STRINGSTRING
SCO5146 SCO5146 SCP1.216Ac SCP1.216Ac SCP1.136 SCP1.136 SCP1.114 SCP1.114 SCO7845 SCO7845 SCO7813 SCO7813 SCO7715 SCO7715 SCO7701 SCO7701 SCO7698 SCO7698 SCO7688 SCO7688 SCO7670 SCO7670 SCO7620 SCO7620 SCO7617 SCO7617 SCO7589 SCO7589 SCO7580 SCO7580 SCO7404 SCO7404 SCO7305 SCO7305 SCO7213 SCO7213 SCO7118 SCO7118 SCO7062 SCO7062 SCO7055 SCO7055 SCO6971 SCO6971 SCO6948 SCO6948 SCO6928 SCO6928 SCO6885 SCO6885 SCO6877 SCO6877 SCO6844 SCO6844 SCO6627 SCO6627 SCO6607 SCO6607 SCO6606 SCO6606 SCO6541 SCO6541 SCO6536 SCO6536 SCO6510 SCO6510 SCO6485 SCO6485 SCO6462 SCO6462 SCO6461 SCO6461 SCO6443 SCO6443 SCO6151 SCO6151 SCO6150 SCO6150 SCO6137 SCO6137 SCO6089 SCO6089 SCO5972 SCO5972 SCO5901 SCO5901 SCO5743 SCO5743 SCO5645 SCO5645 SCO5594 SCO5594 SCO5589 SCO5589 SCO5567 SCO5567 SCO5493 SCO5493 SCO5361 SCO5361 SCO5331 SCO5331 SCO5094 SCO5094 SCO5026 SCO5026 SCO4872 SCO4872 SCO4758 SCO4758 SCO4638 SCO4638 SCO4556 SCO4556 SCO4504 SCO4504 SCO4478 SCO4478 SCO4236 SCO4236 SCO4111 SCO4111 SCO3885 SCO3885 SCO3866 SCO3866 SCO3836 SCO3836 SCO3598 SCO3598 SCO3545 SCO3545 SCO3535 SCO3535 SCO3510 SCO3510 SCO3459 SCO3459 SCO3452 SCO3452 SCO3391 SCO3391 SCO3340 SCO3340 SCO3317 SCO3317 SCO3307 SCO3307 SCO3215 SCO3215 SCO3153 SCO3153 SCO3149 SCO3149 SCO3132 SCO3132 SCO3104 SCO3104 SCO2872 SCO2872 SCO2814 SCO2814 SCO2670 SCO2670 SCO2606 SCO2606 SCO2552 SCO2552 SCO2338 SCO2338 SCO2317 SCO2317 SCO2312 SCO2312 SCO2282 SCO2282 SCO2092 SCO2092 SCO1999 SCO1999 SCO1973 SCO1973 SCO1969 SCO1969 SCO1857 SCO1857 SCO1856 SCO1856 SCO1855 SCO1855 SCO1853 SCO1853 SCO1782 SCO1782 SCO1731 SCO1731 SCO1717 SCO1717 SCO1657 SCO1657 SCO1651 SCO1651 SCO1597 SCO1597 SCO1555 SCO1555 SCO1553 SCO1553 SCO1552 SCO1552 SCO1472 SCO1472 SCO1279 SCO1279 SCO1247 SCO1247 SCO1162 SCO1162 SCO1041 SCO1041 SCO0002 SCO0002 SCO0034 SCO0034 SCO0190 SCO0190 SCO0405 SCO0405 SCO0408 SCO0408 SCO0525 SCO0525 SCO0594 SCO0594 SCO0648 SCO0648 SCO0705 SCO0705 SCO0760 SCO0760 SCO0778 SCO0778 SCO0826 SCO0826 SCO0835 SCO0835 SCO0913 SCO0913 SCO0929 SCO0929 SCO0985 SCO0985
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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SCO5146SCP8.09c, probable methyltransferase, len: 174 aa; similar to SW:MDMC_STRMY (EMBL:M93958) Streptomyces mycarofaciens O-methyltransferase (EC 2.1.1.-) MdmC, 221 aa; fasta scores: opt: 253 z-score: 313.8 E(): 5.2e-10; 31.5% identity in 178 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase. (174 aa)
SCP1.216AcSCP1.216Ac, possible helicase, len: 610aa; inverted and duplicated therefore similar to SCP1.136 (879 aa) fasta scores; .opt: 3788, z-score: 4060.4, E(): 0, 93.0% identity in 599 aa overlap. (610 aa)
SCP1.136Submitted with label=helicase?; SCP1.136, possible helicase, len: 879aa; similar to other large proteins eg. TR:Q9L8V8 (EMBL:AF194023) helicase-like protein (881 aa) fasta scores; opt: 377, z-score: 397.0, E(): 1.2e-14, 37.2% identity in 916 aa overlap. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Note that this protein is inverted and repeated at complement(215655..217487) CDS SCP1.216Ac fasta scores; opt: 3788, z-score: 3530.0, E(): 0, 93.0% identity in 599 aa overlap. SCP1.216Ac is truncated at the N-terminus suggesting that either SCP1.216 [...] (879 aa)
SCP1.114Hypothetical protein; SCP1.114, unknown, len: 152aa. (152 aa)
SCO7845Hypothetical protein; SCJ24.01c, unknown, partial CDS, len: >457 aa; strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores; opt: 2191, z-score: 2490.1, E(): 0, 72.5% identity in 458 aa overlap; SC8E7.42c, partial CDS, unknown, len:> 431 aa. Highly similar to Streptomyces lividans TR:AAF36550 (EMBL:AF194023) helicase-like protein found in the chromosome terminal region (881 aa), fasta scores opt: 1940 z-score: 2170.3 E():0 66.9% identity in 438 aa overlap. (853 aa)
SCO7813Conserved hypothetical protein SC8E7.10; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. (283 aa)
SCO7715SC8D11.06, hypothetical protein, len: 267 aa; similar to TR:Q9RK84 (EMBL:AL132662) Streptomyces coelicolor hypothetical 29.4 kDa protein SCF11.05, 271 aa; fasta scores: opt: 918 z-score: 1092.7 E(): 0; 55.9% identity in 254 aa overlap. (267 aa)
SCO7701Putative methyltransferase; Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP). (292 aa)
SCO7698SC1A4.06c, probable merR-family transcriptional regulator, len: 380 aa; N-terminal region similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA, 253 aa; fasta scores: opt: 404 z-score: 467.3 E(): 1.7e-18; 40.0% identity in 185 aa overlap and C-terminal region similar to TR:O87011 (EMBL:U93274) Pseudomonas aeruginosa hypothetical protein YafE, 187 aa; blastp scores: Score= 121 (42.6 bits), Expect= 1.6e-05, P= 1.6e-05; Identities= 51/144 (35%), Positives= 72/144 (50%). Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR fam [...] (380 aa)
SCO7688SC4C2.23, hypothetical protein, len: 242 aa; similar to TR:CAC04224 (EMBL:AL391515) Streptomyces coelicolor hypothetical 27.9 kDa protein SC4B10.19c, 254 aa; fasta scores: opt: 222 z-score: 264.0 E(): 3.6e-07; 31.8% identity in 214 aa overlap and to Streptomyces coelicolor hypothetical protein SC4C2.20, 677 aa; fasta scores: opt: 705 z-score: 683.1 E(): 2.2e-32; 49.8% identity in 243 aa overlap. (242 aa)
SCO7670SC4C2.05c, conserved hypothetical protein, len: 171 aa; similar to TR:O06539 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 19.0 kDa protein MTCI65.06c, 166 aa; fasta scores: opt: 697 z-score: 858.3 E(): 0; 62.4% identity in 165 aa overlap. (171 aa)
SCO7620SC2H2.18, hypothetical protein, len: 119 aa; similar to TR:Q9K4K9 (EMBL:AL357613) Streptomyces coelicolor hypothetical 13.1 kDa protein SC5F8.15c, 117 aa; fasta scores: opt: 382 z-score: 486.2 E(): 1.5e-19; 53.0% identity in 117 aa overlap. (119 aa)
SCO7617SC2H2.15, hypothetical protein, len: 271 aa; similar to many Streptomyces coelicolor hypothetical proteins, e.g. TR:O86718 (EMBL:AL031515) hypothetical 29.3 kDa protein SC5C7.21c, 271 aa; fasta scores: opt: 863 z-score: 1030.6 E(): 0; 51.5% identity in 274 aa overlap. (271 aa)
SCO7589Hypothetical protein; SC7H9.01c, unknown (fragment), len: >158; SC5F1.43c, unknown (fragment), len: >161 aa. (282 aa)
SCO7580SC5F1.34, hypothetical protein, len: 271 aa; similar to many Streptomyces coelicolor hypothetical proteins, e.g. TR:Q9WX26 (EMBL:AL079345) hypothetical 33.1 kDa protein SCE68.05c, 300 aa; fasta scores: opt: 794 z-score: 946.3 E(): 0; 51.6% identity in 248 aa overlap. (271 aa)
SCO7404Conserved hypothetical protein SC10G8.32c; SC10G8.32c, unknown, len: 263 aa. Highly similar to a number of proteins of undefined function from Streptomyces coelicolor including: TR:O86541 (EMBL:AL031350) SC1F3.04 (261 aa), fasta scores opt: 1155 z-score: 1354.8 E():0 67.9% identity in 262 aa overlap and TR:O86718 (EMBL:AL031515) SC5C7.21C (271 aa), fasta scores opt: 894 z-score: 1050.3 E(): 0 54.0% identity in 272 aa overlap. (263 aa)
SCO7305Conserved hypothetical protein SC5F8.15c; SC5F8.15c, unknown, len: 117 aa. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis SW:YD08_MYCTU(EMBL:Z83866) (118 aa), fasta scores opt: 334 z-score: 429.2 E(): 1.9e-16 49.1% identity in 112 aa overlap and Escherichia coli SW:YEAO_ECOLI(EMBL:AE000274) (122 aa), fasta scores opt: 296 z-score: 382.1 E(): 8.2e-14 42.7% identity in 110 aa overlap. (117 aa)
SCO7213Conserved hypothetical protein SC2H12.12; SC2H12.12, unknown, len: 248 aa. Similar to Streptomyces coelicolor TR:CAB89463(EMBL:AL354048) putative fatty acid synthase, SCE25.32C (438 aa), fasta scores opt: 195 z-score: 237.4 E(): 9.5e-06 26.3% identity in 232 aa overlap. Also highly similar to Escherichia coli SW:YJHP_ECOLI(EMBL:U14003) hypothetical 27.4 kd protein (248 aa), fasta scores opt: 1174 z-score: 1413.2 E():0 66.5% identity in 248 aa overlap. (248 aa)
SCO7118Hypothetical protein SC4B10.19c; SC4B10.19c, unknown, len: 254 aa. (254 aa)
SCO7062SC4G1.28, possible methylase, len: 280 aa; similar to TR:P72542 (EMBL:U60417) Streptomyces pristinaespiralis PapM, 292 aa; fasta socres: opt: 401 z-score: 442.7 E(): 3.4e-17; 35.2% identity in 264 aa overlap and to SW:HEMK_ECOLI (EMBL:D28567) Escherichia coli HemK protein, 277 aa; fasta scores: opt: 299 z-score: 332.7 E(): 4.6e-11; 32.3% identity in 254 aa overlap. (280 aa)
SCO7055SC4G1.21, possible methyltransferase, len: 241 aa; similar to TR:P72459 (EMBL:Y08763) Streptomyces griseus methyltransferase StsG, 253 aa; fasta scores: opt: 207 z-score: 238.8 E(): 7.8e-06; 34.1% identity in 138 aa overlap. (241 aa)
SCO6971SC6F7.24c, possible methylase, len: 257 aa. Highly similar to Pseudomonas denitrificans SW:COBF_PSEDE(EMBL:M59301) cobalamin biosynthesis protein, CobF (261 aa), fasta scores opt: 869 z-score: 1009.4 E():0 53.6% identity in 252 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (257 aa)
SCO6948Hypothetical protein; SC6F7.01, unknown, partial CDS, len:> 157 aa. Weakly similar to several including: Aeropyrum pernix TR:Q9YFC8 (EMBL:AP000059) hypothetical protein (168 aa), fasta scores opt: 231 z-score: 293.6 E(): 6.5e-09 35.8% identity in 137 aa overlap; SC1G8.20, unknown, len: 183 aa. Weakly similar to several including: Aeropyrum pernix TR:Q9YFC8 (EMBL:AP000059) hypothetical protein (168 aa), fasta scores opt: 231 z-score: 290.8 E(): 9.8e-09 35.8% identity in 137 aa overlap. Overlaps and extends into CDS SC6F7.01 on the adjoining cosmid. (183 aa)
SCO6928Putative O-methyltransferase; SC1B2.34c, possible O-methyltransferase, len: 696 aa. Contains a central region which is similar to many protein-L-isoaspartate O-methyltransferases e.g. Escherichia coli SW:PIMT_ECOLI (EMBL:M63493) (207 aa), fasta scores opt: 301 z-score: 340.3 E(): 1.7e-11 31.5% identity in 213 aa overlap and Streptomyces coelicolor TR:CAB71208 (EMBL:AL138538) SC6D10.13C (324 aa), fasta scores opt: 442 z-score: 493.8 E(): 4.8e-20 36.9% identity in 306 aa overlap. Contains a Pfam match to entry PF01135 PCMT, Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT). (696 aa)
SCO6885SC7F9.37, possible DNA methylase, len: 251 aa. Similar to many methylases e.g. Moraxella bovis SW:MT1C_MORBO(EMBL:D13968) modification methylase MboI (EC 2.1.1.72) (273 aa), fasta scores opt:208 z-score: 250.5 E(): 1.5e-06 24.5% identity in 253 aa overlap and Streptomyces coelicolor TR:Q9X866(EMBL:AL049661) putative DNA methylase, SCE134.11c (248 aa), fasta scores opt: 976 z-score: 1145.8 E():0 57.6% identity in 250 aa overlap. Contains a Prosite hit to PS00092 N-6 Adenine-specific DNA methylases signature and a Pfam match to entry PF01555 N6_N4_Mtase, DNA methylase; Belongs to the N(4 [...] (251 aa)
SCO6877Hypothetical protein SC7F9.29c; SC7F9.29c, unknown, len: 260 aa. (260 aa)
SCO6844Putative DNA methylase; SC3D9.12c, possible DNA methylase, len: 423 aa. Weakly similar to Salmonella infantis SW:MTSI_SALIN(EMBL:J03391) modification methylase, SinI (EC 2.1.1.73) (461 aa), fasta scores opt: 244 z-score: 269.9 E(): 1.3e-07 24.5% identity in 355 aa overlap. Contains 2xPfam matches to entries PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase.; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (423 aa)
SCO6627Hypothetical protein; SC4G2.01, unknown, partial CDS, len: >378 aa; continuation of SC1F2.24; SC1F2.24, unknown, partial CDS, len: >862 aa; contains short segment of similarity to a Helicobacter pylori gene described as TR:O26046 (EMBL:AE000649) type IIS restriction enzyme R and M protein (1279 aa), fasta scores; opt: 92 z-score: 267.0 E(): 1.3e-07, 30.5% identity in 118 aa overlap. Also contains PS00092 N-6 Adenine-specific DNA methylases signature and probable coiled-coil from a 5-39. Note that this CDS is relatively more AT rich (approx 60% GC) than the genomic average (72%). (1210 aa)
SCO6607Conserved hypothetical protein SC1F3.04; SC1F3.04, unknown, len: 261 aa; similar to many Streptomyces coelicolor e.g. upstream gene SC1F2.03c,E(): 0, 48.8% identity in 260 aa overlap. (261 aa)
SCO6606Conserved hypothetical protein SC1F2.03c; SC1F2.03c, unknown, len: 300 aa; similar to upstream gene SC1F3.04, E(): 0, 48.8% identity in 260 aa overlap anbd to TR:Q9L173 (EMBL:AL158057) Streptomyces coelicolor hypothetical protein SC10G8.32c, 263 aa; fasta scores: opt: 791 Z-score: 879.8 E(): 2.3e-41; 49.237% identity in 262 aa overlap. (300 aa)
SCO6541SC5C7.26, unknown, len: 248 aa; similar to hypothetical proteins and to TR:Q54529 (EMBL:U10405) Streptomyces purpurascens RdmD gene (required for modification on 10-position of aklavinone during anthracycline antibiotic synthesis) (237 aa), fasta scores; opt: 162 z-score: 217.3 E(): 7.4e-05, 36.1% identity in 158 aa overlap. (248 aa)
SCO6536SC5C7.21c, unknown, len: 271 aa; similar to two S. coelicolor hypothetical proteins SC1F2.04 (E(): 0, 51.3% identity in 269 aa overlap) and SC1F2.03c (E(): 4.5e-21, 44.7% identity in 275 aa overlap). (271 aa)
SCO6510SC1E6.19c, unknown, len: 273 aa; similar to hypothetical proteins e.g. M. tuberculosis TR:O53851 (EMBL:AL022004) MTV043.32 (270 aa), fasta scores; opt: 1102 z-score: 1628.2 E(): 0, 58.6% identity in 263 aa overlap, and in part, to several methyltransferases e.g. PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (203 aa), fasta scores; opt: 198 z-score: 248.3 E(): 1.5e-06, 37.3% identity in 102 aa overlap. (273 aa)
SCO6485Hypothetical protein SC9C7.21; SC9C7.21, unknown, len: 240 aa. (240 aa)
SCO6462Putative methylated-DNA-protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (164 aa)
SCO6461SC9B5.28, possible ADA-like regulatory protein, len: 490 aa; similar to SC1A9.14 (EMBL:AL034446) possible ADA-like regulatory protein from Streptomyces coelicolor (477 aa) fasta scores: opt: 1192, z-score: 937.1, E(): 0, (53.3% identity in 501 aa overlap). Also similar to ADA_MYCTU putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 2185, z-score: 2395.4, E(): 0, (66.7% identity in 490 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 257, z- [...] (490 aa)
SCO6443Conserved hypothetical protein SC9B5.10; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. (303 aa)
SCO6151Putative methylated-DNA-protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (186 aa)
SCO6150SC1A9.14, possible ADA-like regulatory protein, len: 477 aa; similar to ADA_MYCTU (EMBL:Z73902) putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 1135, z-score: 1376.3, E(): 0, (51.6% identity in 486 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI (EMBL:M10211) ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 302, z-score: 255.8, E(): 5.7e-07, (34.5% identity in 171 aa overlap) and C-terminal region similar to 3MG2_ECOLI AlkA, 3-methyladenine DNA glycosylase II involved in DNA repair (2 [...] (477 aa)
SCO6137SC1A9.01c, possible transferase, partial CDS, len: 219 aa, similar to TR:O53185 (EMBL:AL021246) a proposed transferase from Mycobacterium tuberculosis (302 aa), fasta scores: opt: 764, z-score: 1097.3, E(): 0, (62.1% identity in 203 aa overlap (302 aa). Also weakly similar to several methyltransferases eg. METH_ECOLI (EMBL:X16584)5-methyltetrahydrofolate-homocysteine methyltransferase (1226 aa), fasta scores; opt:160, z-score: 234.8, E(): 8.4e-06, (30.0% identity in 220 aa overlap); SC9B2.24c, partial CDS, possible transferase, len: 113aa; constitutes the C-terminal end of SC1A9.01c (E [...] (304 aa)
SCO6089SCBAC1A6.13, antibiotic resistance rRNA adenine methyltransferase, len: 260 aa; identical to TR:Q54386 (EMBL:M74717) Streptomyces lividans lincomycin resistance methylase Lrm, 260 aa and similar to many other macrolide antibiotic resistance proteins, e.g. SW:ERMS_STRFR (EMBL:M19269) Streptomyces fradiae rRNA adenine N-6-methyltransferase (EC 2.1.1.48) ErmSF, 319 aa; fasta scores: opt: 1003 z-score: 1217.4 E(): 0; 64.2% identity in 257 aa overlap. Contains Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylase and match to Prosite entry PS01131 Ribosomal RNA adenine dimet [...] (260 aa)
SCO5972SCBAC16H6.07, hypothetical protein with conserved region, len: 307aa: 300-500 aa region similar to many eg. TR:Q9V662 (EMBL:AE003823) CG12367 protein from Drosophila melanogaster (309 aa) fasta scores; opt: 294, Z-score: 338.2, 34.194% identity (37.324% ungapped) in 155 aa overlap. (531 aa)
SCO5901Putative RNA methyltransferase; SC10A5.06, unknown, len: 458; similar to M. tuberculosis hypothetical protein TR:O07191 (EMBL:Z96072) MTCY05A6. 10C (405 aa), fasta scores; opt: 455 z-score: 878.5 E(): 0, 38.4% identity in 417 aa overlap, and weakly similar to several putative RNA methyltransferases eg. YGCA_ECOLI P5513 5 hypothetical RNA methyltransferase (433 aa), fasta scores; opt: 358 z-score: 331.2 E(): 3e-11, 27.4% identity in 441 aa overlap; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (458 aa)
SCO5743Conserved hypothetical protein SC9A10.07; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
SCO5645Conserved hypothetical protein SC6A9.22c; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
SCO5594tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (277 aa)
SCO5589Hypothetical protein SC2E1.06c; SC2E1.06c, unknown, len: 295 aa. (295 aa)
SCO5567SC7A1.11, possible DNA methylase, len: 195aa; similar to many hypotheticals some of which contain PS00092 N-6 Adenine-specific DNA methylases signature eg. SW:YHHF_ECOLI hypothetical protein from Escherichia coli (198 aa) fasta scores; opt: 340, z-score: 430.7, E(): 1.1e-16, (35.8% identity in 193 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature although not in the expected N-terminal region. (195 aa)
SCO5493Conserved hypothetical protein; SC8D9.05, unknown, len: 331aa; similar to others of undefined function eg. TR:O53262 (EMBL:AL021287) hypothetical protein from Mycobacterium tuberculosis (337 aa) opt: 774, z-score: 895.1, E(): 0, (43.4% identity in 334 aa overlap). (331 aa)
SCO5361Putative methylase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (281 aa)
SCO5331SC6G9.02, possible DNA methylase, len: 1200 aa; highly similar to TR:O86561 (EMBL:AL031350) (71.5% identity in 867 aa overlap) and TR:O86674 (EMBL:AL031371) (90.8% identity in 370 aa overlap) which together constitute a single hypothetical protein split across the join between S.coelicolor cosmids 1F2 and 4G2. It has very weak similarity to DNA methylases, which combined with the presence of a DNA methylases signature and possible DNA-binding region (helix-turn-helix) provides circumstantial evidence of DNA-methylase function. The central third of the CDS is relatively AT rich. Contain [...] (1200 aa)
SCO5094SCBAC28G1.20c, ORF8, putative methyltransferase, len: 208 aa; identical to previously sequenced TR:Q9X9V1 (EMBL:Y18817) Streptomyces coelicolor A3(2) putative methyltransferase ORF8, 208 aa. (208 aa)
SCO5026SCK15.28, hypothetical protein, len: 272 aa; similar to TR:O06593 (EMBL:Z95586) Mycobacterium tuberculosis hypothetical 27.9 kD protein MTCY336.07c, 252 aa; fasta scores: opt: 968 z-score: 1156.3 E(): 0; 57.5% identity in 254 aa overlap. (272 aa)
SCO4872Hypothetical protein SCK20.13c; SCK20.13c, unknown, len: 338 aa. (338 aa)
SCO4758SC6G4.36c, similar to hypothetical proteins e.g. M. tuberculosis TR:O53284 (EMBL:AL021287) MTV012.52c (358 aa), fasta scores; opt: 545 z-score: 329.5 E(): 4.1e-11, 36.2% identity in 354 aa overlap. (426 aa)
SCO4638SCD82.09c, hypothetical protein, len: 274 aa; similar to TR:Q9XBC9 (EMBL:AL078635) Streptomyces coelicolor putative rRNA methylase CZA382.22c, 259 aa; fasta scores: opt: 259 z-score: 291.0 E(): 8.7e-09; 30.8% identity in 221 aa overlap. (274 aa)
SCO4556Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (231 aa)
SCO4504SCD35.11c, possible methyltransferase, len: 241 aa; similar to TR:CAB61165 (EMBL:AL132973) Streptomyces coelicolor putative methyltransferase SCF91.08, 231 aa; fasta scores: opt: 214 z-score: 264.5 E(): 2.7e-07; 29.1% identity in 206 aa overlap and to SW:BIOC_SERMA (EMBL:D17468) Serratia marcescens biotin synthesis protein BioC, 255 aa; fasta scores: opt: 179 z-score: 222.0 E(): 6.2e-05; 34.0% identity in 100 aa overlap. (214 aa)
SCO4478SCD65.21, possible transferase, len: 203 aa; similar to TR:Q9RWR3 (EMBL:AE001918) Deinococcus radiodurans cytidine/deoxycytidylate deaminase/nudix/methyltransferase domains protein DR603, 548 aa; fasta scores: opt: 447 z-score: 514.2 E(): 3.6e-21; 44.1% identity in 186 aa overlap. Contains match to Prosite entry PS00847 MCM family signature. (203 aa)
SCO4236SCD8A.09, possible tRNA/rRNA methyltransferase, len: 314 aa; similar to TR:P96861 (EMBL:Z92774) Mycobacterium tuberculosis hypothetical 34.0 kD protein MTCY06G11.26c, 322 aa; fasta scores: opt: 937 z-score: 1001.6 E(): 0; 56.7% identity in 319 aa overlap and to SW:YJFH_ECOLI (EMBL:U14003) Escherichia coli hypothetical tRNA/rRNA methyltransferase YjfH (EC 2.1.1.-), 243 aa; fasta scores: opt: 519 z-score: 560.7 E(): 8.5e-24; 38.6% identity in 249 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; Belongs to the class IV-like SAM-binding methyltra [...] (314 aa)
SCO4111Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (271 aa)
SCO3885Conserved hypothetical GidB-family protein; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. (239 aa)
SCO3866SCH18.03c, hypothetical protein, len: 291 aa; similar to TR:P74357 (EMBL:D90914) Synechocystis sp. hypothetical 43.7 kD protein, 368 aa; fasta scores: opt: 243 z-score: 281.6 E(): 3.3e-08; 29.1% identity in 206 aa overlap. (291 aa)
SCO3836SCH69.06c, possible rRNA methylase, len: 261aa; similar to many eg. TR:O84408 (EMBL:AE001313) rRNA methylase (269 aa) fasta scores; opt: 197 z-score: 225.0 E(): 3.3e-05 (26.8% identity in 235 aa overlap). Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. (261 aa)
SCO3598SC66T3.09c, possible membrane protein, len: 254 aa; unknown function, similar to TR:O26720 (EMBL:AE000843) Methanobacterium thermoautotrophicum hypothetical protein, fasta scores; opt: 319 z-score: 383.6 E(): 4.9e-14, 28.7% identity in 251 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (254 aa)
SCO3545SCH5.08c, possible transferase, len: 505 aa; limited similarity to many proteins of undefined function e.g. TR:O27384 (EMBL:AE000896) methyltransferase related protein (196 aa) fasta scores; opt: 162, z-score: 186.2, E(): 0.0046, (28.9% identity in 152 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature; Belongs to the methyltransferase superfamily. (505 aa)
SCO3535Hypothetical protein; SCE2.16, unknown, len: 706aa. (706 aa)
SCO3510SCE134.11c, possible DNA methylase, len: 248 aa; similar to many e.g. TR:O68789 (EMBL:AF053947) adenine methyltransferase homolog from Yersinia pestis (213 aa) fasta scores; opt: 246, z-score: 300.2, E(): 2.1e-09, (30.8% identity in 224 aa overlap). Contains Prosite match to PS00092 N-6 Adenine-specific DNA methylases signature; Belongs to the N(4)/N(6)-methyltransferase family. (248 aa)
SCO3459SCE46.16c, hypothetical protein, len: 287 aa; similar to various hypothetical proteins, e.g. TR:CAB52055 (EMBL:AL109732) Streptomyces coelicolor hypothetical 24.3kD protein; fasta scores: opt: 165 z-score: 195.9 E(): 0.0014; 37.4% identity in 131 aa overlap. (287 aa)
SCO3452SCE46.09c, probable methyltransferase, len: 359 aa; similar to TR:AAF00618 (EMBL:AF166383) Mus musculus methyltransferase, 336 aa; fasta scores: opt: 868 z-score: 1022.0 E(): 0; 44.7% identity in 320 aa overlap and to SW:GRC2_LACLA (EMBL:L14679) Lactococcus lactis probable menaquinone biosynthesis methyltransferase (EC 2.1.1.-), 252 aa; fasta scores: opt: 221 z-score: 265.2 E(): 2e-07; 38.7% identity in 111 aa overlap. Contains Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. (359 aa)
SCO3391Hypothetical protein; SCE126.09, unknown,len: 362aa; similar to TR:O25492 (EMBL:AE000593) hypothetical protein from Helicobacter pylori (336 aa) fasta scores; opt: 143, z-score: 161.4, E(): 0.11, (31.5% identity in 111 aa overlap). (362 aa)
SCO3340Hypothetical protein; SCE7.07c, unknown, len: 400 aa; similar to TR:O53392 (EMBL:AL021841) hypothetical protein from Mycobacterium tuberculosis (243 aa) fasta scores; opt: 424, z-score: 497.4, E(): 2.2e-20, (35.8% identity in 226 aa overlap). (260 aa)
SCO3317SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...] (565 aa)
SCO3307SCE68.05c, conserved hypothetical protein, len: 300 aa; unknown function, similar to others from S.coelicolor e.g. TR:O86541 (EMBL:AL031350), SC1F3.04, hypothetical protein (261 aa), fasta scores; opt: 791 z-score: 916.0 E(): 0, 48.9% identity in 262 aa overlap. (300 aa)
SCO3215Hypothetical protein; SCE8.08c, unknown, len: 338 aa. (338 aa)
SCO3153Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (286 aa)
SCO3149Putative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (286 aa)
SCO3132Putative trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate. (303 aa)
SCO3104Hypothetical protein SCE41.13c; SCE41.13c, unknown, len: 679 aa. (679 aa)
SCO2872Hypothetical protein SCE6.09; SCE6.09, unknown, len: 410 aa. Weakly similar to several methyltransferase e.g. Streptomyces coelicolor TR:CAB71208(EMBL:AL138538) putative O-methyltransferase, SC6D10.13C (324 aa), fasta scores opt: 337 z-score: 387.6 E(): 3.7e-14 37.2% identity in 277 aa overlap. (410 aa)
SCO2814SCBAC17F8.05c, possible methyltransferase, len: 285 aa: similar to many some of which reside within antibiotic biosynthetic clusters e.g. TR:Q54818 (EMBL:L35560) doxorubicin polyketide biosynthesis gene from Streptomyces peucetius (286 aa) fasta scores; opt: 258, Z-score: 287.1, 38.136% identity (39.130% ungapped) in 118 aa overlap, TR:Q9S0N6 (EMBL:AB032524) C5-O-methyltransferase AveD from the avermectin biosynthetic cluster of Streptomyces avermitilis (283 aa) fasta scores; opt: 249, Z-score: 277.5, 30.508% identity (34.123% ungapped) in 236 aa overlap and TR:AAK64748 (EMBL:AE007203) [...] (285 aa)
SCO2670SC6D10.13c, probable O-methyltransferase, len: 324 aa; similar to TR:O30199 (EMBL:AE001104) Archaeoglobus fulgidus L-isoaspartyl protein carboxyl methyltransferase AF0036, 216 aa; fasta scores: opt: 373 z-score: 428.9 E(): 1.8e-16; 36.8% identity in 209 aa overlap and to SW:PIMT_METJA (EMBL:U67474) Methanococcus jannaschii protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77), 215 aa; fasta scores: opt: 356 z-score: 407.3 E(): 2.8e-15; 42.1% identity in 140 aa overlap. Contains Pfam match to entry PF01135 PCMT, Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) and match [...] (324 aa)
SCO2606SCC88.17c, orfsyn, hypothetical protein, len: 661 aa; N-terminal region identical to previously sequenced TR:O33624 (EMBL:Y14206) Streptomyces coelicolor ORFSYN (fragment) and similar to TR:P73260 (EMBL:D90905) Synechocystis sp. hypothetical 97.4 kD protein 865 aa; fasta scores: opt: 1055 z-score: 1198.6 E(): 0; 41.2% identity in 624 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. (661 aa)
SCO2552Conserved hypothetical protein SCC77.19c; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (249 aa)
SCO2338SCC53.29, possible O-methyltransferase, len: 223 aa; similar to many e.g. SW:Q00719 (MDMC_STRMY) macrolide O-methyltransferase (EC 2.1.1.-) from Streptomyces mycarofaciens (221 aa) fasta scores; opt: 405, z-score: 484.6, E(): 1.6e-19, 41.1% identity in 190 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase. (223 aa)
SCO2317SCC53.08c, possible methyltransferase, len: 244 aa; region similar to many methyltransferases e.g. TR:O82720 (EMBL:U81312) S-adenosyl-methionine-sterol-C-methyltransferase from Nicotiana tabacum (Common tobacco) (346 aa) fasta scores; opt: 228, z-score: 285.6, E(): 1.9e-08, 33.1% identity in 139 aa overlap. (244 aa)
SCO2312SCC53.03, putative secreted protein, len: 238 aa. Contains possible N-terminal region signal peptide sequence. (238 aa)
SCO2282SCC75A.28c, hypothetical protein, len: 326 aa; similar to TR:Q984U3 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) MLL7840 protein 323 aa; fasta scores: opt: 712 Z-score: 794.8 E(): 1.2e-36; 38.365% identity in 318 aa overlap. (326 aa)
SCO2092Conserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (310 aa)
SCO1999SC7H2.13, hypothetical protein, len: 220 aa; similar to many some of which are proposed to have methyltransferase activity egs. TR:CAB44537 (EMBL:AL078618) putative ubiquinone/menaquinone methyltransferase from Streptomyces coelicolor (231 aa) fasta scores; opt: 199, z-score: 247.0, E(): 2e-06, (40.4% identity in 104 aa overlap) and TR:O06424 (EMBL:Z95558) hypothetical protein from Mycobacterium tuberculosis (234 aa) fasta scores; opt: 191, z-score: 237.3, E(): 6.8e-06, (42.7% identity in 96 aa overlap). (220 aa)
SCO1973SC3C9.08c,conserved hypothetical protein, len: 264 aa; low similarity to SW:YT37_STRFR (EMBL:M29297) Streptomyces fradiae hypothetical 37.1 kDa protein in transposon TN4556, 345 aa; fasta scores: opt: 224 Z-score: 256.6 bits: 55.5 E(): 1.1e-06; 29.259% identity in 270 aa overlap. (264 aa)
SCO1969Putative DNA-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (184 aa)
SCO1857SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...] (583 aa)
SCO1856SCI39.03, probable precorrin-6Y C5,15-methyltransferase, len: 410 aa; similar to SW:COBL_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CobL, 413 aa; fasta scores: opt: 614 Z-score: 634.0 bits: 126.3 E(): 1e-27; 37.500% identity in 408 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (410 aa)
SCO1855SCI39.02, probable precorrin-4 C11-methyltransferase, len: 281 aa; similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF, 258 aa; fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35; 41.502% identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM, 253 aa; fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34; 43.145% identity in 248 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (281 aa)
SCO1853SCI8.38, cobI, precorrin-2 C20-methyltransferase (EC 2.1.1.130), len: 243 aa. Similar to many including: Pseudomonas denitrificans SW:COBI_PSEDE (EMBL: M59301) precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine-precorrin-2 methyltransferase) (SP2MT) (244 aa), fasta scores opt: 322 z-score: 369.3 E(): 3.3e-13 30.0% identity in 240 aa overlap and to the N-terminus of the CobI/J fusion protein from Mycobacterium tuberculosis SW:COBI_MYCTU (EMBL: Z73966) cobalamin biosynthesis protein CobIJ [includes: precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-met [...] (243 aa)
SCO1782SCI51.22c, possible membrane protein, len: 271 aa; unknown function, similar to hemolysins and hemolysin-like hypothetical proteins e.g. SW:HLYA_TREHY (EMBL:X61684), tlyA, Treponema hyodysenteriae hemolysin A (240 aa), fasta scores; opt: 457 z-score: 532.9 E(): 2.5e-22, 35.4% identity in 240 aa overlap and TR:Q50760 (EMBL:X98295), tlyA, Mycobacterium tuberculosis. Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF01479 S4, S4 domain and PS00017 ATP/GTP-binding site motif A (P-loop). (271 aa)
SCO1731SCI11.20c, hypothetical protein, len: 205 aa; weakly similar to parts of many hypothetical proteins, many of which resemble methyltransferases e.g. TR:Q48938 (EMBL:X93084) Methanosarcina barkeri ORF3 from molybdenum formylmethanofuran dehydrogenase cluster (262 aa), fasta scores; opt: 445 z-score: 518.9 E(): 1.4e-21, 37.8% identity in 193 aa overlap. Weak similarity to many others from S.coelicolor e.g. TR:Q9ZC03 (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.2% identity in 142 aa overlap). (205 aa)
SCO1717SCI11.06, hypothetical protein, len: 391 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition. (391 aa)
SCO1657Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1170 aa)
SCO1651Conserved hypothetical protein SCI41.34c; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (300 aa)
SCO1597SCI35.19c, probable rRNA methylase, len: 282 aa; similar to many members of ther spoU famil e.g. TSNR_STRLU 23s rRNA methyltransferase (270 aa), fasta scores; opt: 254 z-score: 251.7 E(): 9e-07, 27.0% identity in 270 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 107.90, E-value 1.9e-28; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (282 aa)
SCO1555SCL11.11c, probable methyltransferase, len: 408 aa; similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE, 425 aa; fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15; 29.9% identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE, 201 aa; fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08; 33.3% identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (408 aa)
SCO1553SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...] (410 aa)
SCO1552SCL11.08c, probable rRNA methylase, len: 272 aa; similar to SW:Y881_MYCTU (EMBL:Z73101) Mycobacterium tuberculosis hypothetical tRNA/rRNA methyltransferase RV0881 (EC 2.1.1.-), 288 aa; fasta scores: opt: 726 z-score: 879.9 E(): 0; 45.2% identity in 259 aa overlap and to SW:TSNR_STRAZ (EMBL:X02392) Streptomyces azureus rRNA (adenosine-2'-O-)-mehtyltransferase (EC 2.1.1.66) TsnR, 269 aa; fasta scores: opt: 226 z-score: 279.3 E(): 3.9e-08; 29.0% identity in 269 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. (272 aa)
SCO1472SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (475 aa)
SCO1279Putative secreted protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. (292 aa)
SCO12472SCG1.22, conserved hypothetical protein, len: 225 aa; similar to TR:O06547 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 23.4 kD protein MTCI65.14, 216 aa; fasta scores: opt: 500 z-score: 599.5 E(): 6.3e-26; 45.9% identity in 209 aa overlap. (225 aa)
SCO1162SCG8A.16, possible methyltransferase, len: 199 aa; similar to TR:Q55214 (EMBL:L35154) aklanonic acid methyltransferase from Streptomyces sp. (220 aa) fasta scores; opt: 228, z-score: 264.1, E(): 2.9e-07, 34.1% identity in 123 aa overlap. (199 aa)
SCO1041Conserved hypothetical protein SCG20A.21; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (407 aa)
SCO0002Hypothetical protein; SCEND.01c, unknown, partial CDS, len: >27aa; strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores; opt: 114, z-score: 206.0, E(): 0.00052, 80.0% identity in 25 aa overlap; SCJ24.01c, unknown, partial CDS, len: >457aa; strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores; opt: 2191, z-score: 2490.1, E(): 0, 72.5% identity in 458 aa overlap.; SC8E7.42c, partial CDS, unknown, len:> 431 aa. Highly similar to Streptomyces lividans TR:AAF36 [...] (853 aa)
SCO0034Hypothetical protein; SCJ4.15, unknown, len: 159 aa. (159 aa)
SCO0190SCJ12.02c, crtT, probable methyltransferase, len: 246 aa. Shares a high level of sequence similarity with Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores opt: 984 z-score: 1164.2 E(): 0 65.0% identity in 234 aa overlap. Contains a Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. (246 aa)
SCO0405SCF51.04, conserved hypothetical protein, len: 272 aa; similar to TR:O86540 (EMBL:AL031350) Streptomyces coelicolor hypothetical 32.8 kD protein, 300 aa; fasta scores: opt: 656 z-score: 793.0 E(): 0; 43.1% identity in 246 aa overlap. (272 aa)
SCO0408SCF51.07, probable methyltransferase, len: 262 aa; some similarity to TR:Q9ZGH6 (EMBL:AF079762) Streptomyces venezuelae N,N-dimethyltransferase DesVI 273 aa; fasta scores: opt: 165 z-score: 205.9 E(): 0.00043; 28.3% identity in 237 aa overlap and to TR:CAB49808 (EMBL:AJ248285) Pyrococcus abyssi menaquinone biosynthesis methyltransferase, 248 aa; fasta scores: opt: 165 z-score: 205.6 E(): 0.00044; 27.3% identity in 183 aa overlap. (262 aa)
SCO0525SCF11.05, hypothetical protein, len: 271 aa; similar to various hypothetical proteins, e.g. TR:CAB45341 (EMBL:AL079345) Streptomyces coelicolor SCE68.05C hypothetical 33.1 KD protein, 300 aa; fasta scores: opt: 808 z-score: 960.4 E(): 0; 53.2% identity in 250 aa overlap. (271 aa)
SCO0594SCF55.18c, possible methyltransferase, len: 246 aa; similar to TR:CAB48912 (EMBL:AL096837) Streptomyces ceolicolor putative methyltransferase SCF43A.25c, 215 aa; fasta scores: opt: 190 z-score: 231.6 E(): 1.6e-05; 34.9% identity in 126 aa overlap and to SW:BIOC_SERMA biotin synthesis protein, BioC, 255 aa; fasta scores: opt: 179 z-score: 217.7 E(): 9.4e-05; 32.3% identity in 130 aa overlap. (246 aa)
SCO0648SCF91.08, possible methyltransferase, len: 231 aa. Similar in parts to several including: Streptomyces avermitilis TR:BAA84602(EMBL:AB032524) C5-O-methyltransferase (283 aa), fasta scores opt: 243 z-score: 292.9 E(): 6.1e-09 34.5% identity in 168 aa overlap and Streptomyces lavendulae TR:AAD28458(EMBL:AF127374) methyltransferase (275 aa), fasta scores opt: 235 z-score: 283.7 E(): 2e-08 32.9% identity in 167 aa overlap. (231 aa)
SCO0705Conserved hypothetical protein; SCF42.15c, unknown, len: 272 aa. Similar to several proteins of undefined function from Streptomyces coelicolor TR:O86540(EMBL:AL031350) SC1F2.03C (300 aa), fasta scores opt: 639 z-score: 770.1 E():0 41.4% identity in 261 aa overlap and TR:CAB59702(EMBL:AL132707) probable mannanase SCF51.04C (272 aa), fasta scores opt: 744 z-score: 896.2 E():0 49.6% identity in 248 aa overlap. (272 aa)
SCO0760SCF81.19, probable methyltransferase, len: 220 aa; similar to TR:O27384 (EMBL:AE000896) Methanobacterium thermoautotrophicum methyltransferase related protein MTH1329, 196 aa; fasta scores: opt: 454 z-score: 525.3 E(): 6.9e-22; 44.2% identity in 190 aa overlap and to TR:Q53742 (EMBL:X92429) Streptomyces lipmanii (Streptomyces alboniger) N-methyl-transferase Pur5, 228 aa; fasta scores: opt: 228 z-score: 268.6 E(): 1.4e-07; 33.3% identity in 192 aa overlap. Contains match to Prosite entry PS00092 N-6 Adenine-specific DNA methylases signature. (220 aa)
SCO07783SCF60.10, possible integral membrane protein, len: 102 aa. Contains possible hydrophobic membrane spanning regions. (102 aa)
SCO0826SCF43A.16, hypothetical protein, len: 266 aa; unknown function, shares short internal regions of similarity with several methyltransferases e.g. TR:O82434 (EMBL:AF053766) Nicotiana tabacum S-adenosyl-methionine cycloartenol-C24-methyltransferase (349 aa), fasta scores; opt: 165 z-score: 206.0 E(): 0.00038, 29.8% identity in 104 aa overlap. Weakly similar to part of SC1E6.19C (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.1% identity in 131 aa overlap). (266 aa)
SCO0835SCF43A.25c, possible methyltransferase, len: 215 aa; weakly similar to methyltransferases e.g. SW:UBIG_ECOLI (EMBL:Y00544), UbiG, Escherichia coli 3-demethylubiquinone-9 3-methyltransferase (240 aa), fasta scores; opt: 206 z-score: 249.1 E(): 1.5e-06, 31.1% identity in 148 aa overlap and TR:Q53137 (EMBL:L21196), CobL, Rhodococcus erythropolis methyltransferase/decarboxylase (447 aa) (40.6% identity in 138 aa overlap). (215 aa)
SCO0913Hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (323 aa)
SCO0929SCM10.17c, hypothetical protein, len: 270 aa; similar to various S. coelicolor hypothetical proteins, e.g. TR:O86540 (EMBL:AL031350) Streptomyces coelicolor hypothetical 32.8 kD protein SC1F2.03c, 300 aa; fasta scores: opt: 713 z-score: 830.1 E(): 0; 45.0% identity in 262 aa overlap. (270 aa)
SCO0985Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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