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SCO0436 SCO0436 SCO4659 SCO4659 SCO4653 SCO4653 SCO4652 SCO4652 SCO4649 SCO4649 SCO4648 SCO4648 SCO0570 SCO0570 SCO1505 SCO1505 SCO1598 SCO1598 SCO1599 SCO1599 SCO2563 SCO2563 SCO2596 SCO2596 SCO3124 SCO3124 SCO3425 SCO3425 SCO3909 SCO3909 SCO3908 SCO3908 SCO3430 SCO3430 SCO3429 SCO3429 SCO3428 SCO3428 SCO4660 SCO4660 SCO4701 SCO4701 SCO4702 SCO4702 SCO4705 SCO4705 SCO4706 SCO4706 SCO4707 SCO4707 SCO4708 SCO4708 SCO4709 SCO4709 SCO4710 SCO4710 SCO4711 SCO4711 SCO4712 SCO4712 SCO4713 SCO4713 SCO4714 SCO4714 SCO4715 SCO4715 SCO4716 SCO4716 SCO4717 SCO4717 SCO4718 SCO4718 SCO4719 SCO4719 SCO4720 SCO4720 SCO4721 SCO4721 SCO4727 SCO4727 SCO4728 SCO4728 SCO4730 SCO4730 SCO4734 SCO4734 SCO4735 SCO4735 SCO5571 SCO5571 SCO5591 SCO5591 SCO5595 SCO5595 SCO5624 SCO5624 SCO5736 SCO5736
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0436SCF51A.14, possible 50S ribosomal protein L32, len: 56 aa. Similar to many including: Helicobacter pylori J99 SW:RL32_HELPY (EMBL; AE000540) 50S ribosomal protein L32 (48 aa), fasta scores opt: 85 z-score: 146.1 E(): 0.89 30.2% identity in 43 aa overlap and highly similar to the N-terminus of Streptomyces coelicolor TR:Q9ZBQ8 (EMBL; AL034447) 50S ribosomal protein L32 SC7A1.15 (57 aa), fasta scores opt: 165 z-score: 258.9 E(): 4.6e-07 82.1% identity in 28 aa overlap. (56 aa)
SCO465930S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS12 family. (123 aa)
SCO465350S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
SCO465250S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (176 aa)
SCO464950S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (241 aa)
SCO464850S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa)
SCO0570SC5G5.02c, rpmG2, 50S ribosomal protein L33, len: 54 aa; highly similar to SW:R331_STRCO (EMBL:AL049841) Streptomyces coelicolor 50S ribosomal protein L33 RpmG1 or SCE9.35c, 54 aa; fasta scores: opt: 294 Z-score: 436.0 bits: 83.8 E(): 1.1e-16; 81.481% identity in 54 aa overlap. Contains Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
SCO150530S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa)
SCO159850S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (127 aa)
SCO1599SCI35.21c, rpmI, 50S ribosomal protein L35, len: 64 aa; similar to many e.g. RL35_BACSU 50S ribosomal protein L35 (65 aa), fasta scores; opt: 179 z-score: 355.6 E(): 1.5e-12, 45.9% identity in 61 aa overlap; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
SCO256330s ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
SCO2596SCC88.07c, rpmA, 50S ribosomal protein L27, len: 84 aa; identical to SW:RL27_STRGR (EMBL:D87916) Streptomyces griseus 50S ribosomal protein L27 RpmA, 85 aa. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 proteinand match to Prosite entry PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family. (84 aa)
SCO3124Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (198 aa)
SCO3425Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
SCO390950S ribosomal protein L9; Binds to the 23S rRNA. (148 aa)
SCO3908Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
SCO3430Putative 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
SCO3429SCE9.36, rpmB, probable 50S ribosomal protein L28, len: 73 aa; similar to many e.g. SW:RL28_ECOLI (EMBL:J01677), rpmB, Escherichia coli 50S ribosomal protein L28 (77 aa), fasta scores; opt: 235 z-score: 344.6 E(): 7.1e-12, 47.8% identity in 69 aa overlap. Contains Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 88.70, E-value 1.2e-22; Belongs to the bacterial ribosomal protein bL28 family. (73 aa)
SCO3428SCE9.35c, rpmG, probable 50S ribosomal protein L33, len: 54 aa; similar to many e.g. SW:RL33_ECOLI (EMBL:J01677), rpmG, Escherichia coli 50S ribosomal protein L33 (54 aa), fasta scores; opt: 162 z-score: 270.5 E(): 9.5e-08, 46.9% identity in 49 aa overlap. Contains Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 37.80, E-value 2e-08; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
SCO466030S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
SCO470130S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
SCO470250S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (214 aa)
SCO470550S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
SCO470630S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
SCO470750S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (125 aa)
SCO470830S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (277 aa)
SCO470950S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
SCO4710SCD31.35, rpmC, 50S ribosomal protein L29, len: 74 aa; highly similar to SW:RL29_BACST (PIR:A02825) Bacillus stearothermophilus 50S ribosomal protein L29 RpmC, 66 aa; fasta scores: opt: 244 z-score: 361.6 E(): 1e-12; 63.9% identity in 61 aa overlap. Contains Pfam match to entry PF00831 Ribosomal_L29, Ribosomal L29 protein and match to Prosite entry PS00323 Ribosomal protein S19 signature. (74 aa)
SCO471130S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (95 aa)
SCO471250S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
SCO471350S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (107 aa)
SCO471450S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa)
SCO471530S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
SCO471630S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
SCO471750S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
SCO471850S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (127 aa)
SCO471930S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (201 aa)
SCO4720SCD31.45, rpmD, 50S ribosomal protein L30, len: 60 aa; identical to previously sequenced SW:RL30_STRCO (EMBL:X83011) Streptomyces coelicolor 50S ribosomal protein L30 RpmD, 60 aa. Contains Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e and match to Prosite entry PS00634 Ribosomal protein L30 signature. (60 aa)
SCO472150S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (151 aa)
SCO472730S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
SCO472830S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
SCO4730SC6G4.08, rplQ, 50S ribosomal protein L17, len: 168 aa; highly similar to many e.g. RL17_BACST 50S ribosomal protein L17 (119 aa), fasta scores; opt: 339 z-score: 597.2 E (): 5.3e-26, 47.4% identity in 116 aa overlap. Contains approx 50 aa C-terminal extension, not present in other RplQ. (168 aa)
SCO473450S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
SCO4735SC6G4.13, rpsI, 30S ribosomal protein S9, len: 170 a a; identical to RS9_STRCO 30S ribosomal protein S9 (170 aa) and highly similar to many e.g.RS9_ECOLI (129 aa), fasta s cores; opt: 408 z-score: 663.5 E(): 1.1e-29, 49.2% identity in 124 aa overlap. Contains PS00360 Ribosomal protein S9 s ignature and Pfam match to entry PF00380 S9, Ribosomal prot ein S9, score 162.60, E-value 1e-49; Belongs to the universal ribosomal protein uS9 family. (170 aa)
SCO5571SC7A1.15, rpmF, 50S ribosomal protein L32, len: 57 aa; similar to many eg. SW:RL32_BACST 50S PrmF, ribosomal protein L32 from Bacillus stearothermophilus (56 aa) fasta scores; opt: 180, z-score: 341.1, E(): 1.1e-11, (48.1% identity in 54 aa overlap). (57 aa)
SCO5591SC2E1.08, rpsP, 30S ribosomal protein S16, highly similar to many e.g. RS16_MYCTU (162 aa), fatsa scores; opt:480 z-score: 771.3 E(): 0, 56.3% identity in 144 aa overlap. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family. (139 aa)
SCO559550S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
SCO5624SC2E1.41, rpsB, 30S ribosomal protein S2, len: 310 aa; almost identical to RS2_STRCO 30S ribosomal protein S2 (242 aa), E(): 0, 96.7% identity in 242 aa overlap and also highly similar to many others e.g. RS2_ECOLI 30S ribosomal protein S2 (240 aa), fasta scores; opt: 744 z-score: 950.7 E(): 0, 50.4% identity in 224 aa overlap. Contains PS00962 Ribosomal protein S2 signature 1 and PS00211 ABC transporters family signature (probably a false positive). Also contains Pfam matches to entry S2 PF00318, Ribosomal protein S2, score 304.89 and to entry 60s_ribosomal PF00428, 60s Acidic ribosom [...] (310 aa)
SCO573630S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (95 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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