STRINGSTRING
SCO2505 SCO2505 SCO2506 SCO2506 SCO2550 SCO2550 SCO2730 SCO2730 SCO2781 SCO2781 SCO3159 SCO3159 SCO3161 SCO3161 SCO3185 SCO3185 SCO3564 SCO3564 SCO3601 SCO3601 SCO3603 SCO3603 SCO3609 SCO3609 SCO3716 SCO3716 SCO3717 SCO3717 SCO3718 SCO3718 SCO3826 SCO3826 SCO1623 SCO1623 SCO1218 SCO1218 SCO1215 SCO1215 SCO3216 SCO3216 SCO1045 SCO1045 SCO0963 SCO0963 SCO0490 SCO0490 SCO0476 SCO0476 SCO0473 SCO0473 SCO0459 SCO0459 SCO0285 SCO0285 SCO0152 SCO0152 SCO0015 SCO0015 SCO3964 SCO3964 SCO4048 SCO4048 SCO4053 SCO4053 SCO4332 SCO4332 SCO4993 SCO4993 SCO5154 SCO5154 SCO5157 SCO5157 SCO2277 SCO2277 SCO2275 SCO2275 SCO2186 SCO2186 SCO2113 SCO2113 SCO2071 SCO2071 SCO2027 SCO2027 SCO1854 SCO1854 SCO1826 SCO1826 SCO1714 SCO1714 SCO1667 SCO1667 SCO5245 SCO5245 SCO5246 SCO5246 SCO5320 SCO5320 SCO5648 SCO5648 SCO5783 SCO5783 SCO5818 SCO5818 SCO5875 SCO5875 SCO5876 SCO5876 SCO5904 SCO5904 SCO5958 SCO5958 SCO5960 SCO5960 SCO5961 SCO5961 SCO6158 SCO6158 SCO6447 SCO6447 SCO6455 SCO6455 SCO6987 SCO6987 SCO7180 SCO7180 SCO7187 SCO7187 SCO7196 SCO7196 SCO7197 SCO7197 SCO7296 SCO7296 SCO7451 SCO7451 SCO7660 SCO7660 SCO7819 SCO7819 SCO7832 SCO7832 SCO2347 SCO2347 SCO2499 SCO2499
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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textmining
co-expression
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Your Input:
SCO2505SCC121.08, probable ABC-transporter metal-binding lipoprotein, len: 328 aa; similar to TR:O05703 (EMBL:Z71552) Streptococcus pneumoniae AdcA protein (fragment), 423 aa; fasta scores: opt: 551 z-score: 603.5 E(): 3.2e-26; 39.7% identity in 305 aa overlap and to SW:ZNUA_ECOLI (EMBL:U38702) Escherichia coli, high-affinity zinc uptake system protein ZnuA precursor ZnuA, 328 aa; fasta scores: opt: 294 z-score: 327.0 E(): 8e-11; 26.5% identity in 283 aa overlap. Contains Pfam match to entry PF01297 Lipoprotein_4 and match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attach [...] (328 aa)
SCO2506SCC121.09, probable metal transport ABC transporter, len: 256 aa; similar to TR:Q9XDA6 (EMBL:AF104349) Listeria monocytogenes ABC transporter ZurA, 257aa; fasta scores: opt: 468 z-score: 522.7 E(): 1e-21; 38.0% identity in 237 aa overlap and to SW:FHUC_ECOLI (EMBLX05810:) Escherichia coli ferrichrome transport ATP-binding protein FhuC, 265 aa; fasta scores: opt: 416 z-score: 465.6 E(): 1.5e-18; 34.8% identity in 256 aa overlap. Contains Pfam match to entry PF00005 ABC_tran and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (256 aa)
SCO2550Putative lipoprotein; SCC77.17c, possible lipoprotein, len: 171 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. (171 aa)
SCO2730SCC57A.01, possible regulator, partial CDS, len: > 47 aa. Similar to the C-terminus of Streptomyces coelicolor TR:CAB61163 (EMBL:AL132973) putative TetR-family transcriptional regulator (194 aa), fasta scores opt: 85 z-score: 133.1 E():5 58.1% identity in 31 aa overlap; SCC46.15, possible regulator (fragment), len: >89 aa; N-terminal region of TR:CAB66269 (EMBL:AL136519) Streptomyces coelicolor putative regulator (fragment) SCC57A.01. (101 aa)
SCO2781SCC105.12, hypothetical protein, len: 281 aa; similar to TR:CAB56689 (EMBL:AL121596) Streptomyces coelicolor hypothetical 28.7 kD protein, 259 aa; fasta scores: opt: 261 z-score: 302.6 E(): 2e-09; 34.9% identity in 255 aa overlap. (281 aa)
SCO3159SCE87.10, possible membrane protein, len: 353 aa. Weakly similar to Salmonella typhimurium SW:CBIM_SALTY (EMBL:L12006) cobalamin biosynthesis protein CbiM (245 aa), fasta scores opt: 224 z-score: 251.7 E(): 1.2e-06 32.8% identity in 180 aa overlap. Also similar to Methanobacterium thermoautotrophicum TR: O27742 (EMBL:AE000928) cobalamin biosynthesis protein M (217 aa), fasta scores opt: 495 z-score: 544.6 E(): 5.9e-23 41.4% identity in 220 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. (353 aa)
SCO3161Putative ABC transport protein, ATP-binding subunit; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (260 aa)
SCO3185SCE22.02, possible Na+/H+ antiporter, len: 515 aa; similar to TR:Q9XAJ9 (EMBL:AL079348) Streptomyces coelicolor putative Na(+)/H(+) antiporter SC66T3.14c, 514 aa; fasta scores: opt: 1828 z-score: 1992.7 E(): 0; 55.1% identity in 497 aa overlap. Contains Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family and possible hydrophobic membrane spanning regions. (515 aa)
SCO3564Putative sodium/proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (474 aa)
SCO3601SC66T3.12, conserved hypothetical protein, len: 161 aa; unknown function, similar to hypothetical proteins from several organisms, often adjacent to a putative ion transport protein e.g. TR:O05882 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical protein (160 aa), fasta scores; opt: 348 z-score: 435.7 E(): 6.1e-17, 44.1% identity in 152 aa overlap. Similar to TR:O69959 (EMBL:AL022268) S.coelicolor hypothetical protein (161 aa) (68.9% identity in 161 aa overlap), which is also adjacent to a possible ion transport protein. (161 aa)
SCO3603SC66T3.14c, probable Na(+)/H(+) antiporter, len: 514 aa; weakly similar to SW:NAPA_ENTHR (EMBL:M81961), napA, Enterococcus hirae probable Na(+)/H(+) antiporter (383 aa), fasta scores; opt: 270 z-score: 297.1 E(): 3.2e-09, 24.9% identity in 305 aa overlap and to many putative Na(+)/H(+) antiporters. Contains hydrophobic, possible membrane-spanning regions. Weakly similar to TR:O69958 (EMBL:AL022268) S.coelicolor possible transmembrane transport protein (411 aa) (25.4% identity in 413 aa overlap). Contains Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family. (514 aa)
SCO3609SC66T3.20, possible membrane protein, len: 623 aa; unknown function, C-terminus shares weak similarity with other hypothetical membrane proteins e.g. TR:P74405 (EMBL:D90914) Synechocystis sp. hypothetical protein (568 aa), fasta scores; opt: 250 z-score: 272.0 E(): 8e-08, 24.3% identity in 576 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (623 aa)
SCO3716Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (225 aa)
SCO3717Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (707 aa)
SCO3718Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (554 aa)
SCO3826SCGD3.27c, possible membrane protein, len: 365 aa; unknown function, weakly similar to C-terminal half of SW:KEFC_ECOLI (EMBL:X56742), KefC, Escherichia coli glutathione-regulated potassium-efflux system protein (620 aa), fasta scores; opt: 164 z-score: 190.7 E(): 0.0027, 21.4% identity in 308 aa overlap. Highest similarity to TR:O53346 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical protein (355 aa) (49.8% identity in 325 aa overlap). Also weakly similar to C-terminal half of SC66T3.20, S.coelicolor possible membrane protein (623 aa) (24.6% identity in 329 aa overlap) and shar [...] (365 aa)
SCO1623SCI41.06, unknown, len: 280 aa; similar to e.g. YX26_MYCTU hypothetical 30.6 KD protein CY274.26C, 283 aa; fasta scores: opt: 641 z-score: 744.6 E()0; 45.9% identity in 294 aa overlap. (280 aa)
SCO12182SCG58.18c, possible transmembrane transport protein, len: 611 aa; similar to TR:Q9RX38 (EMBL:AE001907) Deinococcus radiodurans sodium:solute symporter protein DR0477, 528 aa; fasta scores: opt: 379 z-score: 407.0 E(): 3.3e-15; 30.5% identity in 564 aa overlap. Contains Pfam match to entry PF00474 SSF, Sodium:solute symporter family and match to Prosite entry PS00457 Sodium:solute symporter family signature 2. Also contains possible hydrophobic membrane spanning regions and 4x conserved repeat unit: RTDLL; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (611 aa)
SCO12152SCG58.15, possible integral membrane protein, len: 316 aa; similar to SW:CTAG_BACSU (EMBL:Z98682) Bacillus subtilis CtaG protein, 297 aa; fasta scores: opt: 139 z-score: 169.9 E(): 0.053; 24.7% identity in 292 aa overlap. Contains possible hydrophobic membrane spanning regions. (316 aa)
SCO3216SCE8.09, probable integral membrane ATPase, len: 796 aa; member of a large family including SW:Y1B2_MYCTU putative cation-transporting ATPase from Mycobacterium tuberculosis (797 aa) fasta scores; opt: 2741, z-score: 2896.9, E(): 0, (56.8% identity in 791 aa overlap). Contains two Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPases, score 109.40, E-value 9.7e-30 and score 155.80, E-value 7.3e-43, and Prosite match to PS00154 E1-E2 ATPases phosphorylation site. (796 aa)
SCO1045SCG20A.25, possible metal associated protein, len: 77 aa; similar to SW:COPP_HELFE (EMBL:AJ001932) Helicobacter felis cop associated protein (copper ion binding protein) CopP, 66 aa; fasta scores: opt: 153 z-score: 210.7 E(): 0.00029; 40.7% identity in 59 aa overlap and to TR:Q9RDJ5 (EMBL:AL136519) Streptomyces coelicolor putative regulator (fragment) SCC57A.01, >47 aa; fasta scores: opt: 146 z-score: 186.0 E(): 9.3e-05; 53.2% identity in 47 aa overlap. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain. (77 aa)
SCO0963SCM11.18c, hypothetical protein, len: 297 aa; C-terminal region identical to previously sequenced TR:Q9X9U6 (EMBL:AJ243803) Streptomyces coelicolor hypothetical 18.7 kD protein (fragment), 181 aa. Contains proline-rich C-terminal region. (297 aa)
SCO0490SCF34.09, possible esterase, len: 363 aa; similar to enterochelin esterases e.g. SW:FES_ECOLI (EMBL:J04216), Fes, Escherichia coli enterochelin esterase (374 aa), fasta scores; opt: 422 z-score: 474.2 E(): 4.7e-19, 32.5% identity in 332 aa overlap. (363 aa)
SCO0476SCF76.16, ABC transport protein, ATP-binding subunit, len: 252 aa. Similar to many e.g. Haemophilus influenzae SW:FECE_HAEIN (EMBL; U32720) iron(III) dicitrate transport ATP-binding protein FecE homolog (306 aa), fasta scores opt: 375 z-score: 413.4 E(): 1.2e-15 37.3% identity in 185 aa overlap. Contains a Prosite hit to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). (252 aa)
SCO0473SCF76.13c, possible solute-binding lipoprotein, len: 329 aa. Similar to many e.g. Streptococcus parasanguis SW:ADHS_STRPA (EMBL; M26130) adhesin B precursor (saliva-binding protein) (309 aa), fasta scores opt: 354 z-score: 399.1 E(): 7.2e-15 23.7% identity in 317 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site, a Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein and a possible N-terminal signal sequence. (329 aa)
SCO0459Hypothetical protein SCF51A.37; SCF51A.37, unknown, len: 259 aa. Similar to Mycobacterium tuberculosis SW:YX26_MYCTU (EMBL; Z74024) hypothetical 30.6 KD protein CY274.26C (283 aa), fasta scores opt: 268 z-score: 318.2 E(): 2.3e-10 28.9% identity in 263 aa overlap. (259 aa)
SCO0285Putative sodium/proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (629 aa)
SCO0152SCJ1.01, possible transmembrane transport protein, partial CDS, len: >284 aa; similar to S. coelicolor putative transmembrane transport protein SC5B8.17 TR:O70003 (EMBL: AL022374) (530 aa), fasta scores; opt: 513 z-score: 549.9 E(): 2.9e-23 38.1% identity in 270 aa overlap, Rhodobacter capsulatus transmembrane protein TR:O68042(EMBL: AF010496)(578 aa), fasta scores opt: 243 z-score: 263.6 E(): 2.5e-07 26.3% identity in 281 aa overlap and Pseudomonas putida TR:O50471 (EMBL; Z71176) phenylacetic acid permease (520 aa), fasta scores opt: 233 z-score: 253.6 E(): 9.1e-07 31.1% identity in 2 [...] (536 aa)
SCO0015Putative Na+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (410 aa)
SCO3964Hypothetical protein SCD78.31c; SCBAC25E3.01c, possible integral membrane protein, len: >433aa: similar to TR:Q9AK64 (EMBL:AL583944) putative transport integral membrane protein 2SCD60.19 from Streptomyces coelicolor (589 aa) fasta scores; opt: 852, Z-score: 887.7, 51.646% identity (53.968% ungapped) in 395 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions; SCD78.31c, unknown, partial CDS len: >180 aa; contains two hydrophobic domains, 6 degenerate repeats of (G /T)KAS and 4 degenerate repeats of TAKGSG; putative integral membrane protein. (680 aa)
SCO40482SCD60.14c, hypothetical protein, len: 241 aa; similar to TR:Q9RL28 (EMBL:AL121596) Streptomyces coelicolor hypothetical 28.7 kDa protein SCF51A.37, 259 aa; fasta scores: opt: 255 z-score: 307.0 E(): 1.5e-09; 30.2% identity in 225 aa overlap. (241 aa)
SCO40532SCD60.19, possible transport integral membrane protein, len: 589 aa; similar to TR:P94432 (EMBL:D50453) Bacillus subtilis homologue of copper export protein YcnJ, 541 aa; fasta scores: opt: 394 z-score: 369.0 E(): 5.4e-13; 27.8% identity in 442 aa overlap. Contains possible hydrophobic membrane spanning regions. (589 aa)
SCO4332SCD12A.15c, possible integral membrane ATPase, len: 802 aa; similar to TR:Q9Z4W5 (EMBL:AL035654) Streptomyces coelicolor putative integral membrane ATPase SCE8.09, 796 aa; fasta scores: opt: 3320 z-score: 3591.6 E(): 0; 67.0% identity in 796 aa overlap and to TR:O93862 (EMBL:AF043332) Aspergillus nidulans plasma membrane H(+)ATPase PmaA, 990 aa; fasta scores: opt: 504 z-score: 543.3 E(): 8.4e-23; 25.4% identity in 808 aa overlap. Contains 2x Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase and match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site. Contains also possib [...] (802 aa)
SCO49932SCK36.16, possible metal ion transport protein, len: 456 aa; similar to SW:MNTH_SALTY (EMBL:AF161317) Salmonella typhimurium manganese transport protein MntH, 413 aa; fasta scores: opt: 241 Z-score: 273.7 bits: 59.8 E(): 1.2e-07; 20.824% identity in 437 aa overlap. Contains possible hydrophobic membrane spanning regions. (456 aa)
SCO5154SCP8.17c, hypothetical protein, len: 433 aa; highly similar to TR:O86315 (EMBL:Z98260) Mycobacterium tuberculosis hypothetical 47.4 kD protein MTV006.04c, 435 aa; fasta scores: opt: 1335 z-score: 1494.5 E(): 0; 49.9% identity in 425 aa overlap and C-terminal region similar to C-terminal region of TR:Q9X0P4 (EMBL:AE001773) Thermotoga maritima Mg2+ transporter MgtE, putative, 446 aa; fasta scores: opt: 390 z-score: 439.1 E(): 5.4e-17; 31.3% identity in 240 aa overlap. (433 aa)
SCO5157SCP8.20c, probable metal-transport protein, len: 371 aa; similar to TR:O50455 (EMBL:AL021006) Mycobacterium tuberculosis putative magnesium and cobalt transport protein MTV006.11c, 366 aa; fasta scores: opt: 1137 z-score: 1293.8 E(): 0; 47.8% identity in 370 aa overlap and to SW:CORA_ECOLI (EMBL:L11042) Escherichia coli magnesium and cobalt transport protein CorA, 316 aa; fasta scores: opt: 211 z-score: 245.7 E(): 3.2e-06; 23.2% identity in 306 aa overlap. Contains Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein and possible hydrophobic membrane spanning region at [...] (371 aa)
SCO2277SCC75A.23, possible membrane protein, len: 290 aa. Highly similar to many proteins of undefined function including: Escherichia coli SW:YCDN_ECOLI(EMBL:AE000203) YcdN (276 aa), fasta scores opt: 693 z-score: 817.1 E():0 41.6% identity in 267 aa overlap and Synechocystis sp. (strain PCC 6803) SW:Y964_SYNY3(EMBL:D90901) (308 aa), fasta scores opt: 363 z-score: 431.0 E(): 1.2e-16 30.4% identity in 303 aa overlap. (290 aa)
SCO2275Putative lipoprotein; SCC75A.21, possible lipoprotein, len: 384 aa. Similar to several proteins of undefined function including: Escherichia coli TR:BAA35799(EMBL:D90739) (362 aa), fasta scores opt: 783 z-score: 851.0 E():0 39.2% identity in 365 aa overlap and Bacillus subtilis SW:YWBM_BACSU(EMBL:X73124) (385 aa), fasta scores opt: 675 z-score: 734.3 E():0 34.9% identity in 387 aa overlap. Contains a N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (384 aa)
SCO2186Hypothetical protein; SC5F7.15, unknown, len: 234aa. (234 aa)
SCO2113Putative bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. (167 aa)
SCO2071Putative Na+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (528 aa)
SCO2027SC3A3.05c, possible membrane protein, len: 243 aa; unknown function, shows weak similarity to TR:Q9ZUA5 (EMBL:AC006069) Arabidopsis thaliana hypothetical protein (250 aa), fasta scores; opt: 347 z-score: 387.7 E(): 3e-14, 29.7% identity in 229 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (243 aa)
SCO1854Putative permease; SCI39.01c, possible integral membrane protein (fragment), len: >174 aa. Contains possible hydrophobic membrane spanning regions; SCI8.39, possible permease, partial CDS, len: > 104 aa. Weakly similar to Escherichia coli SW:BTUC_ECOLI (EMBL: M14031) vitamin B12 transport system permease protein (326 aa), fasta scores opt: 101 z-score: 140.5 E():1.9 32.5% identity in 77 aa overlap. Contains possible membrane spanning hydrophobic domains. (242 aa)
SCO1826Putative membrane protein; SCI8.11, possible membrane protein, len: 335 aa. Contains multiple possible membrane spanning hydrophobic domains. (335 aa)
SCO1714SCI11.03c, possible secreted protein, len: 189 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition. Contains a probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, so may be a lipoprotein. (189 aa)
SCO1667Putative ion transport protein; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (334 aa)
SCO52452SC7G11.07c, hypothetical protein, len: 86 aa; identical to previously sequenced TR:Q9R3I9 (EMBL:AJ249450) Streptomyces coelicolor A3(2) hypothetical 9.6 kDa protein UshY, 86 aa. Contains Pfam match to entry PF02148 zf-UBP, Zn-finger in ubiquitin-hydrolases and other proteins. (86 aa)
SCO5246Putative Na+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (530 aa)
SCO5320SC6G9.13, whiE ORF I, len: 397 aa; unknown function, whiE locus protein previously sequenced from S. coelicolor as SW:WH42_STRCO (EMBL:X55942); Belongs to the SchA/CurD family. (397 aa)
SCO5648ABC transporter ATP binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (348 aa)
SCO5783SC4H2.04c, hypothetical protein, len: 161 aa; similar to hypothetical proteins from several organisms e.g. M. tuberculosis TR:O05882 (EMBL:Z95121) MTCY20B11.12C (160 aa), fasta scores; opt: 315 z-score: 557.4 E(): 8e-24, 40.0% identity in 150 aa overlap (also upstream of a putative transport protein). (161 aa)
SCO5818SC5B8.08, probable ABC transporter, len: 744 aa; N-t erminus is similar to several ABC transporters e.g. NODI_RH IGA P50332 from Rhizobium galegae nodulation atp-binding pr otein (347 aa), fasta scores; opt: 285 z-score: 225.2 E():2 .4e-05, 34.5% identity in 197 aa overlap, and contains PS00 017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry ABC_tran PF00005, ABC transporters, score 135.08. Th e C-terminus (approx aa 500-744) contains several probable transmembrane domains. In the centre is a repetitive region containing 10 copies of a degenerate 7 aa Proline-rich rep eat. (744 aa)
SCO5875SC2E9.16c, possible potassium uptake protein; len: 226 aa; similar to many homologs of trkA eg. Mycobacterium tuberculosis TR:O07194 (EMBL:Z96072) MTCY05A6.13 (220 aa), fasta scores; opt: 870 z-score: 1486.1 E(): 0, 58.8% identity in 216 aa overlap. Also similar to upstream ORF SC2E9.17c, trkA, (E(): 1.8e-05, 22.6% identity in 212 aa overlap). (226 aa)
SCO5876Potassium uptake protein; Part of a potassium transport system. (223 aa)
SCO5904Conserved hypothetical protein; SC10A5.09c, unknown, len: 126 aa; similar to Mycobac terium tuberculosis hypothetical protein TR:O06156 (EMBL:Z9 5555) MTCY06F7.02C (105 aa), fasta scores; opt: 125 z-score : 213.5 E(): 0.00011, 37.7% identity in 69 aa overlap. (126 aa)
SCO5958Cobalt transport system ATP binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (284 aa)
SCO5960Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (118 aa)
SCO5961Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (257 aa)
SCO6158Hypothetical protein SC1A9.22c; SC1A9.22c, unknown, len: 281 aa. (281 aa)
SCO6447SC9B5.14c, possible NAD(P)H oxidoreductase, len: 246aa; similar to many (prokaryotic and eukaryotic) eg. SW:DHQV_HUMAN NAD(P)H dehydrogenase from Homo sapiens (human) (231 aa) fasta scores; opt: 182, z-score: 338.0, E(): 1.6e-11, (30.9% identity in 181 aa overlap). (246 aa)
SCO6455SC9B5.22, probable ABC transporter ATP-binding protein, len: 222aa; fifth of a five gene operon probably involved in peptide uptake, similar to many eg. SW:OPPF_SALTY oligopeptide transport ATP-binding protein, OppF, from Salmonella typhimurium (334 aa) fasta scores: opt: 412, z-score: 569.7, E(): 1.9e-24, (35.1% identity in 194 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00005 ABC_tran, ABC transporters. (222 aa)
SCO6987SC8F11.13, putative membrane protein, len: 85 aa. Contains possible hydrophobic membrane spanning regions. (155 aa)
SCO7180SC8A11.08c, hypothetical protein, len: 117 aa; similar to TR:AAF70105 (EMBL:AF257324) Streptomyces galilaeus polyketide oxygenase AknX, 122 aa; fasta scores: opt: 151 z-score: 213.3 E(): 0.00021; 34.3% identity in 105 aa overlap. (117 aa)
SCO7187SC8A11.15c, possible lipoprotein, len: 672 aa; similar to TR:Q98LR9 (EMBL:AP002996) Rhizobium loti probable secreted protein MLL0907, 622 aa; fasta scores: opt: 1110 Z-score: 1188.9 E(): 1.4e-58; 33.122% identity in 631 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (672 aa)
SCO7196SC8A11.24c, possible ion transport integral membrane protein, len: 288 aa; similar to SW:KCSA_STRLI (EMBL:Z37969) Streptomyces lividans voltage-gated potassium channel KcsA, 160 aa; fasta scores: opt: 302 z-score: 373.1 E(): 2.6e-13; 41.0% identity in 156 aa overlap. Contains possible hydrophobic membrane spanning regions. (288 aa)
SCO7197SC8A11.25c, probable amino acid transport integral membrane protein, len: 512 aa; similar to SW:ALST_BACSU (EMBL:Z73234) Bacillus subtilis amino acid carrier protein AlsT, 465 aa; fasta scores: opt: 560 z-score: 628.4 E(): 1.6e-27; 35.2% identity in 454 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family and possible hydrophobic membrane spanning regions. (512 aa)
SCO7296Hypothetical protein SC5F8.06c; SC5F8.06c, unknown, len: 117 aa. Similar in parts to Streptomyces coelicolor TR:Q9R3I9(EMBL:AJ249450) hypothetical 9.6 kd protein (86 aa), fasta scores opt: 295 z-score: 318.5 E(): 2.8e-10 51.4% identity in 72 aa overlap. (117 aa)
SCO7451SC5C11.08, unknown, len: 398 aa. Highly similar to several proteins of undefined function associated with polyketide biosynthesis including: Streptomyces coelicolor SW:WH42_STRCO(EMBL:X55942) 42.8 KD protein in whiE locus (WhiE ORF I) SC6G9.13 (397 aa), fasta scores opt: 1392 z-score: 1637.1 E():0 56.1% identity in 401 aa overlap and Streptomyces cyaneus (Streptomyces curacoi) SW:CURD_STRCN(EMBL:X62518) polyketide synthase, CurD (367 aa), fasta score opt: 1451 z-score: 1706.9 E():0 62.0% identity in 368 aa overlap. (398 aa)
SCO7660Voltage-gated potassium channel; Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. (160 aa)
SCO7819SC8E7.16c, possible integral membrane protein, len: 282 aa. Similar to the several e.g. Myxococcus xanthus SW:GUFA_MYXXA(EMBL:X71062) integral membrane protein found within the carotenogenesis operon, GufA (254 aa), fasta scores opt: 173 z-score: 197.7 E(): 0.001625.8% identity in 252 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (282 aa)
SCO7832Putative Na+/H+ antiporter; SC8E7.29, possible Na+/H+ antiporter, len: 410 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X8(EMBL:AL109973) putative Na+/H+ antiporter, SCJ30.11c (410 aa). Also highly similar to many other antiporters e.g. Haemophilus influenzae SW:NHAA_HAEIN(EMBL:U32708) Na(+)/H(+) antiporter 1 (400 aa), fasta scores opt: 504 z-score: 559.3 E(): 1.1e-23 36.6% identity in 391 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (410 aa)
SCO2347SCC8A.05c, possible integral membrane protein, len: aa; similar to others of undefined function eg. TR:P96229 (EMBL:Z83864) hypothetical 32.0 kD protein from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 245, z-score: 295.9, E(): 5.1e-09, 32.8% identity in 195 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01169 UPF0016, Uncharacterized protein family UPF0016. (193 aa)
SCO2499SCC121.02c, possible transport ATPase, len: 1472 aa; similar to TR:P96271 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 159.8 kD protein MTCY22G10.22c, 1539 aa; fasta scores: opt: 2216 z-score: 2157.1 E(): 0; 38.4% identity in 1543 aa overlap and N-terminal region similar to SW:ATMA_SALTY (EMBL:U07843) Salmonella typhimurium Mg(2+) transport atpase, P-type 1 (EC 3.6.1.-) MgtA, 902 aa; fasta scores: opt: 800 z-score: 779.8 E(): 0; 28.0% identity in 880 aa overlap. Contains Pfam match to entry PF00122 E1-E2_ATPase, match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site [...] (1472 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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