 626 z-score: 747.0 E(): 0; 40.0% identity in 280 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 25..46 (+4.46 SD). Also contains a TTA leucine codon (58), possible target for bldA regulation. (286 aa)
SCO1978SC3C9.13c, possible AbaA-like protein, len: 91 aa; similar to TR:Q9F3E1 (EMBL:AL450289) Streptomyces coelicolor putative AbaA-like protein SC2H2.14, 89 aa; fasta scores: opt: 371 Z-score: 479.1 bits: 93.2 E(): 4.5e-19; 69.863% identity in 73 aa overlap and to TR:Q53896 (EMBL:X60316) Streptomyces coelicolor AbaA gene (putative regulator) SCF42.13, 75 aa; fasta scores: opt: 220 Z-score: 293.4 bits: 58.6 E(): 9.9e-09; 50.000% identity in 74 aa overlap. (91 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
SCO3365Conserved hypothetical protein; SCE94.16c, unknown, len: aa; similar to others from Streptomyces coelicolor eg. TR:E1370777 (EMBL:AL035212) possible DNA binding protein (303 aa) fasta scores; opt: 420, z-score: 512.3, E(): 3.2e-21, (32.5% identity in 265 aa overlap). (280 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO3424SCE9.31c, possible regulator, len: 83 aa; similar to TR:Q53896 (EMBL:X60316), abaA, Streptomyces coelicolor ORFD from AbaA regulatory locus for antibiotic production (75 aa), fasta scores; opt: 307 z-score: 422.3 E(): 3.4e-16, 64.9% identity in 74 aa overlap and to TR:Q53842 (EMBL:U28930), BldB, S.coelicolor developmental protein (98 aa) (41.8% identity in 67 aa overlap). (83 aa)
SCO4301SCD95A.34c, possible DNA-binding protein, len: 279 aa; similar to various S. coelicolor hypothetical proteins, e.g. TR:CAB69734 (EMBL:AL137166) Streptomyces coelicolor hypothetical 30.4 kD protein SCC121.16, 277 aa; fasta scores: opt: 731 z-score: 897.3 E(): 0; 45.2% identity in 259 aa overlap and to TR:CAB88448 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 388 z-score: 478.8 E(): 3.3e-19; 34.3% identity in 286 aa overlap. Contains TTA leucine codon, possible target for bldA regulation and a possible helix-turn-helix motif at r [...] (279 aa)
SCO6606Conserved hypothetical protein SC1F2.03c; SC1F2.03c, unknown, len: 300 aa; similar to upstream gene SC1F3.04, E(): 0, 48.8% identity in 260 aa overlap anbd to TR:Q9L173 (EMBL:AL158057) Streptomyces coelicolor hypothetical protein SC10G8.32c, 263 aa; fasta scores: opt: 791 Z-score: 879.8 E(): 2.3e-41; 49.237% identity in 262 aa overlap. (300 aa)
SCO6607Conserved hypothetical protein SC1F3.04; SC1F3.04, unknown, len: 261 aa; similar to many Streptomyces coelicolor e.g. upstream gene SC1F2.03c,E(): 0, 48.8% identity in 260 aa overlap. (261 aa)
SCO7715SC8D11.06, hypothetical protein, len: 267 aa; similar to TR:Q9RK84 (EMBL:AL132662) Streptomyces coelicolor hypothetical 29.4 kDa protein SCF11.05, 271 aa; fasta scores: opt: 918 z-score: 1092.7 E(): 0; 55.9% identity in 254 aa overlap. (267 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.