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SCO2014 SCO2014 SCO2119 SCO2119 SCO2126 SCO2126 SCO2181 SCO2181 SCO2183 SCO2183 SCO2285 SCO2285 SCO2291 SCO2291 SCO2371 SCO2371 SCO2462 SCO2462 SCO2542 SCO2542 SCO6976 SCO6976 SCO6975 SCO6975 SCO6944 SCO6944 SCO6818 SCO6818 SCO6776 SCO6776 SCO6659 SCO6659 SCO6596 SCO6596 SCO6595 SCO6595 SCO6594 SCO6594 SCO6570 SCO6570 SCO6548 SCO6548 SCO6546 SCO6546 SCO6525 SCO6525 SCO6523 SCO6523 SCO6340 SCO6340 SCO6255 SCO6255 mmyG mmyG SCO7708 SCO7708 SCO7638 SCO7638 SCO7633 SCO7633 SCO7630 SCO7630 SCO7629 SCO7629 SCO7576 SCO7576 SCO7559 SCO7559 SCO7511 SCO7511 SCO7492 SCO7492 SCO7485 SCO7485 SCO7484 SCO7484 SCO7338 SCO7338 SCO7254 SCO7254 SCO7228 SCO7228 SCO7225 SCO7225 SCO7124 SCO7124 SCO7123 SCO7123 SCO7073 SCO7073 SCO7071 SCO7071 SCO7070 SCO7070 SCO7057 SCO7057 SCO7004 SCO7004 SCO6988 SCO6988 SCO6984 SCO6984 SCO2543 SCO2543 SCO2727 SCO2727 SCO2749 SCO2749 SCO2752 SCO2752 SCO2821 SCO2821 SCO2833 SCO2833 SCO2847 SCO2847 SCO3026 SCO3026 SCO6232 SCO6232 SCO6178 SCO6178 SCO6082 SCO6082 SCO5954 SCO5954 SCO5423 SCO5423 SCO4939 SCO4939 SCO4209 SCO4209 SCO3829 SCO3829 SCO3815 SCO3815 SCO3444 SCO3444 SCO3649 SCO3649 SCO3475 SCO3475 SCO3138 SCO3138 SCO5938 SCO5938 SCO5932 SCO5932 SCO5931 SCO5931 SCO5852 SCO5852 SCO5846 SCO5846 SCO5808 SCO5808 SCO5456 SCO5456 SCO5426 SCO5426 SCO6977 SCO6977 SCO3096 SCO3096 SCO4914 SCO4914 SCO0087 SCO0087 SCO0105 SCO0105 SCO0118 SCO0118 SCO0263 SCO0263 SCO0274 SCO0274 SCO0342 SCO0342 SCO0361 SCO0361 SCO0481 SCO0481 SCO0509 SCO0509 SCO0545 SCO0545 SCO0578 SCO0578 SCO0579 SCO0579 SCO0580 SCO0580 SCO0714 SCO0714 SCO0716 SCO0716 SCO0765 SCO0765 SCO1049 SCO1049 SCO1130 SCO1130 SCO1170 SCO1170 SCO1188 SCO1188 SCO1214 SCO1214 SCO1268 SCO1268 SCO1337 SCO1337 SCO1429 SCO1429 SCO1451 SCO1451 SCO1464 SCO1464 SCO1660 SCO1660 SCO1734 SCO1734 SCO1777 SCO1777 SCO1830 SCO1830 SCO1844 SCO1844 SCO1880 SCO1880 SCO1883 SCO1883 SCO1884 SCO1884 SCO1885 SCO1885 SCO1895 SCO1895 SCO1942 SCO1942 SCO1945 SCO1945 SCO1946 SCO1946 SCO1947 SCO1947
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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SCO2014SC7H2.28c, pyk1, pyruvate kinase, len: 478 aa; strongly similar to many e.g. SW:KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores; opt: 1800, z-score: 2008.1, E(): 0, (59.6% identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. (478 aa)
SCO21196-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa)
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)
SCO2181SC5F7.20, sucB, possible dihydrolipoamide succinyltransferase, len: 590 aa; similar to many egs. TR:AAC23517 (EMBL:AF068740) dihydrolipoamide succinyltransferase from Pseudomonas ovalis (407 aa) fasta scores; opt: 847, z-score: 602.5, E(): 3.2e-26, (41.9% identity in 453 aa overlap) and SW:ODO2_MYCTU dihydrolipoamide succinyltransferase from Mycobacterium tuberculosis (553 aa) fasta scores; opt: 1232, z-score: 866.2, E(): 0, (56.2% identity in 596 aa overlap). Contains two Pfam matches to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2 [...] (590 aa)
SCO2183Putative pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (899 aa)
SCO2285SCC75A.31, possible oxidoreductase, len: 351 aa. Similar to many Eukaryotic dimeric dihydrodiol dehydrogenases e.g. Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) TR:BAA83489(EMBL:AB021932) dimeric dihydrodiol dehydrogenase (EC 1.3.1.20) (334 aa), fasta scores opt: 741 z-score: 868.2 E():0 39.1% identity in 335 aa overlap. Also similar to Prokaryotic oxidoreductases e.g. Streptomyces antibioticus TR:AAD55450(EMBL:AF055579) putative 3-ketoreductase (328 aa), fasta scores opt: 434 z-score: 510.8 E(): 4.5e-21 34.0% identity in 300 aa overlap. Contains a Pfam match to entry [...] (351 aa)
SCO2291SCC75A.37, axeA, secreted acetylxylan esterase, len: 335 aa. Almost identical in sequence with Streptomyces lividans TR:Q54413 (EMBL:M64552) acetylxylan esterase precursor (EC 3.1.1.72) (335 aa), fasta scores opt: 2197 z-score: 2058.4 E(): 0 98.5% identity in 335 aa overlap. Also highly similar to the C-terminus of Cellulomonas fimi SW:XYND_CELFI (EMBL:X76729) endo-1,4-beta-xylanase D precursor (EC 3.2.1.8) (644 aa), fasta scores opt: 1108 z-score: 1040.5 E(): 0 50.0% identity in 346 aa overlap. Also similar to the adjoining CDS on this cosmid, xlnB, (335 aa), fasta scores opt: 652 z-s [...] (335 aa)
SCO2371Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (918 aa)
SCO2462SC7A8.01, probable sugar kinase (fragment), len: >434 aa; similar to TR:CAB61582 (EMBL:AL133210) Streptomyces coelicolor xylulose kinase (fragment) XylB, 432 aa; fasta scores: opt: 822 z-score: 871.9 E(): 0; 38.8% identity in 418 aa overlap and to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB, 481 aa; fasta scores: opt: 814 z-score: 862.8 E(): 0; 39.5% identity in 423 aa overlap. Contains Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases and PS00445 FGGY family of carbohydrate kinases signature 2; SCC24.33, probable sugar ki [...] (482 aa)
SCO2542Putative glucarate dehydratase; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc).; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. (431 aa)
SCO6976Conserved hypothetical protein; SC8F11.02c, unknown, len: 298 aa. Similar to the Bacillus subtilis SW:IOLB_BACSU(EMBL:D14399) hypothetical protein, IolB, found within the inositol utilisation operon (271 aa), fasta scores opt: 443 z-score: 516.6 E(): 2.4e-21 34.9% identity in 281 aa overlap. (298 aa)
SCO6975Putative acetolactate synthase; SC8F11.01c, possible amino acid synthase, partial CDS, len: > 237 aa. Similar to several enzymes requiring TPP as a cofactor including: Spirulina platensis SW:ILVB_SPIPL(EMBL:M75907) acetolactate synthase (EC 4.1.3.18) IlvY (579 aa), fasta scores opt: 166 z-score: 195.5 E(): 0.0019 27.7% identity in 238 aa overlap. Also highly similar, in parts, to the Bacillus subtilis SW:IOLD_BACSU(EMBL:D14399) hypothetical protein, IolD found within the inositol utilisation operon (580 aa), fasta scores opt: 577 z-score: 669.1 E(): 7.7e-30 47.2% identity in 178 aa ove [...] (624 aa)
SCO6944SC1G8.16c, conserved hypothetical protein, len: 633 aa. Highly similar to several proteins of undefined function including: Streptomyces coelicolor TR:CAB52841 (EMBL:AL109848) SCI51.17 (612 aa), fasta scores opt: 2658 z-score: 3108.3 E():0 64.4% identity in 590 aa overlap and Schizosaccharomyces pombe (Fission yeast) SW:YAY3_SCHPO (EMBL:Z69380) SPAC4H3.03C (649 aa), fasta scores opt: 943 z-score: 1101.2 E():0 32.8% identity in 640 aa overlap. (633 aa)
SCO6818Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
SCO6776Conserved hypothetical protein; SC6A5.25, unknown, len: 370 aa; similar to SW:YZ34_MYCTU hypothetical protein from Mycobacterium tuberculosis (372 aa) fasta scores; opt: 1125, z-score: 1301.0, E(): 0, (51.3% identity in 335 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (370 aa)
SCO6659SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266. (550 aa)
SCO6596SC8A6.17, probable secreted protein, len: 589 aa; co ntains N-terminal signal sequence and PS00213 Lipocalin sig nature. (589 aa)
SCO6595SC8A6.16, probable secreted protein, len: 380 aa; co ntains N-terminal signal sequence and TTA Leu codon, possib le target for action of bldA. (360 aa)
SCO6594SC8A6.15c, probable secreted protein, len: 602 aa; c ontains probable N-terminal signal sequence. (602 aa)
SCO6570SC3F9.05, possible oxidoreductase, len: 430 aa; similar to e.g. Zymomonas mobilisTR:P75002 (EMBL:Z80356) glucose-fructose oxidoreductase (433 aa), fasta scores; opt: 310 z-score: 305.5 E(): 8.4e-10, 27.2% identity in 426 aa overlap. (430 aa)
SCO6548SC5C7.33, probable secreted cellulase, len: 579 aa; similar to many, e.g. TR:Q60029 (EMBL:U18978) beta-1,4-exocellulase precursor (596 aa), fasta scores; opt: 2131 z-score: 2323.9 E(): 0, 62.1% identity in 585 aa overlap. Contains possible N-terminal signal sequence, PS00655 Glycosyl hydrolases family 6 signature 1 and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 161.20, E-value 9.8e-46 near C-terminus. (579 aa)
SCO6546SC5C7.31c, probable secreted cellulase, len: 973 aa; N-terminus is similar to the cellulose binding domain of e.g. GUN4_THEFU endoglucanase E-4 precursor (880 aa), fasta scores; opt: 341 z-score: 352.0 E(): 2.3e-12, 43.7% identity in 103 aa overlap. C-terminus is similar to many cellulases e.g. GUXB_CELFI exoglucanase B precursor (1090 aa), fasta scores; opt: 2997 z-score: 2688.8 E(): 0, 61.4% identity in 699 aa overlap. Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 122.30, E-value 2.4e-34 near N-terminus. (973 aa)
SCO6525SC5C7.10c, unknown, len: 255 aa; similar to hypothetical proteins from many organisms e.g. M. tuberculosis YZ34_MYCTU MTCY31.34 (372 aa), fasta scores; opt: 221 z-score: 293.2 E(): 4.4e-09, 30.7% identity in 251 aa overlap. (255 aa)
SCO6523SC5C7.08, unknown, len: 346 aa; similar to hypothetical proteins from M. tuberculosis YZ34_MYCTU MTCY31.34 (372 aa), fasta scores; opt: 678 z-score: 492.0 E(): 3.7e-20, 42.3% identity in 298 aa overlap, and to Saccharomyces cerevisiae TR:Q02883 (EMBL:U43281) LPG6P (468 aa), fasta scores; opt: 491 z-score: 495.9 E(): 2.2e-20, 35.5% identity in 262 aa overlap. (346 aa)
SCO6340SC3A7.08, unknown, len: 211 aa; similar to hypothetical proteins e.g. S. coelicolor TR:O54167 (EMBL:AL021411) SC7H1.08C (202 aa), fasta scores; opt: 243 z-score: 810.6 E(): 0, 43.8% identity in 210 aa overlap. (211 aa)
SCO6255SCAH10.20, possible dehydrogenase, len: 337 aa; similar to SW:STRI_STRGR (EMBL:Y00459) Stretomyces griseus streptomycin resistance protein StrI, 348 aa; fasta scores: opt: 582 z-score: 670.0 E(): 6.1e-30; 39.5% identity in 344 aa overlap and to SW:MI2D_BACSU (EMBL;M76431) Bacillus subtilis myo-inositol dehydrogenase (EC 1.1.1.18) Idh or IolG OR e83G, 330 aa; fasta scores: opt: 534 z-score: 615.6 E(): 6.5e-27; 28.8% identity in 351 aa overlap. Contains match to Pfam entry PF01408 GFO_IDH_MocA, oxidoreductase family. (337 aa)
mmyGSCP1.239c, mmyG, possible oxidoreductase, len: 393aa; previously sequenced and annotated as TR:Q9JN86 (EMBL:AJ276673). Similar to many eg. TR:Q9RK99 (EMBL:AL117322) putative oxidoreductase from Streptomyces coelicolor (371 aa) fasta scores; opt: 675, z-score: 754.9, E(): 0, 36.4% identity in 357 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (393 aa)
SCO7708SCBAC12C8.09c, conserved hypothetical protein, len: 216aa: similar to many eg. TR:O86609 (EMBL:AL031155) hypothetical protein from Streptomyces coelicolor (211 aa) fasta scores; opt: 764, Z-score: 865.8, 54.673% identity (55.981% ungapped) in 214 aa overlap. (216 aa)
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
SCO7633SC10F4.06c, secreted endo-beta-N-acetylglucosaminidase, len: 309 aa; highly similar to SW:EBAG_STRPL (EMBL:K02182) Streptomyces plicatus endo-beta-n-acetylglucosaminidase H precursor (EC 3.2.1.96), 313 aa; fasta scores: opt: 1769 z-score: 1916.4 E(): 0; 86.9% identity in 312 aa overlap. Contains match to Prosite entry PS01095 Chitinases family 18 active site and possible N-terminal region signal peptide sequence; Belongs to the glycosyl hydrolase 18 family. (309 aa)
SCO7630SC10F4.03, probable isomerase, len: 224 aa; similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB, 215 aa; fasta scores: opt: 190 z-score: 225.8 E(): 4.8e-05; 28.5% identity in 214 aa overlap and to TR:Q9ZAX0 (EMBL:U73808) Amycolatopsis methanolica 2,3-PDG dependent phosphoglycerate mutase PGM, 205 aa; fasta scores: opt: 518 z-score: 596.0 E(): 1.2e-25; 45.5% identity in 202 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family and match to Prosite entry PS00175 Phosphoglycerate mutase family phospho [...] (224 aa)
SCO7629SC10F4.02, spaA, probable starvation sensing protein, len: 413 aa; identical to previously sequenced TR:P95726 (EMBL:X94190) Streptomyces coelicolor spaA gene, 413 aa. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family and match to Prosite entry PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. (413 aa)
SCO7576SC5F1.30c, probable secreted hydrolase, len: 397 aa; highly similar to TR:Q9Z4I2 (EMBL:AB019428) Streptomyces matensis laminaripentaose-producing beta-1,3-guluase (LPHase) precursor LPH, 401 aa; fasta scores: opt: 1827 z-score: 1870.8 E(): 0; 65.0% identity in 394 aa overlap and to Streptomyces coelicolor SC5F1.13c, 398 aa; fasta scores: opt: 1795 z-score: 1665.4 E(): 0; 66.6% identity in 386 aa overlap. Contains possible N-terminal region signal peptide sequence. (397 aa)
SCO7559SC5F1.13c, probable secreted sugar hydrolase, len: 398 aa; similar to SW:E13B_ARTSP (EMBL:D23668) Arthrobacter sp. glucan endo-1,3-beta-glucosidase precursor (EC 3.2.1.39) GlcI, 548 aa; fasta scores: opt: 1570 z-score: 1670.2 E(): 0; 59.7% identity in 387 aa overlap and to Streptomyces coelicolor probable secreted hydrolase SC5F1.30c, 397 aa; fasta scores: opt: 1795 z-score: 1707.3 E(): 0; 66.6% identity in 386 aa overlap. Contains possible N-terminal signal peptide sequence. (398 aa)
SCO7511SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...] (332 aa)
SCO7492Hypothetical protein; SCBAC17A6.25, unknown, len: 454 aa; no significant database matches. (454 aa)
SCO7485SCBAC17A6.18c, possible oxidoreductase, len: 228aa; similar to many eg. TR:Q9L2J5 (EMBL:AL137165) putative oxidoreductase SCF42.24 from Streptomyces coelicolor (295 aa) fasta scores; opt: 450, Z-score: 508.6, 43.850% identity (45.304% ungapped) in 187 aa overlap and TR:BAB49857 (EMBL:AP003000) probable oxidoreductase from Rhizobium loti (319 aa) fasta scores; opt: 243, Z-score: 278.7, 31.980% identity (35.795% ungapped) in 197 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold. (228 aa)
SCO7484Hypothetical protein; SCBAC17A6.17c, unknown, len: 78 aa: no significant database matches. (78 aa)
SCO7338SC4G10.17, glgX, possible glycogen debranching enzyme, len: 715 aa. Previously sequenced region: Streptomyces coelicolor TR:Q9X947(EMBL:AJ001206) (715 aa). Highly similar to Escherichia coli SW:GLGX_ECOLI(EMBL:J01616) glycogen operon protein, GlgX (EC 3.2.1.-) (657 aa), fasta scores opt: 1948 z-score: 2333.6 E():0 47.5% identity in 673 aa overlap and Streptomyces coelicolor TR:CAB76010(EMBL:AL157916) putative glycosyl hydrolase, GlgX2 or SC3D11.13c (782 aa), fasta scores opt: 2622 z-score: 3141.4 E(): 0 58.5% identity in 725 aa overlap. Contains a Pfam match to entry PF00128 alpha-amyl [...] (715 aa)
SCO7254Putative myo-inositol dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (342 aa)
SCO7228SC2H12.27c, possible polysaccharide lyase, len: 554 aa. Similar to regions within several pectate lyases e.g. Erwinia chrysanthemi SW:PELX_ERWCH(EMBL:M62739) exopolygalacturonate lyase precursor (EC 4.2.2.9), PelX (749 aa), fasta scores opt: 441 z-score: 462.5 E(): 2.7e-18 33.2% identity in 455 aa overlap. (554 aa)
SCO7225SC2H12.24, secreted chitinase, len: 244 aa. The N-terminal is highly similar to several chitin binding proteins e.g. Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (CHB2) (201 aa), fasta scores opt: 181 z-score: 193.2 E(): 0.0027 38.4% identity in 203 aa overlap. The C-terminal is similar to many chitinases e.g. Streptomyces olivaceoviridis TR:CAB83055(EMBL:AJ276990) chitinase precursor (EC 3.2.1.14) (781 aa), fasta scores opt: 322 z-score: 324.1 E(): 1.4e-10 36.5% identity in 167 aa overlap. Also highly similar to several Streptomyces coelicolor chitinases e.g. TR [...] (244 aa)
SCO7124Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
SCO7123SC4B10.24c, probable acyltransferase, len: 417 aa; similar to SW:ODO2_ALCEU (EMBL:X91877) Alcaligenes eutrophus dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 416 aa; fasta scores: opt: 793 z-score: 570.6 E(): 2.6e-24; 39.0% identity in 421 aa overlap, to C-terminal region of TR:Q9Z6I4 (EMBL:AF047034) Streptomyces seoulensis dihydrolipoamide acetyltransferase PdhB, 612 aa; fasta scores: opt: 1251 z-score: 887.0 E(): 0; 61.0% identity in 474 aa overlap and to TR:CAB51265 (EMBL:AL096872) Streptomyces coelicolor putative dihydrol [...] (417 aa)
SCO7073SC4G1.39c, hypothetical protein, len: 330 aa; similar to SW:YCGT_ECOLI (EMBL:AE000218) Escherichia coli hypothetical 39.5 kDa protein in TreA-Pth intergenic region YcgT, 366 aa; fasta scores: opt: 876 z-score: 955.5 E(): 0; 46.2% identity in 355 aa overlap, to N-terminal region of SW:DAK1_YEAST (EMBL:Z38114) Saccharomyces cerevisiae dihydroxyacetone kinase 1 (EC 2.7.1.29) Dak1, 584 aa; fasta scores: opt: 516 z-score: 562.8 E(): 7e-24; 34.0% identity in 312 aa overlap and to TR:AAK84068 (EMBL:AF297121) Selenomonas ruminantium subsp. ruminantium dihydroxyacetone kinase DhaK1, 329 aa; fas [...] (330 aa)
SCO7071SC4G1.37c, conserved hypothetical protein, len: 130 aa; similar to TR:Q9RZR3 (EMBL:AE001826) Deinococcus radiodurans conserved hypothetical protein DRB0052, 133 aa; fasta scores: opt: 250 z-score: 278.2 E(): 5e-08; 42.2% identity in 135 aa overlap. (130 aa)
SCO7070Hypothetical protein SC4G1.36; SC4G1.36, unknown, len: 388 aa. High content in alanine, arginine, glycine and proline amino acid residues. Also contains TTA leucine codon, possible target for bldA regulation. (388 aa)
SCO7057SC4G1.23c, possible esterase, len: 322 aa; similar to TR:O33842 (EMBL:U58632) Thermotoga neapolitana acetyl xylan esterase AxeA, 325 aa; fasta scores: opt: 1173 z-score: 1264.6 E(): 0; 54.2% identity in 321 aa overlap. (322 aa)
SCO7004SC8F11.30, probable carbohydrate kinase,len: 479 aa. Highly similar to many e.g. Bacillus subtilis SW:GLPK_BACSU(EMBL:M34393) glycerol kinase (EC 2.7.1.30), GlpK (496 aa), fasta scores opt: 688 z-score: 766.4 E():0 35.1% identity in 496 aa overlap. Contains a Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases. (479 aa)
SCO6988Putative oxidoreductase; SC8F11.14c, possible oxidoreductase, len: 387 aa. Similar to several including: Sinorhizobium meliloti TR:O68965(EMBL:) myo-inositol dehydrogenase (EC 1.1.1.18) IdhA (330 aa), fasta scores opt: 287 z-score: 332.8 E(): 4.2e-11 30.1% identity in 356 aa overlap and Streptomyces coelicolor TR:O69945(EMBL:AL023862) putative oxidoreductase, SC3F9.05 (430 aa), fasta scores opt: 721 z-score: 825.3 E():0 34.6% identity in 390 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (387 aa)
SCO6984Putative oxidoreductase; SC8F11.10c, possible oxidoreductase, len: 358 aa. Similar to many including: Sinorhizobium meliloti TR:O68965(EMBL:) myo-inositol dehydrogenase (EC 1.1.1.18) IdhA (330 aa), fasta scores opt: 715 z-score: 789.8 E(): 0 39.6% identity in 338 aa overlap and Streptomyces coelicolor TR:CAB60174(EMBL:AL132824) putative dehydrogenase, SCAH10.20C (337 aa), fasta scores opt: 1068 z-score: 1176.0 E(): 0 50.8% identity in 333 aa overlap. Note codon 25 offers an alternative translational start site. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (358 aa)
SCO2543SCC77.10c, possible dihydrodipicolinate synthase. len: 322 aa. Similar to many dihydrodipicolinate synthases including: Bacillus subtilis SW:DAPA_BACSU (EMBL:L08471) dihydrodipicolinate synthase (EC 4.2.1.52) (290 aa), fasta scores opt: 341 z-score: 396.9 E(): 1e-14 26.8% identity in 284 aa overlap and Streptomyces coelicolor TR:Q9X9X7 (EMBL:AL096743) putative dihydropicolinate synthase SCI7.13C (316 aa), fasta scores opt: 927 z-score: 1065.7 E():0 53.1% identity in 294 aa overlap. Contains a Pfam match to entry PF00701 DHDPS; Belongs to the DapA family. (322 aa)
SCO2727Hypothetical protein SCC46.12c; SCC46.12c, improbable CDS predicted by HMM, len: 125 aa. (125 aa)
SCO2749Carbohydrate transport protein; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (129 aa)
SCO2752SCC57A.23c, possible oxidoreductase, len: 378 aa. Weakly similar to several other putative oxidoreductases e.g. Streptomyces coelicolor TR:O69945 (EMBL:AL023862) putative oxidoreductase (430 aa), fasta scores opt: 252 z-score: 300.4 E(): 2.4e-09 28.8% identity in 278 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (378 aa)
SCO2821SCBAC17F8.12c, possible secreted pectate lyase, len: 521 aa: similar to many e.g. TR:Q9KGY6 (EMBL:AF278705) pectate lyase B from Alteromonas haloplanktis (658 aa) fasta scores; opt: 1744, Z-score: 1590.1, 63.301% identity (65.859% ungapped) in 515 aa overlap and SW:P04959 (PELB_ERWCH) pectate lyase B from Erwinia chrysanthemi (375 aa) fasta scores; opt: 413, Z-score: 386.2, 29.167% identity (32.464% ungapped) in 384 aa overlap. Contains Pfam match to entry PF00544 pec_lyase, Pectate lyase and a probable N-terminal signal sequence. (521 aa)
SCO2833SCE20.07c, chb, secreted chitin binding protein, len: 201 aa. Highly similar to several including: Streptomyces olivaceoviridis (Streptomyces corchorusii) TR:Q54501(EMBL:X78535) chitin binding protein precursor Chb1 (201 aa), fasta scores opt: 1185 z-score: 1303.0 E():0 83.7% identity in 202 aa overlap and Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 1161 z-score: 1276.8 E(): 0 79.1% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (201 aa)
SCO2847Putative oxidoreductase; SCE20.21, possible oxidoreductase, len: 360 aa. Similar to several other putative oxidoreductases e.g. Escherichia coli SW:YDGJ_ECOLI(EMBL:AE000258) hypothetical oxidoreductase (346 aa), fasta scores opt: 873 z-score: 972.9 E():0 45.0% identity in 353 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (360 aa)
SCO3026SCE34.07c, hypothetical protein, len: 375 aa; similar to TR:O05899 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 35.3 kD protein RV3256c, 346 aa; fasta scores: opt: 171 z-score: 187.3 E(): 0.0057; 31.1% identity in 376 aa overlap. (375 aa)
SCO6232SC2H4.14, probable beta-mannosidase, len: 820 aa; similar to several eukaryotic beta-mannosidases, e.g. MANB_HUMAN beta-mannosidase precursor (EC 3.2.1.25) (879 aa), fasta scores; opt: 679 z-score: 909.3 E(): 0, 31.4% identity in 684 aa overlap. (820 aa)
SCO6178SC6C5.14c, possible deacetylase (putative secreted protein), len: 260 aa; similar to many e.g. SW:NODB_RHILT NodB, chitooligosaccharide deacetylase, nodulation protein B, from Rhizobium leguminosarum (215 aa) fasta scores; opt: 321, z-score: 420.9, E(): 3.7e-16, (35.0% identity in 197 aa overlap). Contains possible N-terminal region signal peptide sequence. (260 aa)
SCO6082SCBAC1A6.06c, glgX3, glycogen debranching enzyme, len: 702 aa; similar to SW:GLGX_ECOLI (EMBL:J01616) Escherichia coli glycogen operon protein GlgX or GlyX (EC 3.2.1.*), 657 aa; fasta scores: opt: 1883 z-score: 2219.2 E(): 0; 45.5% identity in 664 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase; Belongs to the glycosyl hydrolase 13 family. (702 aa)
SCO5954SC7H1.24, probable chitinase (putative secreted protein), len: 765 aa; similar to many eg. S. lividans CHIT_STRLI P36909 chitinase c precursor (ec 3.2.1.14) (619 aa), fasta scores; opt: 292 z-score: 779.5 E(): 0, 35.1% identity in 752 aa overlap. Contains PS01095 Chitinases family 18 active site signature, and possible N-terminal region signal peptide sequence. (765 aa)
SCO5423SC8F4.27c, pyk2, pyruvate kinase, len: 476 aa; strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt: 1693, z-score: 1907.7, E(): 0, 55.3% identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt: 2185, z-score: 2461.2, E(): 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. (476 aa)
SCO4939Hypothetical protein SCK31.31c; SCK13.31c, unknown, len: 260 aa. (260 aa)
SCO4209Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
SCO3829SCGD3.30c, bkdC2, probable dihydrolipoamide acyltransferase component E2, len: 491 aa; similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa), fasta scores; opt: 672 z-score: 634.2 E(): 5.4e-28, 33.2% identity in 482 aa overlap. Highly similar to SCGD3.16c, probable dihydrolipoamide acyltransferase component E2 (469 aa) (40.0% identity in 492 aa overlap), in a duplication of this region downstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases a [...] (491 aa)
SCO3815SCGD3.16c, bkdC1, probable dihydrolipoamide acyltransferase component E2, len: 469 aa; similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa), fasta scores; opt: 733 z-score: 672.8 E(): 3.8e-30, 38.7% identity in 460 aa overlap. Highly similar to SCGD3.30c, probable dihydrolipoamide acyltransferase component E2 (491 aa) (40.1% identity in 494 aa overlap), in a duplication of this region upstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acy [...] (469 aa)
SCO3444SCE46.01c, hypothetical protein (partial CDS), len: >38 aa; similar to TR:CAB52841 (EMBL:AL109848) Streptomyces coelicolor hypothetical 68.4 kD protein; fasta scores: opt: 152 z-score: 252.5 E(): 1e-06; 52.8% identity in 36 aa overlap; SCE36.11c, partial CDS, conserved hypothetical protein, len: 612aa; similar to TR:P71741 (EMBL:Z81368) hypothetical protein from Mycobacterium tuberculosis (642 aa) fasta scores; opt: 1283, z-score: 1479.1, E(): 0, (41.9% identity in 623 aa overlap) and SW:YAY3_SCHPO hypothetical protein from Schizosaccharomyces pombe (649 aa) fasta scores; opt: 883, z-s [...] (617 aa)
SCO3649Putative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
SCO3475SCE65.11c, possible isomerase, len: 377 aa; similar to SW:ATB_RHOOP (EMBL:X99622) Rhodococcus opacus muconate cycloisomerase I (EC 5.5.1.1) CatB, 373 aa; fasta scores: opt: 390 z-score: 443.3 E(): 2.6e-17; 31.1% identity in 357 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. (377 aa)
SCO3138SCE66.17c, galT, galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), len: 353aa; similar to many especially SW:P13212 (GAL7_STRLI) galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa) fasta scores; opt: 1998, z-score: 2363.0, E(): 0, 87.2% identity in 352 aa overlap. Contains Pfam match to entry PF01087 GalP_UDP_transf, Galactose-1-phosphate uridyl transferase and Prosite match to PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. (353 aa)
SCO5938Conserved hypothetical protein SC7H1.08c; SC7H1.08c, unknown, len: 202 aa; some similarity in C-terminus to Mycobacterium tuberculosis hypothetical protein TR:P71839 (EMBL:Z80226) MTCY369.30C (129 aa), fasta scores; opt: 240 z-score: 383.0 E(): 3.8e-14, 41.2% identity in 102 aa overlap. (202 aa)
SCO5932Arabinofuranosidase; Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well (By similarity); Belongs to the glycosyl hydr olase 62 family. (475 aa)
SCO5931SC10A5.36c, xlnA, xylanase A precursor, partial CDS, len >383 aa; overlaps and extends ORF from neighbouring cosmid SC7H1.01c; almost identical to XYNA_STRLI P26514 endo- 1,4-beta-xylanase a precursor (477 aa) (99.2% identity in 383 aa overlap). Conatains PS00591 Glycosyl hydrolases famil y 10 active site and Pfam match to entry glycosyl_hydro3 PF 00331, Glycosyl hydrolases family 10, score 183.41. Also si milar in part to S. coelicolor SC7H1.02, abfB, arabinofuran osidase (E(): 1.4e-35, 58.4% identity in 149 aa overlap); SC7H1.01c, xlnA, xylanase A precursor, partial CDS, len >147 aa; [...] (477 aa)
SCO5852SC9B10.19, agaY, possible tagatose-bisphosphate aldolase, len: 282 aa; similar to eg. AGAY_ECOLI P42908 tagatose-bisphosphate aldolase agaY (286 aa), fasta scores; opt: 585 z-score: 725.0 E(): 3.2e-33, 37.6% identity in 279 aa overlap. (282 aa)
SCO5846SC9B10.13c, putative secreted protein, len: 689 aa. Contains possible N-terminal region signal peptide sequence. (689 aa)
SCO5808Conserved hypothetical protein SC4H2.29; SC4H2.29, unknown, len: 219 aa; highly similar to several eukaryotic hypothetical proteins e.g. Arabidopsis thaliana TR:O04035 (EMBL:AC000106) F7G19.18 (281 aa), fasta scores; opt: 482 z-score: 1008.5 E(): 0, 47.0% identity in 217 aa overlap. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature and Pfam match to entry PGAM PF00300, Phosphoglycerate mutase family, score 20.30. (219 aa)
SCO5456SC3D11.13c, glgX2, possible glycosyl hydrolase (putative secreted protein), len: 782 aa; similar to many eg. TR:Q9X947 (EMBL:AJ001206) putative glycogen debranching enzyme from Streptomyces coelicolor (715 aa) fasta scores; opt: 2630, z-score: 2693.4, E(): 0, 58.5% identity in 725 aa overlap and SW:P15067 (GLGX_ECOLI) glycogen operon protein from Escherichia coli (657 aa) fasta scores; opt: 1608, z-score: 1647.7, E(): 0, 47.2% identity in 669 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase. Contains possible N-terminal region signal peptide sequence. (782 aa)
SCO54266-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO6977Hypothetical protein SC8F11.03c; SC8F11.03c, unknown, len: 298 aa. weakly similar to Streptomyces coelicolor TR:CAB59608 (EMBL:AL132662) putative histidine kinase protein, SCF11.31C (442 aa), fasta scores opt: 131 z-score: 160.7 E(): 0.16 30.2% identity in 265 aa overlap. (298 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO4914Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (331 aa)
SCO0087SCJ11.16c, putative secreted protein, len: 349 aa; similar to TR:P97061 (EMBL:Z81324) hypothetical protein downstream of a beta-lactam regulatory protein in Streptomyces clavuligerus (338 aa) fasta scores; opt: 548, z-score: 613.6, E(): 8.1e-27, (40.6% identity in 330 aa overlap). (349 aa)
SCO0105SCJ11.34c, xlnC, endo-1,4-beta-xylanase (putative secreted protein), len: 241 aa; highly similar to many endo-1,4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores; opt: 1605, z-score: 1785.1, E(): 0, (97.9% identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores; opt: 813, z-score: 910.7, E(): 0, (58.8% identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11, Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl [...] (241 aa)
SCO0118SCJ11.47, possible xylosidase/arabinosidase, len: 509aa; similar to many xylosidase/arabinosidases especially in the N-terminal xylosidase region e.g. SW:XYLB_BUTFI xylosidase/arabinosidase from Butyrivibrio fibrisolvens (517 aa) fasta scores; opt: 582, z-score: 640.5, E(): 2.6e-28, (35.2% identity in 526 aa overlap); Belongs to the glycosyl hydrolase 43 family. (509 aa)
SCO0263SCF1.05c, possible oxidoreductase, len: 371 aa; weakly similar to many e.g. TR:O69945 (EMBL:AL023862) putative oxidoreductase from Streptomyces coelicolor (430 aa) fasta scores; opt: 224, z-score: 247.7, E(): 2e-06, (26.0% identity in 392 aa overlap). Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (371 aa)
SCO0274SCF85.02, possible alpha-galactosidase, len: 499 aa. Similar to many alpha galactosidases e.g. Thermus aquaticus TR:AAD32628(EMBL; AF135399) alpha-galactosidase (476 aa), fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8% identity in 487 aa overlap. (499 aa)
SCO0342SCF41.01c, partial CDS, possible secreted protein, len: >350 aa. Contains a possible N-terminal signal sequence; SCF12.21c, partial CDS, unknown, len: >533aa. (629 aa)
SCO0361Conserved hypothetical protein SCF41.20c; SCF41.20c, unknown, len: 390 aa. Highly similar, over available sequence, to Caulobacter crescentus TR: Q46022 (EMBL; X98879) xylX gene (fragment) (>140 aa), fasta scores opt: 276 z-score: 326.5 E(): 7.8e-11 50.0% identity in 122 aa overlap. (390 aa)
SCO0481SCF80.02, possible secreted chitin binding protein, len: 172 aa. This CDS has been previously sequenced but was unclassified: Streptomyces coelicolor TR:Q9Z9M5 (EMBL; AB017013) gene for ChiG, partial CDS (fragment) (172 aa), fasta scores opt: 1151 z-score: 1339.7 E():0 99.4% identity in 172 aa overlap. This CDS is similar to several e.g. Streptomyces reticuli TR:O87962 (EMBL; Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 193 z-score: 234.7 E(): 1e-05 37.3% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (172 aa)
SCO0509Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
SCO0545SCF11.25, possible secreted protein, len: 843 aa; similar to TR:O87849 (EMBL:AL031013) Streptomyces coelicolor putative secreted protein, 602 aa; fasta scores: opt: 2859 z-score: 3026.4 E(): 0; 72.1% identity in 555 aa overlap. Contains possible N-terminal signal sequence. (848 aa)
SCO0578SCF55.02c, possible triosephosphate isomerase, len: 259 aa; similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA, 261 aa; fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20; 38.9% identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM, Triosephosphate isomerase. (259 aa)
SCO0579Putative ribose 5-phosphate isomerase; SCF55.03c, possible sugar-phosphate isomerase, len: 170 aa; similar to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) (phosphoriboisomerase B) RpiB, 149 aa; fasta scores: opt: 299 z-score: 364.4 E(): 6.3e-13; 38.5% identity in 148 aa overlap. (170 aa)
SCO0580SCF55.04c, possible glycerone kinase, len: 593 aa; similar to SW:DHAK_YEAST (EMBL:D50617) Saccharomyces cerevisiae dihydroxyacetone kinase 2 (EC 2.7.1.29) (glycerone kinase) Dak2, 591 aa; fasta scores: opt: 646 z-score: 660.2 E(): 2.1e-29; 29.9% identity in 561 aa overlap. (593 aa)
SCO0714SCF42.24, possible oxidoreductase, len: 295 aa. Identical to the previously sequenced Streptomyces coelicolor TR:Q9ZIW7 (EMBL:AF009336) Orf1 (fragment) (>195 aa). Also weakly similar to Sinorhizobium meliloti TR:O68965 (EMBL:AF059313) myo-inositol dehydrogenase (EC 1.1.1.18) (330 aa), fasta scores opt: 242 z-score: 275.5 E(): 5.9e-08 26.5% identity in 302 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (295 aa)
SCO0716SCF42.26, possible glycosyl hydrolase (putative secreted protein), len: 400 aa. Similar to several including: Arthrobacter sp. (strain YCWD3) SW:E13B_ARTSP(EMBL:D23668) glucan endo-1,3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa), fasta scores opt: 425 z-score: 452.8 E(): 7.8e-18 34.5% identity in 414 aa overlap and Streptomyces matensis TR:Q9Z4I2(EMBL:AB019428) laminaripentaose-producing beta-1,3-guluase (lphase) precursor (401 aa), fasta scores opt: 477 z-score: 509.6 E(): 5.4e-21 38.7% identity in 413 aa overlap. Contains a possible N-terminal signal sequence. (400 aa)
SCO0765SCF81.24c, cel1, secreted endoglucanase, len: 747 aa; highly similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticulii cellulase 1 precursor (EC 3.2.1.4) (endoglucanase) (endo-1,4-beta-glucanase) (avicelase) Cel1, 746 aa; fasta scores: opt: 4213 z-score: 4621.9 E(): 0; 80.3% identity in 747 aa overlap. Contains two matches to Pfam entries PF00759 Glyco_hydro_9, Glycosyl hydrolase family 9 and to Prosite entry PS00698 Glycosyl hydrolases family 9 active sites signature 2. Also contains N-terminal region signal peptide sequence and a possible helix-turn-helix motif at residues 119..1 [...] (747 aa)
SCO1049SCG20A.29c, probable secreted oxidoreductase, len: 387 aa; similar to SW:GFO_ZYMMO (EMBL:M97379) Zymomonas mobilis glucose-fructose oxidoreductase precursor (EC 1.1.99.28) Gfo, 439 aa; fasta scores: opt: 287 z-score: 318.4 E(): 2.9e-10; 26.6% identity in 350 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family and possible N-terminal region signal peptide sequence. (387 aa)
SCO11302SCG38.23, conserved hypothetical protein, len: 591 aa; similar to TR:P71741 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical 72.7 kDa protein MTCY253.18c, 642 aa; fasta scores: opt: 339 z-score: 399.9 E(): 7.9e-15; 29.0% identity in 628 aa overlap. (591 aa)
SCO1170Xylulose kinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate; Belongs to the FGGY kinase family. (481 aa)
SCO1188SCG11A.19, celS2, secreted cellulose binding protein len: 364 aa; highly similar to TR:AAD27623 (EMBL:AF126376) Streptomyces viridosporus cellulose binding protein CelS2, 358 aa; fasta scores: opt: 2109 z-score: 2160.9 E(): 0; 81.9% identity in 364 aa overlap and to SW:GUNA_MICBI Microbispora bispora endoglucanase A precursor (EC 3.2.1.4) (endo-1,4-beta-glucanase) (CELLULASE) CelA, 456 aa; fasta scores: opt: 350 z-score: 363.9 E(): 6.8e-13; 30.6% identity in 278 aa overlap. Contains match to Pfam entry PF00553 CBD_2, Cellulose binding domain. Contains also possible signal peptide sequence. (364 aa)
SCO12146-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO12682SCG18.15c, probable acyltransferase, len: 372 aa; similar to SW:ODO2_ECOLI (EMBL:J01619) Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 404 aa; fasta scores: opt: 281 z-score: 311.6 E(): 7.1e-10; 24.8% identity in 400 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. (372 aa)
SCO13372SCG61.19c, possible oxidoreductase, len: 301 aa; similar to SW:P37168 (MVIM_SALTY) virulence factor MviM from Salmonella typhimurium (307 aa) fasta scores; opt: 467, z-score: 533.5, E(): 3.1e-22, 33.9% identity in 304 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (301 aa)
SCO1429SC6D7.10, chiD, chitinase (putative secreted protein), len: 417 aa. Previously sequenced and characterised TR:Q9Z9M7(EMBL:AB017011) fasta scores opt: 2877 z-score: 3125.2 E():0 100.0% identity in 417 aa overlap. Contains a Pfam match to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and a Prosite hit to PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence. (417 aa)
SCO1451SCL6.08c, probable endoglucanase precursor, len: 383 aa; similar to SW:GUN1_STRSQ (EMBL:L03218) Streptomyces sp. endoglucanase 1 precursor (EC 3.2.1.4) CasA, 359 aa; fasta scores: opt: 1042 z-score: 1000.3 E(): 0; 50.6% identity in 324 aa overlap. Contains Pfam match to entry PF01341 Glyco_hydro_6, Glycosyl hydrolases family 6 and possible N-terminal region signal peptide sequence. (383 aa)
SCO1464Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
SCO1660Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (512 aa)
SCO1734SCI11.23, possible secreted cellulose-binding protein, len: 356 aa; similar cellulose-binding proteins e.g. TR:O07862 (EMBL:U51222) Streptomyces halstedii cellulose-binding protein (364 aa), fasta scores; opt: 584 z-score: 557.4 E(): 1e-23, 35.7% identity in 305 aa overlap. Weaker similarity to chitin-binding proteins e.g. TR:O87962 (EMBL:Y14315) Streptomyces reticuli chitin-binding protein (201 aa) (32.7% identity in 214 aa overlap) secreted when co-cultivated with chitin-containing fungi. Weak similarity to TR:O86614 (EMBL:AL031155) S.coelicolor possible secreted chitinase (252 aa) ( [...] (356 aa)
SCO1777SCI51.17, conserved hypothetical protein, len: 612 aa; unknown function, similar to TR:P71741 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical protein (642 aa), fasta scores; opt: 1146 z-score: 1320.1 E(): 0, 40.6% identity in 623 aa overlap and SW:YAY3_SCHPO (EMBL:Z69380) Schizosaccharomyces pombe hypothetical protein (649 aa) (33.5% identity in 641 aa overlap). Also similar to SCE36.11C (EMBL:AL049763) S.coelicolor conserved hypothetical protein (fragment) (612 aa) (42.6% identity in 615 aa overlap). (612 aa)
SCO1830SCI8.15, unknown, len: 595 aa. Similar to several proteins of unknown function from Streptomyces coelicolor, including TR:CAB52841 (EMBL: AL109848) hypothetical 68.4 KD protein SCI51.17 (612 aa), fasta scores pt: 2473 z-score: 2932.7 E(): 0 60.7% identity in 596 aa overlap and TR:CAB42080 (EMBL: AL049763) conserved hypothetical protein SCE36.11C (612 aa) fasta scores opt: 1389 z-score: 1396.7 E():0 45.8% identity in 605 aa overlap. As well as Mycobacterium tuberculosis TR:P71741 (EMBL; Z81368) hypothetical 72.7 KD protein (642 aa), fasta scores opt: 1152 z-score: 1364.6 E(): 0 39.9% id [...] (595 aa)
SCO1844SCI8.29c, possible aldolase, len: 240 aa. Similar to many aldolases e.g. Escherichia coli SW:FUCA_ECOLI (EMBL: M31059) L-fuculose phosphate aldolase (EC 4.1.2.17) (215 aa), fasta scores opt: 485 z-score: 552.3 E(): 2.1e-23 42.3% identity in 194 aa overlap. Contains a Pfam match to entry PF00596 Aldolase_II, Class II Aldolase and Adducin N-terminal domain. (240 aa)
SCO1880SCI39.27c, probable secreted pectate lyase, len: 444 aa; similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel, 420 aa; fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62; 42.431% identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase, Pectate lyase. Contains also possible N-terminal region signal peptide sequence. (444 aa)
SCO1883Putative xylanase; SCI7.01c, partial CDS, possible xylanase, len: >95aa; similar to the N-terminal region of many eg. TR:O30426 (EMBL:AF005383) xylanase from the thermophile Caldocellum saccharolyticum (1347 aa) fasta scores; opt: 263, z-score: 357.5, E(): 1.4e-12, (35.2% identity in 91 aa overlap); SCI39.30c, probable xylanase (fragment), len: >458 aa; similar to TR:Q9WXE8 (EMBL:AB022865) Prevotella ruminicola xylosidase, 452 aa; fasta scores: opt: 553 Z-score: 572.6 bits: 115.2 E(): 2.6e-24; 37.954% identity in 303 aa overlap; Belongs to the glycosyl hydrolase 43 family. (514 aa)
SCO1884Hypothetical protein; SCI7.02c, unknown, len: 281aa. (281 aa)
SCO1885SCI7.03c, possible oxidoreductase, len: 385 aa; similar to many proteins of undefined function eg. TR:Q45376 (EMBL:X90711) from a locus required for lipopolysaccharide biosynthesis in Bordetella pertussis (350 aa) fasta scores; opt: 232, z-score: 266.7, E(): 1.6e-07, (28.0% identity in 275 aa overlap). Contains Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family. (385 aa)
SCO1895SCI7.13c, probable dihydropicolinate synthase, len: 316 aa; similar to many egs. SW:KDGD_PSEPU 5-dehydro-4-deoxyglutarate dehydratase from Pseudomonas putida (303 aa) fasta scores; opt: 731, z-score: 838.6, E(): 0, (41.1% identity in 302 aa overlap) and SW:DAPA_BACSU dihydropicolinate synthase from Bacillus subtilis (290 aa) fasta scores; opt: 374, z-score: 432.9, E(): 8.8e-17, (29.2% identity in 288 aa overlap). Contains Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family. (316 aa)
SCO1942SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] (551 aa)
SCO1945Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). (258 aa)
SCO1946SCC54.06c, pgk, phosphoglycerate kinase, len: 403 aa; member of a family of proteins highly conserved across prokaryotes and eukaryotes, e.g. SW:PGK_BACSU Pgk, phosphoglycerate kinase from Bacillus subtilis (394 aa) fasta scores; opt: 1263, z-score: 1322.3, E(): 0, (51.2% identity in 404 aa overlap) and SW:PGKH_SPIOL phosphoglycerate kinase from Spinacia oleracea (Spinach) (433 aa) fasta scores; opt: 1200, z-score: 1256.1, E(): 0, (49.9% identity in 407 aa overlap). Contains PS00111 Phosphoglycerate kinase signature and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases, score 6 [...] (403 aa)
SCO1947Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (336 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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