STRINGSTRING
SCO0870 SCO0870 SCO0871 SCO0871 SCO0872 SCO0872 SCO4066 SCO4066 SCO5748 SCO5748 SCO7327 SCO7327
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0870SCM1.03c, probable two-component system response regulator, len: 149 aa. Highly similar to the response regulator receiver domains of putative two-component regulatory proteins including: Synechocystis sp. (strain PCC 6803) TR:P72781(EMBL:D90900) regulatory components of sensory transduction system (282 aa), fasta scores opt: 229 z-score: 290.6 E(): 7.7e-09 31.8% identity in 129 aa overlap and Methanobacterium thermoautotrophicum TR:O26545(EMBL:AE000828) sensory transduction regulatory protein (145 aa), fasta scores opt: 422 z-score: 531.6 E(): 2.9e-22 47.2% identity in 142 aa overlap. [...] (149 aa)
SCO0871SCM1.04c, possible two-component sensor protein. Len: 545 aa. Similar, in parts, to many others including: Methanobacterium thermoautotrophicum TR:O26544(EMBL:AE000828) signal-transducing histidine kinase (373 aa), fasta scores opt: 509 z-score: 548.0 E(): 3.5e-23 34.2% identity in 313 aa overlap and Streptomyces coelicolor TR:O88056(EMBL:AL031541) putative two-component sensor (379 aa), fasta scores opt:350 z-score: 378.5 E(): 9.7e-14 35.6% identity in 233 aa overlap. Contains a Pfam matches to entries PF00512 signal, Histidine kinase and Pfam match to entry PF00672 DUF5, Domain found [...] (531 aa)
SCO0872Conserved hypothetical protein SCM1.05c; SCM1.05c, unknown, len: 445 aa. Weakly similar to several Streptomyces coelicolor proteins including: TR:O86807(EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 306 z-score: 336.6 E(): 2.1e-11 30.7% identity in 264 aa overlap and TR:CAB59599(EMBL:AL132662) hypothetical regulatory protein SCF11.22 (877 aa), fasta scores opt: 284 z-score: 312.7 E(): 4.5e-10 34.6% identity in 243 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain. (445 aa)
SCO4066Hypothetical protein SCD25.02; SCD25.02, unknown, len: 357 aa. (357 aa)
SCO5748SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...] (1829 aa)
SCO7327SC4G10.06c, possible two-component system sensory histidine kinase, len: 1331 aa. Highly similar in parts to many including: Pseudomonas syringae (pv. syringae) SW:LEMA_PSESY(EMBL:M80477) sensor protein, LemA (EC 2.7.3.-), (907 aa), fasta scores opt: 641 z-score: 627.6 E(): 1.7e-27 31.2% identity in 872 aa overlap and Streptomyces coelicolor TR:O86808(EMBL:AL031031) putative sensory histidine kinase, SC7C7.03 (1829 aa), fasta scores opt: 2600 z-score: 2540.8 E():0 59.1% identity in 1346 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domai [...] (1331 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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