STRINGSTRING
SCO0012 SCO0012 SCO0105 SCO0105 SCO0158 SCO0158 SCO0163 SCO0163 SCO0219 SCO0219 SCO0265 SCO0265 SCO0304 SCO0304 SCO0316 SCO0316 SCO0321 SCO0321 SCO0359 SCO0359 SCO0386 SCO0386 SCO0481 SCO0481 SCO0516 SCO0516 SCO0518 SCO0518 SCO0528 SCO0528 SCO0545 SCO0545 SCO0554 SCO0554 SCO0587 SCO0587 SCO0638 SCO0638 SCO0643 SCO0643 SCO0667 SCO0667 SCO0677 SCO0677 SCO0683 SCO0683 SCO0736 SCO0736 SCO0762 SCO0762 SCO0779 SCO0779 SCO0787 SCO0787 SCO0838 SCO0838 SCO0896 SCO0896 SCO0906 SCO0906 SCO0936 SCO0936 SCO0982 SCO0982 SCO1021 SCO1021 SCO1031 SCO1031 SCO1052 SCO1052 SCO1092 SCO1092 SCO1093 SCO1093 SCO1105 SCO1105 SCO1129 SCO1129 SCO1146 SCO1146 SCO1155 SCO1155 SCO1159 SCO1159 SCO1188 SCO1188 SCO1194 SCO1194 SCO1226 SCO1226 SCO1230 SCO1230 SCO1240 SCO1240 SCO1265 SCO1265 SCO1289 SCO1289 SCO1360 SCO1360 SCO1396 SCO1396 SCO1401 SCO1401 SCO1417 SCO1417 SCO1429 SCO1429 SCO1441 SCO1441 SCO1444 SCO1444 SCO1451 SCO1451 SCO1466 SCO1466 SCO1485 SCO1485 SCO1572 SCO1572 SCO1587 SCO1587 SCO1629 SCO1629 SCO1674 SCO1674 SCO1675 SCO1675 SCO1725 SCO1725 SCO1734 SCO1734 SCO1735 SCO1735 SCO1782 SCO1782 SCO1794 SCO1794 SCO1795 SCO1795 SCO1800 SCO1800 SCO1817 SCO1817 SCO1847 SCO1847 SCO1880 SCO1880 SCO1893 SCO1893 SCO1935 SCO1935 SCO1948 SCO1948 SCO1979 SCO1979 SCO2001 SCO2001 SCO2024 SCO2024 SCO2135 SCO2135 SCO2153 SCO2153 SCO2183 SCO2183 SCO2237 SCO2237 SCO2276 SCO2276 SCO2291 SCO2291 SCO2292 SCO2292 SCO2371 SCO2371 SCO2409 SCO2409 SCO2417 SCO2417 SCO2457 SCO2457 SCO2460 SCO2460 SCO2474 SCO2474 SCO2503 SCO2503 SCO2516 SCO2516 SCO2528 SCO2528 SCO2529 SCO2529 SCO2625 SCO2625 SCO2627 SCO2627 SCO2655 SCO2655 SCO2663 SCO2663 SCO2664 SCO2664 SCO2699 SCO2699 SCO2704 SCO2704 SCO2705 SCO2705 SCO2710 SCO2710 SCO2714 SCO2714 SCO2716 SCO2716 SCO2717 SCO2717 SCO2718 SCO2718 SCO2719 SCO2719 SCO2799 SCO2799 SCO2821 SCO2821 SCO2833 SCO2833 SCO2837 SCO2837 SCO2880 SCO2880 SCO2920 SCO2920 SCO3055 SCO3055 SCO3056 SCO3056 SCO3065 SCO3065 SCO3096 SCO3096 SCO3116 SCO3116 SCO3150 SCO3150 SCO3180 SCO3180 SCO3184 SCO3184 SCO3194 SCO3194 SCO3227 SCO3227 SCO3274 SCO3274 SCO3288 SCO3288 SCO3299 SCO3299 SCO3306 SCO3306 SCO3312 SCO3312 SCO3326 SCO3326 SCO3408 SCO3408 SCO3421 SCO3421 SCO3471 SCO3471 SCO3511 SCO3511 SCO3540 SCO3540 SCO3551 SCO3551 SCO3559 SCO3559 SCO3596 SCO3596 SCO3671 SCO3671 SCO3712 SCO3712 SCO3713 SCO3713 SCO3745 SCO3745 SCO3753 SCO3753 SCO3772 SCO3772 SCO3887 SCO3887 SCO3921 SCO3921 SCO3963 SCO3963 SCO4018 SCO4018 SCO4026 SCO4026 SCO4043 SCO4043 SCO4049 SCO4049 SCO4135 SCO4135 SCO4186 SCO4186 SCO4202 SCO4202 SCO4222 SCO4222 SCO4241 SCO4241 SCO4246 SCO4246 SCO4298 SCO4298 SCO4356 SCO4356 SCO4422 SCO4422 SCO4436 SCO4436 SCO4486 SCO4486 SCO4498 SCO4498 SCO4509 SCO4509 SCO4552 SCO4552 SCO4561 SCO4561 SCO4589 SCO4589 SCO4590 SCO4590 SCO4624 SCO4624 SCO4674 SCO4674 SCO4759 SCO4759 SCO4760 SCO4760 SCO4796 SCO4796 SCO4799 SCO4799 SCO4815 SCO4815 SCO4836 SCO4836 SCO4853 SCO4853 SCO4868 SCO4868 SCO4934 SCO4934 SCO4935 SCO4935 SCO4950 SCO4950 SCO4975 SCO4975 SCO4994 SCO4994 SCO5003 SCO5003 SCO5015 SCO5015 SCO5043 SCO5043 SCO5053 SCO5053 SCO5062 SCO5062 SCO5067 SCO5067 SCO5179 SCO5179 SCO5180 SCO5180 SCO5248 SCO5248 SCO5290 SCO5290 SCO5294 SCO5294 SCO5312 SCO5312 SCO5436 SCO5436 SCO5446 SCO5446 SCO5457 SCO5457 SCO5458 SCO5458 SCO5527 SCO5527 SCO5539 SCO5539 SCO5543 SCO5543 SCO5673 SCO5673 SCO5724 SCO5724 SCO5725 SCO5725 SCO5797 SCO5797 SCO5853 SCO5853 SCO5898 SCO5898 SCO5912 SCO5912 SCO5926 SCO5926 SCO5932 SCO5932 SCO5945 SCO5945 SCO5954 SCO5954 SCO5999 SCO5999 SCO6003 SCO6003 SCO6012 SCO6012 SCO6043 SCO6043 SCO6050 SCO6050 SCO6068 SCO6068 SCO6075 SCO6075 SCO6127 SCO6127 SCO6131 SCO6131 SCO6178 SCO6178 SCO6206 SCO6206 SCO6232 SCO6232 SCO6234 SCO6234 SCO6304 SCO6304 SCO6345 SCO6345 SCO6348 SCO6348 SCO6375 SCO6375 SCO6393 SCO6393 SCO6407 SCO6407 SCO6418 SCO6418 SCO6444 SCO6444 SCO6450 SCO6450 SCO6479 SCO6479 SCO6493 SCO6493 SCO6497 SCO6497 SCO6519 SCO6519 SCO6532 SCO6532 SCO6537 SCO6537 SCO6572 SCO6572 SCO6594 SCO6594 SCO6595 SCO6595 SCO6609 SCO6609 SCO6663 SCO6663 SCO6682 SCO6682 SCO6691 SCO6691 SCO6711 SCO6711 SCO6714 SCO6714 SCO6772 SCO6772 SCO6795 SCO6795 SCO6884 SCO6884 SCO6942 SCO6942 SCO6966 SCO6966 SCO7000 SCO7000 SCO7070 SCO7070 SCO7124 SCO7124 SCO7211 SCO7211 SCO7212 SCO7212 SCO7225 SCO7225 SCO7228 SCO7228 SCO7256 SCO7256 SCO7257 SCO7257 SCO7267 SCO7267 SCO7283 SCO7283 SCO7339 SCO7339 SCO7406 SCO7406 SCO7421 SCO7421 SCO7432 SCO7432 SCO7464 SCO7464 SCO7513 SCO7513 SCO7575 SCO7575 SCO7579 SCO7579 SCO7608 SCO7608 SCO7615 SCO7615 SCO7630 SCO7630 SCO7633 SCO7633 SCO7638 SCO7638 SCO7650 SCO7650 SCO7653 SCO7653 SCO7695 SCO7695 SCO7697 SCO7697 SCO7739 SCO7739 SCO7835 SCO7835 sapD sapD SCP1.104 SCP1.104 parB1 parB1 SCP1.148 SCP1.148 parB2 parB2 sapD-2 sapD-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SCO0012Hypothetical protein; SCJ30.07c, unknown, len: 136 aa; predicted by GC Frameplot, Hidden Markov model and amino acid usage. (136 aa)
SCO0105SCJ11.34c, xlnC, endo-1,4-beta-xylanase (putative secreted protein), len: 241 aa; highly similar to many endo-1,4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores; opt: 1605, z-score: 1785.1, E(): 0, (97.9% identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores; opt: 813, z-score: 910.7, E(): 0, (58.8% identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11, Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl [...] (241 aa)
SCO0158SCJ1.07, probable oxidoreductase, len: 409 aa; similar to e.g. Synechocystis sp. (strain PCC 6803) TR:P73735 (EMBL:D90909) NADH dehydrogenase (404 aa), fasta scores opt: 358 z-score: 399.1 E(): 7.1e-15 28.9% identity in 353 aa overlap and Rhodococcus globerulus TR:Q57031(EMBL:X80041) ferredoxin reductase BPH (412 aa), fasta scores opt:294 z-score: 328.8 E(): 5.9e-11 31.3% identity in 358 aa overlap. (409 aa)
SCO0163Conserved hypothetical protein SCJ1.12; SCJ1.12 unkown, len: 508 aa, similar to Mycobacterium tuberculosis SW:YW13_MYCTU (EMBL; Z74025) hypothetical 54.4 KD protein CY39.13 (498 aa),fasta scores opt: 1192 z-score: 1332.4 E(): 0 43.8% identity in 470 aa overlap and Aquifex aeolicus TR:O66641 (EMBL: AE000682) hypothetical 38.3 KD protein (322 aa), fasta scores opt: 550 z-score: 618.7 E(): 4.2e-27 35.5% identity in 279 aa overlap. Contains a PS00017 ATP/GTP-binding site motif A (P-loop). (508 aa)
SCO0219SCJ12.31, narI2, possible nitrate reductase gamma chain, len: 256 aa. Similar to many including: Streptomyces coelicolor TR:O86714 (EMBL:AL031515) putative nitrate reductase gamma chain NarI SC5C7.17c (240 aa), fasta scores: opt: 755 z-score: 891.5 E(): 0 46.8% identity in 235 aa overlap and Bacillus subtilis SW:NARI_BACSU (EMBL:Z49884) nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores: opt: 668 z-score: 790.4 E(): 0 43.6% identity in 225 aa overlap. Contains possible membrane spanning hydrophobic domains. (256 aa)
SCO0265SCF1.07, possible hydroxylase, len: 263 aa; similar to many from Streptomyces sp. eg. TR:Q55078 (EMBL:U50973) daunomycin C-14 hydroxylase from Streptomyces sp. strain C5 (275 aa) fasta scores; opt: 302, z-score: 356.8, E(): 1.7e-12, (39.3% identity in 270 aa overlap). Also similar to TR:CAB45588 (EMBL:AL079355) putative hydroxylase from Streptomyces coelicolor (263 aa) fasta scores; opt: 746, z-score: 870.2, E(): 0, (44.3% identity in 262 aa overlap). (263 aa)
SCO0304Hypothetical protein SC5G9.13c; SC5G9.13c, unknown, len: 122 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition. (122 aa)
SCO0316Putative DNA-binding protein; SC5G9.25c, hypothetical protein, len: 555 aa; similar to hypothetical proteins e.g. TR:O50442 (EMBL:AL010186) Mycobacterium tuberculosis hypothetical protein (538 aa), fasta scores; opt: 485 z-score: 521.2 E(): 1.2e-21, 32.6% identity in 568 aa overlap and to TR:Q9Z561 (EMBL:AL035569) S.coelicolor putative transcriptional regulator (415 aa) (28.4% identity in 444 aa overlap). Contains probable helix-turn-helix motif at aa 505-526 (Score 1081, +2.87 SD). (555 aa)
SCO0321SC5G9.30, probable carboxylesterase, len: 518 aa; similar to many eukaryotic and bacterial e.g. SW:PNBA_BACSU (EMBL:U06089), PrnbA, Bacillus subtilis 4-nitrobenzyl esterase (489 aa), fasta scores; opt: 718 z-score: 774.9 E(): 0, 36.3% identity in 479 aa overlap. Similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor probable carboxylesterase (502 aa) (41.3% identity in 521 aa overlap). Contains 2 Pfam matches to entry PF00135 COesterase, Carboxylesterases and PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. (518 aa)
SCO0359SCF41.18, hypothetical protein, len: 240 aa; similar to TR:Q9KEZ0 (EMBL:AP001509) Bacillus halodurans BH0709 protein, 242 aa; fasta scores: opt: 515 Z-score: 603.7 E(): 5.4e-26; 36.000% identity in 225 aa overlap. (240 aa)
SCO0386SCF62.12, putative asparagine synthetase, len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL; Z70283) putative asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa), fasta scores opt: 752 z-score: 874.8 E():0 32.8% identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. (644 aa)
SCO0481SCF80.02, possible secreted chitin binding protein, len: 172 aa. This CDS has been previously sequenced but was unclassified: Streptomyces coelicolor TR:Q9Z9M5 (EMBL; AB017013) gene for ChiG, partial CDS (fragment) (172 aa), fasta scores opt: 1151 z-score: 1339.7 E():0 99.4% identity in 172 aa overlap. This CDS is similar to several e.g. Streptomyces reticuli TR:O87962 (EMBL; Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 193 z-score: 234.7 E(): 1e-05 37.3% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (172 aa)
SCO0516SCF6.12, possible lipoprotein, len:392 aa. Weakly similar to Methylobacterium extorquens TR:O30796 (EMBL; AF017434) hypothetical protein MxaE (281 aa), fasta scores opt: 205 z-score: 214.7 E(): 0.00014 32.5% identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (392 aa)
SCO0518SCF6.14, hypothetical protein, len: 86 aa. Gene fragment that is highly similar to Streptomyces coelicolor TR:Q9RI29 (EMBL:AL109989) putative nitrate reductase delta chain NarI2 (256 aa); fasta scores: opt: 409 Z-score: 526.8 bits: 103.5 E(): 9.3e-22; 74.390% identity in 82 aa overlap. (86 aa)
SCO0528SCF11.08, possible lipoprotein, len: 261 aa; similar to various hypothetical proteins, e.g. TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 KD protein, 218 aa; fasta scores: opt: 157 z-score: 172.7 E(): 0.03; 25.3% identity in 194 aa overlap. Contains a Prosite match correctly situated to entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains probable N-terminal signal sequence. (250 aa)
SCO0545SCF11.25, possible secreted protein, len: 843 aa; similar to TR:O87849 (EMBL:AL031013) Streptomyces coelicolor putative secreted protein, 602 aa; fasta scores: opt: 2859 z-score: 3026.4 E(): 0; 72.1% identity in 555 aa overlap. Contains possible N-terminal signal sequence. (848 aa)
SCO0554SCF73.01c, manA, probable secreted beta-mannosidase, len: 327 aa; similar to many e.g. MANA_STRLI P51529 mannan endo-1,4-beta-mannosidase precursor (EC 3.2.1.78) (363 aa), fasta scores; opt: 1189 z-score: 1332.7 E(): 0, 61.1% identity in 288 aa overlap. Contains N-terminal signal sequence, and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5). Also similar to SC2H4.16 (62.2% identity in 288 aa overlap); SCF11.34c, possible sugar hydrolase, partial CDS, len: >278 aa; C-teminus similar to SW:GUN4_THEFU (EMBL:L20093) Thermomonospora fusca endoglucanase E-4 pre [...] (565 aa)
SCO0587SCF55.11c, cvnB11, hypothetical protein, len: 152 aa; similar to various hypothetical proteins, e.g. TR:O86521 (EMBL:AL031124) Streptomyces coelicolor hypothetical 14.7 KD protein SC1C2.20c, 140 aa; fasta scores: opt: 337 z-score: 422.9 E(): 3.5e-16; 41.3% identity in 138 aa overlap, to TR:CAB41561 (EMBL:AL049727) Streptomyces coelicolor hypothetical 14.4 KD protein SC9B1.15c, 139 aa; fasta scores: opt: 314 z-score: 395.1 E(): 1.2e-14; 41.5% identity in 142 aa overlap and to TR:Q9L138 (EMBL:AL158061c) Streptomyces coelicolor hypothetical protein SC6D11.17c, 135 aa; fasta scores: opt: 6 [...] (152 aa)
SCO0638SCF56.22c, possible lipoprotein, len: 219 aa; similar to TR:O86667 (EMBL:AL031182) Streptomyces coelicolor putative secreted protein SC4A2.11c, 220 aa; fasta scores: opt: 549 z-score: 568.6 E(): 2.7e-24; 45.2% identity in 219 aa overlap and to SW:MP83_MYCTU (EMBL:X94597) Mycobacterium tuberculosis cell surface lipoprotein MPT83 precursor, 220 aa; fasta scores: opt: 497 z-score: 516.2 E(): 2.3e-21; 44.8% identity in 230 aa overlap. Contains N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (219 aa)
SCO0643SCF91.03c, possible secreted cellulose-binding protein, len: 228 aa. Similar to several including: Streptomyces coelicolor TR:CAB50949 (EMBL:AL096849) putative secreted cellulose-binding protein SCI11.23 (356 aa), fasta scores opt: 349 z-score: 417.9 E(): 6.7e-16 32.2% identity in 227 aa overlap. Also weakly similar to chitin-binding proteins e.g. Streptomyces olivaceoviridis TR:Q54501 (EMBL:X78535) chitin binding protein precursor (201 aa), fasta scores opt: 203 z-score: 249.8 E(): 1.5e-06 29.3% identity in 222 aa overlap. Contains a possible N-terminal signal sequence. (228 aa)
SCO0667SCF91.27c, putative secreted protein, len: 293 aa. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53526(EMBL:AL021925) hypothetical 32.8 KD protein (309 aa), fasta scores opt: 441 z-score: 476.5 E(): 3.6e-19 32.8% identity in 299 aa overlap. Contains possible N-terminal region signal peptide sequence. (293 aa)
SCO0677Secreted chitosanase; Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan. (280 aa)
SCO0683SCF15.04c, hypothetical protein, len: 174 aa. Weakly similar to several conserved proteins of undefined function e.g. Methanococcus jannaschii SW:Y714_METJA(EMBL:U67518) hypothetical protein (118 aa), fasta scores opt: 182 z-score: 196.7 E(): 0.0014 30.4% identity in 115 aa overlap. (174 aa)
SCO07363SC5B7.14c, possible secreted protein, len: 231 aa. Contains possible N-terminal region cleavable signal peptide sequence. (231 aa)
SCO0762Protease inhibitor precursor; Strong inhibitory activity toward subtilisin BPN' and, to a lesser extent, toward trypsin; Belongs to the protease inhibitor I16 (SSI) family. (144 aa)
SCO07793SCF60.11c, conserved hypothetical protein, len: 131 aa; identical to TR:O85701 (EMBL:AF072709) Streptomyces lividans hypothetical 14.2 kDa protein, 131 aa and similar to TR:Q9L0J1 (EMBL:AL161691) Streptomyces coelicolor hypothetical 15.7 kDa protein SCD40A.20, 145 aa; fasta scores: opt: 179 z-score: 233.2 E(): 1.8e-05; 31.8% identity in 110 aa overlap. (131 aa)
SCO07873SCF60.19, probable secreted hydrolase, len: 422 aa; similar to TR:O68641 (EMBL:AF052745) Oerskovia xanthineolytica beta-1,3-glucanase II BglII, 435 aa; fasta scores: opt: 999 z-score: 1047.9 E(): 0; 52.4% identity in 443 aa overlap. Contains Pfam match to entry PF00722 Glyco_hydro_16, Glycosyl hydrolases family 16 and PF00652 Ricin_B_lectin, Similarity to lectin domain of ricin beta-chain, 3 copies and match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Also contains possible N-terminal region signal peptide sequence. (422 aa)
SCO0838SCF43A.28, conserved hypothetical protein, len: 141 aa; unknown function, similar to SW:YY13_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis hypothetical protein (137 aa), fasta scores; opt: 393 z-score: 495.0 E(): 3.1e-20, 52.9% identity in 121 aa overlap Weakly similar to SC6G9.21 (EMBL:AL079356) S.coelicolor conserved hypothetical protein (144 aa) (35.7% identity in 126 aa overlap). (141 aa)
SCO0896Putative oxidoreductase; SCM1.29c, possible oxidoreductase, len: 141 aa. Similar to many including Methanopyrus kandleri SW:IMDH_METKA (EMBL:U31567) putative inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (172 aa), fasta scores opt: 227 z-score: 288.9 E(): 9.5e-09 31.6% identity in 117 aa overlap and Bacillus subtilis SW:YHCV_BACSU (EMBL:X96983) hypothetical 14.9 KD protein (140 aa), fasta scores opt: 295 z-score: 372.8 E(): 2e-13 40.0% identity in 135 aa overlap. Contains 2x Pfam match to entry PF00571 CBS, CBS domains. (141 aa)
SCO0906Hypothetical protein SCM1.39c; SCM1.39c, unknown, len: 165 aa. Weakly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53240(EMBL:AL021287) hypothetical 18.2 KD protein (163 aa), fasta scores opt: 148 z-score: 178.3 E(): 0.014 30.9% identity in 139 aa overlap. (165 aa)
SCO0936SCM10.24, probable oligosaccharide deacetylase, len: 201 aa; similar to SW:NODB_RHIGA (EMBL:X87578) Rhizobium galegae chitooligosaccharide deacetylase (EC 3.5.1.-) (nodulation protein B) NodB, 214 aa; fasta scores: opt: 461 z-score: 581.4 E(): 5.4e-25; 45.1% identity in 153 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase. (201 aa)
SCO0982SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature. (426 aa)
SCO1021Hypothetical protein; SCG20A.01, unknown (fragment), len: >110 aa; 2SCG2.35, unknown (fragment), len: >72 aa. (149 aa)
SCO1031SCG20A.11c, possible ABC transport system integral membrane protein, len: 855 aa; similar to TR:CAB89462 (EMBL:AL354048) Streptomyces coelicolor putative ABC transporter integral membrane protein SCE25.31, 843 aa; fasta scores: opt: 1459 z-score: 1443.9 E(): 0; 34.7% identity in 864 aa overlap. Contains possible hydrophobic membrane spanning regions. (855 aa)
SCO1052SCG20A.32c, possible regulatory protein, len: 222 aa; similar to C-terminal part of TR:CAB91114 (EMBL:AL355913) Streptomyces coelicolor putative regulatory protein SC5H4.02, 552 aa; fasta scores: opt: 195 z-score: 192.1 E(): 0.0032; 30.5% identity in 210 aa overlap. Contains possible helix-turn-helix motif at residues 172..193 (+3.29 SD). (222 aa)
SCO10922SCG4.08, conserved hypothetical protein, len: 130 aa; similar to TR:O06412 (EMBL:Z95558;) Mycobacterium tuberculosis hypothetical 14.3 kD protein MTCY25D10.25c, 128 aa; fasta scores: opt: 399 z-score: 498.2 E(): 2.9e-20; 48.4% identity in 128 aa overlap. (130 aa)
SCO10932SCG4.09, possible hydroxylase, len: 283 aa; similar to TR:O50527 (EMBL:AL009204) Streptomyces coelicolor putative hydroxylase SC9B10.20c, 267 aa; fasta scores: opt: 534 z-score: 593.2 E(): 1.5e-25; 37.0% identity in 270 aa overlap. Contains a TTA leucine codon, possible target for bldA regulation. (283 aa)
SCO11052SCG4.21c, possible secreted protein, len: 500 aa. Contains possible N-terminal region signal peptide sequence. (500 aa)
SCO11292SCG38.22, probable secreted deacetylase, len: 282 aa; similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) NodB, 217 aa; fasta scores: opt: 363 z-score: 383.5 E(): 6.5e-14; 38.5% identity in 195 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase and possible N-terminal region signal peptide sequence. (282 aa)
SCO11462SCG38.39c, possible lipoprotein, len: 252 aa; similar to TR:Q9RK82 (EMBL:AL132662) Streptomyces coelicolor hypothetical 26.4 kDa protein SCF11.08, 250 aa; fasta scores: opt: 645 z-score: 660.7 E(): 2.4e-29; 42.1% identity in 247 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (252 aa)
SCO1155SCG8A.09c, conserved hypothetical protein, len: 137aa; strongly similar to many from Streptomyces coelicolor eg. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores; opt: 366, z-score: 458.5, E(): 4.3e-18, 48.0% identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.13c. Contains Pfam match to entry PF01860 DUF42, Protein of unknown function. (137 aa)
SCO1159SCG8A.13c, cvnB3, hypothetical protein, len: 145 aa; strongly similar to many from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores; opt: 412, z-score: 512.5, E(): 4.2e-21, 52.8% identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.09c. Contains Pfam match to entry PF01860 DUF42, Protein of unknown function. (145 aa)
SCO1188SCG11A.19, celS2, secreted cellulose binding protein len: 364 aa; highly similar to TR:AAD27623 (EMBL:AF126376) Streptomyces viridosporus cellulose binding protein CelS2, 358 aa; fasta scores: opt: 2109 z-score: 2160.9 E(): 0; 81.9% identity in 364 aa overlap and to SW:GUNA_MICBI Microbispora bispora endoglucanase A precursor (EC 3.2.1.4) (endo-1,4-beta-glucanase) (CELLULASE) CelA, 456 aa; fasta scores: opt: 350 z-score: 363.9 E(): 6.8e-13; 30.6% identity in 278 aa overlap. Contains match to Pfam entry PF00553 CBD_2, Cellulose binding domain. Contains also possible signal peptide sequence. (364 aa)
SCO1194SCG11A.25, probable export protein, len: 496 aa; similar to TR:P72184 (EMBL:U51164) Propionibacterium freudenreichii membrane-bound transport protein HemX, 487 aa; fasta scores: opt: 1371 z-score: 1416.9 E(): 0; 47.0% identity in 474 aa overlap and to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger) puromycin resistance protein Pur8, 503aa; fasta scores: opt: 576 z-score: 598.4 E(): 5.9e-26; 30.2% identity in 493 aa overlap; Belongs to the major facilitator superfamily. (496 aa)
SCO1226Putative bifunctional protein; 2SCG1.01c, possible secreted metallopeptidase (fragment), len: >385 aa; similar to TR:CAB76001 (EMBL:AL157916) Streptomyces coelicolor putative neutral zinc metallopeptidase SC3D11.04c, 684 aa; fasta scores: opt: 504 z-score: 545.2 E(): 6.7e-23; 35.2% identity in 406 aa overlap. Contains match to Prosite entry PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Also contains possible N-terminal region signal peptide sequence; 2SCG58.26c, possible bifunctional protein (fragment), len: >713 aa; middle region highly similar to SW:APX_STRGR [...] (1066 aa)
SCO1230Putative secreted tripeptidylaminopeptidase; Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides (By similarity); Belongs to the peptidase S33 family. (541 aa)
SCO12402SCG1.15, possible NLP/P60 family protein (putative secreted protein), len: 157 aa; similar to C-terminal region of TR:CAB92659 (EMBL:AL356832) Streptomyces coelicolor putative NLP/P60 family secreted protein SCD63A.07c, 398 aa; fasta scores: opt: 351 z-score: 415.4 E(): 1.1e-15; 42.5% identity in 134 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Contains possible N-terminal region signal peptide sequence. (157 aa)
SCO12652SCG18.12c, probable lipase, len: 289 aa; similar to TR:Q59644 (EMBL:X99255) Propionibacterium acnes triacylglycerol lipase precursor (EC 3.1.1.3) GehA, 339 aa; fasta scores: opt: 423 z-score: 498.8 E(): 2.7e-20; 36.9% identity in 233 aa overlap and to TR:Q9S295 (EMBL:AL096849) Streptomyces coelicolor putative secreted lipase SCI11.24c, 290 aa; fasta scores: opt: 682 z-score: 722.5 E(): 1.2e-34; 47.0% identity in 264 aa overlap. Contains Pfam match to entry PF01674 Lipase_2, Lipase. (289 aa)
SCO12892SCG18.36, probable gntR-family regulatory protein, len: 507 aa; similar to TR:CAB89055 (EMBL:AL353872) Streptomyces coelicolor putative gntR-family regulator SC5G8.04, 462 aa; fasta scores: opt: 1289 z-score: 1152.7 E(): 0; 49.3% identity in 436 aa overlap and to SW:MOCR_RHIME (EMBL:X78503) Rhizobium meliloti probable rhizopine catabolism regulatory protein MocR, 493 aa; fasta scores: opt: 584 z-score: 527.8 E(): 6.5e-22; 34.8% identity in 451 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family. (507 aa)
SCO1360SC10A9.02c, probable gntR-family transcriptional regulator, len: 445 aa; similar to SW:PTSJ_SALTY (EMBL:U11243) Salmonella typhimurium putative transcriptional regulatory protein PtsJ, 430 aa; fasta scores: opt: 968 z-score: 1010.8 E(): 0; 40.4% identity in 433 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and possible helix-turn-helix motif at residues 35..56 (+4.36 SD). (445 aa)
SCO1396Putative D-alanyl-D-alanine dipeptidase (putative secreted protein); Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (274 aa)
SCO1401Conserved hypothetical protein; SC1A8A.21c, cvnB4, unknown, len: 144 aa; similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis e.g. TR:Q9X835 (EMBL:AL049727) hypothetical protein from Streptomyces coelicolor (139 aa) fasta scores; opt: 408, z-score: 500.5, E(): 1.9e-20, 47.6% identity in 143 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues. (144 aa)
SCO1417SC6D7.22, possible GntR-family regulatory protein, len: 500 aa. Similar to several including: Streptomyces coelicolor TR:O88047 (EMBL:AL031541) putative transcriptional regulator SCI35.09C (480 aa), fasta scores opt: 403 z-score: 439.9 E(): 4e-17 29.0% identity in 483 aa overlap and Streptomyces venezuelae TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) (507 aa), fasta scores opt: 444 z-score: 484.0 E(): 1.4e-19 31.8% identity in 462 aa overlap. Contains a Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and a Prosite hit to PS00043 Bacteria [...] (500 aa)
SCO1429SC6D7.10, chiD, chitinase (putative secreted protein), len: 417 aa. Previously sequenced and characterised TR:Q9Z9M7(EMBL:AB017011) fasta scores opt: 2877 z-score: 3125.2 E():0 100.0% identity in 417 aa overlap. Contains a Pfam match to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and a Prosite hit to PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence. (417 aa)
SCO14413,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (429 aa)
SCO1444SCL6.01, probable chitinase precursor, len: 791 aa; similar to TR:CAB62382 (EMBL:AJ250585) Arthrobacter sp chitinase precursor (EC 3.2.1.14) ChitIA, 880 aa; fasta scores: opt: 2788 z-score: 2817.6 E(): 0; 56.3% identity in 764 aa overlap and to SW:CHID_VIBFU (EMBL:U41418) Vibrio furnissii chitodextrinase precursor (EC 3.2.1.14) EndoI, 1046 aa; fasta scores: opt: 2055 z-score: 2075.7 E(): 0; 53.8% identity in 746 aa overlap. Contains three Pfam matches to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and match to Prosite entry PS01095 Chitinases family 18 active site. Cont [...] (791 aa)
SCO1451SCL6.08c, probable endoglucanase precursor, len: 383 aa; similar to SW:GUN1_STRSQ (EMBL:L03218) Streptomyces sp. endoglucanase 1 precursor (EC 3.2.1.4) CasA, 359 aa; fasta scores: opt: 1042 z-score: 1000.3 E(): 0; 50.6% identity in 324 aa overlap. Contains Pfam match to entry PF01341 Glyco_hydro_6, Glycosyl hydrolases family 6 and possible N-terminal region signal peptide sequence. (383 aa)
SCO1466SCL6.23c, possible integral membrane protein, len: 312 aa. Contains possible hydrophobic membrane spanning regions. (312 aa)
SCO1485SC9C5.09c, possible integral membrane protein, len: 191 aa; similar to TR:P71810 (EMBL:Z81011) Mycobacterium tuberculosis hypothetical 18.2 kD protein, 165 aa; fasta scores: opt: 301 z-score: 362.9 E(): 9.7e-13; 33.1% identity in 148 aa overlap. Contains possible hydrophobic membrane spanning region. (191 aa)
SCO1572SCL24.08, possible secreted protein, len: 238 aa; similar to TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 kD protein MTCY63.14, 218 aa; fasta scores: opt: 315 z-score: 359.1 E(): 1.4e-12; 31.2% identity in 218 aa overlap. Contains possible N-terminal region signal peptide sequence. (238 aa)
SCO1587SCI35.09c, possible transcriptional regulator, len: 480 aa; similar to hypothetical proteins e.g. TR:P96681 (EMBL:AB001488) YdfD (B. subtilis) (482 aa), fasta scores; opt: 535 z-score: 419.1 E(): 4.2e-16, 26.1% identity in 471 aa overlap and YRDX_RHOSH hypothetical transcriptional regulator (456 aa), fasta scores; opt: 299 z-score: 407.0 E(): 2e-15, 27.2% identity in 464 aa overlap. Contains probable helix-turn-helix motif at aa 17-38 (Score 1327, +3.71 SD) and Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 41.30, E-value 3.4e-11. (480 aa)
SCO1629Conserved hypothetical protein SCI41.12c; SCI41.12c, cvnB9, unknown, len: 135 aa. Similar to TR:CAB41561 (EMBL:AL049727) Streptomyces coelicolor SC9B1.15C hypothetical 14.3 kD protein, 137 aa; fasta scores: opt: 266 z-score: 339.1 E(): 1.6e-11; 37.0% identity in 127 aa overlap and to TR:Q9AJP3 (EMBL:AB044803) Streptomyces girseus ORF2, 135 aa; fasta scores: opt: 559 Z-score: 671.5 E(): 9e-30; 62.687% identity in 134 aa overlap. (135 aa)
SCO1674Putative secreted protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. A minimal chaplin strain capable of forming aerial mycelium/hyphae o [...] (259 aa)
SCO1675Putative small membrane protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic [...] (77 aa)
SCO1725Putative secreted hydrolase; Catalyzes the hydrolysis of fatty acid esters with a preference for mid-length acyl chain (C10-C16). Is able to hydrolyze the triacylglycerol triolein and mixed triacylglycerols from a wide range of natural oils; better activity is obtained with corn-, wheat germ- and olive oil that have higher content of linoleic and/or oleic acid (C18:2; C18:1, cis). Tween detergents are also substrates for this enzyme. Displays arylesterase activity towards p-nitrophenyl alkanoate esters and alpha- and beta-naphthyl esters. Belongs to the 'GDSL' lipolytic enzyme family. (268 aa)
SCO1734SCI11.23, possible secreted cellulose-binding protein, len: 356 aa; similar cellulose-binding proteins e.g. TR:O07862 (EMBL:U51222) Streptomyces halstedii cellulose-binding protein (364 aa), fasta scores; opt: 584 z-score: 557.4 E(): 1e-23, 35.7% identity in 305 aa overlap. Weaker similarity to chitin-binding proteins e.g. TR:O87962 (EMBL:Y14315) Streptomyces reticuli chitin-binding protein (201 aa) (32.7% identity in 214 aa overlap) secreted when co-cultivated with chitin-containing fungi. Weak similarity to TR:O86614 (EMBL:AL031155) S.coelicolor possible secreted chitinase (252 aa) ( [...] (356 aa)
SCO1735SCI11.24c, probable secreted lipase, len: 290 aa; similar to many lipases e.g. TR:O33969 (EMBL:U80063), lipA, Streptomyces cinnamoneus lipase (275 aa), fasta scores; opt: 575 z-score: 653.1 E(): 4.8e-29, 47.6% identity in 254 aa overlap. Contains probable N-terminal signal sequence. (290 aa)
SCO1782SCI51.22c, possible membrane protein, len: 271 aa; unknown function, similar to hemolysins and hemolysin-like hypothetical proteins e.g. SW:HLYA_TREHY (EMBL:X61684), tlyA, Treponema hyodysenteriae hemolysin A (240 aa), fasta scores; opt: 457 z-score: 532.9 E(): 2.5e-22, 35.4% identity in 240 aa overlap and TR:Q50760 (EMBL:X98295), tlyA, Mycobacterium tuberculosis. Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF01479 S4, S4 domain and PS00017 ATP/GTP-binding site motif A (P-loop). (271 aa)
SCO1794SCI5.02, conserved hypothetical protein, len: 179 aa; similar to many eg. TR:O06235 (EMBL:Z95388) hypothetical protein from Mycobacterium tuberculosis (176 aa) fasta scores; opt: 581, z-score: 658.0, E(): 2.6e-29, (52.9% identity in 172 aa overlap); Belongs to the UPF0098 family. (179 aa)
SCO1795Conserved hypothetical protein; SCI5.03, unknown, len: 168 aa; similar to TR:P72833 (EMBL:D90901) hypothetical protein from Synechocystis sp. PCC6803 (165 aa) fasta scores; opt: 417, z-score: 517.5, E(): 1.7e-21, (46.9% identity in 143 aa overlap). (168 aa)
SCO1800Putative small secreted protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic [...] (82 aa)
SCO1817SCI8.02, unknown, len: 464 aa. Similar to many proteins of undefined function e.g. Mycobacterium tuberculosis TR: P71898 (EMBL; Z79702) hypothetical 48.7 KD protein MTCY3G12.20 (457 aa), fasta scores opt: 1485 z-score: 1670.5 E():0 53.5% identity in 454 aa overlap. Contains a Pfam match to entry PF01523 PmbA_TldD, Putative modulator of DNA gyrase. (464 aa)
SCO1847Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (327 aa)
SCO1880SCI39.27c, probable secreted pectate lyase, len: 444 aa; similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel, 420 aa; fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62; 42.431% identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase, Pectate lyase. Contains also possible N-terminal region signal peptide sequence. (444 aa)
SCO1893SCI7.11c, possible lyase, len: 130aa; similar to many egs. TR:O86701 (EMBL:AL031515) putative lyase from Streptomyces coelicolor (138 aa) fasta scores; opt: 153, z-score: 201.1, E(): 0.00072, (30.5% identity in 131 aa overlap) and SW:LGUL_ECOLI lactolylglutathione lyase from Escherichia coli (135 aa) fasta scores; opt: 111, z-score: 150.2, E(): 0.49, (28.3% identity in 138 aa overlap). (130 aa)
SCO1935Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (695 aa)
SCO1948SCC54.08c, possible secreted zinc-binding carboxypeptidase, len: 999 aa; N-terminal region similar to many carboxypeptidases eg. SW:CBPS_STRGR zinc-carboxypeptidase from Streptomyces griseus (451 aa) fasta scores; opt: 565, z-score: 581.4, E(): 4.4e-25, (31.8% identity in 456 aa overlap). Contains PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature and Pfam match to entry PF00246 Zn_carbOpept, Zinc carboxypeptidase, score 143.40, E-value 4e-39. Also contains probable N-terminal signal sequence. (999 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
SCO2001SC7H2.15c, putative secreted protein, len: 597 aa; similar to TR:O86313 (EMBL:Z98260) hypothetical protein from Mycobacterium tuberculosis (411 aa) fasta scores; opt: 548, z-score: 447.1, E(): 1.4e-17, (33.7% identity in 380 aa overlap). Contains possible N-terminal region signal peptide sequence. (597 aa)
SCO2024Putative chitosanase (putative secreted protein); Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan. (305 aa)
SCO2135SC6G10.08c, possible secreted protein, len: 338 aa; similar to TR:O69580 (EMBL:AL022602) putative secreted protein from Mycobacterium leprae (374 aa) fasta scores; opt: 382, z-score: 384.3, E(): 4.2e-14, (32.4% identity in 358 aa overlap). Also similar to several examples of Listeria P60 a major extracellular protein involved in the invasion of non-professional phagocytic cells eg. SW:P60_LISIV from Listeria ivanovii (524 aa) fasta scores; opt: 337, z-score: 338.3, E(): 1.5e-11, (29.1% identity in 309 aa overlap). Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family and the C- [...] (338 aa)
SCO2153SC6G10.26c, possible secreted protein, len: 424aa; similar to many of undefined function eg. TR:O53223 (EMBL:AL021185) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores; opt: 867, z-score: 941.5, E(): 0, (35.2% identity in 403 aa overlap). Contains Prosite matches to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00213 Lipocalin signature. Also contains possible N-terminal signal sequence. (424 aa)
SCO2183Putative pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (899 aa)
SCO2237SCBAC17D6.04, possible lyase, len: 148 aa; similar to TR:Q9FBS1 (EMBL:AL391072) Streptomyces coelicolor putative lyase SC9A4.33c, 143 aa; fasta scores: opt: 287 Z-score: 354.0 bits: 71.5 E(): 3.9e-12; 41.497% identity in 147 aa overlap. Contains 2x Pfam matches to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (148 aa)
SCO2276Putative membrane protein; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (420 aa)
SCO2291SCC75A.37, axeA, secreted acetylxylan esterase, len: 335 aa. Almost identical in sequence with Streptomyces lividans TR:Q54413 (EMBL:M64552) acetylxylan esterase precursor (EC 3.1.1.72) (335 aa), fasta scores opt: 2197 z-score: 2058.4 E(): 0 98.5% identity in 335 aa overlap. Also highly similar to the C-terminus of Cellulomonas fimi SW:XYND_CELFI (EMBL:X76729) endo-1,4-beta-xylanase D precursor (EC 3.2.1.8) (644 aa), fasta scores opt: 1108 z-score: 1040.5 E(): 0 50.0% identity in 346 aa overlap. Also similar to the adjoining CDS on this cosmid, xlnB, (335 aa), fasta scores opt: 652 z-s [...] (335 aa)
SCO2292SCC75A.38, xlnB, secreted endo-1,4-beta-xylanase B (xylanase B), len: 335 aa. Almost identical to Streptomyces lividans SW:XYNB_STRLI(EMBL:M64552) endo-1,4-beta-xylanase B precursor (xylanase B) (EC 3.2.1.8) (334 aa), fasta scores opt: 2266 z-score: 2249.3 E():0 98.2% identity in 335 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52919 (EMBL:AL109949) endo-1,4-beta-xylanase, XlnC (241 aa), fasta scores opt: 1087 z-score: 970.6 E():0 71.9% identity in 224 aa overlap and to the adjoining CDS on this cosmid, AxeA, (335 aa), fasta scores opt: 652 z-score: 585.8 E(): 2.9e-27 56.2 [...] (335 aa)
SCO2371Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (918 aa)
SCO2409SC4A7.37c, possible secreted protein, len: 421 aa; similar to various hypothetical proteins, e.g. TR:CAB52057 (EMBL:AL109732) Streptomyces coelicolor hypothetical 61.4 kD protein SC7H2.15c, 597 aa; fasta scores: opt: 1148 z-score: 809.3 E(): 0; 51.3% identity in 388 aa overlap. Contains proline-rich region and possible N-terminal region signal peptide sequence. (421 aa)
SCO2417SC8A2.05c, possible secreted protein, len: 351 aa; similar to TR:O53969 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 43.7 kDa protein MTV051.06, 410 aa; fasta scores: opt: 683 z-score: 769.5 E(): 0; 33.4% identity in 368 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence. (351 aa)
SCO2457SCC24.28c, possible lipoprotein, len: 131 aa; similar to SW:Y0B2_MYCTU (EMBL:Z77724) Mycobacterium tuberculosis hypothetical 15.0 kD protein CY227.02c precursor, MTCY227.02c, 143 aa; fasta scores: opt: 130 z-score: 169.2 E(): 0.054; 26.5% identity in 136 aa overlap. Contains match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (131 aa)
SCO2460SCC24.31c, hypothetical protein, len: 142 aa; similar to TR:O06633 (EMBL:Z95618) Mycobacterium tuberculosis hypothetical 12.5 kD protein MTCY07H7A.08c, 115 aa; fasta scores: opt: 109 z-score: 150.6 E(): 0.59; 35.0% identity in 140 aa overlap. (142 aa)
SCO2474Putative metalloproteinase (putative secreted protein); Extracellular zinc metalloprotease. (547 aa)
SCO2503SCC121.06, probable chitinase precursor, len: 358 aa; similar to C-terminal region of SW:CHID_BACCI (EMBL:D10594) Bacillus circulans chitinase D precursor (EC 3.2.1.14) ChiD, 497 aa; fasta scores: opt: 471 z-score: 502.4 E(): 1.4e-20; 33.0% identity in 370 aa overlap and to SW:CHIX_STROI (EMBL:X71080) Streptomyces olivaceoviridis (Streptomyces corchorusii exochitinase 1 precursor (EC 3.2.1.14) Chi01, 597 aa; fasta scores: opt: 249 z-score: 267.3 E(): 1.7e-07; 31.2% identity in 391 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18 and match to Prosite enry PS01095 Chitinas [...] (358 aa)
SCO2516SCC121.19, possible secreted protein, len: 499 aa; similar to TR:O69831 (EMBL:AL023517) Streptomyces coelicolor putative secreted protease SC1B5.03C, 543 aa; fasta scores: opt: 772 z-score: 821.6 E(): 0; 32.2% identity in 537 aa overlap. Contains possible N-terminal region signal peptide sequence. (499 aa)
SCO25282-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
SCO2529Putative metalloprotease; Extracellular zinc metalloprotease. (356 aa)
SCO2625SCC80.10, hypothetical protein, len: 413 aa; similar to TR:CAB94090 (EMBL:AL358692) Streptomyces coelicolor conserved hypothetical protein SCD66.23, 418 aa; fasta scores: opt: 698 z-score: 807.3 E(): 0; 35.8% identity in 419 aa overlap. (413 aa)
SCO2627SC8E4.02c, probable sugar-phosphate isomerase, len: 159 aa; similar to TR:O53192 (EMBL:AL021246) Mycobacterium tuberculosis putative isomerase MTV008.21c, 162 aa; fasta scores: opt: 665 z-score: 811.6 E(): 0; 62.1% identity in 153 aa overlap and to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) (phosphoriboisomerase B) RpiB, 149 aa; fasta scores: opt: 294 z-score: 366.6 E(): 5.2e-13; 37.5% identity in 144 aa overlap. (159 aa)
SCO2655SC8E4A.25c, hypothetical protein, len: 178 aa; similar to various hypothetical proteins, e.g. TR:Q9X7B4 (EMBL:AL049913) Mycobacterium leprae hypothetical 23.9 kD protein MLCB1610.15, 215 aa; fasta scores: opt: 589 z-score: 757.6 E(): 0; 52.8% identity in 161 aa overlap. Contains Pfam match to entry PF01844 HNH, HNH endonuclease. (178 aa)
SCO2663SC6D10.06, possible secreted protein, len: 429 aa; similar to TR:P96258 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 47.1 kD protein MTCY22G10.08c, 439 aa; fasta scores: opt: 430 z-score: 482.8 E(): 1.8e-19; 30.9% identity in 427 aa overlap and to TR:Q9ZBL6 (EMBL:AL035159) Mycobacterium leprae putative membrane protein MLCB1450.21c, 403 aa; fasta scores: opt: 412 z-score: 463.3 E(): 2.1e-18; 29.6% identity in 423 aa overlap. Contains possible N-terminal region signal peptide sequence. (429 aa)
SCO2664SC6D10.07, possible sugar-binding protein, len: 352 aa; similar to TR:O34563 (EMBL:Z99117) Bacillus subtilis glutamine ABC transporter (glutamine-binding protein) GlnH, 27 33; fasta scores: opt: 474 z-score: 507.4 E(): 7.5e-21; 32.6% identity in 285 aa overlap and to SW:GLNH_BACST (EMBL:M61017) Bacillus stearothermophilus glutamine-binding protein precursor GlnH, 262 aa; fasta scores: opt: 414 z-score: 444.6 E(): 2.4e-17; 33.1% identity in 236 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, to Prosite entry PS01039 [...] (352 aa)
SCO2699Putative small membrane protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic [...] (90 aa)
SCO2704SCC61A.25c, possible secreted protein, len: 244aa; contains a possible cleavable N-terminal signal sequence. (244 aa)
SCO2705Putative membrane protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic surfa [...] (88 aa)
SCO2710SCC61A.31, possible polysaccharide deacetylase, len: 229 aa; weakly similar to many e.g. TR:Q9XDJ5 (EMBL:AF048749) putative deacetylase from Bacteroides fragilis (259 aa) fasta scores; opt: 135, z-score: 169.7, E(): 0.054, 22.6% identity in 137 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase. (229 aa)
SCO2714SCC61A.35, possible secreted protein, len: 395aa; contains a possible non-cleavable N-terminal signal sequence; Belongs to the glycosyl hydrolase 26 family. (395 aa)
SCO2716Putative secreted protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. A minimal chaplin strain capable of forming aerial mycelium/hyphae o [...] (252 aa)
SCO2717Putative small membrane protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic [...] (75 aa)
SCO2718Putative secreted protein; Probably forms part of the rodlet layer on the spore surface; despite their high similarity both RdlA and RdlB are required for rodlet formation. Plays a role in cell adhesion to polystyrene plates. Does not form amyloid fibrils in vitro, unlike RdlB. Belongs to the rodlin family. (131 aa)
SCO2719Putative secreted protein; Forms part of the rodlet layer on the spore surface; despite their high similarity both RdlA and RdlB are required for rodlet formation. Plays a role in cell adhesion to polystyrene plates. Forms amyloid-like fibrils in vitro composed of stacked beta-sheets. Belongs to the rodlin family. (147 aa)
SCO27992SCC13.07c, possible secreted sugar hydrolase, len: 489 aa; similar to the C-terminal region of TR:Q9UWR7 (EMBL:AB024740) Pyrococcus kodakaraensis chitinase PK-ChiA, 1215 aa; fasta scores: opt: 671 z-score: 561.2 E(): 9.4e-24; 31.6% identity in 471 aa overlap. Contains Pfam match to entry PF00553 CBD_2, Cellulose binding domain and 3x degenerate repeat: PAPT(P/G)TP. Also possible N-terminal region signal peptide sequence. (489 aa)
SCO2821SCBAC17F8.12c, possible secreted pectate lyase, len: 521 aa: similar to many e.g. TR:Q9KGY6 (EMBL:AF278705) pectate lyase B from Alteromonas haloplanktis (658 aa) fasta scores; opt: 1744, Z-score: 1590.1, 63.301% identity (65.859% ungapped) in 515 aa overlap and SW:P04959 (PELB_ERWCH) pectate lyase B from Erwinia chrysanthemi (375 aa) fasta scores; opt: 413, Z-score: 386.2, 29.167% identity (32.464% ungapped) in 384 aa overlap. Contains Pfam match to entry PF00544 pec_lyase, Pectate lyase and a probable N-terminal signal sequence. (521 aa)
SCO2833SCE20.07c, chb, secreted chitin binding protein, len: 201 aa. Highly similar to several including: Streptomyces olivaceoviridis (Streptomyces corchorusii) TR:Q54501(EMBL:X78535) chitin binding protein precursor Chb1 (201 aa), fasta scores opt: 1185 z-score: 1303.0 E():0 83.7% identity in 202 aa overlap and Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 1161 z-score: 1276.8 E(): 0 79.1% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (201 aa)
SCO2837Putative secreted protein; SCE20.11, possible secreted protein, len: 645 aa. Weakly similar to a Eukaryotic galactose oxidase precursor (EC 1.1.3.9) from Dactylium dendroides (Cladobotryum dendroides) SW:GAOA_DACDE(EMBL:M86819) (680 aa), fasta scores opt: 350 z-score: 374.4 E(): 1.8e-13 26.8% identity in 400 aa overlap. Contains a possible N-terminal signal sequence. (645 aa)
SCO2880Conserved hypothetical protein SCE6.17; SCE6.17, cvnB12, unknown, len: 140 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) SC9B1.15C (139 aa), fasta scores opt: 222 z-score: 297.5 E(): 3.9e-09 34.3% identity in 134 aa overlap and TR:CAB61281 (EMBL:AL132991) SCF55.11C (152 aa), fasta scores opt: 221 z-score: 295.6 E(): 4.9e-09 32.6% identity in 138 aa overlap. Contains a Pfam match to entry PF01860 DUF42, Protein of unknown function. (140 aa)
SCO2920SCE19A.20c, probable secreted protease, len: 781 aa; similar to SW:INA_BACTL (EMBL:X55436), Ina, Bacillus thuringiensis inhibitor A (a protease) (687 aa), fasta scores; opt: 924 z-score: 991.3 E(): 0, 32.9% identity in 747 aa overlap and TR:O07351 (EMBL:Y00557), PrtV, Vibrio cholerae protease precursor (919 aa) (33.2% identity in 794 aa overlap). Contains probable N-terminal signal sequence and PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. (781 aa)
SCO3055SCBAC19G2.10, conserved hypothetical protein, len: 119aa: similar to many in Streptomyces coelicolor e.g. TR:O85701 (EMBL:AF072709) 3SCF60.11c conserved hypothetical protein (131 aa) fasta scores; opt: 322, Z-score: 387.9, 42.017% identity in 119 aa overlap and downstream neighbouring CDS SCBAC19G2.11. (119 aa)
SCO3056SCBAC19G2.11, conserved hypothetical protein, len: aa: similar to many in Streptomyces coelicolor eg. TR:Q9F3E9 (EMBL:AL450289) SC2H2.06 hypothetical protein (150 aa) fasta scores; opt: 340, Z-score: 415.4, 46.032% identity in 126 aa overlap and upstream neighbouring CDS SCBAC19G2.10. (130 aa)
SCO3065SCE25.06, hypothetical protein, len: 145 aa; similar to TR:CAB86125 (EMBL:AL163003) Streptomyces coelicolor hypothetical 16.0 kD protein, SCC24.31c, 142 aa; fasta scores: opt: 338 z-score: 419.4 E(): 6.6e-16; 42.6% identity in 141 aa overlap. (145 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO3116Hypothetical protein SCE41.25c; SCE41.25c, unknown, len: 335 aa. (335 aa)
SCO3150Hypothetical protein; SCE87.01c, unknown, partial CDS, len: > 329 aa. Similar in parts to Mycobacterium tuberculosis TR:O05594 (EMBL:Z94752) hypothetical 38.1 KD protein (362 aa), fasta scores opt: 365 z-score: 372.3 E(): 2.3e-13 34.1% identity in 232 aa overlap and Bacillus subtilis SW:YABE_BACSU (EMBL:D26185) hypothetical 47.7 KD protein (437 aa), fasta scores opt: 315 z-score: 321.5 E(): 1.5e-10 29.2% identity in 233 aa overlap; SCE66.29c, unknown, partial CDS, len: >165aa; similar to TR:O05594 (EMBL:Z94752) hypothetical protein from Mycobacterium tuberculosis (362 aa) fasta scores; [...] (458 aa)
SCO3180Molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (170 aa)
SCO3184Putative penicillin acylase (EC 3.5.1.11); SCE22.01c, possible secreted penicillin acylase (fragment), len: >162 aa; similar to C-terminal region of SW:PAC2_PSES3 (EMBL:M18278) Pseudomonas sp. penicillin acylase II precursor (EC 3.5.1.11) AcyII, 773 aa; fasta scores: opt: 291 z-score: 347.5 E(): 6.8e-12; 39.1% identity in 110 aa overlap. Contains possible N-terminal signal peptide sequence; SCE87.35c, possible penicillin acylase (EC 3.5.1.11) partial CDS, len: > 808 aa. Similar to many penicillin acylases including: Pseudomonas sp. (strain SE83) SW:PAC2_PSES3c (EMBL:M18278) penicillin [...] (936 aa)
SCO3194SCE22.11, possible lipoprotein, len: 407 aa; similar to TR:CAB76012 (EMBL:AL157916) Streptomyces coelicolor putative lipoprotein SC3D11.15, 400 aa; fasta scores: opt: 1416 z-score: 1518.4 E(): 0; 52.4% identity in 403 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal domain signal peptide sequence. (407 aa)
SCO3227SCE8.20c, partial CDS, possible aminotransferase, len: 431 aa; similar to many of undefined function e.g. TR:O52815 (EMBL:AJ223998) a protein similar to aminotransferase, from a cluster of genes involved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (438 aa) fasta scores; opt: 953, z-score: 1093.1, E(): 0, (48.4% identity in 426 aa overlap). Also similar to TR:Q64602 (EMBL:Z50144) kynurenine/alpha-aminoadipate aminotransferase from rat (Rattus norvegicus) kidney (425 aa) fasta scores; opt: 293, z-score: 338.4, E(): 1.5e-11, (25.8% ident [...] (444 aa)
SCO3274Hypothetical protein; SCE39.24, unknown, len: 148aa. (148 aa)
SCO3288SCE15.05, possible integral membrane protein, len: 243aa; similar to TR:Q53715 (EMBL:L06249) hypothetical protein from Streptomyces antibioticus (234 aa) fasta scores; opt: 292, z-score: 298.6, E(): 2.5e-09, (33.2% identity in 241 aa overlap). Contains a possible membrane spanning hydrophobic region and a 8x5 degenerate repeat of GT***. (243 aa)
SCO3299Conserved hypothetical protein; SCE15.16c, unknown, len: 397aa; similar to many e.g. SW:RTCB_ECOLI hypothetical protein from Escherichia coli (408 aa) fasta scores; opt: 809, z-score: 903.2, E(): 0, 46.8% identity in 408 aa overlap. Contains Pfam match to entry PF01139 UPF0027, Uncharacterized protein family UPF0027. (397 aa)
SCO3306SCE68.04c, possible aminotransferase, len: 404 aa; similar to TR:Q56232 (EMBL:D38459), aspC, Thermus aquaticus aspartate aminotransferase (385 aa), fasta scores; opt: 379 z-score: 433.6 E(): 7.9e-17, 28.9% identity in 370 aa overlap and to many hypothetical aminotransferases. Similar to many from S.coelicolor e.g. SCH10.36 (EMBL:AL049754) probable aspartate aminotransferase (396 aa) (33.2% identity in 404 aa overlap). Alternative start codons are present at codons 3 and 7. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. (404 aa)
SCO3312SCE68.10, hypothetical protein, len: 136 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Similar to TRNEW:CAC46514 (EMBL:AL591789) hypothetical protein SMC04265 from Rhizobium meliloti (Sinorhizobium meliloti) (147 aa) fasta scores; opt: 380, Z-score: 458.7, E(): 6.5e-18, 46.875% identity (47.244% ungapped) in 128 aa overlap. (136 aa)
SCO3326SCE68.24c, possible epimerase, len: 353 aa; similar to many e.g. SW:GALE_SALT (EMBL:M33681), galE, Salmonella typhimurium UDP-glucose 4-epimerase (337 aa), fasta scores; opt: 209 z-score: 250.6 E(): 1.2e-06, 32.1% identity in 193 aa overlap. Similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV28_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis putative UDP-glucose 4-epimerase (376 aa) (45.0% identity in 353 aa overlap). N-terminal half weakly similar to the corresponding region of TR:O54156 (EMBL:AL021409), SC3F7.13, S.coelicolor probable o [...] (353 aa)
SCO3408Conserved hypothetical protein; SCE9.15c, possible penicillin-binding protein, len: 459 aa; weakly similar to penicillin-binding proteins e.g. SW:DAC_ACTSP (EMBL:X64790), dac, Actinomadura sp. D-alanyl-D-alanine carboxypeptidase precursor (538 aa), fasta scores; opt: 248 z-score: 243.2 E(): 3.2e-06, 29.5% identity in 499 aa overlap and TR:O85665 (EMBL:AF071224), pbp3, Neisseria gonorrhoeae penicillin binding protein 3 (469 aa) (26.8% identity in 399 aa overlap). Similar to SC9B2.18c (EMBL:AL035212) S.coelicolor probable carboxypeptidase (451 aa) (36.1% identity in 429 aa overlap). The [...] (459 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO3471SCE65.07c, dagA, extracellular agarase precursor, len: 309 aa; identical to previously sequenced SW:AGAR_STRCO (EMBL:X05811) Streptomyces coelicolor extracellular agarase precursor (EC 3.2.1.81) DagA, 309 aa and similar to TR:Q59078 (EMBL:M73783) Alteromonas atlantica (Pseudomonas atlantica) beta-agarase I precursor (EC 3.2.1.81), 290 aa; fasta scores: opt: 385 z-score: 446.1 E(): 1.8e-17; 33.2% identity in 304 aa overlap. Contains match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Contains N-terminal region signal sequence peptide. (309 aa)
SCO3511SCE134.12, possible lipoprotein, len: 381aa; similar to many, mostly hypotheticals, eg. TR:P71594 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (281 aa) fasta scores; opt: 288, z-score: 295.1, E(): 4e-09, (40.9% identity in 132 aa overlap). Also similar to SW:SPR_ECOLI lipoprotein Spr precusror from Escherichia coli (188 aa) fasta scores; opt: 201, z-score: 211.7, E(): 0.00018, (37.2% identity in 113 aa overlap). Contains a possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains Pfam mat [...] (381 aa)
SCO3540SCH5.02c, slpD, proteinase (putative secreted protein), len: 539 aa; identical to the previously sequenced TR:Q54398 (EMBL:L42758) SlpD, mycelium-associated (lipoprotein) proteinase from Streptomyces lividans 66 (539 aa) fasta scores; opt: 3608, z-score: 3750.3, E(): 0, (100.0% identity in 539 aa overlap). Also similar to two other peptidases from Streptomyces coelicolor SC9C7.15c (EMBL:AL035161) fasta scores; opt: 666, z-score: 603.6, E(): 9.4e-29, (35.7% identity in 502 aa overlap) and SC1B5.03c (EMBL:AL023517) fasta scores; opt: 661, z-score: 598.9, E(): 1.7e-28, (32.6% identity in [...] (539 aa)
SCO3551SCH5.14c, possible membrane spanning protein, len: 230aa; This CDS has been designated based on Hidden-Markoff Model and Frameplot predictions, lies in a region of high %GC DNA and contains a potential membrane spanning hydrophobic region. Glycine rich N-terminal. (230 aa)
SCO3559SCH5.22c, possible oxidoreductase, len: 274aa; similar to TR:O69630 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (256 aa) fasta scores; opt: 289, z-score: 335.7, E(): 2.1e-11, (39.3% identity in 270 aa overlap). Also contains a region of similarity to many fatty acid desaturases from plants eg. SW:STAD_RICCO Stearoyl-acyl-carrier-protein desaturase from Ricinus communis (castor bean) (396 aa) fasta scores; opt: 112, z-score: 133.1, E(): 4.1, (25.3% identity in 146 aa overlap). (274 aa)
SCO3596Putative D-alanine:D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor. (202 aa)
SCO3671Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. (618 aa)
SCO3712SCH35.12c, possible hydrolase, len: 278aa; similar to many polysaccharide deacetylases from Rhizobia spp. eg. SW:NODB_RHIME chito-oligosaccharide deacetylase from Rhizobium meliloti (217 aa) fasta scores; opt: 399, z-score: 428.0, E(): 1.6e-16, (36.9% identity in 187 aa overlap). (278 aa)
SCO3713Hypothetical protein; SCH35.11, unknown, len: 57aa. (57 aa)
SCO3745SCH22A.23c, possible lipoprotein, len: 163 aa; similar to TR:P96401 (EMBL:Z92669) Mycobacterium tuberculosis hypothetical 20.1 kD protein, 182 aa; fasta scores: opt: 287 z-score: 377.4 E(): 1.3e-13; 38.9% identity in 162 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. Also contains possible hydrophobic membrane spanning regions. (163 aa)
SCO3753SCH22A.31, possible integral membrane, len: 850 aa. Contains possible hydrophobic membrane spanning regions. (850 aa)
SCO3772SCH63.19c, possible secreted protein, len: 348 aa; similar to TR:AAG03932 (EMBL:AE004490) Pseudomonas aeruginosa hypothetical 35.1 kDa protein PA0543, 322 aa; fasta scores: opt: 419 z-score: 410.9 E(): 2.3e-15; 33.6% identity in 295 aa overlap. Contains possible N-terminal region signal peptide sequence. (348 aa)
SCO3887StH24.09, possible partitioning or sporulation protein, len: 328 aa; previously sequenced as TR:O07327 (EMBL:Y16311), but with different putative start codon. Similar to many e.g. SW:SP0J_BACSU (EMBL:D26185), spo0J, Bacillus subtilis stage 0 sporulation protein (282 aa), fasta scores; opt: 686 z-score: 757.0 E(): 0, 42.7% identity in 262 aa overlap, TR:O05190 (EMBL:U87804), parB, Caulobacter crescentus chromosome partitioning protein (293 aa) (37.1% identity in 264 aa overlap) and TR:O53595 (EMBL:AL021426), parA, Mycobacterium tuberculosis hypothetical protein (344 aa) (51.4% identity [...] (328 aa)
SCO3921Low molecular weight protein-tyrosine-phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (164 aa)
SCO3963Conserved hypothetical protein SCD78.30c; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (445 aa)
SCO40182SC10A7.22c, conserved hypothetical protein, len: 177 aa; highly similar to SW:YL40_MYCTU (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 18.6 kDa protein MTCY270.28, 176 aa; fasta scores: opt: 672 z-score: 724.7 E(): 7.4e-33; 57.7% identity in 175 aa overlap. Contains Pfam match to entry PF01161 PBP, Phosphatidylethanolamine-binding protein. (177 aa)
SCO40262SC10A7.30c, possible ATP binding protein, len: 156 aa; similar to TR:Q9XAG1 (EMBL:AL079356) Streptomyces coelicolor hypothetical 15.6 kDa protein SC6G9.21, 144 aa; fasta scores: opt: 278 z-score: 351.7 E(): 4.4e-12; 42.5% identity in 120 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (156 aa)
SCO40432SCD60.09c, conserved hypothetical protein, len: 98 aa; similar to TR:O05823 (EMBL:Z95208) Mycobacterium tuberculosis hypothetical 12.0 kDa protein MTCY27.05c, 105 aa; fasta scores: opt: 419 z-score: 582.4 E(): 7e-25; 62.2% identity in 98 aa overlap. (98 aa)
SCO4049Putative antibiotic binding protein; 2SCD60.15, probable antibiotic hydrolase, len: 782 aa; similar to SW:PAC2_PSES3 (EMBL:M18278) Pseudomonas sp. penicillin acylase II precursor (EC 3.5.1.11) AcyII, 773 aa; fasta scores: opt: 701 z-score: 597.1 E(): 1.1e-25; 33.5% identity in 841 aa overlap. Contains 3x Pfam matches to entry PF01804 Penicil_amidase, Penicillin amidase. Also contains 11x degenerate repeat (S/P)(E/K)(A/T)A(L/P)- and 4x degenerate repeat TP(L/E). (782 aa)
SCO4135SCD84.02, possible lipoprotein, len: 297 aa; similar to TR:CAB75314 (EMBL:AL139164) Streptomyces coelicolor putative lipoprotein SCC46.10, 285 aa; fasta scores: opt: 180 z-score: 203.0 E(): 0.00075; 22.4% identity in 232 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (297 aa)
SCO4186SCD66.23, conserved hypothetical protein, len: 418 aa; highly similar to TR:Q54238 (EMBL:D63706;) Streptomyces griseus hypothetical protein ORF5, 416 aa; fasta scores: opt: 1720 z-score: 2020.0 E(): 0; 62.6% identity in 414 aa overlap. (418 aa)
SCO42022SCD46.16c, possible NLP/P60-family secreted protein, len: 386aa; similar to many from Streptomyces coelicolor eg. TR:Q9XAE3 (EMBL:AL079356) putative secreted protein (391 aa) fasta scores; opt: 781, z-score: 663.2, E(): 1.9e-29, 38.9% identity in 378 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family, a possible cleavable N-terminal signal sequence and coiled-coil regions at 75-118 and 196-233 residues. (386 aa)
SCO42222SCD46.36, conserved hypothetical protein, len: 126aa; similar to others from actinomycetes eg. TR:O06633 (EMBL:Z95618) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores; opt: 256, z-score: 332.9, E(): 4.5e-11, 36.1% identity in 119 aa overlap. (126 aa)
SCO4241SCD8A.14c, possible proteinase precursor, len: 545 aa; similar to TR:Q54398 (EMBL:L42758) Streptomyces lividans proteinase SlpD, 539 aa; fasta scores: opt: 1116 z-score: 1193.2 E(): 0; 40.1% identity in 541 aa overlap and to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa; fasta scores: opt: 1004 z-score: 1074.0 E(): 0; 47.7% identity in 539 aa overlap, and to TR:Q54398 (EMBL:AL035636) Streptomyces coelicolor SCH5.02c, proteinase SlpD, 539 aa; fasta scores: opt: 1116 z-score: 1004.4 E(): 0; 40.1% identity in 541 aa overlap. Contains Pfam match to entry PF00561 abh [...] (545 aa)
SCO4246Hypothetical protein SCD8A.19c; SCD8A.19c, unknown, len: 643 aa. (643 aa)
SCO4298SCD95A.31, probable carboxylesterase, len: 513 aa; similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor putative carboxylesterase SC9B2.14, 502 aa; fasta scores: opt: 1093 z-score: 1041.3 E(): 0; 44.6% identity in 511 aa overlap and to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.-) PnbA, 489 aa; fasta scores: opt: 823 z-score: 786.2 E(): 0; 38.1% identity in 501 aa overlap. Contains Pfam match to entry PF00135 COesterase, Carboxylesterases and match to Prosite entry PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B [...] (513 aa)
SCO4356Hypothetical protein SCD19.11c; SCD19.11c, unknown, len: 229 aa. (229 aa)
SCO4422SC6F11.20, possible hydrolase, len: 252 aa; similar to TR:Q9X7R7 (EMBL:AL049863) Streptomyces coelicolor putative hydrolase SC5H1.09c, 265 aa; fasta scores: opt: 465 z-score: 555.8 E(): 1.9e-23; 40.1% identity in 252 aa overlap. (252 aa)
SCO4436SCD6.14, possible lyase, len: 136 aa; highly similar to TR:O86701 (EMBL:AL031515) Streptomyces coelicolor putative lyase SC5C7.04, 138 aa; fasta scores: opt: 532 z-score: 662.4 E(): 2e-29; 53.7% identity in 136 aa overlap. (136 aa)
SCO4486SCD69.06, hypothetical protein, len: 135 aa; similar to TR:Q9Z549 (EMBL:AL035212) Streptomyces coelicolor putative quinone protein SC9B2.10c, 130 aa; fasta scores: opt: 191 z-score: 257.8 E(): 6.8e-07; 34.6% identity in 127 aa overlap and to TR:Q98IY9 (EMBL:AP002999) Rhizobium loti (Mesorhizobium loti) MLR2185 protein, 133 aa; fasta scores: opt: 522 Z-score: 639.6 E(): 5.4e-28; 64.122% identity in 131 aa overlap. (135 aa)
SCO4498SCD35.05, probable proton transport protein, len: 440 aa; similar to TR:Q54104 (EMBL:X92556) Saccharopolyspora erythraea similar to GltP glutamate transporters HgtA, 449 aa; fasta scores: opt: 1339 z-score: 1482.7 E(): 0; 50.2% identity in 422 aa overlap and to SW:GLTP_BACSU (EMBL:U15147) Bacillus subtilis proton glutamate symport protein (glutamate-aspartate carrier protein) GltP, 414 aa; fasta scores: opt: 684 z-score: 760.6 E(): 0; 28.9% identity in 409 aa overlap. Contains Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family and possible hydrophobic membrane spann [...] (440 aa)
SCO4509Hypothetical protein SCD35.16; SCD35.16, unknown, len: 124 aa. Contains possible coiled-coil region at aprox. residues 40..56; Belongs to the WXG100 family. (124 aa)
SCO4552Putative hydrolase; SCD16A.31, possible secreted hydrolase, len: 334aa; similar to eg. TR:Q59145 (EMBL:D31818) chitinases II precursor from Aeromonas sp. NO.10S-24 (542 aa) fasta scores; opt: 482, z-score: 492.4, E(): 4.2e-20, (36.6% identity in 273 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (334 aa)
SCO4561SCD16A.22, possible NLP/P60 family protein, len: 277aa; similar to many eg. TR:CAB39862 (EMBL:AL049497) putative secreted protein from Streptomyces coelicolor (338 aa) fasta scores; opt: 386, z-score: 364.3, E(): 5.8e-13, (35.1% identity in 251 aa overlap) and the C-terminal half of many Listeria spp. extracellular proteins eg. SW:P60_LISIN P60 Listeria innocua (481 aa) fasta scores; opt:, z-score: 328.5, E(): 5.7e-11, (28.9% identity in 242 aa overlap). Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Also contains coiled-coil region at 92-125aa and possible hydrophobic [...] (277 aa)
SCO4589SCD20.07c, probable aminopeptidase (putative secreted protein), len: 324 aa; similar to SW:APX_STRGR Streptomyces griseus aminopeptidase (EC 3.4.11.-) SgaP, 284 aa; fasta scores: opt: 1532 z-score: 1626.6 E(): 0; 76.8% identity in 276 aa overlap and to (EMBL:AL391754) Streptomyces coelicolor putative hydrolase SCK7.16c, 486 aa; fasta scores: opt: 980 z-score: 845.8 E(): 0; 52.1% identity in 288 aa overlap. Contains possible N-terminal region signal peptide sequence. (324 aa)
SCO4590SCD20.08c, hypothetical protein, len: 156 aa; similar to TR:CAB86125 (EMBL:AL163003) Streptomyces coelicolor hypothetical 16.0 kDa protein SCC24.31c, 142 aa; fasta scores: opt: 205 z-score: 265.0 E(): 2.7e-07; 34.0% identity in 156 aa overlap. (156 aa)
SCO4624Hypothetical protein SCD39.24c; SCD39.24c, unknown, len: 111 aa. (111 aa)
SCO4674SCD40A.20, hypothetical protein, len: 145 aa; similar to TR:O06633 (EMBL:Z95618) Mycobacterium tuberculosis hypothetical 12.5 kD protein MTCY07H7A.08c, 115 aa; fasta scores: opt: 249 z-score: 314.3 E(): 4.5e-10; 39.5% identity in 119 aa overlap. (145 aa)
SCO4759SC6G4.37, probable secreted protein, len: 264 aa; contains possible N-terminal signal sequence. Similar to down stream gene SC6G4.38 (E(): 3.9e-19, 38.7% identity in 248 aa overlap). (291 aa)
SCO4760SC6G4.38, probable secreted protein, len: 249 aa; slight similarity to S. lividans TR:Q54413 (EMBL:M64552) acetyl-xylan esterase precursor (335 aa), fasta scores; opt: 16 3 z-score: 197.4 E(): 0.00099, 28.9% identity in 180 aa overlap. Contains N-terminal signal sequence. (249 aa)
SCO4796SCD63A.07c, possible NLP/P60 family secreted protein, len: 398 aa; similar to TR:Q9XAQ3 (EMBL:AL078618) Streptomyces coelicolor putative NLP/P60 family secreted protein SCD16A.22, 277 aa; fasta scores: opt: 479 z-score: 430.6 E(): 1.6e-16; 39.1% identity in 233 aa overlap, to TR:Q9X7Z5 (EMBL:AL049497) Streptomyces coelicolor putative secreted protein SC6G10.09c, 347 aa; fasta scores: opt: 576 z-score: 513.3 E(): 4e-21; 41.5% identity in 395 aa overlap and to Streptomyces coelicolor SCD63A.04c, 347 aa. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Contains also possible [...] (398 aa)
SCO4799SCD63A.10c, possible secreted lipase, len: 331 aa; similar to SW:LIP_BACSU (EMBL:M74010) Bacillus subtilis lipase precursor (EC 3.1.1.3) LipA, 212 aa; fasta scores: opt: 188 z-score: 190.5 E(): 0.0038; 26.5% identity in 211 aa overlap and to TR:AAF11628 (EMBL:AE002044) Deinococcus radiodurans lipase, putative, 237 aa; fasta scores: opt: 309 z-score: 302.6 E(): 2.2e-09; 32.0% identity in 200 aa overlap. Contains match to Prosite entry PS00120 Lipases, serine active site and possible N-terminal region signal peptide sequence. (331 aa)
SCO4815SCD63A.26c, possible secreted protein, len: 214 aa. Contains possible N-terminal signal peptide sequence. (214 aa)
SCO4836SC5G8.04, possible gntR-family regulator, len: 462 aa; similar to many proposed regulators eg. TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) from Streptomyces venezuelae (507 aa) fasta scores; opt: 1010, z-score: 1115.6, E(): 0, 45.2% identity in 389 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family. (462 aa)
SCO4853Hypothetical protein; SC5G8.21c, unknown, len: 136 aa; weakly similar to other hypothetical proteins eg. TR:AAF12497 (EMBL:AE001863) from Deinococcus radiodurans (117 aa) fasta scores; opt: 109, z-score: 149.3, E(): 0.74, 26.1% identity in 111 aa overlap. (136 aa)
SCO4868SCK20.09c, possible lipoprotein, len: 281 aa; similar to TR:CAC14938 (EMBL:AL449216) Streptomyces coelicolor putative secreted protein 3SC5B7.14c, 231 aa; fasta scores: opt: 330 z-score: 353.2 E(): 3.9e-12; 35.3% identity in 218 aa overlap. Contains Pfam match to entry PF01471 PG_binding_1, Putative peptidoglycan binding domain and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (281 aa)
SCO4934SCK13.26, possible lipoprotein, len: 414 aa; similar to TR:Q9KYV1 (EMBL:AL355832) Streptomyces coelicolor putative lipoprotein SCE22.11, 407 aa; fasta scores: opt: 1603 z-score: 1740.6 E(): 0; 60.5% identity in 415 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (414 aa)
SCO4935SCK13.27, possible integral membrane protein, len: 496 aa; C-terminal region similar to C-terminal region of similar to TR:Q9UX75 (EMBL:Y18930) Sulfolobus solfataricus hypothetical 43.0 kDa protein ORF-C10_044, 418 aa; fasta scores: opt: 332 z-score: 303.7 E(): 2.2e-09; 27.1% identity in 325 aa overlap. Contains 4 possible hydrophobic membrane spanning regions. (496 aa)
SCO49502SCK31.10, narI3, nitrate reductase gamma chain, len: 237 aa; highly similar to SW:NARI_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase gamma chain (EC 1.7.99.4) NarI, 223 aa; fasta scores: opt: 792 z-score: 991.9 E(): 0; 49.6% identity in 234 aa overlap and to TR:Q9RI29 (EMBL:109989) Streptomyces coelicolor putative nitrate reductase delta chain NarI2 SCJ12.31, 256 aa; fasta scores: opt: 813 z-score: 891.7 E(): 0; 54.3% identity in 230 aa overlap. Contains possible hydrophobic membrane spanning regions. (237 aa)
SCO49752SCK31.35, conserved hypothetical protein, len: 680 aa; similar to SW:YYAL_BACSU (EMBL:D26185) Bacillus subtilis hypothetical 78.8 kDa protein in TetB-ExoA intergenic region YyaL, 689 aa; fasta scores: opt: 1541 z-score: 1751.9 E(): 0; 39.2% identity in 683 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. (686 aa)
SCO4994Hypothetical protein 2SCK36.17; 2SCK36.17, unknown, len: 317 aa. (317 aa)
SCO5003SCK15.05c, chiA, chinitase A precursor, len: 571 aa; identical to previously sequenced TR:Q9Z9M9 (EMBL:AB017008) Streptomyces coelicolor chinitase A precursor ChiA, 571 aa and to TR:Q59924 (EMBL:D13775) Streptomyces lividans chitinase A precursor (EC 3.2.1.14) ChiA, 571 aa. Contains Pfam match to entry PF02018 CBD_6, Cellulose binding domain, PF00041 fn3, Fibronectin type III domain, PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and matches to Prosite entries PS00678 Trp-Asp (WD) repeats signature and PS01095 Chitinases family 18 active site. Contains also possible N-terminal r [...] (571 aa)
SCO5015SCK15.17, possible secreted protein, len: 203 aa; similar to many other membrane proteins, e.g. TR:Q9S6B8 (EMBL:AF115336) Pseudomonas fluorescens major outer membrane protein OprF, 343 aa; fasta scores: opt: 247 z-score: 285.4 E(): 2e-08; 34.3% identity in 181 aa overlap. Contains Pfam match to entry PF00691 OmpA, OmpA family and possible N-terminal region signal peptide sequence. (203 aa)
SCO5043SCK7.16c, probable hydrolase (putative membrane protein), len: 486 aa; N-terminal similar to SW:APX_STRGR Streptomyces griseus aminopeptidase (EC 3.4.11.-), 284 aa; fasta scores: opt: 967 z-score: 1057.3 E(): 0; 53.7% identity in 283 aa overlap and C-terminal region similar to TR:O69311 (EMBL:D84193) Streptomyces lividans chitinase (EC 3.2.1.14) ChiB, 610 aa; blastp scores: Score = 87 (30.6 bits), Expect = 2.1, P = 0.87; Identities = 46/159 (28%), Positives = 60/159 (37%). Contains possible hydrophobic membrane spanning region. (486 aa)
SCO5053SCK7.26, possible secreted protein, len: 519 aa. Contains possible N-terminal region signal peptide sequence. (519 aa)
SCO5062SCBAC20F6.05c, hypothetical protein, len: 130 aa; similar to TR:Q9X8E7 (EMBL:AL049573) Streptomyces coelicolor hypothetical 16.4 kDa protein SCE39.24, 148 aa; fasta scores: opt: 257 Z-score: 327.8 bits: 66.5 E(): 1.1e-10; 39.394% identity in 132 aa overlap. (130 aa)
SCO5067SCBAC20F6.10, probable carboxylesterase, len: 497 aa; similar to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.*) PnbA, 489 aa; fasta scores: opt: 784 Z-score: 827.6 bits: 162.6 E(): 1.6e-38; 37.205% identity in 508 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase, Carboxylesterase and match to Prosite entry PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. (497 aa)
SCO5179Peptidase; 2SC3B6.03c, peptidase, len: 513 aa; identical to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa and highly similar to Streptomyces coelicolor 2SC3B6.04c, 516 aa; fasta scores: opt: 1544 z-score: 1384.8 E(): 0; 50.2% identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (513 aa)
SCO51802SC3B6.04c, peptidase, len: 516 aa; highly similar to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa; fasta scores: opt: 1543 z-score: 1741.5 E(): 0; 50.2% identity in 526 aa overlap and to Streptomyces coelicolor putative peptidase 2SC3B6.03c, 513 aa; fasta scores: opt: 1544 z-score: 1465.5 E(): 0; 50.2% identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal [...] (516 aa)
SCO52482SC7G11.10c, hypothetical protein, len: 192 aa; similar to TR:O06288 (EMBL:Z95557) Mycobacterium tuberculosis hypothetical 30.6 kDa protein MTCY07H7.28c, 275 aa; fasta scores: opt: 180 z-score: 221.9 E(): 6.8e-05; 31.8% identity in 176 aa overlap. (192 aa)
SCO5290SC6G9.43c, cvnB5, conserved hypothetical protein, len: 150 aa; similar to hypothetical proteins from S. coelicolor and Mycobacterium tuberculosis e.g. TR:O86524 (EMBL:AL031124) S.coelicolor hypothetical protein (173 aa), fasta scores; opt: 316 z-score: 394.7 E(): 1.2e-14, 48.1% identity in 131 aa overlap and TR:O50393 (EMBL:AL009198) Mycobacterium tuberculosis hypothetical protein (130 aa) (36.7% identity in 120 aa overlap). (150 aa)
SCO5294SC6G9.39, probable secreted protein, len: 391 aa; similar to mycobacterial hypothetical proteins e.g. TR:O69580 (EMBL:AL022602) Mycobacterium leprae probable secreted protein (374 aa), fasta scores; opt: 347 z-score: 354.0 E(): 2.2e-12, 29.1% identity in 337 aa overlap. Similar to part of Listeria p60 attachment/invasion proteins e.g. SW:P60_LISWE (EMBL:M80354) Listeria welshimeri protein p60 precursor (524 aa) (37.8% identity in 98 aa overlap). Similar to other putative secreted proteins from S.coelicolor e.g. (EMBL:AL049497), SC6G10.08C, S.coelicolor putative secreted protein (338 aa [...] (391 aa)
SCO5312SC6G9.21, conserved hypothetical protein, len: 144 aa; unknown function, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. TR:O06553 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical protein (147 aa), fasta scores; opt: 478 z-score: 561.4 E(): 6.1e-24, 55.7% identity in 140 aa overlap. (144 aa)
SCO5436SC6A11.12, possible sodium:dicarboxylate symporter, len: 466 aa; similar to many e.g. SW:P50334 (DCTA_SALTY) C4-dicarboxylate transport protein from Salmonella typhimurium (428 aa) fasta scores: opt: 1320, z-score: 1451.6, E(): 0, 48.9% identity in 419 aa overlap. Contains Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (466 aa)
SCO5446Neutral metalloproteinase; Extracellular zinc metalloprotease. (549 aa)
SCO5457SC3D11.14, possible lipoprotein, len: 416aa; similar to many eg. TR:O53223 (EMBL:AL021185) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores; opt: 737, z-score: 800.7, E(): 0, 32.9% identity in 413 aa overlap. Also similar to neighbouring CDS SC3D11.15 fasta scores; opt: 1348, z-score: 1271.2, E(): 0, 53.3% identity in 394 aa overlap. Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (416 aa)
SCO5458SC3D11.15, possible lipoprotein, len: 400aa; similar to many eg. TR:Q9X811 (EMBL:AL049497) putative secreted protein from Streptomyces coelicolor (424 aa) fasta scores; opt: 755, z-score: 799.1, E(): 0, 33.0% identity in 409 aa overlap. Also similar to neighbouring CDS SC3D11.14 fasta scores; opt: 1348, z-score: 1211.8, E(): 0, 53.3% identity in 394 aa overlap. Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (400 aa)
SCO5527SC1C2.08, unknown, len: 339 aa; similar to two hypothetical proteins TR:O41120 (EMBL:U42580) A638R protein from Paramecium bursaria chlorella virus 1 (360 aa), fasta scores; opt: 635 z-score: 688.3 E(): 4.4e-31, 35.0% identity in 343 aa overlapTR:O24890 (EMBL:AE000526) HP0049 from Helicobacter pylori (330 aa)opt: 416 z-score: 316.9 E(): 2.1e-10, 25.5% identity in 337 aa overlap. (339 aa)
SCO5539SC1C2.20c, cvnB2, unknown, len: 140 aa; similar to M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa), fasta scores; opt: 445 z-score: 754.7 E(): 0, 56.9% identity in 116 aa overlap. 94.2% identical to upstream gene SC1C2.24c. (140 aa)
SCO5543SC1C2.24c, cvnB1, unknown, len: 137 aa; M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa), fasta scores; opt: 466 z-score: 804.8 E(): 0, 58.6% identity in 116 aa overlap. 94.2% identical to downstream gene SC1C2.20c. (137 aa)
SCO5673SC8B7.05c, chiB, secreted chitinase, len: 610 aa; almost identical to S. lividans TR:D1026067 (EMBL:D84193) chitinase ChiB (EC 3.2.1.14) (610 aa), 99.3% identity in 610 aa overlap, and highly similar to many e.g. CHIX_STROI Streptomyces olivaceoviridis exochitinase 1 precursor (EC 3.2.1.14) (597 aa), fasta scores; opt: 3484 z-score: 2485.6 E(): 0, 86.1% identity in 596 aa overlap. Contains PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence. (610 aa)
SCO5724Hypothetical protein SC3C3.10; SC3C3.10, unknown, len: 124 aa; Belongs to the WXG100 family. (124 aa)
SCO5725Hypothetical protein SC3C3.11; SC3C3.11, unknown, len: 103 aa; Belongs to the WXG100 family. (103 aa)
SCO5797SC4H2.18c, probable secreted protein, len: 405 aa; Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Highly similar to upstream CDS SC4H2.19c (409 aa), fasta scores; E(): 0, 61.8% identity in 406 aa overlap. (405 aa)
SCO5853SC9B10.20c, unknown, len: 267 aa; similar to several hypothetical proteins eg.TR:Q55078 (EMBL:U50973) OrfA from Streptomyces sp. (275 aa), fasta scores; opt: 418 z-score: 665.7 E(): 6.4e-30, 37.1% identity in 267 aa overlap. (267 aa)
SCO5898SC10A5.03, redF, probable membrane protein, len: 226 aa. Contains possibe hydrophobic membrane spanning regions. (226 aa)
SCO5912SC10A5.17, probable secreted protease, len: 865 aa; similar to many members of the peptidase family M9 (zinc me talloprotease) eg. COLA_VIBAL P43154 microbial collagenase precursor from VIBRIO ALGINOLYTICUS (814 aa), fasta scores; opt: 1357 z-score: 1196.6 E(): 0, 36.0% identity in 773 aa overlap. Contains N-terminal signal sequence and PS00142 N eutral zinc metallopeptidases, zinc-binding region signatur e. (865 aa)
SCO5926Conserved hypothetical protein; SC10A5.31c, unknown, len: 173 aa; highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa), fasta scores; opt: 422 z-score: 567.1 E(): 2.2e-2 4, 49.3% identity in 138 aa overlap; Belongs to the LeuD family. (173 aa)
SCO5932Arabinofuranosidase; Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well (By similarity); Belongs to the glycosyl hydr olase 62 family. (475 aa)
SCO5945SC7H1.15, probable transferase, len: 606 aa; similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa), fasta scores; opt: 921 z-score: 1470.0 E(): 0, 45.8% identity in 600 aa overlap and to other gamma-glutamyl transferases. (606 aa)
SCO5954SC7H1.24, probable chitinase (putative secreted protein), len: 765 aa; similar to many eg. S. lividans CHIT_STRLI P36909 chitinase c precursor (ec 3.2.1.14) (619 aa), fasta scores; opt: 292 z-score: 779.5 E(): 0, 35.1% identity in 752 aa overlap. Contains PS01095 Chitinases family 18 active site signature, and possible N-terminal region signal peptide sequence. (765 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6003SCBAC1C11.06c, possible DNA-binding protein, len: 286 aa; similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28; 37.4% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD). (286 aa)
SCO6012SC7B7.09c, probable hydrolase (putative secreted protein), len: 507 aa; similar to many chitinases eg. TR:Q59145 (EMBL:D31818) chitinase II precursor (EC 3.2.1.14) Aeromonas sp. (542 aa), fasta scores; opt: 410 z-score: 512.7 E(): 2.1e-21, 32.1% identity in 498 aa overlap. Contains N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop). (507 aa)
SCO6043SC1B5.03c, probable secreted protease, len: 543 aa;similar to e.g. Streptomyces lividans TR:Q54410 (EMBL:L27466) tripeptidylaminopeptidase (537 aa), fasta scores; opt: 1839 z-score: 1633.9 E(): 0, 51.9% identity in 538 aa overlap. Contains possible N-terminal signal sequence. (543 aa)
SCO6050SC1B5.10c, probable lipoprotein, len: 289 aa; contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (289 aa)
SCO6068Conserved hypothetical protein; SC9B1.15c, cvnB6, unknown, len: 119 aa; similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86521 (EMBL:AL031124) (140 aa) fasta scores; opt: 331, z-score: 424.2, E(): 2.6e-16, (41.5% identity in 130 aa overlap) and TR:O86524 (EMBL:AL031124) (137 aa) fasta scores; opt: 325, z-score: 416.9, E(): 6.7e-16, (44.3% identity in 122 aa overlap), and TR:O50393 (EMBL:AL009198) from Mycobacterium tuberculosis (130 aa) fasta scores; opt: 282, z-score: 364.1, E(): 5.8e-13, (39.1% identity in 115 aa overlap). (139 aa)
SCO6075Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (273 aa)
SCO6127SC9B2.14, probable carboxylesterase, len: 502aa; similar to many both prokaryotic and eukaryotic eg. SW:PCD_ARTOX phenylcarbamate hydrolase, Pcd, from Arthrobacter oxidans (493 aa) fasta scores; opt: 924, z-score: 897.3, E(): 0, (37.2% identity in 503 aa overlap). Contains PS00122 Carboxylesterases type-B serine active site and 2x Pfam match to entry PF00135 COesterase, Carboxylesterases; Belongs to the type-B carboxylesterase/lipase family. (502 aa)
SCO6131SC9B2.18c, probable carboxypeptidase, len: 451aa; similar to SW:DAC_ACTSP D-alanyl-D-alanine carboxypeptidase precursor from Actinomadura sp. (strain R39) (538 aa) fasta scores; opt: 399, z-score: 430.8, E(): 1e-16, (30.9% identity in 512 aa overlap) and PBP4_ECOLI penicillin-binding protein 4 precursor (PBP-4) (D-alanyl-D-alanine carboxypeptidase) from Escherichia coli (477 aa) fasta scores; opt: 383, z-score: 414.4, E(): 8.6e-16, (29.4% identity in 445 aa overlap). Contains probable hydrophobic membrane spanning region. (451 aa)
SCO6178SC6C5.14c, possible deacetylase (putative secreted protein), len: 260 aa; similar to many e.g. SW:NODB_RHILT NodB, chitooligosaccharide deacetylase, nodulation protein B, from Rhizobium leguminosarum (215 aa) fasta scores; opt: 321, z-score: 420.9, E(): 3.7e-16, (35.0% identity in 197 aa overlap). Contains possible N-terminal region signal peptide sequence. (260 aa)
SCO6206Putative oxidoreductase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (279 aa)
SCO6232SC2H4.14, probable beta-mannosidase, len: 820 aa; similar to several eukaryotic beta-mannosidases, e.g. MANB_HUMAN beta-mannosidase precursor (EC 3.2.1.25) (879 aa), fasta scores; opt: 679 z-score: 909.3 E(): 0, 31.4% identity in 684 aa overlap. (820 aa)
SCO6234SC2H4.16, manA, probable secreted beta-mannosidase, len: 384 aa; 94.5% identical to MANA_STRLI mannan endo-1,4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5), score 104.70, E-value 1.8e-27. (384 aa)
SCO6304SCIF3.06c, probable oxidoreductase, len: 310 aa; similar to SW:MPC2_ALCEU (EMBL:X52415) Alcaligenes eutrophus metapyrocatechase 2 (EC 1.13.11.2) McpII, 320 aa; fasta scores: opt: 301 z-score: 359.5 E(): 1.7e-12; 28.1% identity in 299 aa overlap. Contains Pfam match to entry PF01013 Extradiol_dioxy, Extradiol ring-cleavage dioxygenase. (310 aa)
SCO6345SC3A7.13, possible secreted chitinase, len: 252 aa; Contains two regions separated by a Gly-Asp rich region from aa 171 to 197. The N-terminal region is similar to several chitin binding proteins and chitinases e.g. TR:Q54501 (EMBL:X78535) chitin binding protein precursor from Streptomyces olivaceoviridis (201 aa), fasta scores; opt: 153 z-score: 311.6 E(): 4.2e-10,39.4% identity in 198 aa overlap, the short C-terminal region is similar to parts of many chitinases e.g. CHIA_ALTSO chitinase a precursor (820 aa), fasta scores; opt: 152 z-score: 215.9 E(): 9e-05, 48.6% identity in 37 aa o [...] (252 aa)
SCO6348SC3A7.16c, putative membrane protein, len: 1361 aa. Contains possible hydrophobic membrane spanning regions. (1361 aa)
SCO6375SC4A2.11c, probable secreted protein, len: 220 aa; similar to a set of Mycobacterial secreted antigens e.g. MP83_MYCTU cell surface lipoprotein Mpt83 precursor (239 aa), fasta scores; opt: 376 z-score: 505.8 E(): 6.4e-21, 35.6% identity in 222 aa overlap. (220 aa)
SCO6393SC3C8.12, probable transposase IS21/IS1162 family, len: 487 aa; similar to many e.g. TRA6_BACST putative transposase for insertion sequence element IS5376 (400 aa), fasta scores; opt: 377 z-score: 617.9 E(): 3.6e-27, 29.9% identity in 351 aa overlap. Contains probable helix-turn-helix motif at aa 39 to 60 (Score 2208, +6.71 SD)). (487 aa)
SCO6407SC3C8.26, possible gamma-glutamyltranspeptidase (putative secreted protein), len: 603 aa; similar to many e.g. GGT_BACSU gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa), fasta scores; opt: 705 z-score: 863.9 E(): 0, 36.9% identity in 591 aa overlap, and to PAC1_PSESV cephalosporin acylase I (EC 3.5.1.-) (557 aa), fasta scores; opt: 377 z-score: 819.8 E(): 0, 34.1% identity in 569 aa overlap. Contains probable N-terminal signal sequence. (603 aa)
SCO6418Hypothetical protein; SC1A6.07c, unknown, len: 813. (542 aa)
SCO6444SC9B5.11, probable gamma-glutamyl transferase, len: 647 aa; similar to many gamma-glutamyl transferases eg. TR:Q54353 (EMBL:X79146) LmbA, gamma-glutamyl transferase involved in lincomycin production in Streptomyces lincolnensis 78-11 (601 aa) fasta scores; opt: 871, z-score: 1756.8, E(): 0, (48.1% identity in 619 aa overlap). Also similar to TR:O54174 (EMBL:AL021411) probable transferase (606aa) from Streptomyces coelicolor fasta scores: opt: 953, z-score: 1203.1, E(): 0, (53.7% identity in 635 aa overlap). Contains Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase. (647 aa)
SCO6450SC9B5.17, conserved hypothetical protein, len: 169 aa; similar to several hypothetical proteins eg. TR:Q44020 (EMBL:L36817) hypothetical protein from Alcaligenes eutrophus (173 aa) fasta scores; opt: 482, z-score: 757.7, E(): 0, (50.6% identity in 174 aa overlap). Also similar to TR:O75377 (EMBL:AF044286) histone macro 2A1.1 from Homo sapiens (369 aa) fasta scores; opt: 256, z-score: 321.4, E(): 1.3e-10, (29.4% identity in 170 aa overlap). (169 aa)
SCO6479SC9C7.15c, probable secreted peptidase, len: 529aa; similar to many eg. TR:Q54410(EMBL:L27466) secreted tripeptidyl aminopeptidase from Streptomyces lividans 66 (537 aa) fasta scores; opt: 1362, z-score: 1170.0, E(): 0, (43.2% identity in 526 aa overlap), has probable N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha /beta hydrolase fold. Also similar to TR:O69831 (EMBL:AL023517) from Streptomyces coelicolor cosmid 1B5 (543 aa) fasta scores; opt: 1205, z-score: 1105.7, E(): 0, (42.3% identity in 541 aa overlap). (529 aa)
SCO6493Hypothetical protein SC1E6.02c; SC1E6.02c, unknown, len: 115 aa. (115 aa)
SCO6497SC1E6.06, tktA2, probable transketolase, len: 615 aa; highly similar to eukaryotic transketolases e.g. TKT_HUMAN transketolase (EC 2.2.1.1) (623 aa), fasta scores; opt: 1909 z-score: 2169.3 E(): 0, 50.0% identity in 614 aa overlap; less similar to prokaryotic transketolases e.g. TKT_RHOSH transketolase (657 aa), fasta scores; opt: 477 z-score: 830.4 E(): 0, 31.3% identity in 635 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 397.70, E-value 1.1e-115. Also similar to S. coelicolor tkt (SC5A7.13c) E(): 4.2e-20, 2 [...] (615 aa)
SCO6519SC5C7.04, possible lyase, similar to e.g. LGUL_HAEIN lactoylglutathione lyase (EC 4.4.1.5) (135 aa), fasta scores; opt: 124 z-score: 215.2 E(): 9.7e-05, 29.0% identity in 131 aa overlap. (138 aa)
SCO6532SC5C7.17c, narI, probable nitrate reductase gamma chain; len: 240 aa; similar to many e.g. NARI_BACSU nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores; opt: 664 z-score: 1084.3 E(): 0, 41.5% identity in 217 aa overlap. Contains possible hydrophobic membrane spanning regions. (240 aa)
SCO6537SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD). (287 aa)
SCO6572SC3F9.07, possible glycosyl hydrolase (putative secreted protein), len: 1238 aa; similar to TR:Q9K473 (EMBL:AL359215) putative glycosyl hydrolase from Streptomyces coelicolor (962 aa) fasta scores; opt: 3614, Z-score: 3774.0, 63.899% identity (65.074% ungapped) in 831 aa overlap. Contains possible N-terminal region signal peptide sequence. (1238 aa)
SCO6594SC8A6.15c, probable secreted protein, len: 602 aa; c ontains probable N-terminal signal sequence. (602 aa)
SCO6595SC8A6.16, probable secreted protein, len: 380 aa; co ntains N-terminal signal sequence and TTA Leu codon, possib le target for action of bldA. (360 aa)
SCO6609SC1F2.06, probable secreted protein, len: 342 aa; some similatity to secreted antigenic proteins 85A, 85B and 85C from Mycobacteria e.g. A85B_MYCLE (327 aa), fasta scores; opt: 325 z-score: 247.2 E(): 1.6e-06, 28.5% identity in 319 aa overlap and to secreted antigenic protein PS1 from Cornebacterium glutamicum CSP1_CORGL (657 aa), fasta scores; opt: 479 z-score: 421.7 E(): 3e-16, 28.2% identity in 333 aa overlap. Contains possible N-terminal signal sequence. (342 aa)
SCO6663SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family. (698 aa)
SCO6682Hypothetical protein SC5A7.32; [Lanthionine-containing peptide SapB precursor RamS]: Stably accumulated precursor of SapB. Belongs to the lanthionine-containing morphogen family. (42 aa)
SCO6691SC4C6.01, probable phospholipase C, partial CDS, len: >501 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 1073 z-score: 1149.1 E(): 0, 44.7% identity in 524 aa overlap; SC6G3.07, probable phospholipase C, partial CDS, len: >221 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 853 z-score: 1021.1 E(): 0, 51.3% identity in 232 aa overlap. Continues in cosmid 4C6 (EMBL:AL079355) as SC4C6.01. (687 aa)
SCO6711SC4C6.21c, hypothetical protein, len: 781 aa; unknown function, C-terminal half similar to N-terminal region of TR:O69947 (EMBL:AL023862) S.coelicolor hypothetical protein (1238 aa), fasta scores; opt: 818 z-score: 850.9 E(): 0, 38.5% identity in 535 aa overlap. The downstream ORF SC4C6.20c has weak similarity to the C-terminal half of this hypothetical protein. (781 aa)
SCO6714SC4C6.24c, possible hydroxylase, len: 263 aa; similar to TR:Q55078 (EMBL:U50973) Streptomyces sp. strain C5 daunomycin C-14 hydroxylase (275 aa), fasta scores; opt: 422 z-score: 482.3 E(): 1.5e-19, 38.5% identity in 273 aa overlap. Similar to TR:O50527 (EMBL:AL009204) S.coelicolor hypothetical protein (267 aa) (37.9% identity in 253 aa overlap) and to (EMBL:AL049863), SC5H1.09c, S.coelicolor possible hydroxylase (265 aa) (35.7% identity in 258 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis and to Mycobacterium tuberculosis 27.3 kDa MAb HBT7 reactive [...] (263 aa)
SCO6772Conserved hypothetical protein; SC6A5.21c, unknown, len: 287aa; similar to TR:P96830 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (276 aa) fasta scores; opt: 189, z-score: 220.4, E(): 5.6e-05, (32.3% identity in 279 aa overlap). (287 aa)
SCO6795Conserved hypothetical protein SC1A2.04; SC1A2.04, cvnB7, unknown, len: 124 aa. Highly similar to several proteins of unknown function from Streptomyces coelicolor including: TR:Q9X835(EMBL:AL049727) SC9B1.15C (139 aa), fasta scores opt: 345 z-score: 434.8 E(): 8.2e-17 45.0% identity in 140 aa overlap and TR:CAB61281(EMBL:AL132991) SCF55.11C (152 aa), fasta scores opt:309 z-score:390.4 E(): 2.4e-14 41.0% identity in 134 aa overlap. (144 aa)
SCO6884SC7F9.36c, possible secreted protein, len: 377 aa. Highly similar to Streptomyces coelicolor TR:Q9X867(EMBL:AL049661) putative lipoprotein, SCE134.12 (381 aa), fasta scores opt: 1374 z-score: 1462.4 E():0 56.0% identity in 384 aa overlap. Contains a Pfam match to entry PF00877 NLPC_P60, NLP/P60 family and a possible N-terminal signal sequence. (377 aa)
SCO6942Hypothetical protein SC1G8.14c; SC1G8.14c, cvnB8, unknown, len: 171 aa. Similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61281(EMBL:AL132991) SCF55.11C (152 aa), fasta scores opt: 158 z-score: 212.6 E(): 0.00022 33.1% identity in 160 aa overlap and TR:O86521(EMBL:AL031124) SC1C2.20C (140 aa), fasta scores opt: 177 z-score: 237.3 E(): 9.4e-06 29.4% identity in 143 aa overlap. (171 aa)
SCO6966Putative lipase; SC6F7.19c, possible lipase, len: 269 aa. Similar to many other putative lipases e.g. Thermotoga maritima TR:Q9X171(EMBL:AE001789) lipase, putative (259 aa), fasta scores opt: 345 z-score: 396.1 E(): 1.3e-14 33.1% identity in 239 aa overlap. contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (269 aa)
SCO7000SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. (739 aa)
SCO7070Hypothetical protein SC4G1.36; SC4G1.36, unknown, len: 388 aa. High content in alanine, arginine, glycine and proline amino acid residues. Also contains TTA leucine codon, possible target for bldA regulation. (388 aa)
SCO7124Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
SCO7211SC2H12.10c, possible secreted glycosyl hydrolase, len: 579 aa. Similar in regions to many glycosyl hydrolases including: Arthrobacter sp. SW:E13B_ARTSP(EMBL:D23668) glucan endo-1,3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa), fasta scores opt: 449 z-score: 497.8 E(): 3e-20 27.8% identity in 533 aa overlap. Also similar to the C-terminus of Streptomyces coelicolor TR:O69947(EMBL:AL023862) hypothetical 133.5 kd protein, SC3F9.07 (1238 aa), fasta scores opt: 1923 z-score: 2123.6 E(): 0 66.5% identity in 403 aa overlap. Note, the last 131 aa of this CDS are identical to those in the [...] (579 aa)
SCO7212SC2H12.11c, possible secreted glycosyl hydrolase, len: 962 aa. Similar to many including: Arthrobacter sp. SW:E13B_ARTSP(EMBL:D23668) glucan endo-1,3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa), fasta scores opt: 455 z-score: 456.5 E(): 5.9e-18 29.8% identity in 544 aa overlap. Also similar to the N-terminus of Streptomyces coelicolor TR:O69947(EMBL:AL023862) hypothetical 133.5 kd protein, SC3F9.07 (1238 aa), fasta scores opt: 3612 z-score: 3597.9 E(): 0 63.9% identity in 831 aa overlap. Note, the last 131 aa of this CDS are identical to those in the analogous position on the adj [...] (962 aa)
SCO7225SC2H12.24, secreted chitinase, len: 244 aa. The N-terminal is highly similar to several chitin binding proteins e.g. Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (CHB2) (201 aa), fasta scores opt: 181 z-score: 193.2 E(): 0.0027 38.4% identity in 203 aa overlap. The C-terminal is similar to many chitinases e.g. Streptomyces olivaceoviridis TR:CAB83055(EMBL:AJ276990) chitinase precursor (EC 3.2.1.14) (781 aa), fasta scores opt: 322 z-score: 324.1 E(): 1.4e-10 36.5% identity in 167 aa overlap. Also highly similar to several Streptomyces coelicolor chitinases e.g. TR [...] (244 aa)
SCO7228SC2H12.27c, possible polysaccharide lyase, len: 554 aa. Similar to regions within several pectate lyases e.g. Erwinia chrysanthemi SW:PELX_ERWCH(EMBL:M62739) exopolygalacturonate lyase precursor (EC 4.2.2.9), PelX (749 aa), fasta scores opt: 441 z-score: 462.5 E(): 2.7e-18 33.2% identity in 455 aa overlap. (554 aa)
SCO7256SC5H1.36, probable protease (putative secreted protein), len: 543 aa; similar to many e.g. TR:Q54398 (EMBL:L42758), SlpD, Streptomyces lividans protease, (539 aa), fasta scores; opt: 697 z-score: 769.7 E(): 0,35.8% identity in 545 aa overlap. Similar to other S.coelicolor proteases e.g. SlpD, SCH5.02c (EMBL:AL03563) proteinase (539 aa) (35.8% identity in 545 aa overlap). Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 55.00, E-value 1.6e-12. (543 aa)
SCO7257Putative secreted protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. The long chaplins (ChpA, ChpB, ChpC) are not absolutely necessary fo [...] (237 aa)
SCO7267SC5H1.25c, conserved hypothetical protein, len: 131 aa; similar to e.g. SW:YFC3_SHEPU (EMBL:L04283) Shewanella putrefaciens hypothetical protein (118 aa), fasta scores; opt: 372 z-score: 466.1 E(): 1.2e-18, 52.2% identity in 115 aa overlap. Weakly similar to some lyases e.g. SW:LGUL_SALTY (EMBL:U57364), gloA, Salmonella typhimurium lactoylglutathione lyase (135 aa) (23.6% identity in 127 aa overlap). Also similar to TR:O86701 (EMBL:AL031515) S.coelicolor possible lyase (138 aa) (33.1% identity in 127 aa overlap). (131 aa)
SCO7283SC5H1.09c, possible hydroxylase, len: 265 aa; similar to e.g. TR:Q55078 (EMBL:U50973), doxA, Streptomyces sp. daunomycin C-14 hydroxylase (275 aa), fasta scores; opt: 440 z-score: 519.4 E(): 1.3e-21, 37.5% identity in 259 aa overlap. Similar to SC9B10.20c (EMBL:AL009204) S.coelicolor hypothetical protein (267 aa) (34.1% identity in 249 aa overlap). (265 aa)
SCO7339Conserved hypothetical protein SC4G10.18c; SC410.18c, unknown, len: 278 aa. Partially sequenced previously: Streptomyces coelicolor TR:Q9X946(EMBL:AJ001206) hypothetical 17.2 kd protein (>161 aa). Also highly similar to Streptomyces griseus TR:P95754(EMBL:D89734) SgaA protein, a suppressor of growth disturbance in the presence of high osmolarity and high concentrations of A-factor (264 aa), fasta scores opt: 807 z-score: 948.0 E():0 52.0% identity in 250 aa overlap. (278 aa)
SCO7406Putative secreted protein; SC6D11.02C, possible secreted protein, len: 691 aa. Contains a 8xGT repeat region within the C-terminus and a possible N-terminal signal sequence. (691 aa)
SCO7421SC6D11.17c, cvnB10, unknown, len: 135 aa. Highly similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61281 (EMBL:AL132991) SCF55.11c (152 aa), fasta scores opt: 634 z-score: 769.3 E():0 71.9% identity in 128 aa overlap and TR:Q9X835(EMBL:AL049727) SC9B1.15C (139 aa), fasta scores opt: 329 z-score: 407.1 E(): 3e-15 40.9% identity in 132 aa overlap. (135 aa)
SCO7432SC6D11.28c, mprA2, secreted extracellular small neutral protease (EC 3.4.24.-), len: 227 aa. Identical to Streptomyces lividans SW:SNPA_STRLI(EMBL:M81703) extracellular small neutral protease precursor, SnpA (227 aa), fasta scores opt: 1483 z-score: 1546.5 E(): 0 100.0% identity in 227 aa overlap. Also highly similar to Streptomyces coelicolor SW:SNPA_STRCO(EMBL:Z11929) extracellular small neutral protease precursor, MprA (215 aa), fasta scores opt: 854 z-score: 896.8 E():0 65.6% identity in 218 aa overlap. Contains a possible N-terminal signal sequence. (227 aa)
SCO7464SCBAC14E8.04, cvnB13, hypothetical protein, len: 133 aa; similar to TR:Q9L138 (EMBL:AL158061) Streptomyces coelicolor hypothetical 14.a kDa protein SC6D11.17c, 135 aa; fasta scores: opt: 321 Z-score: 425.0 bits: 84.4 E(): 4.3e-16; 40.476% identity in 126 aa overlap. (133 aa)
SCO7513Putative secreted hydrolase; Catalyzes the hydrolysis of fatty acid esters with a preference for long chain fatty acids (C16-C18); Belongs to the 'GDSL' lipolytic enzyme family. (295 aa)
SCO7575SC5F1.29c, probable secreted hydrolase, len: 285 aa; similar to SW:GUB_RHOMR (EMBL:U04836) Rhodothermus marinus beta-glucanase precursor (EC 3.2.1.73) BglA, 286 aa; fasta scores: opt: 626 z-score: 709.7 E(): 5.3e-32; 40.5% identity in 296 aa overlap and to N-terminal region of TR:CAC14352 (EMBL:AL445945) Streptomyces coelicolor putative secreted hydrolase 3SCF60.19, 422 aa; fasta scores: opt: 1508 z-score: 1618.5 E(): 0; 75.9% identity in 299 aa overlap. Contains Pfam match to entry PF00722 Glyco_hydro_16, Glycosyl hydrolases family 16 and match to Prosite entry PS01034 Glycosyl hydrol [...] (285 aa)
SCO7579SC5F1.33, possible DNA-binding protein, len: 291 aa; similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 643 z-score: 787.2 E(): 0; 37.0% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD). (291 aa)
SCO7608SC2H2.06, hypothetical protein, len: 150 aa; similar to TR:Q9L0J1 (EMBL:AL161691) Streptomyces coelicolor hypothetical 15.7 kDa protein SCD40A.20, 145 aa; fasta scores: opt: 335 z-score: 414.8 E(): 1.4e-15; 45.0% identity in 120 aa overlap. (150 aa)
SCO7615SC2H2.13, possible DNA-binding protein, len: 290 aa; similar to many Streptomyces coelicolor putative DNA-binding proteins, e.g. TR:CAC01466 (EMBL:AL391014) putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 613 z-score: 722.6 E(): 1e-32; 41.8% identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c, 287 aa; fasta scores: opt: 917 z-score: 1027.9 E(): 0; 50.0% identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD). (290 aa)
SCO7630SC10F4.03, probable isomerase, len: 224 aa; similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB, 215 aa; fasta scores: opt: 190 z-score: 225.8 E(): 4.8e-05; 28.5% identity in 214 aa overlap and to TR:Q9ZAX0 (EMBL:U73808) Amycolatopsis methanolica 2,3-PDG dependent phosphoglycerate mutase PGM, 205 aa; fasta scores: opt: 518 z-score: 596.0 E(): 1.2e-25; 45.5% identity in 202 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family and match to Prosite entry PS00175 Phosphoglycerate mutase family phospho [...] (224 aa)
SCO7633SC10F4.06c, secreted endo-beta-N-acetylglucosaminidase, len: 309 aa; highly similar to SW:EBAG_STRPL (EMBL:K02182) Streptomyces plicatus endo-beta-n-acetylglucosaminidase H precursor (EC 3.2.1.96), 313 aa; fasta scores: opt: 1769 z-score: 1916.4 E(): 0; 86.9% identity in 312 aa overlap. Contains match to Prosite entry PS01095 Chitinases family 18 active site and possible N-terminal region signal peptide sequence; Belongs to the glycosyl hydrolase 18 family. (309 aa)
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
SCO7650SC10F4.23, possible secreted hydrolase, len: 490 aa; similar to TR:Q9ZBJ5 (EMBL:AL035161) Streptomyces coelicolor putative secreted peptidase SC9C7.15c, 529 aa; fasta scores: opt: 678 z-score: 721.7 E(): 1.2e-32; 36.6% identity in 514 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and possible N-terminal region signal peptide sequence. (490 aa)
SCO7653SC10F4.26c, hypothetical fusion protein, len: 240 aa; N-terminal and C-terminal domains both similar to the same proteins, e.g. TR:Q9KZ80 (EMBL:AL354048) Streptomyces coelicolor hypothetical 15.9 kDa protein SCE25.06, 145 aa; blastp scores for N-terminal domain: Score = 130 (45.8 bits), Expect = 3.2e-11, Sum P(2) = 3.2e-11; Identities = 39/92 (42%), Positives = 50/92 (54%) and for C-terminal domain: Score = 72 (25.3 bits), Expect = 0.22, Sum P(2) = 0.20; Identities = 29/90 (32%), Positives = 44/90 (48%). (240 aa)
SCO7695SC1A4.03c, hypothetical protein, len: 122 aa; similar to TR:Q9K3Q6 (EMBL:AL360034) Streptomyces coelicolor conserved hypothetical protein 2SCG4.08, 130 aa; fasta scores: opt: 140 z-score: 184.4 E(): 0.0098; 31.3% identity in 112 aa overlap. (122 aa)
SCO7697SC1A4.05, probable secreted hydrolase, len: 435 aa; similar to SW:PHYT_BACSU (EMBL:AF015775) Bacillus subtilis 3-phytase precursor (EC 3.1.3.8) Phy, 382 aa; fasta scores: opt: 203 z-score: 223.6 E(): 6.5e-05; 31.0% identity in 387 aa overlap. Contains Pfam match to entry PF02333 Phytase. Also contains possible N-terminal region signal peptide sequence. (435 aa)
SCO7739SC8D11.30c, possible hydrolase, len: 235 aa; similar to C-terminal region of SW:PCD_ARTOX (EMBL:M94965) Arthrobacter oxidans phemedipham hydrolase (EC 3.1.1.-) Pcd, 493 aa; fasta scores: opt: 219 z-score: 259.2 E(): 6.7e-07; 28.1% identity in 199 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase, Carboxylesterases. (235 aa)
SCO7835Hypothetical protein SC8E7.32; SC8E7.32, unknown, len: 136 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y2(EMBL:AL109973) hypothetical 15.5 kd protein, SCJ30.07c (136 aa). (136 aa)
sapDSCP1.50c, spore associated protein, SapD, len: 296aa. (400 aa)
SCP1.104Hypothetical protein; SCP1.104, unknown, len: 154aa; weakly similar to SW:P71686 (YE17_MYCTU) fasta scores; opt: 113, z-score: 145.5, E(): 1.2, 33.6% identity in 107 aa overlap. (154 aa)
parB1SCP1.139, parB1, plasmid probable partitioning protein, len: 375aa; weakly similar to many ParB-like proteins eg. TR:Q9RFM2 (EMBL:AF187159) ParB partitioning protein from Streptomyces coelicolor (368 aa) fasta scores; opt: 176, z-score: 188.6, E(): 0.0049, 32.3% identity in 192 aa overlap. Contains Pfam match to entry PF02195 ParBc, ParB-like nuclease domain. This CDS is directly duplicated at 130087..131214 (ParB2, SCP1.222) fasta scores; opt: 566, z-score: 524.0 E(): 1.2e-24, 33.6% identity in 384 aa overlap; Belongs to the ParB family. (375 aa)
SCP1.148SCP1.148, possible secreted protein, len: 384aa; similar to many especially TR:Q9L1N1 (EMBL:AL138977) putative secreted protein from Streptomyces coelicolor (377 aa) fasta scores; opt: 1234, z-score: 1291.1, E(): 0, 52.2% identity in 385 aa overlap. Contains a possible cleavable N-terminal signal sequence. Also contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. (384 aa)
parB2SCP1.222, parB2, possible plasmid partitioning protein, len: 381aa; weakly similar to many eg. SW:P26497 (SP0J_BACSU) Spo0J protein required for initiation of sporulation and normal chromosome segregation in Bacillus subtilis (282 aa) fasta scores; opt: 213, z-score: 210.9, E(): 5.3e-05, 30.2% identity in 212 aa overlap. Contains Pfam match to entry PF02195 ParBc, ParB-like nuclease domain. This CDS is directly duplicated at 130087..131214 (ParB1, SCP1.139) fasta scores; opt: 566, z-score: 538.4, E(): 1.8e-25, 33.6% identity in 384 aa overlap; Belongs to the ParB family. (381 aa)
sapD-2SCP1.304, spore associated protein, SapD, len: 296aa. (400 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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