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SCO0208 SCO0208 SCO0546 SCO0546 SCO0922 SCO0922 SCO0923 SCO0923 SCO0924 SCO0924 SCO2494 SCO2494 SCO2736 SCO2736 SCO2951 SCO2951 SCO3127 SCO3127 SCO3563 SCO3563 SCO4388 SCO4388 SCO4578 SCO4578 SCO4594 SCO4594 SCO4595 SCO4595 SCO4808 SCO4808 SCO4809 SCO4809 SCO4827 SCO4827 SCO4855 SCO4855 SCO4856 SCO4856 SCO4857 SCO4857 SCO4858 SCO4858 SCO4979 SCO4979 SCO5042 SCO5042 SCO5044 SCO5044 SCO5106 SCO5106 SCO5107 SCO5107 SCO5108 SCO5108 SCO5109 SCO5109 SCO5261 SCO5261 SCO5831 SCO5831 SCO5832 SCO5832 SCO5926 SCO5926 SCO5999 SCO5999 SCO6243 SCO6243 SCO6269 SCO6269 SCO6270 SCO6270 SCO6585 SCO6585 SCO6586 SCO6586 SCO7000 SCO7000 SCO7109 SCO7109
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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SCO0208SCJ12.20, pyruvate phosphate dikinase, len: 898 aa. Highly similar to many pyruvate phosphate dikinases e.g. Clostridium symbiosum SW:PODK_CLOSY (EMBL; M60920)(EC 2.7.9.1) (873 aa), fasta scores opt: 1626 z-score: 1761.3 E():0 48.7% identity in 895 aa overlap and Microbispora rosea SW:BAA76347 (EMBL; AB025020) (878 aa), fasta scores opt: 3060 z-score: 3317.5 E(): 0 67.5% identity in 898 aa overlap. Contains a PS00370 PEP-utilizing enzymes phosphorylation site signature, Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain and a Pfam match to [...] (898 aa)
SCO0546Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0923SCM10.11c, probable reductase flavoprotein subunit, len: 649 aa; similar to SW:DHSA_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 585 aa;fasta scores: opt: 580 z-score: 658.7 E(): 2.7e-29; 36.8% identity in 609 aa overlap and to SW:FRDA_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase flavoprotein subunit FrdA, 583 aa; fasta scores: opt: 443 z-score: 503.1 E(): 1.2e-20; 32.2% identity in 574 aa overlap. Contains three Pfam matches to entry Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (649 aa)
SCO0924SCM10.12c, possible cytochrome B subunit subunit, len: 243 aa; similar to SW:FRDC_HELPY (EMBL:U78101) Helicobacter pylori fumarate reductase cytochrome B subunit FrdC, 255aa; fasta scores: opt: 106 z-score: 139.5 E(): 2.2; 22.1% identity in 181 aa overlap. (243 aa)
SCO2494SC7A8.33c, probable pyruvate phosphate dikinase, len: 909 aa; similar to TR:CAB53432 (EMBL:AL109989) Streptomyces coelicolor pyruvate phosphate dikinase SCJ12.20, 898 aa; fasta scores: opt: 3956 z-score: 4354.7 E(): 0; 66.7% identity in 889 aa overlap and to SW:PODK_CLOSY (EMBL:M60920) Clostridium symbiosum pyruvate, phosphate dikinase (EC 2.7.9.1) (pyruvate,orthophosphate dikinase) PpdK, 873 aa; fasta scores: opt: 1765 z-score: 1941.1 E():; 51.7% identity in 899 aa overlap. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain, two [...] (909 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2951SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. (471 aa)
SCO3127Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (911 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4578Hypothetical protein; SCD16A.05, unknown, len: 74aa; predicted based upon amino acid and codon usage. (74 aa)
SCO4594SCD20.12c, probable oxidoreductase, len: 352 aa; highly similar to TR:Q9RKS5 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase beta-subunit SCAH10.34c, 350 aa; fasta scores: opt: 2267 z-score: 2567.5 E(): 0; 98.0% identity in 349 aa overlap and to SW:KORB_ARCFU (EMBL:AE001072) Archaeoglobus fulgidus 2-oxoglutarate synthase subunit KorB (EC 1.2.7.3), 267 aa; fasta scores: opt: 529 z-score: 605.9 E(): 2.8e-26; 37.6% identity in 221 aa overlap. (352 aa)
SCO4595SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus). (645 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4856SC5G8.24c, dhsA, probable succinate dehydrogenase flavoprotein subunit, len: 584aa; strongly similar to many eg. SW:P10444 (DHSA_ECOLI) succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa) fasta scores; opt: 1842, z-score: 2076.6, E(): 0, 48.4% identity in 591 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and Prosite match to PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. (584 aa)
SCO4857SC5G8.25c, dhsD, possible succinate dehydrogenase membrane subunit, len: 160 aa; similar to TR:O53369 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 553, z-score: 702.9, E(): 1.1e-31, 58.9% identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores; opt: 126, z-score: 172.2, E(): 0.039, 23.5% identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match [...] (160 aa)
SCO4858SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...] (126 aa)
SCO4979Putative phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
SCO5042Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
SCO5044Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (558 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5107SCBAC31E11.03c, shdA2, probable succinate dehydrogenase flavoprotein subunit, len: 653 aa; highly similar to TR:AAK44480 (EMBL:AE006934) Mycobacterium tuberculosis CDC1551 FAD flavoprotein oxidase, putative MT0262, 646 aa; fasta scores: opt: 2941 Z-score: 3164.4 bits: 595.8 E(): 1.2e-168; 70.416% identity in 649 aa overlap and to SW:DHSA_RICPR (EMBL:M88696) Rickettsia prowazekii succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 596 aa; fasta scores: opt: 643 Z-score: 693.1 bits: 138.4 E(): 5.4e-31; 35.218% identity; in 619 aa overlap. Contains Pfam matches to entries PF0 [...] (653 aa)
SCO5108SCBAC31E11.04c, possible integral membrane protein, len: 278 aa; similar to TR:O53671 (EMBL:AL021929) Mycobacterium tuberculosis hypothetical 31.1 kDa protein MTV034.15c, 273 aa; fasta scores: opt: 1010 Z-score: 1230.3 bits: 235.4 E(): 6.5e-61; 54.545% identity in 275 aa overlap. Contains possible hydrophobic membrane spanning regions. (278 aa)
SCO5109Hypothetical protein SCBAC31E11.05c; SCBAC31E11.05c, unknown, len: 146 aa. Contains a possible coiled-coil region at approx. residues 60..87. (146 aa)
SCO52612SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. (409 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
SCO5926Conserved hypothetical protein; SC10A5.31c, unknown, len: 173 aa; highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa), fasta scores; opt: 422 z-score: 567.1 E(): 2.2e-2 4, 49.3% identity in 138 aa overlap; Belongs to the LeuD family. (173 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6243SCAH10.08c, aceB1, malate synthase, len: 540 aa; highly similar to SW:MASY_STAE (EMBL:U63518) Streptomyces arenae, malate synthase (EC 4.1.3.2) AceB, 543 aa; fasta scores: opt: 2625 z-score: 3156.2 E(): 0; 78.2% identity in 551 aa overlap. Contains match to Pfam entry PF01274 Malate_synthase, Malate synthase and to Prosite entry PS00510 Malate synthase signature. (540 aa)
SCO6269SCAH10.34c, possible oxidoreductase beta-subunit, 350 aa; highly similar to TR:O53181 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase beta-subunit, 373 aa; fasta scores: opt: 1415 z-score: 1622.6 E(): 0; 64.0% identity in 342 aa overlap. Contains possible N-terminal region signal sequence. (350 aa)
SCO6270SCAH10.35c, possible oxidoreductase alpha-subunit, len: 630 aa; similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores: opt: 2008 z-score: 2153.9 E(): 0; 66.4% identity in 614 aa overlap. (630 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO7000SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. (739 aa)
SCO7109SC4B10.10c, possible oxidoreductase, len: 576 aa; similar to TR:O27546 (EMBL:AE000910) Methanobacterium thermoautotrophicum succinate dehydrogenase, flavoprotein subunit MTH1502, 558 aa; fasta scores: opt: 1262 z-score: 1392.4 E(): 0; 41.0% identity in 542 aa overlap and to TR:O53141 (EMBL:AJ000941) Methanobacterium thermoautotrophicum strain marburg, thiol:fumarate reductase subunit A Tfr, 545 aa; fasta scores: opt: 1184 z-score: 1306.6 E(): 0; 40.5% identity in 536 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (576 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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