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SCO5831 SCO5831 SCO5281 SCO5281 SCO5106 SCO5106 SCO5042 SCO5042 SCO4858 SCO4858 SCO4857 SCO4857 SCO4855 SCO4855 SCO4827 SCO4827 SCO4809 SCO4809 SCO4808 SCO4808 SCO4595 SCO4595 SCO7123 SCO7123 SCO7376 SCO7376 SCO0922 SCO0922 SCO7005 SCO7005 SCO7000 SCO7000 SCO6586 SCO6586 SCO6585 SCO6585 SCO6270 SCO6270 SCO6269 SCO6269 SCO6243 SCO6243 SCO5999 SCO5999 SCO5926 SCO5926 SCO4594 SCO4594 SCO4388 SCO4388 SCO4113 SCO4113 SCO3127 SCO3127 SCO2736 SCO2736 SCO2181 SCO2181 SCO2130 SCO2130 SCO1268 SCO1268 SCO0983 SCO0983 SCO0982 SCO0982 SCO5832 SCO5832
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5281SCCB12.05c, probable 2-oxoglutarate dehydrogenase, len: 1272 aa; similar to TR:P96746 (EMBL:D84102) Corynebacterium glutamicum 2-oxoglutarate dehydrogenase (EC 1.2.4.2) OdhA, 1257 aa; fasta scores: opt: 4321 z-score: 3452.7 E(): 0; 54.8% identity in 1262 aa overlap and to SW:ODO1_ECOLI (EMBL:J01619) Escherichia coli 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) SucA, 933 aa; fasta scores: opt: 2568 z-score: 2056.0 E(): 0; 46.5% identity in 881 aa overlap. Contains Pfam matches to entries PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and PF0 [...] (1272 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5042Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
SCO4858SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...] (126 aa)
SCO4857SC5G8.25c, dhsD, possible succinate dehydrogenase membrane subunit, len: 160 aa; similar to TR:O53369 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 553, z-score: 702.9, E(): 1.1e-31, 58.9% identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores; opt: 126, z-score: 172.2, E(): 0.039, 23.5% identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match [...] (160 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4595SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus). (645 aa)
SCO7123SC4B10.24c, probable acyltransferase, len: 417 aa; similar to SW:ODO2_ALCEU (EMBL:X91877) Alcaligenes eutrophus dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 416 aa; fasta scores: opt: 793 z-score: 570.6 E(): 2.6e-24; 39.0% identity in 421 aa overlap, to C-terminal region of TR:Q9Z6I4 (EMBL:AF047034) Streptomyces seoulensis dihydrolipoamide acetyltransferase PdhB, 612 aa; fasta scores: opt: 1251 z-score: 887.0 E(): 0; 61.0% identity in 474 aa overlap and to TR:CAB51265 (EMBL:AL096872) Streptomyces coelicolor putative dihydrol [...] (417 aa)
SCO7376Conserved hypothetical protein SC10G8.03c; SC10G8.03c, unknown, len: 242 aa. Weakly similar to Aeropyrum pernix TR:Q9Y911 (EMBL:AP000064) hypothetical protein (205 aa), fasta scores opt: 226 z-score: 263.2 E(): 3e-07 31.8% identity in 211 aa overlap and to TR:CAC48481 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMB20081, 236 aa; fasta scores: opt: 577 Z-score: 646.5 E(): 2.2e-28; 46.256% identity in 227 aa overlap. (242 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO7005Putative oxidoreductase; SC8F11.31, possible oxidoreductase, len: 467 aa. Similar to several including: Homo sapiens TR:AAF21941(EMBL:AF111858) dimethylglycine dehydrogenase precursor (EC 1.5.99.2) (866 aa), fasta scores opt: 217 z-score: 242.0 E(): 4.7e-06 24.7% identity in 372 aa overlap and Pyrococcus abyssi TR:CAB49193(EMBL:AJ248283) glycerol-3-phosphate dehydrogenase, GlpA (497 aa), fasta scores opt: 787 z-score: 883.5 E(): 0 36.1% identity in 454 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase. Also contains a poss [...] (467 aa)
SCO7000SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. (739 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6270SCAH10.35c, possible oxidoreductase alpha-subunit, len: 630 aa; similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores: opt: 2008 z-score: 2153.9 E(): 0; 66.4% identity in 614 aa overlap. (630 aa)
SCO6269SCAH10.34c, possible oxidoreductase beta-subunit, 350 aa; highly similar to TR:O53181 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase beta-subunit, 373 aa; fasta scores: opt: 1415 z-score: 1622.6 E(): 0; 64.0% identity in 342 aa overlap. Contains possible N-terminal region signal sequence. (350 aa)
SCO6243SCAH10.08c, aceB1, malate synthase, len: 540 aa; highly similar to SW:MASY_STAE (EMBL:U63518) Streptomyces arenae, malate synthase (EC 4.1.3.2) AceB, 543 aa; fasta scores: opt: 2625 z-score: 3156.2 E(): 0; 78.2% identity in 551 aa overlap. Contains match to Pfam entry PF01274 Malate_synthase, Malate synthase and to Prosite entry PS00510 Malate synthase signature. (540 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO5926Conserved hypothetical protein; SC10A5.31c, unknown, len: 173 aa; highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa), fasta scores; opt: 422 z-score: 567.1 E(): 2.2e-2 4, 49.3% identity in 138 aa overlap; Belongs to the LeuD family. (173 aa)
SCO4594SCD20.12c, probable oxidoreductase, len: 352 aa; highly similar to TR:Q9RKS5 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase beta-subunit SCAH10.34c, 350 aa; fasta scores: opt: 2267 z-score: 2567.5 E(): 0; 98.0% identity in 349 aa overlap and to SW:KORB_ARCFU (EMBL:AE001072) Archaeoglobus fulgidus 2-oxoglutarate synthase subunit KorB (EC 1.2.7.3), 267 aa; fasta scores: opt: 529 z-score: 605.9 E(): 2.8e-26; 37.6% identity in 221 aa overlap. (352 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4113SCD17A.05c, conserved hypothetical protein, len: 426 aa; similar to TR:P74590 (EMBL:D90916) Synechocystis sp. hypothetical 43.5 kDa protein SLL1495, 397 aa; fasta scores: opt: 1264 z-score: 1402.4 E(): 0; 49.1% identity in 401 aa overlap. (426 aa)
SCO3127Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (911 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2181SC5F7.20, sucB, possible dihydrolipoamide succinyltransferase, len: 590 aa; similar to many egs. TR:AAC23517 (EMBL:AF068740) dihydrolipoamide succinyltransferase from Pseudomonas ovalis (407 aa) fasta scores; opt: 847, z-score: 602.5, E(): 3.2e-26, (41.9% identity in 453 aa overlap) and SW:ODO2_MYCTU dihydrolipoamide succinyltransferase from Mycobacterium tuberculosis (553 aa) fasta scores; opt: 1232, z-score: 866.2, E(): 0, (56.2% identity in 596 aa overlap). Contains two Pfam matches to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2 [...] (590 aa)
SCO2130SC6G10.03c, hypothetical protein, len: 265 aa; weak similarity to many eg. TR:P95860 (EMBL:Y08256) Sulfolobus solfataricus hypothetical protein ORF CO6013 (309 aa) fasta scores; opt: 152, z-score: 186.9, E(): 0.0041, (24.8% identity in 270 aa overlap). (265 aa)
SCO12682SCG18.15c, probable acyltransferase, len: 372 aa; similar to SW:ODO2_ECOLI (EMBL:J01619) Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 404 aa; fasta scores: opt: 281 z-score: 311.6 E(): 7.1e-10; 24.8% identity in 400 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. (372 aa)
SCO0983SCBAC19F3.10, aceB2, malate synthase, len: 530 aa; strongly similar to many e.g. SW:Q9ZH77 (MASY_STRCL) malate synthase AceB from Streptomyces clavuligerus (541 aa) fasta scores; opt: 1923, Z-score: 2204.2, 58.889% identity (61.390% ungapped) in 540 aa overlap and TR:Q9RKU9 (EMBL:AL132824) malate synthase AceB1 (StAH10.08c) from Streptomyces coelicolor (540 aa) fasta scores; opt: 1930, Z-score: 2212.2, 61.895% identity (63.090% ungapped) in 475 aa overlap. Contains Pfam match to entry PF01274 Malate_synthase, Malate synthase and Prosite match to PS00510 Malate synthase signature. (530 aa)
SCO0982SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature. (426 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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