STRINGSTRING
SCO1244 SCO1244 SCO1176 SCO1176 SCO1134 SCO1134 SCO0989 SCO0989 SCO0963 SCO0963 SCO0922 SCO0922 SCO0816 SCO0816 SCO0815 SCO0815 SCO0773 SCO0773 SCO0761 SCO0761 SCO0689 SCO0689 SCO0258 SCO0258 SCO0216 SCO0216 SCO0188 SCO0188 SCO0103 SCO0103 SCO6148 SCO6148 SCO6158 SCO6158 SCO6171 SCO6171 SCO6290 SCO6290 SCO6481 SCO6481 SCO6535 SCO6535 SCO6559 SCO6559 SCO6560 SCO6560 SCO6561 SCO6561 SCO6678 SCO6678 SCO6680 SCO6680 SCO6715 SCO6715 SCO6766 SCO6766 SCO6767 SCO6767 SCO6922 SCO6922 SCO7106 SCO7106 SCO7110 SCO7110 SCO7155 SCO7155 SCO7306 SCO7306 SCO7374 SCO7374 SCO7402 SCO7402 SCO7427 SCO7427 SCO7474 SCO7474 SCO5645 SCO5645 SCO7475 SCO7475 SCO7525 SCO7525 SCO7572 SCO7572 SCO7676 SCO7676 SCP1.95 SCP1.95 SCP1.160c SCP1.160c SCP1.161c SCP1.161c SCO5696 SCO5696 SCO5752 SCO5752 SCO5787 SCO5787 SCO5897 SCO5897 SCO5901 SCO5901 SCO5926 SCO5926 SCO5966 SCO5966 SCO5999 SCO5999 SCO6051 SCO6051 SCO6100 SCO6100 SCO6102 SCO6102 SCO4855 SCO4855 SCO4767 SCO4767 SCO4603 SCO4603 SCO4600 SCO4600 SCO4570 SCO4570 SCO4568 SCO4568 SCO4567 SCO4567 SCO4566 SCO4566 SCO4563 SCO4563 SCO4550 SCO4550 SCO4495 SCO4495 SCO4494 SCO4494 SCO4429 SCO4429 SCO4367 SCO4367 SCO4086 SCO4086 SCO4047 SCO4047 SCO3938 SCO3938 SCO3928 SCO3928 SCO3867 SCO3867 SCO3673 SCO3673 SCO3662 SCO3662 SCO3579 SCO3579 SCO3569 SCO3569 SCO3462 SCO3462 SCO3355 SCO3355 SCO3345 SCO3345 SCO3332 SCO3332 SCO3034 SCO3034 SCO2941 SCO2941 SCO2606 SCO2606 SCO2600 SCO2600 SCO2573 SCO2573 SCO2559 SCO2559 SCO2488 SCO2488 SCO2487 SCO2487 SCO2473 SCO2473 SCO2222 SCO2222 SCO2194 SCO2194 St6G10A.01 St6G10A.01 SCO2161 SCO2161 SCO2149 SCO2149 SCO2114 SCO2114 SCO4947 SCO4947 SCO4971 SCO4971 SCO5044 SCO5044 SCO5046 SCO5046 SCO5058 SCO5058 SCO5106 SCO5106 SCO5135 SCO5135 SCO5152 SCO5152 SCO5190 SCO5190 SCO5240 SCO5240 SCO5273 SCO5273 SCO5274 SCO5274 SCO5469 SCO5469 SCO5486 SCO5486 SCO5553 SCO5553 SCO2026 SCO2026 SCO2025 SCO2025 SCO2004 SCO2004 SCO1990 SCO1990 SCO1977 SCO1977 SCO1955 SCO1955 SCO1923 SCO1923 SCO1920 SCO1920 SCO1919 SCO1919 SCO1888 SCO1888 SCO1821 SCO1821 SCO1763 SCO1763 SCO1711 SCO1711 SCO1649 SCO1649 SCO1356 SCO1356
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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SCO1244Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (407 aa)
SCO1176SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] (596 aa)
SCO11342SCG38.27c, probable oxidoreductase, iron-sulphur binding subunit, len: 200 aa; similar to TR:Q52589 (EMBL:X77931) Pseudomonas thermocarboxydovorans carbon monoxide oxygenase [cytochrome B-561], small chain (EC 1.2.2.4) CutC, 163 aa; fasta scores: opt: 405 z-score: 478.3 E(): 3.4e-19; 45.6% identity in 169 aa overlap and to TR:Q9RK27 (EMBL:AL132856) Streptomyces coelicolor putative oxidoreductase, iron-sulphur binding subunit StF15.10, 211 aa; fasta scores: opt: 729 z-score: 804.0 E(): 0; 62.3% identity in 175 aa overlap. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfu [...] (200 aa)
SCO0989Hypothetical protein 2SCG2.02c; 2SCG2.02c, unknown, len: 134 aa. (134 aa)
SCO0963SCM11.18c, hypothetical protein, len: 297 aa; C-terminal region identical to previously sequenced TR:Q9X9U6 (EMBL:AJ243803) Streptomyces coelicolor hypothetical 18.7 kD protein (fragment), 181 aa. Contains proline-rich C-terminal region. (297 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0816SCF43A.06, conserved possible iron-sulfur protein, len: 492 aa; similar to several putative iron-sulfur proteins e.g. SW:YKGF_ECOLI (EMBL:AE000137) Escherichia coli hypothetical protein (475 aa), fasta scores; opt: 1148 z-score: 1249.5 E(): 0, 39.7% identity in 481 aa overlap, which contains 2 putative 4Fe-4S centres. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. (492 aa)
SCO0815SCF43A.05, conserved hypothetical protein, len: 250 aa; unknown function, similar to other hypothetical proteins e.g. TR:O07020 (EMBL:Z94043) Bacillus subtilis hypothetical protein (238 aa), fasta scores; opt: 720 z-score: 887.0 E(): 0, 46.1% identity in 245 aa overlap. Also similar to the C-terminal half of many Fe-S proteins e.g. SW:GLPC_ECOLI (EMBL:M20938), glpC, Escherichia coli anaerobic glycerol-3-phosphate dehydrogenase subunit C (396 aa) (26.7% identity in 255 aa overlap). (250 aa)
SCO07733SCF60.05c, soyB2, probable ferredoxin, len: 66 aa; identical to TR:O85696 (EMBL:AF072709) Streptomyces lividans putative ferredoxin, 66 aa and similar to SW:FERS_STRGR (EMBL:X63601) Streptomyces griseus ferredoxin SoyB, 65 aa; fasta scores: opt: 269 z-score: 369.1 E(): 5e-13; 61.9% identity in 63 aa overlap. (66 aa)
SCO0761Hypothetical protein SCF81.20; SCF81.20, unknown, len: 59 aa. (59 aa)
SCO0689SCF15.10, possible oxidoreductase, iron-sulphur binding subunit, len: 187 aa. Similar to many multipartite proteins including: the small subunit of quinoline 2-oxidoreductase from Pseudomonas putida TR:P72223(EMBL:X98131) QorS (168 aa), fasta scores opt: 371 z-score: 438.8 E(): 4.6e-17 44.7% identity in 170 aa overlap and Acetobacter europaeus TR:O30328(EMBL:Y08696) aldehyde dehydrogenase subunit III precursor (157 aa), fasta scores opt: 309 z-score: 367.9 E(): 4e-13 39.3% identity in 163 aa overlap. Also similar to the N-terminal iron-sulphur binding domain of Rhodobacter capsulatus ( [...] (211 aa)
SCO0258SCF20.04, hypothetical protein, len: 269 aa; similar to TR:BAA81254 (EMBL:AP000063) hypothetical protein from Aeropyrum pernix (238 aa) fasta scores; opt: 228, z-score: 274.4, E(): 6.4e-08, (29.7% identity in 232 aa overlap). (269 aa)
SCO0216SCJ12.28, narG2, probable nitrate reductase alpha chain, len: 1233 aa. Highly similar to Streptomyces coelicolor TR:O86717 (EMBL; AL031515) putative nitrate reductase alpha chain NarG SC5C7.20c (1231 aa), fasta scores: opt: 5792 z-score: 6544.7 E(): 0 67.6% identity in 1230 aa overlap and Bacillus subtilis SW:NARG_BACSU (EMBL; Z49884) nitrate reductase alpha chain (EC 1.7.99.4) NarG (1228 aa), fasta scores: opt: 4331 z-score: 4891.8 E(): 0 52.9% identity in 1201 aa overlap. Contains a PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, a Pfam match to entry PF00384 molybdopt [...] (1233 aa)
SCO0188SCJ1.37, crtV, probable methylesterase, len: 336 aa. Highly similar to Streptomyces griseus TR:P72448 (EMBL; X95596) methylesterase (338 aa), fasta scores opt: 1315 z-score: 1538.7 E(): 0 60.5% identity in 337 aa overlap. (336 aa)
SCO0103SCJ11.32, probable flavohemoprotein, len: 435aa; C-terminal region similar to many with reductase and dioxygenase activities, typical of flavohemoproteins e.g. TR:Q9ZI75 (EMBL:AF039533) naphthalene dioxygenase reductase from Pseudomonas stutzeri (328 aa) fasta scores; opt: 369, z-score: 419.0, E(): 5.6e-16, (28.6% identity in 241 aa overlap). Also typical of flavohemoprotein, C-terminal region contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain and N-terminal region contains Pfam match to entry PF00042 globin, Globin; Belongs to the globin family. (435 aa)
SCO6148Hypothetical protein SC1A9.12; SC1A9.12, unknown, len: 442 aa. (442 aa)
SCO6158Hypothetical protein SC1A9.22c; SC1A9.22c, unknown, len: 281 aa. (281 aa)
SCO6171Putative oxidoreductase; SC6C5.07, probable iron-sulphur binding oxidoreductase subunit, len: 196aa; similar to many eg. TR:P95635 (EMBL:U65440) 4-hydroxybenzoyl-CoA reductase from Rhodopseudomonas palustris (163 aa) fasta scores; opt: 288, z-score: 720.8, E(): 7.4e-33, (42.2% identity in 187 aa overlap) and TR:P72223 (EMBL:X98131) quinoline 2-oxidoreductase from Pseudomonas putida (168 aa) fasta scores; opt: 264, z-score: 703.7, E(): 6.6e-32, (40.4% identity in 198 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. (196 aa)
SCO6290SCBAC8D1.03, hypothetical protein, len: 84 aa; highly similar to N-terminal part of SW:SOXA_RHIME (EMBL:AF055582) Rhizobium meliloti sarcosine oxidase alpha subunit (EC 1.5.3.1) SoxA, 987 aa; fasta scores: opt: 132 Z-score: 169.8 bits: 39.3 E(): 0.072l; 42.373% identity in 59 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (84 aa)
SCO6481SC9C7.17c, conserved hypothetical protein, len: 348aa; similar to several hypothetical proteins eg. SW:Y0BN_MYCTU from Mycobacterium tuberculosis (340 aa) fasta scores; opt: 998, z-score: 1321.8, E(): 0, (47.6% identity in 355 aa overlap). (348 aa)
SCO6535SC5C7.20c, narG, probable nitrate reductase alpha chain, len: 1231 aa; highly similar to many e.g. NARG_BACSU nitrate reductase alpha chain (EC 1.7.99.4) (1228 aa), fasta scores; opt: 4306 z-score: 3216.7 E(): 0, 51.5% identity in 1235 aa overlap. Contains PS00551 and PS00490 Prokaryotic molybdopterin oxidoreductases signatures 1 and 2 and Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 79.90, E-value 1e-24; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1231 aa)
SCO6559SC4B5.09c, respiratory chain oxidoreductase, len: 286 aa; similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa), fasta scores; opt: 685, z-score: 791.8, E(): 0, (38.4% identity in 284 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and r [...] (286 aa)
SCO6560SC4B5.10c, respiratory chain oxidoreductase, len: 646 aa; C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase, subunit C from Methanobacterium thermoautotrophicum (630 aa), fasta scores; opt: 121,4 z-score: 1170.7, E(): 0, (47.1% identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. (646 aa)
SCO6561SC4B5.11c, respiratory chain oxidoreductase, len: 642 aa; similar to the C-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa) fasta scores; opt: 1532, z-score: 1338.5, E(): 0, (43.1% identity in 619 aa overlap). Contains Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 95.80, E-value 6.2e-30. Considering the corresponding homolgies, this CDS may have previously been located directly downsteam of SC4B5.09c. (642 aa)
SCO6678SC5A7.28c, probable iron-sulfur oxidoreductase beta subunit, len: 313 aa; similar to many e.g. POBB_PSEPS phenoxybenzoate dioxygenase beta subunit (Pseudomonas pseudoalcaligenes) (319 aa), fasta scores; opt: 824 z-score: 993.1 E(): 0, 45.9% identity in 303 aa overlap. C-terminus is a 2Fe-2S ferredoxin domain similar to e.g. FERV_ANAVA ferredoxin, vegetative (Anabaena variabilis) (98 aa), fasta scores; opt: 187 z-score: 222.4 E(): 3.8e-05, 38.2% identity in 68 aa overlap. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00111 fer2, 2Fe- [...] (313 aa)
SCO6680SC5A7.30c, probable oxidoreductase alpha subunit, len: 359 aa; similar to many e.g. VANA_PSES9 vanillate demethylase (monooxygenase) (329 aa), fasta scores; opt: 636 z-score: 695.7 E(): 1.7e-31, 34.6% identity in 338 aa overlap. (359 aa)
SCO6715Putative transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (81 aa)
SCO6766Conserved hypothetical protein; SC6A5.15, unknown, len: 340 aa; similar to many of undefined function e.g. TR:P95416 (EMBL:D84475) NirJ, from a locus for heme D1 biosynthesis in Pseudomonas aeruginosa (387 aa) fasta scores; opt: 222, z-score: 264.2, E(): 2.1e-07, (24.2% identity in 207 aa overlap). (340 aa)
SCO6767GcpE protein homolog, conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
SCO6922Hypothetical protein SC1B2.28c; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (213 aa)
SCO7106Conserved hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (88 aa)
SCO7110Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (129 aa)
SCO7155Hypothetical protein SC9A4.17; SC9A4.17, unknown, len: 355 aa. (355 aa)
SCO7306Regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (83 aa)
SCO7374Nitrate reductase NarB (fragment); SC10G8.01c, possible oxidoreductase, partial CDS, len: > 355 aa. Similar to many e.g. Paracoccus denitrificans SW:NAPA_PARDT (EMBL:Z36773) periplasmic nitrate reductase precursor (EC 1.7.99.4) (831 aa), fasta scores opt: 550 z-score: 651.4 E(): 7.2e-29 33.1% identity in 317 aa overlap; SC9H11.28c, narB, nitrate reductase (EC 1.7.99.4), partial CDS, len: > 508 aa. Highly similar to many including: Synechocystis sp. (strain PCC 7942) SW:NARB_SYNP7 (EMBL:X74597) nitrate reductase (EC 1.7.99.4), NarB (729 aa), fasta scores opt: 583 z-score: 613.8 E(): 1e- [...] (830 aa)
SCO7402Putative lyase; SC10G8.30c, possible lyase, len: 390 aa. Weakly similar to Bacillus subtilis SW:SPL_BACSU(EMBL:L08809) spore photoproduct lyase (EC 4.1.99.-), SplB (342 aa), fasta scores opt: 285 z-score: 328.4 E(): 7.1e-11 26.8% identity in 347 aa overlap. (390 aa)
SCO7427Conserved hypothetical protein SC6D11.23; Binds DNA; this binding is disrupted by nitrosylation upon exposure to nitric oxide (NO) and also by EDTA and iron chelators. The 2Fe-2S cluster is stable in the presence of O(2). (148 aa)
SCO7474SCBAC17A6.07, possible phenylacetic acid degradation protein PaaD, len: 170 aa: similar to many e.g. SW:P76080 (PAAD_ECOLI) phenylacetic acid degradation protein PaaD from Escherichia coli (167 aa) fasta scores; opt: 474, Z-score: 518.6, 45.395% identity (47.586% ungapped) in 152 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59. (170 aa)
SCO5645Conserved hypothetical protein SC6A9.22c; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
SCO7475SCBAC17A6.08, possible phenylacetic acid degradation NADH oxidoreductase PaaE, len: 368 aa; similar to many e.g. SW:P76081 (PAAE_ECOLI) probable phenylacetic acid degradation NADH oxidoreductase PaaE from Escherichia coli (356 aa) fasta scores; opt: 871, Z-score: 943.6, 39.943% identity (40.870% ungapped) in 353 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain; Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain and Prosite match to P [...] (368 aa)
SCO7525SC8G12.01, possible oxidoreductase, partial CDS, len: >169 aa. Highly similar to several including: Streptomyces coelicolor TR:CAB52060(EMBL:AL109732) putative formate dehydrogenase, SC7H2.18 (759 aa), fasta scores opt:670 z-score: 812.0 E(): 0 62.3% identity in 167 aa overlap and Mycobacterium tuberculosis TR:YX31_MYCTU(EMBL:Z74024) hypothetical 84.6 kd protein (779 aa), fasta scores opt: 571 z-score: 692.2 E(): 4.3e-31 55.2% identity in 172 aa overlap; SCBAC25F8.17, probable oxidoreductase (fragment), len: >629 aa; similar to N-terminal reguion of TR:AAK47294 (EMBL:AE007119) Mycobact [...] (764 aa)
SCO7572SC5F1.26, possible oxidoreductase, len: 998 aa; similar to TR:Q9KKW5 (EMBL:AE004425) Vibrio cholerae oxidoreductase/iron-sulfur cluster-binding protein VCA0985, 959 aa; fasta scores: opt: 1999 z-score: 2189.0 E(): 0; 35.3% identity in 966 aa overlap. Contains Pfam matches to entries PF01565 FAD_binding_4, FAD binding domain and PF00037 fer4, 4Fe-4S binding domain and matches to Prosite entries PS00422 Granins signature 1 and PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. (998 aa)
SCO7676SC4C2.11, probable ferredoxin, len: 73 aa; similar to SW:FER2_STRGO (EMBL:M32239) Streptomyces griseolus ferredoxin 2 SubB, 64 aa; fasta scores: opt: 236 z-score: 326.6 E(): 1.2e-10; 55.7% identity in 61 aa overlap. (73 aa)
SCP1.95Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (102 aa)
SCP1.160cSCP1.160c, possible oxidoreductase, len: 525aa; similar to many eg. TR:Q9RDL3 (EMBL:AL136518) putative oxidoreductase from Streptomyces coelicolor (524 aa) fasta scores; opt: 308,1 z-score: 3329.1, E(): 0, 88.9% identity in 523 aa overlap and SW:P56913 (NUF2_RHIME) NADH dehydrogenase I chain F 2 (EC 1.6.5.3) from Rhizobium meliloti (Sinorhizobium meliloti) (421 aa) fasta scores; opt: 367, z-score: 400.3, E(): 7.9e-15, 28.4% identity in 395 aa overlap. (525 aa)
SCP1.161cPutative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. Belongs to the sigma-70 factor family. ECF subfamily. (268 aa)
SCO5696Hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
SCO5752Conserved hypothetical protein SC7C7.07; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (493 aa)
SCO5787Conserved hypothetical protein SC4H2.08; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (505 aa)
SCO5897Putative oxidase; SC10A5.02, redG, probable oxidase, len: 395 aa; similar in N- terminus to many diverse oxidases e.g. TR:P95483 (EMBL:U7449 3) aminopyrrolnitrin oxidase PrnD from Pseudomonas fluorescens (363 aa), fasta scores; opt: 349 z-score: 372.1 E(): 1. 6e-13, 33.3% identity in 165 aa overlap. (395 aa)
SCO5901Putative RNA methyltransferase; SC10A5.06, unknown, len: 458; similar to M. tuberculosis hypothetical protein TR:O07191 (EMBL:Z96072) MTCY05A6. 10C (405 aa), fasta scores; opt: 455 z-score: 878.5 E(): 0, 38.4% identity in 417 aa overlap, and weakly similar to several putative RNA methyltransferases eg. YGCA_ECOLI P5513 5 hypothetical RNA methyltransferase (433 aa), fasta scores; opt: 358 z-score: 331.2 E(): 3e-11, 27.4% identity in 441 aa overlap; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (458 aa)
SCO5926Conserved hypothetical protein; SC10A5.31c, unknown, len: 173 aa; highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa), fasta scores; opt: 422 z-score: 567.1 E(): 2.2e-2 4, 49.3% identity in 138 aa overlap; Belongs to the LeuD family. (173 aa)
SCO5966SCBAC16H6.01c, possible oxidase, len: >1032aa: similar to many of undefined function eg. TR:Q9EZK2 (EMBL:AF289509) putative oxidase YdiJ-like protein from Pseudomonas putida (1006 aa) fasta scores; opt: 880, Z-score: 889.5, 27.930% identity (31.672% ungapped) in 1024 aa overlap and TR:Q9F2Y0 (EMBL:AL392149) putative oxidoreductase SCD19.22 from Streptomyces coelicolor (951 aa) fasta scores; opt: 622, Z-score: 628.7, 49.698% identity (53.813% ungapped) in 994 aa overlap. Contains Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Pfam match to entry PF029 [...] (1047 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6051SC1B5.11c, probable iron-sulfur binding oxidoreductase, len: 513 aa; similar to e.g. ORDL_ECOLI P37906 escherichia coli. probable oxidoreductase (426 aa), fasta scores; opt: 303 z-score: 334.4 E(): 2.1e-11, 25.4% identity in 389 aa overlap. Contains PS00199 and PS00200 Rieske iron-sulfur protein signatures 1 and 2, and Pfam match to entry Rieske PF00355, Rieske iron-sulfur protein, score 49.39. (513 aa)
SCO6100Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (236 aa)
SCO6102SCBAC1A6.26c, probable nitrite/sulphite reductase, len: 565 aa; similar to SW:NIR_SYNP7 (EMBL:D12723) Synechococcus sp. ferredoxin--nitrite reductase (EC 1.7.7.1) NirA, 512 aa; fasta scores: opt: 935 z-score: 1113.1 E(): 0; 35.6% identity in 525 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase 4Fe-4S domain. (565 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4767Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). Plays a positive role in prespore maturation and the initiation of sporulation septation. (112 aa)
SCO4603NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (197 aa)
SCO4600NADH dehydrogenase subunit NuoB2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (232 aa)
SCO4570NuoI, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (211 aa)
SCO4568NuoG, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 75 kDa subunit family. (843 aa)
SCO4567NuoF, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 51 kDa subunit family. (449 aa)
SCO4566SCD16A.17c, nuoE, NADH dehydrogenase subunit, len: 290 aa; similar to many e.g. TR:P95177 (EMBL:Z83867) NuoE, NADH dehydrogenase subunit from Mycobacterium tuberculosis (252 aa) fasta scores; opt: 1002, z-score: 1072.0, E(): 0, (69.5% identity in 213 aa overlap) and SW:NUHM_RAT NADH-ubiquinone dehydrogenase subunit from Rattus norvegicus (Rat) (241 aa) fasta scores; opt: 419, z-score: 454.9, E(): 5.2e-18, (38.1% identity in 181 aa overlap). Contains Pfam match to entry PF01257 complex1_24kD, Respiratory-chain NADH dehydrogenase 24 Kd subunit. (290 aa)
SCO4563NuoB, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
SCO4550Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
SCO4495SCD35.02, possible DNA polymerase related protein, len: 212 aa; similar to TR:AAF11304 (EMBL:AE002016) Deinococcus radiodurans DNA polymerase-related protein DR1751, 237 aa; fasta scores: opt: 380 z-score: 451.4 E(): 1e-1; 41.5% identity in 188 aa overlap and to N-terminal region of SW:DPOL_BPSP1 (EMBL:M84415) Bacteriophage SP01 DNA polymerase (EC 2.7.7.7) 31, 924 aa; fasta scores: opt: 191 z-score: 223.4 E(): 5.2e-05; 33.7% identity in 169 aa overlap. (212 aa)
SCO4494Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
SCO4429Conserved hypothetical protein SCD6.07; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. (867 aa)
SCO4367SCD19.22, possible oxidoreductase, len: 951 aa; N-terminal domain similar to SW:GLCD_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase subunit GlcD, 499 aa; fasta scores: opt: 351 z-score: 387.8 E(): 4.3e-14; 31.2% identity in 497 aa overlap and C-terminal domain similar to SW:GLCF_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase iron-sulfur subunit GlcF, 407 aa; blastp scores: Score= 113 (39.8 bits), Expect= 8.0e-10, Sum P(2)= 8.0e-10; Identities= 26/78 (33%), Positives= 39/78 (50%) and Identities= 61/237 (25%), Positives= 91/237 (38%). Contains Pfam match to entry PF01565 [...] (951 aa)
SCO4086Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (530 aa)
SCO40472SCD60.13c, conserved hypothetical protein, len: 197 aa; similar to TR:O06554 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 20.8 kDa protein MTCI65.23, 197 aa; fasta scores: opt: 741 z-score: 862.4 E(): 0; 60.6% identity in 188 aa overlap. (197 aa)
SCO3938SCD78.05, thiC', probable thiamin biosynthesis protein ThiC, partial CDS, len: 43 aa; simlar to the extreme C-terminus of e.g. THIC_ECOLI thiamin biosynthesis protein ThiC (631 aa), fasta scores; opt: 97 z-score: 137.7 E(): 2, 46.2% identity in 39 aa overlap and THIC_MYCTU (547 aa), fasta scores; opt: 143 z-score: 272.4 E(): 6.4e-08, 53.1% identity in 49 aa overlap. Note that this gene appears to have been interrupted by the integration of the upstream element. (43 aa)
SCO3928Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (612 aa)
SCO3867SCH18.04c, soyB1, probable ferredoxin, len: 70 aa; similar to SW:FERS_STRGR (EMBL:X63601) Streptomyces griseus ferredoxin Soy, SoyB, 65 aa; fasta scores: opt: 169 z-score: 239.4 E(): 7.3e-06; 44.4% identity in 63 aa ovelap. (70 aa)
SCO3673SCH35.51c, probable iron-sulphur-binding reductase, len: 433 aa; similar to many eg. TR:P96797 (EMBL:Y09870) heterodisulphide reductase from Methanosarcina barkeri (409 aa) fasta scores; opt: 427, z-score: 463.9, E(): 1.6e-18, (28.9% identity in 443 aa overlap). Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and 2 Prosite matches to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. Contains also possible hydrophobic membrane spanning regions. (760 aa)
SCO3662Hypothetical protein SCH44.02c; SCH44.02c, unknown, len: 111 aa. (111 aa)
SCO3579Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (112 aa)
SCO3569Putative endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (250 aa)
SCO3462Hypothetical protein SCE46.19; SCE46.19, unknown, len: 478 aa. (478 aa)
SCO3355SCE94.06, mutY, putative adenine glycosylase, len: 308 aa; previously partially sequenced therefore partially identical to TR:E1358524 (EMBL:AJ131213) MutY, putative adenine glycosylase from Streptomyces coelicolor (183 aa) fasta scores; opt: 1220, z-score: 1357.4, E(): 0, (100.0% identity in 183 aa overlap). Also similar to many others e.g. SW:MUTY_SALTY MutY, adenine glycosylase from Salmonella typhimurium (350 aa) fasta scores; opt: 500, z-score: 558.7, E(): 8.3e-24, (39.4% identity in 231 aa overlap). Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III. (308 aa)
SCO3345SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...] (617 aa)
SCO3332SCE68.30c, possible membrane protein, len: 238 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains hydrophobic, possible membrane-spanning regions. Alternative start codons are present at codons 10 and 11. (238 aa)
SCO3034Sporulation regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). Complements a whiB2 disruption mutant in M.smegmatis (AC Q9S426). (87 aa)
SCO2941Conserved hypothetical protein SCE56.05c; SCE56.05c, unknown, len: 773 aa; similar to C-terminal region of TR:Q9VYQ2 (EMBL:AE003488) Drosophila melanogaster CG2779 protein, 1612 aa; fasta scores: opt: 651 Z-score: 464.7 E(): 3e-18; 31.405% identity in 847 aa overlap. High content in proline, glycine and alanine. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2, [2Fe-2S] binding domain and match to Prosite entry PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. (773 aa)
SCO2606SCC88.17c, orfsyn, hypothetical protein, len: 661 aa; N-terminal region identical to previously sequenced TR:O33624 (EMBL:Y14206) Streptomyces coelicolor ORFSYN (fragment) and similar to TR:P73260 (EMBL:D90905) Synechocystis sp. hypothetical 97.4 kD protein 865 aa; fasta scores: opt: 1055 z-score: 1198.6 E(): 0; 41.2% identity in 624 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. (661 aa)
SCO2600SCC88.11c, hypothetical protein, len: 258 aa; similar to TR:P73260 (EMBL:D90905) Synechocystis sp. hypothetical 97.4 kD protein, 865 aa; fasta scores: opt: 290 z-score: 317.3 E(): 2.9e-10; 31.3% identity in 179 aa overlap. (258 aa)
SCO2573Putative oxidoreductase; SCC123.11, possible oxidoreductase, len: 524 aa. Weakly similar to several including: Homo sapiens (Human) SW:NUBM_HUMAN(EMBL:Y17379) NADH-ubiquinone oxidoreductase 51 KD subunit precursor (EC 1.6.5.3) (464 aa), fasta scores opt: 341 z-score: 369.2 E(): 3.6e-13 27.1% identity in 365 aa overlap and Streptomyces coelicolor TR:Q9XAQ9(EMBL:AL078618) NADH dehydrogenase subunit, NuoF (449 aa), fasta scores opt: 398 z-score: 430.5 E(): 1.4e-16 26.5% identity in 392 aa overlap. (524 aa)
SCO2559Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (435 aa)
SCO2488SC7A8.27, nirC, probable nitrite reductase small subunit, len: 131 aa; similar to TR:O53675 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase small subunit NirD, 118 aa; fasta scores: opt: 353 z-score: 455.1 E(): 5.9e-18; 56.5% identity in 92 aa overlap and to SW:NIRD_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4) NirD, 108 aa; fasta scores: opt: 265 z-score: 346.0 E(): 7e-12; 46.9% identity in 96 aa overlap. (131 aa)
SCO2487SC7A8.26, nirB, probable nitrite reductase large subunit, len: 871 aa; similar to TR:Q00943 (EMBL:Z68122) Pichia angusta nitrite reductase Yni1, 1044 aa; fasta scores: opt: 1960 z-score: 2117.6 E(): 0; 43.2% identity in 868 aa overlap and SW:NIRB_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NirB 847 aa; fasta scores:opt: 1609 z-score: 1739.1 E(): 0; 52.1% identity in 845 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase and two matches to Prosite entries PS00136 Serine proteases, subtilase family, asp [...] (871 aa)
SCO2473SC7A8.12, probable nitrate reductase, len: 819 aa; similar to SW:NASC_BACSU (EMBL:D50453) Bacillus subtilis assimilatory nitrate reductase catalytic subunit (EC 1.7.99.4) NasC, 710 aa; fasta scores: opt: 1568 z-score: 1572.1 E(): 0; 37.9% identity in 816 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding, Molydopterin dinucleotide binding domain. Contains also glycine/serine rich region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (819 aa)
SCO2222SC10B7.17, probable iron-sulfur oxidoreductase (putative secreted protein), len: 364 aa; similar to TR:O88034 (EMBL:AL031107) Streptomyces coelicolor iron-sulfur oxidoreductase beta subunit SC5A7.28c, 313 aa; fasta scores: opt: 1032 z-score: 1177.8 E(): 0; 55.2% identity in 310 aa overlap and to SW:POBB_PSEPS (EMBL:X78823) Pseudomonas pseudoalcaligenes phenoxybenzoate dioxygenase beta subunit (EC 1.-.-.-.) PobB, 319 aa; fasta scores: opt: 680 z-score: 777.9 E(): 0; 40.8% identity in 314 aa overlap. Contains two matches to Pfam entries Pfam match to entry PF00175 oxidored_fad, Oxidoredu [...] (364 aa)
SCO2194Putative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (317 aa)
St6G10A.01Putative quinolinate synthetase (fragment); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
SCO2161SC6G10.34c, conserved hypothetical protein, len: 118 aa; similar to many e.g. SW:YM04_MYCTU (EMBL:Z70283) protein RV2204c from Mycobacterium tuberculosis (118 aa) fasta scores; opt: 625, z-score: 766.6, E(): 0, (74.6% identity in 118 aa overlap). Contains PS01152 Hypothetical hesB/yadR/yfhF family signature; Belongs to the HesB/IscA family. (118 aa)
SCO2149Rieske iron-sulfur protein; Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis; Belongs to the Rieske iron-sulfur protein family. (353 aa)
SCO2114SC6E10.08c, hypothetical protein, len: 83 aa; unknown function, similar to part of many nitrate or nitrite reductases e.g. SW:NIR_EMENI (EMBL:M58289), NiiA, Emericella nidulans nitrite reductase (1104 aa), fasta scores; opt: 137 z-score: 178.6 E(): 0.013, 38.0% identity in 50 aa overlap. (83 aa)
SCO49472SCK31.07, narG3, nitrate reductase alpha chain, len: 1227 aa; highly similar to SW:NARG_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase alpha chain (EC 1.7.99.4)NarG, 1228 aa; fasta scores: opt: 4080 z-score: 4618.0 E(): 0; 49.5% identity in 1206 aa overlap and to TR:O86717 (EMBL:AL031515) Streptomyces coelicolor NarG, putative nitrate reductase alpha chain SC5C7.20, 1231 aa; fasta scores: opt: 5648 z-score: 5294.1 E(): 0; 66.6% identity in 1232 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_bin [...] (1227 aa)
SCO49712SCK31.31, possible dehydrogenase, len: 497 aa; similar to N-terminal domain of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh, 1335 aa; fasta scores: opt: 345 z-score: 361.7 E(): 1.3e-12 31.5% identity in 483 aa overlap and to TR:O54050 (EMBL:AJ001013) Rhodobacter capsulatus xanthine dehydrogenase (EC 1.1.1.204) XdhA, 462 aa; fasta scores: opt: 631 z-score: 669.1 E(): 9.8e-30; 38.2% identity in 495 aa overlap. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, PF01799 fer2_2, [2Fe-2S] binding domain and PF00941 dehydr [...] (497 aa)
SCO5044Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (558 aa)
SCO5046Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (125 aa)
SCO5058Hypothetical protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5135Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
SCO5152Putative ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (377 aa)
SCO5190Putative DNA-binding protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (122 aa)
SCO5240Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
SCO52732SC7G11.35, hypothetical protein, len: 620 aa; N-terminal region similar to SW:ASLB_ECOLI (EMBL:M87049) Escherichia coli putative arylsulfatase regulatory protein AslB, 411 aa; blastp (consecutive) scores: Score= 166 (58.4 bits), Expec = 2.6e-19, Sum P(2)= 2.6e-19, Identities= 57/184 (30%), Positives= 82/184 (44%) and Score= 141 (49.6 bits), Expect= 2.6e-19, Sum P(2 = 2.6e-19, Identities= 47/165 (28%), Positives= 73/165 (44%). Contains Pfam match to entry PF01444 MoaA_NifB_PqqE, moaA / nifB / pqqE family. (620 aa)
SCO5274Hypothetical protein 2SC7G11.36; 2SC7G11.36, unknown, len: 541 aa. High content in alanine amino acid residues and in G+C (77.57%). Also contains 3x degenerate repeat: DA(P/T)GA(W/R)(G/S)(T/S)(4). (541 aa)
SCO5469SC2A11.03c, sdaA, probable L-serine dehydratase, len: 455 aa; highly similar to e.g. SDHL_ECOLI L-serine dehydratase 1 (EC 4.2.1.13) (454 aa), fasta scores; opt: 1643 z-score: 1576.6 E(): 0, 55.6% identity in 459 aa overlap. (455 aa)
SCO5486SC2A11.20, probable pyridoxal-phosphate-dependent aminotransferase, len: 389 aa; similar to many e.g. NIFS_ANASP Anaebaena NifS protein (400 aa), fasta scores; opt: 855 z-score: 1070.8 E(): 0, 40.4% identity in 384 aa overlap and SPL1_CANAL Candida albicans tRNA splicing protein SPL1 (488 aa), fasta scores; opt: 791 z-score: 912.8 E(): 0, 36.6% identity in 388 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V, score 259.00, E-value 6.2e-74. (389 aa)
SCO55533-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
SCO2026SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap). (1514 aa)
SCO2025SC3A3.03c, gltD, probable glutamate synthase small subunit, len: 487 aa; similar to bacterial glutamate synthases e.g. TR:Q51584 (EMBL:D85230), gltD, Plectonema boryanum small subunit of NADH-dependent glutamate synthase (492 aa), fasta scores; opt: 1295 z-score: 1405.0 E(): 0, 51.2% identity in 500 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.1% identity in 489 aa overlap). Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulf [...] (487 aa)
SCO2004SC7H2.18, possible formate dehydrogenase, len: 759 aa; similar to many formate dehydrogenase e.g. SW:FDHF_ECOLI formate dehydrogenase H from Escherichia coli (715 aa) fasta scores; opt: 386, z-score: 441.8, E(): 2.8e-17, (26.3% identity in 670 aa overlap). Also similar to SW:YX31_MYCTU hypothetical protein from Mycobacterium tuberculosis (779 aa) fasta scores; opt: 3038, z-score: 3497.1, E(): 0, (59.7% identity in 767 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
SCO1990Conserved hypothetical protein; SC7H2.04c, unknown, len: 237aa; similar to SW:Y08N_MYCTU hypothetical protein from Mycobacterium tuberculosis (350 aa) fasta scores; opt: 870, z-score: 990.4, E(): 0, (57.1% identity in 231 aa overlap). (237 aa)
SCO1977SC3C9.12c, possible glutamate synthase small subunit, len: 496 aa; similar to C-terminal part of SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa glutamate synthase [NADH], chloroplast precursor (EC 1.4.1.14) (NADH-GOGAT) GlsN, 2194 aa; fasta scores: opt: 1473 Z-score: 1543.9 bits: 297.3 E(): 2.2e-78; 47.551% identity in 490 aa overlap and to TR:Q9S2Z0 (EMBL:AL109849) Streptomyces coelicolor putative glutamate synthase small subunit SC3A3.03c, 487 aa; fasta scores: opt: 2145 Z-score: 2259.1 bits: 427.5 E(): 3.2e-118; 66.398% identity in 497 aa overlap. Contains Pfam match to entry PF00070 p [...] (496 aa)
SCO1955SCC54.15c, possible iron sulphur binding membrane lipoprotein, len: 141aa; similar to many of this type eg. SW:UCRI_CHLLT cytochrome B6-F iron-sulphur subunit, petC from chlorobium limicola (180 aa) fasta scores; opt: 197, z-score: 225.2, E(): 3.1e-05, (33.3% identity in 108 aa overlap). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (141 aa)
SCO1923SCC22.05c, possible dioxygenase ferredoxin subunit, len: 105 aa; similar to many e.g. SW:BEDB_PSEPU benzene dioxygenase from Pseudomonas putida ML2 (107 aa) fasta scores; opt: 286, z-score: 390.9, E(): 1.9e-14, (40.6% identity in 101 aa overlap). (105 aa)
SCO1920SCC22.02c, conserved hypothetical protein, len: 156aa; similar to many other hypothetical protein eg. TR:O53156 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 569, z-score: 685.8, E(): 7.2e-31, (56.3% identity in 158 aa overlap) and to SW:NIFU_BACSU (EMBL:Z99120) Bacillus subtilis NifU-like protein NifU, 147 aa; fasta scores: opt: 439 Z-score: 527.7 E(): 9.3e-22; 45.517% identity in 145 aa overlap. (156 aa)
SCO1919SCC22.01c, partial CDS, conserved hypothetical protein, len: >75aa; similar to many other hypothetical proteins eg. TR:O53157 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores; opt: 284, z-score: 392.0, E(): 1.7e-14, (61.3% identity in 80 aa overlap); SCI7.37c, partial CDS, unknown, len: >74aa; similar to TR:O53157 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores; opt: 375, z-score: 536.1, E(): 1.6e-22, (70.1% identity in 77 aa overlap). (110 aa)
SCO1888SCI7.06c, probable dihydroxy-acid dehydratase, len: 576aa; similar to many eg. SW:ILVD_BACSU dihydroxy-acid dehydratase from Bacillus subtilis (557 aa) fasta scores; opt: 1153, z-score: 1290.1, E(): 0, (37.0% identity in 560 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite match to PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. Also contains a helix-turn-helix motif (+3.32 SD) 207-228aa; Belongs to the IlvD/Edd family. (576 aa)
SCO1821Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (341 aa)
SCO1763SCI51.03, possible iron-sulphur protein (putative secreted protein), len: 131 aa; similar to part of many cytochrome B6-F complex iron-sulfur subunits from bacteria and chloroplasts e.g. SW:UCRI_CHLLT (EMBL:X73628), PetC, Chlorobium limicola F. sp. thiosulfatophilum iron-sulfur subunit (180 aa), fasta scores; opt: 198 z-score: 217.9 E(): 8.2e-05, 34.4% identity in 90 aa overlap. Similar to TR:Q9Z510 (EMBL:AL035591) Streptomyces coelicolor putative iron sulphur binding protein (141 aa) (36.6% identity in 131 aa overlap). Contains Pfam match to entry PF00355 Rieske, Rieske iron-sulfur pr [...] (131 aa)
SCO1711SCI30A.32c, possible dehydrogenase, len: 747aa; similar to many e.g. TR:O53648 (EMBL:AL021928) hypothetical protein from Mycobacterium tuberculosis (762 aa) fasta scores; opt: 617, z-score: 625.8, E(): 1.6e-27, (29.9% identity in 762 aa overlap) and SW:FDHF_ECOLI formate dehydrogenase from Escherichia coli (715 aa) fasta scores; opt: 466, z-score: 473.3, E(): 4.9e-19, (24.0% identity in 716 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (747 aa)
SCO1649SCI41.32, putative ferredoxin, len: 101 aa. Identical to TR:087593 (EMBL:AF086832) Streptomyces coelicolor putative ferredoxin, len: 101 aa and similar to SW:FER_BACST (SW:P00212) Bacillus stearothermophilus ferredoxin, fasta scores: opt: 153 z-score: 211.3 E(): 0.00021; 33.3% identity in 69 aa overlap. (101 aa)
SCO13562SCG61.38, possible iron sulphur protein (putative secreted protein), len: 165 aa; similar to TR:Q9S237 (EMBL:AL109848) putative iron sulphur protein from Streptomyces coelicolor (131 aa) fasta scores; opt: 444, z-score: 411.3, E(): 1.9e-15, 53.4% identity in 116 aa overlap. Contains Pfam match to entry PF00355 Rieske, Rieske [2Fe-2S] domain and Prosite match to PS00200 Rieske iron-sulfur protein signature 2. Contains possible N-terminal region signal peptide sequence. (165 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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