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SCO6574 SCO6574 SCO6759 SCO6759 SCO6760 SCO6760 SCO2509 SCO2509 SCO6819 SCO6819 SCO7343 SCO7343 SCO7672 SCO7672 SCP1.212 SCP1.212 SCO2455 SCO2455 St6G10A.01 St6G10A.01 SCO2115 SCO2115 SCO2104 SCO2104 SCO2036 SCO2036 SCO1934 SCO1934 SCO1851 SCO1851 SCO1476 SCO1476 SCO1443 SCO1443 SCO1440 SCO1440 SCO1294 SCO1294 SCO2949 SCO2949 SCO3210 SCO3210 SCO3242 SCO3242 SCO3318 SCO3318 SCO0777 SCO0777 SCO0187 SCO0187 SCO0128 SCO0128 SCO6763 SCO6763 SCO3398 SCO3398 SCO3655 SCO3655 SCO3858 SCO3858 SCO3916 SCO3916 SCO3920 SCO3920 SCO4274 SCO4274 SCO4429 SCO4429 SCO4491 SCO4491 SCO4492 SCO4492 SCO4494 SCO4494 SCO4550 SCO4550 SCO4844 SCO4844 SCO4958 SCO4958 SCO5141 SCO5141 SCO5212 SCO5212 SCO5250 SCO5250 SCO5284 SCO5284 SCO5381 SCO5381 SCO5791 SCO5791
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
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textmining
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SCO6574SC3F9.09, putative membrane protein, len: 363 aa; similar to TR:Q9Z4Y9 (EMBL:AL035707) Streptomyces coelicolor putative transferase SCE29.11c, 291 aa; fasta scores: opt: 666 Z-score: 604.6 E(): 4.8e-26; 51.282% identity in 312 aa overlap. Contains possible hydrophobic membrane spanning regions. (363 aa)
SCO6759SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08. (303 aa)
SCO6760SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...] (312 aa)
SCO2509Undecaprenyl phosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (277 aa)
SCO68193-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa)
SCO7343Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)
SCO7672SC4C2.07, possible integral membrane protein, len: 286 aa. Contains possible hydrophobic membrane spanning regions. (286 aa)
SCP1.212Putative bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase; Catalyzes the reaction from prephytoene diphosphate to phytoene; In the N-terminal section; belongs to the phytoene/squalene synthase family. (564 aa)
SCO2455Putative spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (531 aa)
St6G10A.01Putative quinolinate synthetase (fragment); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
SCO2115SC6E10.09c, aroH, probable 2-dehydro-3-deoxyphosphoheptonate aldolase, len: 450 aa; highly similar to many, especially those from plants e.g. SW:AROF_ARATH (EMBL:M74819), Dhs1, Arabidopsis thaliana phospho-2-dehydro-3-deoxyheptonate aldolase 1 precursor (525 aa), fasta scores; opt: 1633 z-score: 1839.4 E(): 0, 53.8% identity in 437 aa overlap. The N-terminus is similar (but not identical) to the SW:AROF_STRCO, AroH, Streptomyces coelicolor 2-dehydro-3-deoxyphosphoheptonate aldolase N-terminal sequence determined from purified protein (TVNAKTSPSA GNTDDPLQAP S). Similar to TR:O52308 (EMB [...] (450 aa)
SCO2104Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (223 aa)
SCO2036Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)
SCO1934Putative cytochrome oxidase assembly factor; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (340 aa)
SCO1851SCI8.36, cobO, cob(I)alamin adenosyltransferase (EC 2.5.1.17), len: 199 aa. Highly similar to many including: Pseudomonas denitrificans SW:COBO_PSEDE (EMBL: M62866) cob(I)alamin adenosyltransferase (EC 2.5.1.17) (corrinoid adenosyltransferase) (213 aa), fasta scores opt: 418 z-score: 517.2 E(): 1.9e-21 37.0% identity in 200 aa overlap and Mycobacterium tuberculosis TR:O05810 (EMBL: Z95207) cob(I)alamin adenosyltransferase CobA (207 aa), fasta scores opt: 918 z-score: 1124.4 E(): 0 64.7% identity in 207 aa overlap. (199 aa)
SCO1476S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
SCO1443SC6D7A.06c, probable riboflavin synthase, len: 200 aa; similar to SW:RISA_ACTPL (EMBL:U27202) Actinobacillus pleuropneumoniae riboflavin synthase alpha chain (EC 2.5.1.9) RibE or RibB, 215 aa; fasta scores: opt: 607 z-score: 734.5 E(): 0; 50.3% identity in 193 aa overlap. Contains 2x Pfam matches to entry PF00677 Lum_binding, Lumazine binding domain and match to Prosite entry PS00693 Riboflavin synthase alpha chain family signature. (200 aa)
SCO14406,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
SCO1294SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. (407 aa)
SCO2949UDP-N-acetylglucosamine transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (448 aa)
SCO3210SCE8.03c, aro, probable 2-dehydro-3-deoxyheptonate aldolase, len: 484 aa; similar to many e.g. TR:O52308 (EMBL:AF035756) 2-dehydro-3-deoxyheptonate aldolase from Streptomyces sp. fasta scores; opt: 1619, z-score: 1722.0, E(): 0, (54.5% identity in 440 aa overlap) and SW:AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase 1 from Arabidopsis thaliana (525 aa) fasta scores; opt: 1457, z-score: 1549.2, E(): 0, (48.4% identity in 457 aa overlap); Belongs to the class-II DAHP synthase family. (484 aa)
SCO3242SCE29.11c, possible transferase, len: 291 aa; similar to TR:O69949 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (363 aa) fasta scores; opt: 666, z-score: 682.9, E(): 9.9e-31, (51.3% identity in 312 aa overlap). Also similar to SW:UBIA_ECOLI 4-hydroxybenzoate octaprenyl transferase from Escherichia coli (290 aa) fasta scores; opt: 137, z-score: 150.2, E(): 0.47, (31.8% identity in 110 aa overlap). (291 aa)
SCO3318Putative porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (319 aa)
SCO07773SCF60.09, conserved hypothetical protein, len: 341 aa; identical to TR:O85700 (EMBL:AF072709) Streptomyces lividans hypothetical 38.1 kDa protein, 341 aa and similar to TR:AAG05998 (EMBL:AE004689) Pseudomonas aeruginosa conserved hypothetical protein PA2610, 324 aa; fasta scores: opt: 838 z-score: 962.6 E(): 0; 44.6% identity in 323 aa overlap. Contains Pfam match to entry PF00043 GST, Glutathione S-transferases. (341 aa)
SCO0187SCJ1.36, crtI, probable phytoene synthase, len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL; L37405) phytoene synthase (342 aa), fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6% identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL; U92075) phytoene synthase (319 aa), fasta scores opt: 996 z-score: 1191.5 E():0 52.2% identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases. (331 aa)
SCO0128Hypothetical protein SCJ21.09; SCJ21.09, unknown, len: 60 aa. (60 aa)
SCO6763SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...] (378 aa)
SCO3398Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (288 aa)
SCO3655Putative spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (554 aa)
SCO3858Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (258 aa)
SCO3916SCH24.38, conserved hypothetical protein, len: 139 aa; similar to many e.g. SW:YDHY_CITFR (EMBL:U09771) Citrobacter freundii hypothetical protein (142 aa), fasta scores; opt: 257 z-score: 321.3 E(): 1.4e-10, 35.4% identity in 130 aa overlap. (139 aa)
SCO3920SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] (392 aa)
SCO4274SCD95A.07c, possible secreted protein, len: 189 aa; similar to TR:CAA74718 (EMBL:Y14336) Streptomyces reticuli putative extracellular protein containing predicted 35 aa signal peptide precursor, 188 aa; fasta scores: opt: 773 z-score: 786.2 E(): 0; 66.3% identity in 187 aa overlap. Contains possible N-terminal region signal peptide sequence. (189 aa)
SCO4429Conserved hypothetical protein SCD6.07; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. (867 aa)
SCO4491SCD69.11, probable octaprenyltransferase, len: 301 aa; similar to TR:AAF10428 (EMBL:AE001939) Deinococcus radiodurans 4-hydroxybenzoate octaprenyltransferase DR0851, 313 aa; fasta scores: opt: 794 z-score: 949.5 E(): 0; 44.7% identity in 302 aa overlap and to SW:UBIA_ECOLI (EMBL:M93136) Escherichia coli 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) UbiA, 290 aa; fasta scores: opt: 299 z-score: 362.7 E(): 9.7e-13; 27.9% identity in 276 aa overlap. Contains Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family. Contains also possible hydrophobic membrane spanning regions. (301 aa)
SCO4492Putative octaprenyl carboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (216 aa)
SCO4494Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
SCO4550Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
SCO4844SC5G8.12, possible integral membrane protein, len: 322aa; similar to TR:O53583 (EMBL:AL022076) hypothetical protein from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 937, z-score: 1058.4, E(): 0, 51.4% identity in 292 aa overlap. Contains possible membrane-spanning hydrophobic regions; Belongs to the UbiA prenyltransferase family. (322 aa)
SCO49582SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. (386 aa)
SCO5141Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (294 aa)
SCO52123-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa)
SCO52502SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa; previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1; Belongs to the FPP/GGPP synthase family. (386 aa)
SCO5284SCCB12.08c, hypothetical protein, len: 235 aa; similar to TR:Q9RVH7 (EMBL:AE001956) Deinococcus radiodurans hypothetical 24.5 kDa protein DR1052, 230 aa; fasta scores: opt: 403 z-score: 466.7 E(): 1.6e-18; 38.5% identity in 218 aa overlap and to SW:SPEE_ECOLI (EMBL:J02804) Escherichia coli spermidine synthase (EC 2.5.1.16) SpeE, 287 aa; fasta scores: opt: 173 z-score: 204.7 E(): 0.00063; 31.9% identity in 119 aa overlap. (235 aa)
SCO53812SC6G5.25c, conserved hypothetical protein, len: 190aa; similar to many eg. SW:Q10622 (Y02Y_MYCTU) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores; opt: 800, z-score: 984.0, E(): 0, 65.6% identity in 189 aa overlap. Contains Pfam match to entry PF01923 DUF80, Protein of unknown function; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
SCO5791Putative tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (312 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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