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| | SCO1640 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (453 aa) |
| | SCO7509 | SCBAC25F8.01c, conserved hypothetical protein (fragment), len: >291 aa; similar to TR:AAK48168 (EMBL:AE007177) Mycobacterium tuberculosis CDC1551 hypothetical 56.9 kDa protein MT3801, 509 aa; fasta scores: opt: 1078 Z-score: 1264.7 bits: 242.8 E(): 7.8e-63; 52.577% identity in 291 aa overlap and to TR:CAC32297 (EMBL:AL583943) Streptomyces coelicolor conserved hypothetical protein SC10A9.15c, 506 aa; fasta scores: opt: 1071 Z-score: 1149.0 bits: 221.3 E(): 2.8e-58; 54.639% identity in 291 aa overlap; SCBAC17A6.42c, conserved hypothetical protein, len: >234aa; similar to C-terminal regio [...] (492 aa) |
| | SCO7331 | Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (363 aa) |
| | SCO7036 | SC4G1.02, argG, argininosuccinate synthase, len: 481 aa; identical to previously sequenced SW:ASSY_STRCO (EMBL:D00799) Streptomyces coelicolor argininosuccinate synthase (EC 6.3.4.5) ArgG, 480 aa. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase and matches to Prosite entries PS00564 Argininosuccinate synthase signature 1 and PS00565 Argininosuccinate synthase signature 2; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (481 aa) |
| | SCO6962 | Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase. (466 aa) |
| | SCO6898 | Putative carboxylase; SC1B2.04, possible carboxylase, len: 405 aa. Weakly similar to several e.g. Anabaena sp. (strain PCC 7120) SW:ACCC_ANASP(EMBL:L14862) biotin carboxylase (EC 6.3.4.14) (447 aa), fasta scores opt: 226 z-score: 262.2 E(): 3.8e-07 28.5% identity in 214 aa overlap. Contains a Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and a Prosite hit to PS00867 Carbamoyl-phosphate synthase subdomain signature 2. (405 aa) |
| | SCO6821 | Putative transferase; SC1A2.30c, possible transferase, len: 240 aa. Weakly similar to the C-terminal glutamine amide transferase domain of several CTP synthases e.g. Escherichia coli SW:PYRG_ECOLI(EMBL:M12843) CTP synthase (EC 6.3.4.2) (544 aa), fasta scores opt: 184 z-score: 227.2 E(): 3e-05 24.4% identity in 225 aa overlap. (240 aa) |
| | SCO6671 | SC5A7.21c, unknown, len: 388 aa; Similar to TR:Q9RSB2 (EMBL:AE002054) conserved hypothetical protein from Deinococcus radiodurans (338 aa) fasta scores; opt: 415, Z-score: 392.3, E(): 3.2e-14, 31.333% identity (32.639% ungapped) in 300 aa overlap. Contains nine degenerate PA repeats at C-terminus. (388 aa) |
| | SCO6501 | SC1E6.10, gvpF, probable gas vesicle synthesis protein, len: 257 aa; some similarity to GVF2_HALSA GVPF protein, chromosomal (217 aa), fasta scores; opt: 143 z-score: 191.0 E(): 0.0023, 27.1% identity in 247 aa overlap. (257 aa) |
| | SCO6437 | Hypothetical protein SC9B5.04; SC9B5.04, unknown, len: 424 aa; similar to two hypothetical proteins SW:Y4RH_RHISN from Rhizobium sp. fasta scores; opt: 213, z-score: 366.1, E(): 4.2e-13, (26.3% identity in 335 aa overlap) and SW:YWFE_BACSU from Bacillus subtilis (472 aa) fasta scores; opt: 217, z-score: 289.2, E(): 8.1e-09, (29.4% identity in 364 aa overlap). Also weakly similar to carbomylphosphate synthetases eg. TR:O50302 (EMBL:AJ001805) carbomylphosphate synthetase large subunit from Bacillus subtilis (1064 aa) fasta scores; opt: 150, z-score: 196.8, E(): 0.0011, (25.8% identity in [...] (424 aa) |
| | SCO6274 | SC2C4.04c, probable type I polyketide synthase, len: 3576 aa; similar to TR:Q9ZGI4 (EMBL:AF079138) Streptomyces venezuelae type I polyketide synthase PikAII, 3739 aa; fasta scores: opt: 3355 z-score: 3346.1 E(): 0; 39.7% identity in 4066 aa overlap. Also highly similar, in this same cosmid, to SC2C4.03c and to SC2C4.05c.. Contains Pfam matches to entries 2x PF00109 ketoacyl-synt, Beta-ketoacyl synthase, 2x PF00698 Acyl_transf, Acyl transferase domain, 2x PF00550 pp-binding, Phosphopantetheine attachment site and matches to Prosite entries 2x PS00606 Beta-ketoacyl synthases active site, [...] (3576 aa) |
| | SCO6271 | SCAH10.36c, accA1, probable acyl-CoA carboxylase complex (partial), len: >137 aa; identical to previously sequenced TR:AAD28553 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit, AccA1, 590 aa, to TR:AAD37851 (EMBL:AF126429) Streptomyces venezuelae JadJ, 584 aa; fasta scores: opt: 674 z-score: 748.1 E(): 0; 79.7% identity in 138 aa overlap and to TR:Q54119 (EMBL:X92557) Saccharopolyspora erythraea (Streptomyces erythraeus) biotin carboxylase and biotin carboxyl carrier protein BcpA2, 591 aa; fasta scores: opt: 455 z-score: 508.1 E(): 6.3e-21; 55.6% [...] (590 aa) |
| | SCO6227 | Hypothetical protein SC2H4.09; SC2H4.09, unknown, len: 517 aa; some similarity to Rhizobium sp. NGR234 plasmid pNGR234a hypothetical protein Y4XN_RHISN (628 aa), fasta scores; opt: 148 z-score: 254.8 E(): 6e-07, 25.9% identity in 495 aa overlap. Also weak similarity to S. coelicolor SC4H2.21 (E(): 1.8e-06, 33.2% identity in 581 aa overlap) and to divergent CDS SC2H4.08c (E(): 0.0012, 29.1% identity in 553 aa overlap). (517 aa) |
| | SCO6226 | Hypothetical protein SC2H4.08c; SC2H4.08c, unknown, len: 508 aa; some similarity to Rhizobium sp. NGR234 plasmid pNGR234a hypothetical protein Y4XN_RHISN (628 aa), fasta scores; opt: 116 z-score: 207.6 E(): 0.00026, 26.4% identity in 641 aa overlap. Also some similarity to divergent CDS SC2H4.09 (E(): 0.00044, 29.1% identity in 553 aa overlap). (508 aa) |
| | SCO6060 | Putative UDP-N-acetylmuramoyl-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (462 aa) |
| | SCO5910 | SC10A5.15, putative membrane protein, len: 114 aa. Contains possible hydrophobic membrane spanning regions. (114 aa) |
| | SCO5800 | SC4H2.21, unknown, len: 648 aa; similar to proteins implicated in siderophore biosynthesis eg. SW:RHSC_RHIME (EMBL:AF110737) rhizobactin siderophore biosynthesis protein RhsC from Rhizobium meliloti (585 aa) fasta scores; opt: 1215, Z-score: 1075.6, E(): 3.6e-53, 40.000% identity (41.912% ungapped) in 570 aa overlap. Very weak similarity to TR:Q47316 (EMBL:X76100) E. coli plasmid pColV-K30 iucA gene (575 aa), fasta scores; opt: 695 z-score: 458.0 E(): 2.6e-18, 30.1% identity in 555 aa overlap. Contains PS00136 Serine proteases, subtilase family, aspartic acid active site. (648 aa) |
| | SCO5560 | D-alanine-D-alanine ligase; Cell wall formation. (389 aa) |
| | SCO5501 | Probable Glu-tRNAGln amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (504 aa) |
| | SCO5499 | Probable Glu-tRNA Gln amidotransferase subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln) (By similarity). (497 aa) |
| | SCO5498 | Probable Glu-tRNAGln amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatC family. (98 aa) |
| | SCO4927 | SCK13.19, probable ligase, len: 291 aa; similar to C-terminal domain of SW:BIRA_ECOLI (EMBL:M10123) Escherichia coli BirA bifunctional protein [includes: biotin operon repressor biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.1) (biotin--protein ligase)], 321 aa; fasta scores: opt: 340 z-score: 382.0 E(): 9.7e-14; 32.7% identity in 260 aa overlap. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase catalytic domain and PF02237 BPL_C, Biotin protein ligase C terminal domain. (291 aa) |
| | SCO4921 | SCK13.13c, accA2, putative acyl-CoA carboxylase complex A subunit, len: 590 aa; identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit AccA2, 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site. (590 aa) |
| | SCO4785 | GMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa) |
| | SCO4381 | SCD10.13, probable acetyl/propionyl CoA carboxylase, alpha subunit, len: 614 aa; similar to TR:CAB87214 (EMBL:AL163641) Streptomyces coelicolor acetyl/propionyl CoA carboxylase, alpha subunit AccC, 646 aa; fasta scores: opt: 1088 z-score: 1184.1 E(): 0; 46.6% identity in 644 aa overlap and to SW:BCCA_MYCTU (EMBL:Z19549) Mycobacterium tuberculosis acetyl/propionyl-coenzyme A carboxylase alpha chain AccA1, 654 aa; fasta scores: opt: 939 z-score: 1022.0 E(): 0; 43.2% identity in 655 aa overlap. Contains 2x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) [...] (614 aa) |
| | SCO4115 | Putative secreted protein; SCD72A.01, unknown, partial CDS, len: >590 aa; SCD17A.07, possible secreted protein (fragment), len: >151 aa. Contains possible and cleavable N-terminal region signal peptide sequence. (707 aa) |
| | SCO4087 | SCD25.23, purM, phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1), len: 355 aa. Identical to Streptomyces lividans TR:Q9ZB03 (EMBL:U64826) phosphoribosyl aminoimidazole synthetase (EC 6.3.3.1) (355 aa), fasta scores opt: 2313 z-score: 2645.5 E(): 0; 100.0% identity in 355 aa overlap and highly similar to many others e.g. Escherichia coli SW:PUR5_ECOLI (EMBL:M13747) phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (phosphoribosyl-aminoimidazole synthetase) (AIR synthase) (344 aa), fasta scores opt: 1018 z-score: 1167.8 E(): 0; 48.4% identity in 343 aa overlap [...] (355 aa) |
| | SCO4079 | Phosphoribosyl formylglycinamidine synthase II (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thou [...] (752 aa) |
| | SCO4078 | Phosphoribosyl formylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (226 aa) |
| | SCO4077 | Hypothetical protein SCD25.13; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (90 aa) |
| | SCO4071 | SCD25.07, purC, phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6), len: 299 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:PUR7_MYCTU (EMBL; Z80226) phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (saicar synthetase) PurC or MTCY369.24 (297 aa), fasta scores: opt: 1085 z-score: 1276.6 E(): 0 58.3% identity in 278 aa overlap. Contains a PS01057 SAICAR synthetase signature 1, PS01058 SAICAR synthetase signature and a Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase. (299 aa) |
| | SCO4068 | SCD25.04, purD, phosphoribosylamine-glycine ligase (EC 6.3.4.13), len: 416 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:PUR2_MYCTU (EMBL; Z80226) phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) MTCY369.17 (422 aa), fasta scores opt: 957 z-score: 1033.0 E(): 0 58.3% identity in 424 aa overlap. Contains a PS00184 Phosphoribosylglycinamide synthetase signature and a Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). (416 aa) |
| | SCO3629 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa) |
| | SCO3595 | Putative D-alanine:D-lactate ligase; Required for resistance to glycopeptides antibiotics. D-Ala-- D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate by D-alanine but by D-lactate, thus preventing vancomycin binding (By similarity); Belongs to the D-alanine--D-alanine ligase family. (346 aa) |
| | SCO3581 | Conserved hypothetical protein; SCH66.02c, unknown, len: 154aa; similar to many eg. TR:O69656 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (154 aa) fasta scores; opt: 425, z-score: 453.4, E(): 6.2e-18, (46.1% identity in 154 aa overlap). (154 aa) |
| | SCO3406 | Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (352 aa) |
| | SCO3383 | Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (337 aa) |
| | SCO3231 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] (3670 aa) |
| | SCO3183 | SCE87.34, unknown, len: 204 aa. Similar to many proteins of undefined function including: Escherichia coli SW:YGFA_ECOLI (EMBL:M12965) hypothetical 21.1 KD protein in SSR-SERA intergenic region (182 aa), fasta scores opt: 298 z-score: 347.9 E(): 5.3e-12 35.0% identity in 180 aa overlap. Also weakly similar to several Eukaryotic proteins such as: Homo sapiens SW:FTHC_HUMAN (EMBL: L38928) 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (202 aa), fasta scores opt: 183 z-score: 217.8 E(): 9.3e-05 23.4% identity in 188 aa overlap. Contains a Pfam match to entry PF01812 5-FTHF_cyc-lig. (204 aa) |
| | SCO3060 | Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (411 aa) |
| | SCO3037 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (443 aa) |
| | SCO2917 | Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (448 aa) |
| | SCO2871 | Conserved hypothetical protein SCE6.08; SCE6.08, unknown, len: 326 aa. Similar to Streptomyces coelicolor TR:CAB69667(EMBL:AL137165) hypothetical 34.9 kd protein, SCF42.05 (328 aa), fasta scores opt: 371 z-score: 450.8 E(): 1.1e-17 35.6% identity in 334 aa overlap. (326 aa) |
| | SCO2785 | Conserved hypothetical protein; SCC105.16, len: 595 aa; type C NRPS-independent siderophore synthetase; catalyzes ATP- and magnesium-dependent condensation of three molecules of N-hydroxy-N-succinylcadaverine to form desferrioxamine G1 and desferrioxamine E and two molecules of N-hydroxy-N-succinylcadaverine with one molecule of N-acetyl-N-hydroxycadaverine to form desferrioxamine B. (595 aa) |
| | SCO2777 | SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...] (646 aa) |
| | SCO2694 | Hypothetical protein; SCC61A.15, unknown, len: 180aa. (180 aa) |
| | SCO2614 | SCC88.25c, fpgS, folylpolyglutamate synthase, len: 444 aa; identical to previously sequenced TR:O08416 (EMBL:Y13070) Streptomyces coelicolor folylpolyglutamate synthase (EC 6.3.2.17), 444 aa and similar to SW:FOLC_BACSU (EMBL:L04520) Bacillus subtilis folylpolyglutamate synthase (EC 6.3.2.17), FolC, 430 aa; fasta scoreS: opt: 622 z-score: 688.7 E(): 6.1e-31; 32.0% identity in 438 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family and matches to Prosite entries PS00398 Site-specific recombinases signature 2 and PS01012 Folylpolyglutamate synthase signature 2. (444 aa) |
| | SCO2241 | SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa) |
| | SCO2238 | NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (613 aa) |
| | SCO2210 | SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa) |
| | SCO2198 | Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa) |
| | SCO2089 | Putative UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (506 aa) |
| | SCO2088 | Putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (471 aa) |
| | SCO2086 | Putative UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (471 aa) |
| | SCO1852 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa) |
| | SCO1776 | Putative CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa) |
| | SCO1663 | Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins. (409 aa) |
| | SCO1613 | SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39. (462 aa) |
| | SCO1485 | SC9C5.09c, possible integral membrane protein, len: 191 aa; similar to TR:P71810 (EMBL:Z81011) Mycobacterium tuberculosis hypothetical 18.2 kD protein, 165 aa; fasta scores: opt: 301 z-score: 362.9 E(): 9.7e-13; 33.1% identity in 148 aa overlap. Contains possible hydrophobic membrane spanning region. (191 aa) |
| | SCO1484 | SC9C5.08c, pyrAA, carbamoyl-phosphate synthase, pyrimidine-specific, small chain, len: 380 aa; similar to SW:CARA_BACCL (EMBL:X73308) Bacillus caldolyticus carbamoyl-phosphate synthase, pyrimidine-specific, small chain (EC 6.3.5.5) PyrAA, 364 aa; fasta scores: opt: 826 z-score: 913.3 E(): 0; 45.3% identity in 362 aa overlap. Contains Pfam matches to entries PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain and PF00117 GATase, Glutamine amidotransferase class-I and match to Prosite entry PS00442 Glutamine amidotransferases class-I active site; Belongs to t [...] (380 aa) |
| | SCO1483 | SC9C5.07c, pyrA, carbamoylphosphate synthetase large chain, len: 1102 aa; similar to SW:CARB_ECOLI (EMBL:V01500) Escherichia coli carbamoyl-phosphate synthase large chain (EC 6.3.5.5) CarB or PyrA, 1072 aa; fasta scores: opt: 3383 z-score: 3699.6 E(): 0; 55.0% identity in 1102 aa overlap. Contains 3x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and matches to Prosite entries 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and 2x PS00867 Carbamoyl-phosphate synthase subdomain signature. (1102 aa) |
| | SCO1477 | Putative flavoprotein homologue (partial); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (427 aa) |
| | SCO1373 | SC10A9.15c, conserved hypothetical protein, len: 505 aa; similar to TR:O69666 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 56.9 kDa protein MTV025.046, 509 aa; fasta scores: opt: 1720 z-score: 2047.1 E(): 0; 53.6% identity in 494 aa overlap. (505 aa) |
| | SCO1246 | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa) |
| | SCO1213 | Conserved hypothetical protein; 2SCG58.13, hypotetical protein, len: 242 aa; similar to TR:Q9ZGG8 (EMBL:AF080002) Heliobacillus mobilis cobyric acid synthase CobQ, 252 aa; fasta scores: opt: 505 z-score: 574.8 E(): 1.5e-24; 39.5% identity in 238 aa overlap. (242 aa) |
| | SCO1212 | 2SCG58.12, possible ligase, len: 412 aa; similar to TR:Q9ZGG7 (EMBL:AF080002) Heliobacillus mobilis UDP-N-acetylmuramyl tripeptide synthetase MurC, 455 aa; fasta scores: opt: 261 z-score: 287.4 E(): 1.5e-08; 29.3% identity in 441 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. (412 aa) |
| | SCO0993 | 2SCG2.06, conserved hypothetical protein, len: 412 aa; similar to SW:Y4RH_RHISN (EMBL:AE000094) Rhizobium sp. hypothetical 52.5 kDa protein Y4rH, 478 aa; fasta scores: opt: 348 z-score: 384.2 E(): 7.1e-14; 26.3% identity in 400 aa overlap. (412 aa) |
| | SCO0910 | Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (433 aa) |
| | SCO0855 | Putative acetyltransferase; SCM2.08c, possible acetyltransferase, len: 168 aa. Weak similarity to several other putative acetyltransferases e.g. Streptomyces coelicolor TR:CAB51273 (EMBL:AL096872) putative acetyltransferase SC5F7.12C (169 aa), fasta scores opt: 121 z-score: 155.1 E(): 0.29 31.3% identity in 147 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (168 aa) |
| | SCO0770 | 3SCF60.02c, possible membrane protein, len: 185 aa. Contains possible hydrophobic membrane spanning region. (185 aa) |
| | SCO0727 | Hypothetical protein 3SC5B7.05c; 3SC5B7.05c, unknown, len: 307 aa. (307 aa) |
| | SCO0695 | Conserved hypothetical protein SCF42.05; SCF42.05, unknown, len: 328 aa; similar to TR:Q9KZT0 (EMBL:AL353832) hypothetical protein SCE6.08 from Streptomyces coelicolor (326 aa) fasta scores; opt: 371, Z-score: 407.1, E(): 4.8e-15, 35.629% identity (39.145% ungapped) in 334 aa overlap. (328 aa) |
| | SCO0651 | SCF91.11, gvpF2, possible gas vesicle synthesis protein, len: 261 aa. Highly similar to many other gas vesicle synthesis proteins including: Bacillus megaterium TR:O68674(EMBL:AF053765) gas vesicle protein GvpF (255 aa), fasta scores opt: 181 z-score: 209.5 E(): 0.00027 24.2% identity in 211 aa overlap and Streptomyces coelicolor TR:Q9ZC12 (EMBL:AL033505) putative gas vesicle synthesis protein GvpF (257 aa), fasta scores opt: 459 z-score: 515.7 E(): 2.4e-21 38.9% identity in 244 aa overlap. (261 aa) |
| | SCO0546 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa) |
| | SCO0506 | NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa) |
| | SCO0386 | SCF62.12, putative asparagine synthetase, len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL; Z70283) putative asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa), fasta scores opt: 752 z-score: 874.8 E():0 32.8% identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. (644 aa) |
| | SCO0171 | Conserved hypothetical protein SCJ1.20; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (438 aa) |
