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SCO0208 SCO0208 SCO0546 SCO0546 SCO0884 SCO0884 SCO0922 SCO0922 SCO0923 SCO0923 SCO0924 SCO0924 SCO1268 SCO1268 SCO1269 SCO1269 SCO1270 SCO1270 SCO2180 SCO2180 SCO2181 SCO2181 SCO2183 SCO2183 SCO2193 SCO2193 SCO2194 SCO2194 SCO2371 SCO2371 SCO2494 SCO2494 SCO2736 SCO2736 SCO2951 SCO2951 SCO3127 SCO3127 SCO3443 SCO3443 SCO3563 SCO3563 SCO3815 SCO3815 SCO3816 SCO3816 SCO3817 SCO3817 SCO3829 SCO3829 SCO3830 SCO3830 SCO3831 SCO3831 SCO4388 SCO4388 SCO4578 SCO4578 SCO4594 SCO4594 SCO4595 SCO4595 SCO4808 SCO4808 SCO4809 SCO4809 SCO4827 SCO4827 SCO4855 SCO4855 SCO4856 SCO4856 SCO4857 SCO4857 SCO4858 SCO4858 SCO4919 SCO4919 SCO4979 SCO4979 SCO5042 SCO5042 SCO5044 SCO5044 SCO5106 SCO5106 SCO5107 SCO5107 SCO5108 SCO5108 SCO5109 SCO5109 SCO5261 SCO5261 SCO5281 SCO5281 SCO5831 SCO5831 SCO5832 SCO5832 SCO5926 SCO5926 SCO5999 SCO5999 SCO6243 SCO6243 SCO6269 SCO6269 SCO6270 SCO6270 SCO6423 SCO6423 SCO6585 SCO6585 SCO6586 SCO6586 SCO7000 SCO7000 SCO7109 SCO7109 SCO7123 SCO7123 SCO7124 SCO7124
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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SCO0208SCJ12.20, pyruvate phosphate dikinase, len: 898 aa. Highly similar to many pyruvate phosphate dikinases e.g. Clostridium symbiosum SW:PODK_CLOSY (EMBL; M60920)(EC 2.7.9.1) (873 aa), fasta scores opt: 1626 z-score: 1761.3 E():0 48.7% identity in 895 aa overlap and Microbispora rosea SW:BAA76347 (EMBL; AB025020) (878 aa), fasta scores opt: 3060 z-score: 3317.5 E(): 0 67.5% identity in 898 aa overlap. Contains a PS00370 PEP-utilizing enzymes phosphorylation site signature, Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain and a Pfam match to [...] (898 aa)
SCO0546Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
SCO0884SCM1.17c, probable oxidoreductase, len: 477 aa. Highly similar to many mercuric reductases (EC 1.16.1.1) and to dihydrolipoamide dehydrogenases (EC 1.8.1.4)(both enzyme classes belong to the pyridine nucleotide-disulfide oxidoreductases class-I family): Mycobacterium tuberculosis TR:O07268(EMBL:AL021959) mercuric reductase (499 aa), fasta scores opt: 2030 z-score: 2133.1 E():0 63.2% identity in 476 aa overlap and Synechocystis sp. (strain PCC 6803) SW:DLDH_SYNY3(EMBL:D90900) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (473 aa), fasta scores opt: 586 z-score: 619.8 E(): 3.5e-27 29.0% id [...] (477 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0923SCM10.11c, probable reductase flavoprotein subunit, len: 649 aa; similar to SW:DHSA_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 585 aa;fasta scores: opt: 580 z-score: 658.7 E(): 2.7e-29; 36.8% identity in 609 aa overlap and to SW:FRDA_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase flavoprotein subunit FrdA, 583 aa; fasta scores: opt: 443 z-score: 503.1 E(): 1.2e-20; 32.2% identity in 574 aa overlap. Contains three Pfam matches to entry Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (649 aa)
SCO0924SCM10.12c, possible cytochrome B subunit subunit, len: 243 aa; similar to SW:FRDC_HELPY (EMBL:U78101) Helicobacter pylori fumarate reductase cytochrome B subunit FrdC, 255aa; fasta scores: opt: 106 z-score: 139.5 E(): 2.2; 22.1% identity in 181 aa overlap. (243 aa)
SCO12682SCG18.15c, probable acyltransferase, len: 372 aa; similar to SW:ODO2_ECOLI (EMBL:J01619) Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 404 aa; fasta scores: opt: 281 z-score: 311.6 E(): 7.1e-10; 24.8% identity in 400 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. (372 aa)
SCO1269Putative pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (337 aa)
SCO12702SCG18.17c, probable pyruvate dehydrogenase alpha subunit, len: 323 aa; similar to TR:O69011 (EMBL:AF086791) Zymomonas mobilis pyruvate dehydrogenase alpha subunit PdhA, 353 aa; fasta scores: opt: 553 z-score: 643.8 E(): 2.3e-28; 33.4% identity in 314 aa overlap. Contains Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component. (323 aa)
SCO2180SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...] (486 aa)
SCO2181SC5F7.20, sucB, possible dihydrolipoamide succinyltransferase, len: 590 aa; similar to many egs. TR:AAC23517 (EMBL:AF068740) dihydrolipoamide succinyltransferase from Pseudomonas ovalis (407 aa) fasta scores; opt: 847, z-score: 602.5, E(): 3.2e-26, (41.9% identity in 453 aa overlap) and SW:ODO2_MYCTU dihydrolipoamide succinyltransferase from Mycobacterium tuberculosis (553 aa) fasta scores; opt: 1232, z-score: 866.2, E(): 0, (56.2% identity in 596 aa overlap). Contains two Pfam matches to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2 [...] (590 aa)
SCO2183Putative pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (899 aa)
SCO2193Putative lipoate-protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (265 aa)
SCO2194Putative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (317 aa)
SCO2371Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (918 aa)
SCO2494SC7A8.33c, probable pyruvate phosphate dikinase, len: 909 aa; similar to TR:CAB53432 (EMBL:AL109989) Streptomyces coelicolor pyruvate phosphate dikinase SCJ12.20, 898 aa; fasta scores: opt: 3956 z-score: 4354.7 E(): 0; 66.7% identity in 889 aa overlap and to SW:PODK_CLOSY (EMBL:M60920) Clostridium symbiosum pyruvate, phosphate dikinase (EC 2.7.9.1) (pyruvate,orthophosphate dikinase) PpdK, 873 aa; fasta scores: opt: 1765 z-score: 1941.1 E():; 51.7% identity in 899 aa overlap. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain, two [...] (909 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2951SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. (471 aa)
SCO3127Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (911 aa)
SCO3443SCE36.10c, probable pyridine nucleotide-disulphide oxidoreductase, len: 454 aa; similar to many eg. SW:MERA_STRLI mercuric reductase from Streptomyces lividans (474 aa) fasta scores; opt: 752, z-score: 772.0, E(): 0, (34.5% identity in 464 aa overlap). Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase class-I. (454 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SCO3815SCGD3.16c, bkdC1, probable dihydrolipoamide acyltransferase component E2, len: 469 aa; similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa), fasta scores; opt: 733 z-score: 672.8 E(): 3.8e-30, 38.7% identity in 460 aa overlap. Highly similar to SCGD3.30c, probable dihydrolipoamide acyltransferase component E2 (491 aa) (40.1% identity in 494 aa overlap), in a duplication of this region upstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acy [...] (469 aa)
SCO3816SCGD3.17c, bkdB1, probable branched-chain alpha keto acid dehydrogenase E1 beta subunit, len: 326 aa; similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716), BkdB, Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa), fasta scores; opt: 1188 z-score: 1395.2 E(): 0, 53.8% identity in 325 aa overlap and SW:ODPB_BACST (EMBL:X53560), PdhB, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (48.0% identity in 323 aa overlap). Highly simi [...] (326 aa)
SCO3817SCGD3.18c, bkdA1, probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit, len: 417 aa; similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53610 (EMBL:U26308) Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (406 aa), fasta scores; opt: 2177 z-score: 2466.3 E(): 0, 80.9% identity in 409 aa overlap and SW:ODPA_BACST (EMBL:X53560), PdhA, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 alpha subunit (368 aa) (39.7% identity in 325 aa overlap). Simil [...] (417 aa)
SCO3829SCGD3.30c, bkdC2, probable dihydrolipoamide acyltransferase component E2, len: 491 aa; similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa), fasta scores; opt: 672 z-score: 634.2 E(): 5.4e-28, 33.2% identity in 482 aa overlap. Highly similar to SCGD3.16c, probable dihydrolipoamide acyltransferase component E2 (469 aa) (40.0% identity in 492 aa overlap), in a duplication of this region downstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases a [...] (491 aa)
SCO3830SCGD3.31c, bkdB2, probable branched-chain alpha keto acid dehydrogenase E1 beta subunit, len: 334 aa; similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716), BkdB, Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa), fasta scores; opt: 2063 z-score: 2427.3 E(): 0, 91.0% identity in 334 aa overlap and SW:ODPB_BACST (EMBL:X53560), PdhB, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (45.5% identity in 319 aa overlap). Highly simi [...] (334 aa)
SCO3831SCGD3.32c, bkdA2, probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit, partial CDS, len: >179 aa; similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53592 (EMBL:U17169), BkdA, Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (381 aa), fasta scores; opt: 987 z-score: 1131.6 E(): 0, 90.3% identity in 165 aa overlap and SW:ODPA_ACHLA (EMBL:M81753), PdhA, Acholeplasma laidlawii pyruvate dehydrogenase E1 component, alpha subunit (345 aa) (34.6% identity in 162 [...] (388 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4578Hypothetical protein; SCD16A.05, unknown, len: 74aa; predicted based upon amino acid and codon usage. (74 aa)
SCO4594SCD20.12c, probable oxidoreductase, len: 352 aa; highly similar to TR:Q9RKS5 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase beta-subunit SCAH10.34c, 350 aa; fasta scores: opt: 2267 z-score: 2567.5 E(): 0; 98.0% identity in 349 aa overlap and to SW:KORB_ARCFU (EMBL:AE001072) Archaeoglobus fulgidus 2-oxoglutarate synthase subunit KorB (EC 1.2.7.3), 267 aa; fasta scores: opt: 529 z-score: 605.9 E(): 2.8e-26; 37.6% identity in 221 aa overlap. (352 aa)
SCO4595SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus). (645 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4856SC5G8.24c, dhsA, probable succinate dehydrogenase flavoprotein subunit, len: 584aa; strongly similar to many eg. SW:P10444 (DHSA_ECOLI) succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa) fasta scores; opt: 1842, z-score: 2076.6, E(): 0, 48.4% identity in 591 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and Prosite match to PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. (584 aa)
SCO4857SC5G8.25c, dhsD, possible succinate dehydrogenase membrane subunit, len: 160 aa; similar to TR:O53369 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 553, z-score: 702.9, E(): 1.1e-31, 58.9% identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores; opt: 126, z-score: 172.2, E(): 0.039, 23.5% identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match [...] (160 aa)
SCO4858SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...] (126 aa)
SCO4919SCK13.11, probable oxidoreductase, len: 475 aa; similar to SW:DLD2_BACSU (EMBL:D84432) Bacillus subtilis dihydrolipoamide dehydrogenase (EC 1.8.1.4) BfmBC, 474 aa; fasta scores: opt: 753 z-score: 813.4 E(): 0; 29.9% identity in 472 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. (475 aa)
SCO4979Putative phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
SCO5042Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
SCO5044Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (558 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5107SCBAC31E11.03c, shdA2, probable succinate dehydrogenase flavoprotein subunit, len: 653 aa; highly similar to TR:AAK44480 (EMBL:AE006934) Mycobacterium tuberculosis CDC1551 FAD flavoprotein oxidase, putative MT0262, 646 aa; fasta scores: opt: 2941 Z-score: 3164.4 bits: 595.8 E(): 1.2e-168; 70.416% identity in 649 aa overlap and to SW:DHSA_RICPR (EMBL:M88696) Rickettsia prowazekii succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 596 aa; fasta scores: opt: 643 Z-score: 693.1 bits: 138.4 E(): 5.4e-31; 35.218% identity; in 619 aa overlap. Contains Pfam matches to entries PF0 [...] (653 aa)
SCO5108SCBAC31E11.04c, possible integral membrane protein, len: 278 aa; similar to TR:O53671 (EMBL:AL021929) Mycobacterium tuberculosis hypothetical 31.1 kDa protein MTV034.15c, 273 aa; fasta scores: opt: 1010 Z-score: 1230.3 bits: 235.4 E(): 6.5e-61; 54.545% identity in 275 aa overlap. Contains possible hydrophobic membrane spanning regions. (278 aa)
SCO5109Hypothetical protein SCBAC31E11.05c; SCBAC31E11.05c, unknown, len: 146 aa. Contains a possible coiled-coil region at approx. residues 60..87. (146 aa)
SCO52612SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. (409 aa)
SCO5281SCCB12.05c, probable 2-oxoglutarate dehydrogenase, len: 1272 aa; similar to TR:P96746 (EMBL:D84102) Corynebacterium glutamicum 2-oxoglutarate dehydrogenase (EC 1.2.4.2) OdhA, 1257 aa; fasta scores: opt: 4321 z-score: 3452.7 E(): 0; 54.8% identity in 1262 aa overlap and to SW:ODO1_ECOLI (EMBL:J01619) Escherichia coli 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) SucA, 933 aa; fasta scores: opt: 2568 z-score: 2056.0 E(): 0; 46.5% identity in 881 aa overlap. Contains Pfam matches to entries PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and PF0 [...] (1272 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
SCO5926Conserved hypothetical protein; SC10A5.31c, unknown, len: 173 aa; highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa), fasta scores; opt: 422 z-score: 567.1 E(): 2.2e-2 4, 49.3% identity in 138 aa overlap; Belongs to the LeuD family. (173 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6243SCAH10.08c, aceB1, malate synthase, len: 540 aa; highly similar to SW:MASY_STAE (EMBL:U63518) Streptomyces arenae, malate synthase (EC 4.1.3.2) AceB, 543 aa; fasta scores: opt: 2625 z-score: 3156.2 E(): 0; 78.2% identity in 551 aa overlap. Contains match to Pfam entry PF01274 Malate_synthase, Malate synthase and to Prosite entry PS00510 Malate synthase signature. (540 aa)
SCO6269SCAH10.34c, possible oxidoreductase beta-subunit, 350 aa; highly similar to TR:O53181 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase beta-subunit, 373 aa; fasta scores: opt: 1415 z-score: 1622.6 E(): 0; 64.0% identity in 342 aa overlap. Contains possible N-terminal region signal sequence. (350 aa)
SCO6270SCAH10.35c, possible oxidoreductase alpha-subunit, len: 630 aa; similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores: opt: 2008 z-score: 2153.9 E(): 0; 66.4% identity in 614 aa overlap. (630 aa)
SCO6423SC1A6.12c, putative lipoate-protein ligase, len: 388 aa; some similarity inC-terM to LPLA_ECOLI P32099 Escherichia coli putative lipoate-protein ligase A (337 aa), fasta scores; opt: 162 z-score: 223.4E(): 2.5e-05, 27.8% identity in 252 aa overlap. (388 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO7000SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. (739 aa)
SCO7109SC4B10.10c, possible oxidoreductase, len: 576 aa; similar to TR:O27546 (EMBL:AE000910) Methanobacterium thermoautotrophicum succinate dehydrogenase, flavoprotein subunit MTH1502, 558 aa; fasta scores: opt: 1262 z-score: 1392.4 E(): 0; 41.0% identity in 542 aa overlap and to TR:O53141 (EMBL:AJ000941) Methanobacterium thermoautotrophicum strain marburg, thiol:fumarate reductase subunit A Tfr, 545 aa; fasta scores: opt: 1184 z-score: 1306.6 E(): 0; 40.5% identity in 536 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (576 aa)
SCO7123SC4B10.24c, probable acyltransferase, len: 417 aa; similar to SW:ODO2_ALCEU (EMBL:X91877) Alcaligenes eutrophus dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 416 aa; fasta scores: opt: 793 z-score: 570.6 E(): 2.6e-24; 39.0% identity in 421 aa overlap, to C-terminal region of TR:Q9Z6I4 (EMBL:AF047034) Streptomyces seoulensis dihydrolipoamide acetyltransferase PdhB, 612 aa; fasta scores: opt: 1251 z-score: 887.0 E(): 0; 61.0% identity in 474 aa overlap and to TR:CAB51265 (EMBL:AL096872) Streptomyces coelicolor putative dihydrol [...] (417 aa)
SCO7124Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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