STRINGSTRING
SCO0107 SCO0107 SCO0108 SCO0108 SCO0212 SCO0212 SCO0214 SCO0214 SCO0747 SCO0747 SCO0750 SCO0750 SCO2227 SCO2227 SCO2466 SCO2466 SCO2467 SCO2467 SCO2604 SCO2604 SCO2605 SCO2605 SCO2902 SCO2902 SCO2903 SCO2903 SCO2904 SCO2904 SCO2908 SCO2908 SCO2909 SCO2909 SCO3312 SCO3312 SCO3616 SCO3616 SCO3999 SCO3999 SCO4581 SCO4581 SCO5462 SCO5462 SCO5463 SCO5463 SCO5464 SCO5464 SCO5465 SCO5465 SCO5496 SCO5496 SCO5497 SCO5497 SCO7150 SCO7150 SCO7224 SCO7224 SCO7694 SCO7694
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0107Putative aminoglycoside nucleotidyltransferase; SCJ11.36c, possible noncomposite drug resistance transposon aminoglycoside nucleotidyltransferase, len: 185 aa; some similarity to many involved in antibiotic resistance e.g. TR:Q53702 (EMBL:J03947) lincosaminide nucleotidyltransferase from Staphylococcus aureus (161 aa) fasta scores; opt: 176, z-score: 229.0, E(): 2.1e-05, (28.4% identity in 148 aa overlap). (185 aa)
SCO0108Hypothetical protein; SCJ11.37, unknown, len: 49 aa. (49 aa)
SCO0212Hypothetical protein SCJ12.24c; SCJ12.24c, unknown, len: 157 aa. (157 aa)
SCO0214SCJ12.26, hypothetical protein, len: 137 aa. Some similarity to several hypotheticals e.g. Mycobacterium tuberculosis TR:O53625 (EMBL; AL021428) hypothetical 16.6 KD protein (152 aa), fasta scores opt: 291 z-score: 372.0 E(): 2.3e-13 46.5% identity in 129 aa overlap. Also similar to TR:Q9RI49 (EMBL:AL109989) S. coelicolor SCJ12.09c (146 aa), fasta scores opt: 524 z-score: 550.7 E(): 2e-25 62.2% identity in 135 aa overlap. (137 aa)
SCO0747SCF81.06c, hypothetical protein, len: 166 aa; similar to various hypothetical proteins, e.g. TR:AAD36153 (EMBL:AE001768) Thermotoga maritima conserved hypothetical protein TM1076, 157 aa; fasta scores: opt: 293 z-score: 385.9 E(): 4e-14; 39.1% identity in 133 aa overlap and to TR:Q9CCZ0 (EMBL:AL583926) Mycobacterium leprae conserved hypothetical protein ML 2654, 165 aa; fasta scores: opt: 642 Z-score: 785.7 E(): 4e-36; 60.248% identity in 161 aa overlap. (166 aa)
SCO0750Hypothetical protein SCF81.09c; SCF81.09c, unknown, len: 59 aa. (59 aa)
SCO2227SC10B7.22c possible acetyltransferase, len: 186 aa; similar to TR:Q9XAQ0 (EMBL:AL078618) Streptomyces coelicolor putative acetyltransferase SC10A7.25, 187 aa; fasta scores: opt: 160 z-score: 203.0 E(): 0.00063; 29.9% identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (186 aa)
SCO2466SC7A8.05, hypothetical protein, len: 201 aa; identical to C-terminus of previously sequenced TR:CAB51553 (EMBL:AJ244019) Streptomyces coelicolor A3(2) hypothetical 14.6 kD protein, 132 aa. (201 aa)
SCO2467SC7A8.06, hypothetical protein, len: 333 aa; identical to previously sequenced TR:CAB51552 (EMBL:AJ244019) Streptomyces coelicolor A3(2) hypothetical 37.1 kD protein, 333 aa. (333 aa)
SCO2604SCC88.15c, possible secreted protein, len: 311 aa. Contains N-terminal region signal peptide sequence and TTA leucine codon, possible target for bldA regulation. (311 aa)
SCO2605Hypothetical protein SCC88.16; SCC88.16, unknown, len: 233 aa. (233 aa)
SCO2902Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
SCO2903SCE19A.03c, possible secreted protein, len: 134 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, so may be a lipoprotein. (134 aa)
SCO2904Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (245 aa)
SCO2908SCE19A.08c, conserved hypothetical protein, len: 250 aa; unknown function, similar to hypothetical proteins from Mycobacterium leprae, Mycobacterium tuberculosis and bacillus subtilis e.g. SW:Y03O_MYCLE (EMBL:U00014) Mycobacterium leprae hypothetical protein (284 aa), fasta scores; opt: 642 z-score: 777.3 E(): 0, 43.0% identity in 256 aa overlap. Similar to SC66T3.08c (EMBL:AL079348) S.coelicolor hypothetical protein (270 aa) (36.4% identity in 272 aa overlap). (250 aa)
SCO2909SCE19A.09, putative membrane protein, len: 55 aa; unknown function, improbable CDS suggested by GC frameplot. C-terminus is rich in Arg and Pro. Contains possible hydrophobic membrane spanning region. (55 aa)
SCO3312SCE68.10, hypothetical protein, len: 136 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Similar to TRNEW:CAC46514 (EMBL:AL591789) hypothetical protein SMC04265 from Rhizobium meliloti (Sinorhizobium meliloti) (147 aa) fasta scores; opt: 380, Z-score: 458.7, E(): 6.5e-18, 46.875% identity (47.244% ungapped) in 128 aa overlap. (136 aa)
SCO3616SC66T3.27, hypothetical protein, len: 72 aa; unknown function, possible CDS suggested by positional base preference and GC frame analysis. (72 aa)
SCO39992SC10A7.03, possible lipoprotein, len: 376 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (376 aa)
SCO4581SCD16A.02c, conserved hypothetical protein, len: 269aa; similar to many hypothetical proteins egs. TR:CAA22232 (EMBL:AL034355) (280 aa) fasta scores; opt: 1028, z-score: 1143.6, E(): 0, (61.5% identity in 260 aa overlap) and TR:CAA22222 (EMBL:AL034355) (305 aa) fasta scores; opt: 546, z-score: 611.4, E(): 1e-26, (40.2% identity in 271 aa overlap) hypothetical proteins from Streptomyces coelicolor. Also similar to SW:YIDA_ECOLI hypothetical protein from Escherichia coli (270 aa) fasta scores; opt: 314, z-score: 356.2, E(): 1.6e-12, (31.0% identity in 268 aa overlap). Contains Pfam match [...] (269 aa)
SCO5462Hypothetical protein SC3D11.19c; SC3D11.19c, unknown, len: 212 aa; contains a weak Pfam match over much of its length to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (212 aa)
SCO5463SC3D11.20, possible MerR-family transcriptional regulator, len: 304 aa; similar to many e.g. TRNEW:CAB56383 (EMBL:AL118515) putative MerR-family transcriptional regulator from Streptomyces coelicolor (319 aa) fasta scores; opt: 622, z-score: 719.6, E(): 1.2e-32, 41.3% identity in 310 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. (304 aa)
SCO5464SCO5464 protein; SC3D11.21, possible calcium-binding protein, len: 70aa; similar to many eukaryotic calcium-binding proteins eg. TR:Q42470 (EMBL:D63153) calcium-binding protein from Brassica rapa (Turnip), and Brassica napus (Rape) (79 aa) fasta scores; opt: 153, z-score: 214.7, E(): 0.00015, 45.3% identity in 64 aa overlap and SW:P02599 (CALM_DICDI) calmodulin from Dictyostelium discoideum (Slime mold) (151 aa) fasta scores; opt: 155, z-score: 213.0, E(): 0.00019, 43.3% identity in 60 aa overlap. Contains Pfam match to entry PF00036 efhand, EF hand and two Prosite matches to PS00018 E [...] (70 aa)
SCO5465Conserved hypothetical protein; SC3D11.22, unknown, len: 220aa; similar to TRNEW:CAB61931 (EMBL:AL133278) hypothetical protein from Streptomyces coelicolor (219 aa) fasta scores; opt: 519, z-score: 572.9, E(): 1.7e-24, 45.5% identity in 200 aa overlap and TR:O29370 (EMBL:AE001042) hypothetical protein from Archaeoglobus fulgidus fasta scores; opt: 181, z-score: 208.1, E(): 0.00035, 26.2% identity in 206 aa overlap. also to TR:Q98N90 (EMBL:AP002994) Rhizobium loti (Mesorhizobium loti) MLL0243 protein, 231 aa; fasta scores: opt: 789 Z-score: 849.5 E(): 1.1e-39; 56.164% identity in 219 aa [...] (220 aa)
SCO5496SC8D9.08, small hydrophobic membrane protein, len: 123 aa; no significant database similarities. Contains possible hydrophobic membrane spanning regions. (123 aa)
SCO5497Conserved hypothetical protein; SC8D9.09, unknown, len: 164aa; similar to many of undefined function eg. TR:O06336 (EMBL:Z95390) hypothetical protein from Mycobacterium tuberculosis (177 aa) fasta scores; opt: 171, z-score: 213.4, E(): 0.00014, (34.9% identity in 109 aa overlap). (164 aa)
SCO7150SC9A4.12c, possible acetyltransferase, len: 278 aa; similar to TR:Q9V2R3 (EMBL:AJ248283) Pyrococcus abyssi hypothetical 30.2 kDa protein PAB2346, 266 aa; fasta scores: opt: 149 z-score: 182.6 E(): 0.011; 33.3% identity in 90 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (278 aa)
SCO7224SC2H12.23c, possible integral membrane protein, len: 151 aa. Highly similar to several proteins of undefined function e.g. Haemophilus influenzae SW:Y886_HAEIN (EMBL:U32770) hypothetical protein (134 aa), fasta scores opt: 232 z-score: 291.2 E(): 9.6e-09 35.6% identity in 135 aa overlap and Streptomyces coelicolor TR:CAB92826 (EMBL:AL356892) putative integral membrane protein, SCC8A.08 (153 aa), fasta scores opt: 533 z-score: 650.1 E(): 9.8e-29 58.7% identity in 143 aa overlap. Contains possible membrane spanning hydrophobic domains. (151 aa)
SCO7694SC1A4.02, probable tetR-family transcriptional regulator, len: 190 aa; similar to TR:Q9PBQ5 (EMBL:AE004024) Xylella fastidiosa transcriptional regulator (AcrR family) XF2085, 205 aa; fasta scores: opt: 170 z-score: 215.3 E(): 0.00019; 30.8% identity in 117 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 38..59 (+4.46 SD). (190 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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