(20 nodes) Small ribosomal subunit network (Streptomyces coelicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SCO4711	30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (95 aa)
	SCO4708	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (277 aa)
	SCO4706	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
	SCO3425	Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
	SCO2563	30s ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
	SCO5736	30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (95 aa)
	SCO5624	SC2E1.41, rpsB, 30S ribosomal protein S2, len: 310 aa; almost identical to RS2_STRCO 30S ribosomal protein S2 (242 aa), E(): 0, 96.7% identity in 242 aa overlap and also highly similar to many others e.g. RS2_ECOLI 30S ribosomal protein S2 (240 aa), fasta scores; opt: 744 z-score: 950.7 E(): 0, 50.4% identity in 224 aa overlap. Contains PS00962 Ribosomal protein S2 signature 1 and PS00211 ABC transporters family signature (probably a false positive). Also contains Pfam matches to entry S2 PF00318, Ribosomal protein S2, score 304.89 and to entry 60s_ribosomal PF00428, 60s Acidic ribosom [...] (310 aa)
	SCO5591	SC2E1.08, rpsP, 30S ribosomal protein S16, highly similar to many e.g. RS16_MYCTU (162 aa), fatsa scores; opt:480 z-score: 771.3 E(): 0, 56.3% identity in 144 aa overlap. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family. (139 aa)
	SCO4735	SC6G4.13, rpsI, 30S ribosomal protein S9, len: 170 a a; identical to RS9_STRCO 30S ribosomal protein S9 (170 aa) and highly similar to many e.g.RS9_ECOLI (129 aa), fasta s cores; opt: 408 z-score: 663.5 E(): 1.1e-29, 49.2% identity in 124 aa overlap. Contains PS00360 Ribosomal protein S9 s ignature and Pfam match to entry PF00380 S9, Ribosomal prot ein S9, score 162.60, E-value 1e-49; Belongs to the universal ribosomal protein uS9 family. (170 aa)
	SCO4728	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
	SCO4727	30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
	SCO4719	30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (201 aa)
	SCO3430	Putative 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
	SCO4716	30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
	SCO4715	30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
	SCO3908	Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
	SCO4659	30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS12 family. (123 aa)
	SCO4660	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
	SCO4701	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
	SCO1505	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa)

Your Current Organism:

Streptomyces coelicolor

NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCO1505	SCO2563	gene:17759091	gene:17760165	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30s ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.989
SCO1505	SCO3425	gene:17759091	gene:17761047	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.	0.984
SCO1505	SCO3430	gene:17759091	gene:17761052	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	Putative 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.	0.996
SCO1505	SCO3908	gene:17759091	gene:17761535	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.	0.987
SCO1505	SCO4659	gene:17759091	gene:17762308	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS12 family.	0.999
SCO1505	SCO4660	gene:17759091	gene:17762309	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.999
SCO1505	SCO4701	gene:17759091	gene:17762350	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.999
SCO1505	SCO4706	gene:17759091	gene:17762355	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.999
SCO1505	SCO4708	gene:17759091	gene:17762357	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.	0.999
SCO1505	SCO4711	gene:17759091	gene:17762360	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	0.999
SCO1505	SCO4715	gene:17759091	gene:17762364	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.	0.998
SCO1505	SCO4716	gene:17759091	gene:17762365	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.	0.999
SCO1505	SCO4719	gene:17759091	gene:17762368	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.	0.999
SCO1505	SCO4727	gene:17759091	gene:17762376	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.	0.999
SCO1505	SCO4728	gene:17759091	gene:17762377	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.999
SCO1505	SCO4735	gene:17759091	gene:17762384	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	SC6G4.13, rpsI, 30S ribosomal protein S9, len: 170 a a; identical to RS9_STRCO 30S ribosomal protein S9 (170 aa) and highly similar to many e.g.RS9_ECOLI (129 aa), fasta s cores; opt: 408 z-score: 663.5 E(): 1.1e-29, 49.2% identity in 124 aa overlap. Contains PS00360 Ribosomal protein S9 s ignature and Pfam match to entry PF00380 S9, Ribosomal prot ein S9, score 162.60, E-value 1e-49; Belongs to the universal ribosomal protein uS9 family.	0.996
SCO1505	SCO5591	gene:17759091	gene:17763249	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	SC2E1.08, rpsP, 30S ribosomal protein S16, highly similar to many e.g. RS16_MYCTU (162 aa), fatsa scores; opt:480 z-score: 771.3 E(): 0, 56.3% identity in 144 aa overlap. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family.	0.997
SCO1505	SCO5624	gene:17759091	gene:17763282	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	SC2E1.41, rpsB, 30S ribosomal protein S2, len: 310 aa; almost identical to RS2_STRCO 30S ribosomal protein S2 (242 aa), E(): 0, 96.7% identity in 242 aa overlap and also highly similar to many others e.g. RS2_ECOLI 30S ribosomal protein S2 (240 aa), fasta scores; opt: 744 z-score: 950.7 E(): 0, 50.4% identity in 224 aa overlap. Contains PS00962 Ribosomal protein S2 signature 1 and PS00211 ABC transporters family signature (probably a false positive). Also contains Pfam matches to entry S2 PF00318, Ribosomal protein S2, score 304.89 and to entry 60s_ribosomal PF00428, 60s Acidic ribosom [...]	0.999
SCO1505	SCO5736	gene:17759091	gene:17763392	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.	0.999
SCO2563	SCO1505	gene:17760165	gene:17759091	30s ribosomal protein S20; Binds directly to 16S ribosomal RNA.	30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.989