STRINGSTRING
SCO2419 SCO2419 SCO3421 SCO3421 SCO0123 SCO0123 SCO7615 SCO7615 SCO7579 SCO7579 SCO6537 SCO6537 SCO6375 SCO6375 SCO6003 SCO6003 SCO5735 SCO5735 SCO5725 SCO5725 SCO5721 SCO5721 SCO4042 SCO4042 SCO5108 SCO5108 SCO5178 SCO5178 SCO0162 SCO0162 SCO0442 SCO0442 SCO0638 SCO0638 SCO0896 SCO0896 SCO0958 SCO0958 SCO1280 SCO1280 SCO1979 SCO1979 SCO2169 SCO2169
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO2419SC8A2.07c, possible secreted protein, len: 418 aa; similar to TR:O53967 (EMBL:AL022073) Mycobacterium tuberculosis mce-family protein MTV051.04, 425 aa; fasta scores: opt: 548 z-score: 564.7 E(): 6.2e-24; 33.0% identity in 367 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence. (418 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO0123Conserved hypothetical protein SCJ2.04c; SCJ21.04c, unknown, len: 448 aa; some similarity to M. tuberculosis hypothetical protein TR:P71694 (EMBL:Z95844) Rv1425 (459 aa), fasta scores; opt: 150 z-score: 166.6 E(): 0.063, 23.9% identity in 464 aa overlap. (448 aa)
SCO7615SC2H2.13, possible DNA-binding protein, len: 290 aa; similar to many Streptomyces coelicolor putative DNA-binding proteins, e.g. TR:CAC01466 (EMBL:AL391014) putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 613 z-score: 722.6 E(): 1e-32; 41.8% identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c, 287 aa; fasta scores: opt: 917 z-score: 1027.9 E(): 0; 50.0% identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD). (290 aa)
SCO7579SC5F1.33, possible DNA-binding protein, len: 291 aa; similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 643 z-score: 787.2 E(): 0; 37.0% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD). (291 aa)
SCO6537SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD). (287 aa)
SCO6375SC4A2.11c, probable secreted protein, len: 220 aa; similar to a set of Mycobacterial secreted antigens e.g. MP83_MYCTU cell surface lipoprotein Mpt83 precursor (239 aa), fasta scores; opt: 376 z-score: 505.8 E(): 6.4e-21, 35.6% identity in 222 aa overlap. (220 aa)
SCO6003SCBAC1C11.06c, possible DNA-binding protein, len: 286 aa; similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28; 37.4% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD). (286 aa)
SCO5735SC3C3.21, probable integral membrane protein, len: 491 aa; similar to hypothetical membrane protein from M. tuberculosis TR:O06265 (EMBL:Z95389) MTCY77.20 Rv3448 (467 aa), fasta scores; opt: 192 z-score: 322.0 E(): 1.1e-10, 26.9% identity in 495 aa overlap. (491 aa)
SCO5725Hypothetical protein SC3C3.11; SC3C3.11, unknown, len: 103 aa; Belongs to the WXG100 family. (103 aa)
SCO5721SC3C3.07, unknown, len: 508 aa; similar to three hypothetical proteins from M. tuberculosis e.g. TR:O06317 (EMBL:Z95390) MTCY13E12.03C (470 aa), fasta scores; opt: 213 z-score: 330.7 E(): 3.7e-11, 28.0% identity in 508 aa overlap. Contains possible transmembrane domain at N-terminus. (508 aa)
SCO40422SCD60.08c, putative membrane protein, len: 204 aa; similar to TR:O07202 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 22.7 kDa protein MTCY05A6.21, 216 aa; fasta scores: opt: 193 z-score: 226.9 E(): 4.5e-05; 31.3% identity in 192 aa overlap. Contains possible hydrophobic membrane spanning region. (204 aa)
SCO5108SCBAC31E11.04c, possible integral membrane protein, len: 278 aa; similar to TR:O53671 (EMBL:AL021929) Mycobacterium tuberculosis hypothetical 31.1 kDa protein MTV034.15c, 273 aa; fasta scores: opt: 1010 Z-score: 1230.3 bits: 235.4 E(): 6.5e-61; 54.545% identity in 275 aa overlap. Contains possible hydrophobic membrane spanning regions. (278 aa)
SCO51782SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain. (392 aa)
SCO0162Conserved hypothetical protein SCJ1.11; SCJ1.11, unknown, similar to several including: Mycobacterium tuberculosis TR:O53476(EMBL; AL021899) hypothetical 36.6 KD protein (331 aa), fasta scores opt: 394 z-score: 468.4 E(): 1e-18 32.2% identity in 332 aa overlap and Mycobacterium tuberculosis TR:O05800 (EMBL; Z95150) hypothetical 38.5 KD protein (344 aa), fasta scores opt: 345 z-score: 410.5 E(): 1.7e-15 30.2% identity in 324 aa overlap. (330 aa)
SCO0442Conserved hypothetical protein; SCF51A.20, unknown, len: 252 aa. Similar to a number of hypothetical proteins e.g. Escherichia coli SW:YBGJ_ECOLI (EMBL; AE000174) hypothetical 23.9 KD protein in phrB-nei intergenic region (218 aa), fasta scores: opt: 477 z-score: 492.1 E(): 4.7e-20 43.5% identity in 214 aa overlap. (252 aa)
SCO0638SCF56.22c, possible lipoprotein, len: 219 aa; similar to TR:O86667 (EMBL:AL031182) Streptomyces coelicolor putative secreted protein SC4A2.11c, 220 aa; fasta scores: opt: 549 z-score: 568.6 E(): 2.7e-24; 45.2% identity in 219 aa overlap and to SW:MP83_MYCTU (EMBL:X94597) Mycobacterium tuberculosis cell surface lipoprotein MPT83 precursor, 220 aa; fasta scores: opt: 497 z-score: 516.2 E(): 2.3e-21; 44.8% identity in 230 aa overlap. Contains N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (219 aa)
SCO0896Putative oxidoreductase; SCM1.29c, possible oxidoreductase, len: 141 aa. Similar to many including Methanopyrus kandleri SW:IMDH_METKA (EMBL:U31567) putative inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (172 aa), fasta scores opt: 227 z-score: 288.9 E(): 9.5e-09 31.6% identity in 117 aa overlap and Bacillus subtilis SW:YHCV_BACSU (EMBL:X96983) hypothetical 14.9 KD protein (140 aa), fasta scores opt: 295 z-score: 372.8 E(): 2e-13 40.0% identity in 135 aa overlap. Contains 2x Pfam match to entry PF00571 CBS, CBS domains. (141 aa)
SCO0958SCM11.13c, hypothetical protein, len: 446 aa; similar to various Mycobacterium tuberculosis hypothetical proteins, e.g. TR:O07035 (EMBL:Z95150) Mycobacterium tuberculosis hypothetical 50.7 kD protein RV3130c, 463 aa; fasta scores: opt: 491 z-score: 529.2 E(): 4.3e-22; 30.2% identity in 464 aa overlap; Belongs to the long-chain O-acyltransferase family. (446 aa)
SCO12802SCG18.27c, conserved hypothetical protein, len: 413 aa; similar to TR:Q9S203 (EMBL:AL109747) Streptomyces coelicolor hypothetical 48.6 kD protein SCJ21.04c, 448 aa; fasta scores: opt: 360 z-score: 403.3 E(): 5.6e-15; 30.7% identity in 391 aa overlap. (413 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
SCO2169SC5F7.32, possible integral membrane protein, len: 251aa; contains possible membrane spanning hydrophobic regions. some similarity to TR:O32952 (EMBL:Z98741) hypothetical protein from Mycobacterium leprae (247 aa) fasta scores; opt: 335, z-score: 361.2, E(): 8.8e-13, (34.4% identity in 221 aa overlap). (251 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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