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SCO4327 SCO4327 SCO0190 SCO0190 SCO1073 SCO1073 SCO2814 SCO2814 SCO4326 SCO4326 SCO4494 SCO4494 SCO4506 SCO4506 SCO4550 SCO4550 SCO4556 SCO4556 SCO4559 SCO4559 SCO5662 SCO5662 SCO7570 SCO7570 SCO7669 SCO7669
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO4327Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. (209 aa)
SCO0190SCJ12.02c, crtT, probable methyltransferase, len: 246 aa. Shares a high level of sequence similarity with Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores opt: 984 z-score: 1164.2 E(): 0 65.0% identity in 234 aa overlap. Contains a Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. (246 aa)
SCO1073SCG22.19c, possible hydrogenase, len: 422 aa; similar to SW:BCHP_RHOCA (EMBL:Z11165) Rhodobacter capsulatus geranylgeranyl hydrogenase BchP, 391 aa; fasta scores: opt: 386 z-score: 432.9 E(): 1.2e-16; 33.2% identity in 319 aa overlap. Contains Pfam match to entry PF01494 FAD_binding_3, FAD binding domain. (422 aa)
SCO2814SCBAC17F8.05c, possible methyltransferase, len: 285 aa: similar to many some of which reside within antibiotic biosynthetic clusters e.g. TR:Q54818 (EMBL:L35560) doxorubicin polyketide biosynthesis gene from Streptomyces peucetius (286 aa) fasta scores; opt: 258, Z-score: 287.1, 38.136% identity (39.130% ungapped) in 118 aa overlap, TR:Q9S0N6 (EMBL:AB032524) C5-O-methyltransferase AveD from the avermectin biosynthetic cluster of Streptomyces avermitilis (283 aa) fasta scores; opt: 249, Z-score: 277.5, 30.508% identity (34.123% ungapped) in 236 aa overlap and TR:AAK64748 (EMBL:AE007203) [...] (285 aa)
SCO4326Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (282 aa)
SCO4494Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
SCO4506Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily. (282 aa)
SCO4550Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
SCO4556Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (231 aa)
SCO4559SCD16A.24c, possible electron transfer oxidoreductase, len: 430a a; similar to many e.g. TR:O06427 (EMBL:Z95558) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores; opt: 449, z-score: 501.6, E(): 1.3e-20, (34.6% identity in 416 aa overlap) and SW:FIXC_ECOLI probable electron transfer oxidoreductase FixC from Escherichia coli (428 aa) fasta scores; opt: 277, z-score: 311.0, E(): 5.4e-10, (27.0% identity in 367 aa overlap). (430 aa)
SCO5662Putative adenosine deaminase; Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (387 aa)
SCO7570SC5F1.24, probable isomerase, len: 375 aa; similar to SW:GUDH_STRCO (EMBL:AL136503) Streptomyces coelicolor probable glucarate dehydratase (EC 4.2.1.40) GudD or SCC77.09c, 431 aa; fasta scores: opt: 553 z-score: 623.1 E(): 3.6e-27; 37.2% identity in 398 aa overlap and to SW:TFDD_ALCEU (EMBL:M35097) Alcaligenes eutrophu chloromuconate cycloisomerase (EC 5.5.1.7) TfdD, 370 aa; fasta scores: opt: 419 z-score: 474.3 E(): 7e-19; 29.1% identity in 385 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. Contains possible hydrophobi [...] (375 aa)
SCO7669SC4C2.04c, possible oxidoreductase, len: 343 aa; similar to TR:O06538 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 36.3 kDa protein MTCI65.05c, 338 aa; fasta scores: opt: 1020 z-score: 1087.7 E(): 0; 50.7% identity in 339 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase. (343 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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