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SCO2683 SCO2683 SCO3375 SCO3375 SCO3421 SCO3421 SCO3618 SCO3618 SCO3619 SCO3619 SCO3886 SCO3886 SCO3907 SCO3907 SCO4076 SCO4076 SCO7615 SCO7615 SCO7579 SCO7579 SCO7454 SCO7454 SCO7392 SCO7392 SCO6537 SCO6537 SCO6003 SCO6003 SCO5815 SCO5815 SCO5756 SCO5756 SCO4213 SCO4213 SCO4577 SCO4577 SCO5188 SCO5188 SCO0596 SCO0596 SCO7763 SCO7763 parA2 parA2 parA1 parA1 SCO1050 SCO1050 SCO1772 SCO1772 SCO1979 SCO1979 SCO2510 SCO2510
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO2683SCC61A.04c, possible single-strand DNA-binding protein, len: 156 aa; similar to many eg. SW:P71711 (SSB_MYCTU) single-strand binding protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 259, z-score: 301.8, E(): 2.4e-09, 35.5% identity in 141 aa overlap and TR:Q9X8U3 (EMBL:AL049826) putative single-strand binding protein from Streptomyces coelicolor (199 aa) fasta scores; opt: 261, z-score: 302.7, E(): 2.1e-09, 42.5% identity in 120 aa overlap. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family. (156 aa)
SCO3375SCE94.26c, Lsr2-like protein, len: 111 aa; similar to SW:LSR2_MYCLE surface antigen protein from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 358, z-score: 416.0, E(): 7.4e-16, (55.4% identity in 112 aa overlap). (111 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO3618Putative recomination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
SCO3619Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (115 aa)
SCO3886StH24.08, possible partitioning or sporulation protein, len: 275 aa; previously sequenced as TR:O07328 (EMBL:Y16311) Streptomyces coelicolor hypothetical protein (255 aa), but with a different stop codon position. Similar to many e.g. SW:SOJ_BACSU (EMBL:D26185), SOJ, Bacillus subtilis sporulation protein (253 aa), fasta scores; opt: 899 z-score: 1077.0 E(): 0, 56.6% identity in 251 aa overlap, TR:O05189 (EMBL:U87804), parA, Caulobacter crescentus chromosome partitioning protein (266 aa) (49.2% identity in 248 aa overlap) and TR:O53596 (EMBL:AL021426), parB, Mycobacterium tuberculosis h [...] (275 aa)
SCO3907SCH24.29, ssb, probable single-strand DNA-binding protein, len: 199 aa; similar to SW:SSB_SERMA (EMBL:X65080), Ssb, Serratia marcescens single-strand binding protein (175 aa), fasta scores; opt: 278 z-score: 245.3 E(): 2.4e-06, 33.3% identity in 168 aa overlap. C-terminus contains glycine-rich repeats similar to those found in eukaryotic RNA-binding proteins e.g. SW:GRP2_SINAL (EMBL:L31377), Grp2A, Sinapis alba (white mustard) glycine-rich RNA-binding protein (169 aa). Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 143.30, E-value 2.5e-39. (199 aa)
SCO4076SCD25.12c, putative LSR2-like protein, len: 105 aa. Highly similar to Streptomyces coelicolor TR:CAB40875 (EMBL; AL049628) putative LSR2-like protein SCE94.26C (111 aa), fasta scores opt: 335 z-score: 425.4 E(): 2.4e-16 50.5% identity in 109 aa overlap and Mycobacterium leprae SW: LSR2_MYCLE (EMBL; M67510) LSR2 protein precursor (15 KD antigen) (112 aa), fasta scores opt: 287 z-score: 367.2 E(): 4.2e-13 46.8% identity in 111 aa overlap. (105 aa)
SCO7615SC2H2.13, possible DNA-binding protein, len: 290 aa; similar to many Streptomyces coelicolor putative DNA-binding proteins, e.g. TR:CAC01466 (EMBL:AL391014) putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 613 z-score: 722.6 E(): 1e-32; 41.8% identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c, 287 aa; fasta scores: opt: 917 z-score: 1027.9 E(): 0; 50.0% identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD). (290 aa)
SCO7579SC5F1.33, possible DNA-binding protein, len: 291 aa; similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 643 z-score: 787.2 E(): 0; 37.0% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD). (291 aa)
SCO7454SC5C11.11, possible membrane protein, len: 264 aa. Contains possible membrane spanning hydrophobic domains. (264 aa)
SCO7392Hypothetical protein SC10G8.20; SC10G8.20, unknown, len: 163 aa. (163 aa)
SCO6537SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD). (287 aa)
SCO6003SCBAC1C11.06c, possible DNA-binding protein, len: 286 aa; similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28; 37.4% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD). (286 aa)
SCO5815SC5B8.05, probable ATP-dependent DNA helicase, len:7 19 aa; similar in N-terminal half to many e.g. RECQ_ECOLIP1 5043 atp-dependent dna helicase recq (607 aa), fasta score s; opt: 546 z-score: 615.9 E(): 4.1e-27, 35.9% identity in 362 aa overlap. Contains PS00690 DEAH-box subfamily ATP-dep endent helicases signature and Pfam match to entry helicase _C PF00271, Helicases conserved C-terminal domain, score 91 .14. (719 aa)
SCO5756Hypothetical protein SC7C7.11; SC7C7.11, unknown, len: 156 aa; similar to members of the Dps family e.g. FTPA_HAEDU fine tangled pili major subunit (24 KD surface protein) (189 aa), fasta scores; opt: 278 z-score: 370.3 E(): 2.2e-13, 34.4% identity in 151 aa overlap PS_ECOLI DNA protection during starvation protein (166 aa) and, fasta scores; opt: 220 z-score: 261.2 E(): 2.6e-07, 26.8% identity in 153 aa overlap. Contains PS00818 Dps protein family signature 1. (156 aa)
SCO4213Hypothetical protein; 2SCD46.27, unknown, len: 544 aa; C-terminal region similar to that of SW:P24202 (MRR_ECOLI) Mrr restriction system protein from Escherichia coli (304 aa) fasta scores; opt: 199, z-score: 216.8, E(): 0.00013, 28.4% identity in 162 aa overlap. N-terminal region contains possible coiled-coil sequences residues (33-63 and 156-200) and two TTA encoded leucine residues which may be a target for bldA regulation. (544 aa)
SCO4577SCD16A.06c, probable helicase, len: 676aa; similar to many (both prokaryote and eukaryote) egs. TR:AAD05424 (EMBL:AF047374) RecQ helicase from Neisseria gonorrhoeae (767 aa) fasta scores; opt: 1809, z-score: 1769.1, E(): 0, (50.4% identity in 601 aa overlap) and SW:HUS2_SCHPO ATP-dependent helicase from Schizosaccharomyces pombe (1328 aa) fasta scores; opt: 1013, z-score: 988.7, E(): 0, (40.2% identity in 493 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, score 78.40, E-value 1.4e-19. (676 aa)
SCO51882SC3B6.12, probable ATP-dependent DNA helicase, len: 785 aa; similar to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD, 720 aa; fasta scores: opt: 649 z-score: 632.5 E(): 9.2e-28; 31.6% identity in 643 aa overlap. Contains 2x Pfam matches to entry PF00580 UvrD-helicase, UvrD/REP helicase, Pfam match to entry PF00570 HRDC, HRDC domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (785 aa)
SCO0596SCF55.20, probable DNA-binding protein, len: 187 aa; similar to SW:FTPA_HAEDU (EMBL:U18769) Haemophilus ducreyi fine tangled pili major subunit (24 KD surface protein) FtpA, 189 aa; fasta scores: opt: 559 z-score: 670.3 E(): 5.8e-30; 49.1% identity in 171 aa overlap and to SW:DPS_ECOLI (EMBL:X69337) Escherichia coli DNA protection during starvation protein Dps or PexB, 166 aa; fasta scores: opt: 276 z-score: 338.0 E(): 1.9e-11; 34.2% identity in 161 aa overlap. Contains match to Prosite entry PS00818 Dps protein family signature 1; Belongs to the Dps family. (187 aa)
SCO7763SC5E9.11, possible membrane protein, len: 233aa; contains a possible membrane-spanning hydrophobic region. (233 aa)
parA2SCP1.221, parA2, possible plasmid partitioning protein, len: 387aa; weakly similar to many eg. SW:P08866 (SOPA_ECOLI) sopA protein essential for F plasmid partitioning in Escherichia coli (388 aa) fasta scores; opt: 195, z-score: 215.5, E(): 2.9e-05, 27.7% identity in 213 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase. This CDS is directly duplicated at 221485..222648 (ParA1, SCP1.138) fasta scores; opt: 980, z-score: 954.5, E(): 0, 55.4% identity in 424 aa overlap. (387 aa)
parA1SCP1.138, parA1, possible plasmid partitioning protein, len: 420aa; similar to many eg. TR:Q9RFM1 (EMBL:AF187159) ParA partitioning protein from Streptomyces coelicolor (357 aa) fasta scores; opt: 185, z-score: 214.7, E(): 0.00017, 29.0% identity in 314 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase. This CDS is directly duplicated at 221485..222648 (ParA2, SCP1.221) fasta scores; opt: 980, z-score: 1089.9, E(): 0, 55.2% identity in 424 aa overlap. (420 aa)
SCO1050SCG20A.30, possible DNA protection protein, len: 200 aa; similar to SW:DPS_ECOLI (EMBL:X69337) Escherichia coli DNA protection during starvation protein Dps, 166 aa; fasta scores: opt: 200 z-score: 257.4 E(): 7.4e-07; 27.5% identity in 138 aa overlap. Contains Pfam match to entry PF02047 DPS, Dps protein family and matches to Prosite entries PS00818 Dps protein family signature 1 and PS00819 Dps protein family signature 2; Belongs to the Dps family. (200 aa)
SCO1772SCI51.12c, possible partitioning or sporulation protein, len: 340 aa; the C-terminal region is similar to SW:SOJ_BACSU (EMBL:D26185), Soj, Bacillus subtilis sporulation protein (253 aa), fasta scores; opt: 790 z-score: 857.6 E(): 0, 48.8% identity in 250 aa overlap and TR:O05189 (EMBL:U87804), ParA, Caulobacter crescentus chromosome partitioning protein (266 aa) (46.3% identity in 255 aa overlap). It is closer in predicted length to similar proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. TR:O33207 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (318 [...] (340 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
SCO2510Conserved hypothetical protein SCC121.13c; Involved in DNA repair and RecF pathway recombination. (251 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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