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SCO3582 SCO3582 SCO3457 SCO3457 SCO3405 SCO3405 SCO3403 SCO3403 SCO3382 SCO3382 SCO3381 SCO3381 SCO3380 SCO3380 SCO3325 SCO3325 SCO3243 SCO3243 SCO3217 SCO3217 SCO3181 SCO3181 SCO3180 SCO3180 SCO3179 SCO3179 SCO3148 SCO3148 SCO3123 SCO3123 SCO3122 SCO3122 SCO3060 SCO3060 SCO3059 SCO3059 SCO3041 SCO3041 SCO2948 SCO2948 SCO2918 SCO2918 SCO2917 SCO2917 SCO2888 SCO2888 SCO2818 SCO2818 SCO2694 SCO2694 SCO2612 SCO2612 SCO2579 SCO2579 SCO2445 SCO2445 SCO2238 SCO2238 St6G10A.01 St6G10A.01 SCO2122 SCO2122 SCO2109 SCO2109 SCO2108 SCO2108 SCO2107 SCO2107 SCO2104 SCO2104 SCO1996 SCO1996 SCO1975 SCO1975 SCO1945 SCO1945 SCO1841 SCO1841 SCO1821 SCO1821 SCO1781 SCO1781 SCO1776 SCO1776 SCO1760 SCO1760 SCO1759 SCO1759 SCO1752 SCO1752 SCO1686 SCO1686 SCO1566 SCO1566 SCO1527 SCO1527 SCO1523 SCO1523 SCO1522 SCO1522 SCO1514 SCO1514 SCO1513 SCO1513 SCO1487 SCO1487 SCO1486 SCO1486 SCO1485 SCO1485 SCO1484 SCO1484 SCO1483 SCO1483 SCO1482 SCO1482 SCO1481 SCO1481 SCO1479 SCO1479 SCO1477 SCO1477 SCO1461 SCO1461 SCO1433 SCO1433 SCO1393 SCO1393 SCO1389 SCO1389 SCO1270 SCO1270 SCO1254 SCO1254 SCO1228 SCO1228 SCO1203 SCO1203 SCO1085 SCO1085 SCO0993 SCO0993 SCO0920 SCO0920 SCO0855 SCO0855 SCO0782 SCO0782 SCO0770 SCO0770 SCO0723 SCO0723 SCO0667 SCO0667 SCO0603 SCO0603 SCO0578 SCO0578 SCO0549 SCO0549 SCO0506 SCO0506 SCO0410 SCO0410 SCO0171 SCO0171 SCO5628 SCO5628 SCO5694 SCO5694 SCO5696 SCO5696 SCO5711 SCO5711 SCO5743 SCO5743 SCO5753 SCO5753 SCO5754 SCO5754 SCO5845 SCO5845 SCO5868 SCO5868 SCO5899 SCO5899 SCO5910 SCO5910 SCO5983 SCO5983 SCO6013 SCO6013 SCO6186 SCO6186 SCO6195 SCO6195 SCO6325 SCO6325 SCO6415 SCO6415 SCO6437 SCO6437 SCO6467 SCO6467 SCO6468 SCO6468 SCO6511 SCO6511 SCO6558 SCO6558 SCO6573 SCO6573 SCO6611 SCO6611 SCO6647 SCO6647 SCO6750 SCO6750 SCO6752 SCO6752 SCO6755 SCO6755 SCO6763 SCO6763 SCO6767 SCO6767 SCO6768 SCO6768 SCO6821 SCO6821 SCO6898 SCO6898 SCO6983 SCO6983 SCO7081 SCO7081 SCO7215 SCO7215 SCO7268 SCO7268 SCO7528 SCO7528 SCP1.159c SCP1.159c SCP1.162c SCP1.162c mmyX mmyX mmyK mmyK SCO5626 SCO5626 SCO5569 SCO5569 SCO5568 SCO5568 SCO5563 SCO5563 SCO5562 SCO5562 SCO5559 SCO5559 SCO5558 SCO5558 SCO5425 SCO5425 SCO5424 SCO5424 SCO5374 SCO5374 SCO5373 SCO5373 SCO5372 SCO5372 SCO5371 SCO5371 SCO5370 SCO5370 SCO5369 SCO5369 SCO5368 SCO5368 SCO5367 SCO5367 SCO5250 SCO5250 SCO5241 SCO5241 SCO5225 SCO5225 SCO5201 SCO5201 SCO5058 SCO5058 SCO4980 SCO4980 SCO4928 SCO4928 SCO4909 SCO4909 SCO4901 SCO4901 SCO4849 SCO4849 SCO4824 SCO4824 SCO4814 SCO4814 SCO4813 SCO4813 SCO4785 SCO4785 SCO4771 SCO4771 SCO4770 SCO4770 SCO4738 SCO4738 SCO4723 SCO4723 SCO4663 SCO4663 SCO4657 SCO4657 SCO4644 SCO4644 SCO4418 SCO4418 SCO4403 SCO4403 SCO4387 SCO4387 SCO4234 SCO4234 SCO4233 SCO4233 SCO4161 SCO4161 SCO4087 SCO4087 SCO4086 SCO4086 SCO4079 SCO4079 SCO4078 SCO4078 SCO4077 SCO4077 SCO4071 SCO4071 SCO4068 SCO4068 SCO4041 SCO4041 SCO3938 SCO3938 SCO3928 SCO3928 SCO3899 SCO3899 SCO3831 SCO3831 SCO3828 SCO3828 SCO3827 SCO3827 SCO3817 SCO3817 SCO3726 SCO3726 SCO3678 SCO3678 SCO3677 SCO3677 SCO3650 SCO3650 SCO3645 SCO3645 SCO3630 SCO3630 SCO3629 SCO3629 SCO3563 SCO3563
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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SCO3582SCH66.03, putative secreted protein, len: 309 aa; similar to many e.g. TR:O69651 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (319 aa) fasta scores; opt: 610, z-score: 716.1, E(): 1.5e-32, (51.5% identity in 307 aa overlap). Contains possible N-terminal region signal peptide sequence. (309 aa)
SCO3457SCE46.14, possible transmembrane protein, len: 205 aa; similar to TR:P76226 (EMBL:AE000270) Escherichia coli from bases 1830199 to 1840304, 208 aa; fasta scores: opt: 402 z-score: 471.0 E(): 6.9e-19; 37.4% identity in 206 aa overlap and to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi predicted CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PgsA, 185 aa; fasta scores: opt: 216 z-score: 259.1 E(): 4.4e-07; 31.2% identity in 205 aa overlap. (205 aa)
SCO3405SCE9.12c, hprT, probable hypoxanthine phosphoribosyltransferase, len: 187 aa; similar to many e.g. TR:O33799 (EMBL:AF008931), HprT, Salmonella typhimurium hypoxanthine phosphoribosyltransferase (178 aa), fasta scores; opt: 583 z-score: 711.2 E(): 2.7e-32, 54.2% identity in 166 aa overlap. The start codon is uncertain as there are 5 potential. Contains Pfam match to entry PF00156 Pribosyltran, Purine/pyrimidine phosphoribosyl transferases, score 177.70, E-value 1.9e-49 and PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Contains probable coiled-coil from 3 to 39 (37 res [...] (187 aa)
SCO3403SCE9.10c, folE, probable GTP cyclohydrolase I, len: 201 aa; similar to many e.g. SW:GCH1_BACSU (EMBL:M37320), MtrA, Bacillus subtilis GTP cyclohydrolase I (190 aa), fasta scores; opt: 728 z-score: 880.0 E(): 0, 58.9% identity in 185 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I, score 351.80, E-value 7.2e-102, PS00859 GTP cyclohydrolase I signature 1 and PS00860 GTP cyclohydrolase I signature 2. (201 aa)
SCO3382L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (580 aa)
SCO3381SCE94.32c, nadC, nicotinate-nucleotide pyrophophorylase, len: 329 aa; similar to many e.g. SW:NADC_MYCTU NadC, nicotinate-nucleotide pyrophophorylase from Mycobacterium tuberculosis (285 aa) fasta scores; opt: 909, z-score: 1017.8, E(): 0, (57.3% identity in 267 aa overlap); Belongs to the NadC/ModD family. (329 aa)
SCO3380Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (265 aa)
SCO3325SCE68.23c, conserved hypothetical protein, len: 355 aa; similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV29_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (358 aa), fasta scores; opt: 1281 z-score: 1288.1 E(): 0, 56.5% identity in 356 aa overlap. Similar to TR:O54097 (EMBL:AL021529), SC10A5.04, S.coelicolor hypothetical protein (295 aa) (64.4% identity in 278 aa overlap). (355 aa)
SCO3243SCE29.12c, possible myo-inositol phosphate synthase, len: 388 aa; similar to many e.g. TR:O69948 (EMBL:AL023862) from Streptomyces coelicolor (417 aa) fasta scores; opt: 955, z-score: 1034.1, E(): 0, (60.3% identity in 380 aa overlap) and SW:INO1_CITPA myo-inositol phosphate synthase from Citrus paradisi (grapefruit) fasta scores; opt: 323, z-score: 352.1, E(): 2.6e-12, (26.9% identity in 364 aa overlap). (388 aa)
SCO3217Putative transcriptional regulator; SCE8.10, cdaR, transcriptional activator protein, len: 638 aa; Previously sequenced and therefore identical to CdaR (EM:AF124138) transcriptional activator protein for the CDA biosynthesis cluster in Streptomyces coelicolor. Also similar to many including SW:AFSR_STRCO AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2) (993 aa) fasta scores; opt: 972, z-score: 1087.1, E(): 0, (36.6% identity in 610 aa overlap) and SW:REDD_STRCO regulator of undecylprodigiosin production in Streptomyces coelicolor A3( [...] (638 aa)
SCO3181Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (424 aa)
SCO3180Molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (170 aa)
SCO3179SCE87.30c, moaB, probable molybdenum cofactor biosynthesis protein (putative secreted protein), len: 179 aa. Highly similar to many including: Mycobacterium tuberculosis TR:O53877 (EMBL:AL022004) putative molybdopterin biosynthesis Mog protein (160 aa), fasta scores opt: 617 z-score: 660.3 E(): 2.1e-29 60.0% identity in 160 aa overlap and the C-terminus of the Synechococcus sp MoaC, MoaB fusion protein SW:MOCB_SYNP7 (EMBL:X99625) molybdenum cofactor biosynthesis protein CB (319 aa), fasta scores opt: 401 z-score: 430.6 E(): 1.3e-16 41.5% identity in 171 aa overlap. Contains a Prosite h [...] (179 aa)
SCO3148Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (299 aa)
SCO3123Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
SCO3122Putative nucleotidyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (482 aa)
SCO3060Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (411 aa)
SCO3059Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa)
SCO3041SCE34.22, hypothetical protein, len: 263 aa; similar to TR:P96873 (EMBL:Z92771) Mycobacterium tuberculosis hypothetical 23.7 kD protein, 229 aa; fasta scores: opt: 442 z-score: 490.8 E(): 7.1e-20; 40.1% identity in 242 aa overlap. (263 aa)
SCO2948SCE59.07c, hypothetical protein, len: 193 aa; similar to various hypothetical proteins, e.g. TR:P71608 (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 21.8 kD protein CY10H4.38, 202 aa; fasta scores: opt: 525 z-score: 594.5 E(): 1.1e-25; 46.7% identity in 182 aa overlap; Belongs to the UPF0301 (AlgH) family. (193 aa)
SCO2918SCE19A.18, probable nicotinamidase, len: 195 aa; highly similar to nicotinamidases e.g. TR:Q50575 (EMBL:U59967), PncA, Mycobacterium tuberculosis pyrazinamidase/nicotinamidase (186 aa), fasta scores; opt: 801 z-score: 921.3 E(): 0, 65.6% identity in 186 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase, Isochorismatase family. (195 aa)
SCO2917Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (448 aa)
SCO2888Conserved hypothetical protein SCE6.25c; SCE6.25c, unknown, len: 119 aa. similar to TR:CAC46858 (EMBL:AL591790) hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa) fasta scores; opt: 360, Z-score: 449.2, E(): 2.2e-17, 48.305% identity (49.565% ungapped) in 118 aa overlap. Weakly similar in parts to Streptomyces coelicolor TR:O86701(EMBL:AL031515) putative lyase, SC5C7.04 (138 aa), fasta scores opt: 141 z-score: 193.4 E(): 0.0024 33.3% identity in 111 aa overlap. (119 aa)
SCO2818SCBAC17F8.09, hypothetical protein, len: 436 aa: similar TR:Q9Z4X3 (EMBL:AL035654) putative secreted protein SCE8.01 from Streptomyces coelicolor (432 aa) fasta scores; opt: 555, Z-score: 609.9, 33.991% identity (38.945% ungapped) in 456 aa overlap. (436 aa)
SCO2694Hypothetical protein; SCC61A.15, unknown, len: 180aa. (180 aa)
SCO2612Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
SCO2579Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (238 aa)
SCO2445SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap. (458 aa)
SCO2238NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (613 aa)
St6G10A.01Putative quinolinate synthetase (fragment); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
SCO2122SC6E10.16c, conserved hypothetical protein, len: 262 aa; unknown function, similar to part of TR:O33970 (EMBL:U80063) Streptomyces cinnamoneus hypothetical protein (199 aa), fasta scores; opt: 827 z-score: 903.5 E(): 0, 61.9% identity in 202 aa overlap and to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. TR:O69572 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (244 aa) (54.0% identity in 215 aa overlap). Similar to others from S.coelicolor e.g. TR:Q9ZBS1 (EMBL:AL034447) S.coelicolor possible acyltransferase (264 aa) (33.2% identity in 25 [...] (262 aa)
SCO2109Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
SCO2108SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). (66 aa)
SCO2107SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] (401 aa)
SCO2104Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (223 aa)
SCO1996dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
SCO1975Hypothetical protein SC3C9.10c; SC3C9.10c, unknown, len: 210 aa. (210 aa)
SCO1945Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). (258 aa)
SCO1841SCI8.26, unknown, len: 194 aa. Weakly similar to a protein of unknown function from Mycobacterium tuberculosis: SW:YZ15_MYCTU (EMBL: Z73101) hypothetical 16.1 KD protein precursor (152 aa), fasta scores opt: 220 z-score: 256.4 E(): 6.5e-07 33.6% identity in 131 aa overlap. (194 aa)
SCO1821Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (341 aa)
SCO1781Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
SCO1776Putative CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa)
SCO17602SCI34.13c, probable cytidylate kinase, len: 231 aa; similar to SW:KCY_ECOLI (EMBL:X00785) Escherichia coli cytidylate kinase (EC 2.7.4.14) Cmk or MssA, 227 aa; fasta scores: opt: 469 z-score: 501.3 E(): 1.8e-20; 40.3% identity in 226 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (231 aa)
SCO17592SCI34.12c, possible transferase, len: 220 aa; similar to TR:O67841 (EMBL:AE000770) Aquifex aeolicus 2-acylglycerophosphoethanolamine acyltransferase Aas, 211 aa; fasta scores: opt: 325 z-score: 388.0 E(): 3.6e-14; 33.3% identity in 189 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. (220 aa)
SCO17522SCI34.05, possible integral membrane protein, len: 396 aa; similar to TR:Q9L0K6 (EMBL:AL161691) Streptomyces coelicolor putative integral membrane protein SCD40A.03c, 434 aa; fasta scores: opt: 678 Z-score: 715.1 E(): 3.4e-32; 37.530% identity in 413 aa overlap. Contains possible hydrophobic membrane spanning regions. (396 aa)
SCO1686SCI30A.07, possible NTP pyrophosphohydrolase, len: 181 aa; similar to many e.g. TR:Q53738 (EMBL:X92429) from the puromycin biosynthetic pathway of Streptomyces alboniger (152 aa) fasta scores; opt: 170, z-score: 226.2, E(): 2.9e-05, (35.7% identity in 129 aa overlap). Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein. (181 aa)
SCO1566SCL24.02, possible acyltransferase, len: 223 aa; similar to TR:Q9ZBS1 (EMBL:AL034447) Streptomyces coelicolor putative acyltransferase SC7A1.02, 264 aa; fasta scores: opt: 277 z-score: 327.1 E(): 8.5e-11; 30.7% identity in 202 aa overlap and to TR:CAB51970 (EMBL:AL109661) Streptomyces coelicolor hypothetical 28.2 kD protein SC6E10.16c, 262 aa; fasta scores: opt: 858 z-score: 879.9 E(): 0; 59.0% identity in 217 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. (223 aa)
SCO1527SCL2.17c, possible membrane transferase, len: 241 aa; similar to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, 186 aa; fasta scores: opt: 286 z-score: 350.3 E(): 4e-12; 33.0% identity in 203 aa overlap and to TR:O06202 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 23.3 kD protein MTCY1A10.21, 217 aa; fasta scores: opt: 564 z-score: 679.1 E(): 2e-30; 43.4% identity in 212 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase and match to Prosite entry PS00379 [...] (241 aa)
SCO1523Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa)
SCO1522Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (202 aa)
SCO1514Adenine phosphoribosiltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (165 aa)
SCO1513GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions; Belongs to the RelA/SpoT family. (847 aa)
SCO1487SC9C5.11c, pyrB, aspartate carbamoyltransferase, len: 326 aa; similar to SW:PYRB_PSEPU (EMBL:M97253) Pseudomonas putida aspartate carbamoyltransferase (EC 2.1.3.2) PyrB, 334 aa; fasta scores: opt: 902 z-score: 1064.2 E(): 0; 47.3% identity in 311 aa overlap. Contains 2x Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase and match to Prosite entry PS00097 Aspartate and ornithine carbamoyltransferases signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (326 aa)
SCO1486Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
SCO1485SC9C5.09c, possible integral membrane protein, len: 191 aa; similar to TR:P71810 (EMBL:Z81011) Mycobacterium tuberculosis hypothetical 18.2 kD protein, 165 aa; fasta scores: opt: 301 z-score: 362.9 E(): 9.7e-13; 33.1% identity in 148 aa overlap. Contains possible hydrophobic membrane spanning region. (191 aa)
SCO1484SC9C5.08c, pyrAA, carbamoyl-phosphate synthase, pyrimidine-specific, small chain, len: 380 aa; similar to SW:CARA_BACCL (EMBL:X73308) Bacillus caldolyticus carbamoyl-phosphate synthase, pyrimidine-specific, small chain (EC 6.3.5.5) PyrAA, 364 aa; fasta scores: opt: 826 z-score: 913.3 E(): 0; 45.3% identity in 362 aa overlap. Contains Pfam matches to entries PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain and PF00117 GATase, Glutamine amidotransferase class-I and match to Prosite entry PS00442 Glutamine amidotransferases class-I active site; Belongs to t [...] (380 aa)
SCO1483SC9C5.07c, pyrA, carbamoylphosphate synthetase large chain, len: 1102 aa; similar to SW:CARB_ECOLI (EMBL:V01500) Escherichia coli carbamoyl-phosphate synthase large chain (EC 6.3.5.5) CarB or PyrA, 1072 aa; fasta scores: opt: 3383 z-score: 3699.6 E(): 0; 55.0% identity in 1102 aa overlap. Contains 3x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and matches to Prosite entries 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and 2x PS00867 Carbamoyl-phosphate synthase subdomain signature. (1102 aa)
SCO1482Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
SCO1481SC9C5.05c, pyrF, orotidine 5'-phosphate decarboxylase, len: 278 aa; similar to SW:DCOP_MYCTU (EMBL:Z80108) Mycobacterium tuberculosis orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) PyrF or UraA, 274 aa; fasta scores: opt: 800 z-score: 874.6 E(): 0; 51.1% identity in 282 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases and match to Prosite entry PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
SCO1479Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (197 aa)
SCO1477Putative flavoprotein homologue (partial); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (427 aa)
SCO1461SCL6.18c, guaB2, probable inosine monophosphate dehydrogenase, len: 483 aa; similar to SW:IMDH_BACSU (EMBL:X55669) Bacillus subtilis inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) GuaB, 513 aa; fasta scores: opt: 970 z-score: 1018.4 E(): 0; 37.4% identity in 471 aa overlap. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus, two matches to entry PF00571 CBS, CBS domain and to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. (483 aa)
SCO1433Hypothetical protein SC6D7.06c; SC6D7.06c, doubtful CDS, len: 154 aa. (154 aa)
SCO1393SC1A8A.13, acsA, acetoacetyl-CoA synthetase, len: 658 aa; similar to many eg. TR:BAA90828 (EMBL:AB026291) acetoacetyl-CoA synthetase from Rattus norvegicus (Rat) (672 aa) fasta scores; opt: 1133, z-score: 1295.8, E(): 0, 39.9% identity in 667 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and Prosite match to PS00455 Putative AMP-binding domain signature. (658 aa)
SCO1389SC1A8A.09c, possible CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase, len: 206 aa; similar to many eg. SW:Q50611 (PGSA_MYCTU) putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Mycobacterium tuberculosis (209 aa) fasta scores; opt: 504, z-score: 637.7, E(): 4.3e-28, 43.5% identity in 193 aa overlap and SW:P06978 (PGSA_ECOLI) CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Escherichia coli (181 aa) fasta scores; opt: 232, z-score: 299.4 E(): 3e-09, 29.3% identity in 174 aa overlap. Contains Pfam match to entry P [...] (215 aa)
SCO12702SCG18.17c, probable pyruvate dehydrogenase alpha subunit, len: 323 aa; similar to TR:O69011 (EMBL:AF086791) Zymomonas mobilis pyruvate dehydrogenase alpha subunit PdhA, 353 aa; fasta scores: opt: 553 z-score: 643.8 E(): 2.3e-28; 33.4% identity in 314 aa overlap. Contains Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component. (323 aa)
SCO12542SCG18.01, purB, probable adenylosuccino lyase (fragment), len: >362 aa; highly similar to TR:Q9RHX3 (EMBL:AB00316) Corynebacterium ammoniagenes adenylosuccino lyase PurB, 479 aa; fasta scores: opt: 1625 z-score: 1824.6 E(): 0; 69.4% identity in 363 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and match to Prosite entry PS00163 Fumarate lyases signature; 2SCG1.29, purB, adenylosuccino lyase (fragment), len: >149 aa; highly similar to TR:Q9RHX3 (EMBL:AB003161) Corynebacterium ammoniagenes adenylosuccino lyase PurB, 479 aa; fasta scores: opt: 661 z-score: 805.9 E(): 0; [...] (480 aa)
SCO12282SCG1.03, probable acyltransferase, len: 240 aa; similar to TR:CAB76086 (EMBL:AL157956) Streptomyces coelicolor putative acyltransferase SCL24.02, 223 aa; fasta scores: opt: 786 z-score: 912.9 E(): 0; 51.1% identity in 219 aa overlap and to TR:CAB51970 (EMBL:AL109661) Streptomyces coelicolor hypothetical protein SC6E10.16c, 262 aa; fasta scores: opt: 912 z-score: 945.5 E(): 0; 59.6% identity in 240 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. (240 aa)
SCO12032SCG58.03, possible MutT-like protein, len: 153 aa; similar to TR:CAB88476 (EMBL:AL353816) Streptomyces coelicolor putative MutT-like protein SCD84.10c, 142 aa; fasta scores: opt: 135 z-score: 171.1 E(): 0.046; 33.3% identity in 129 aa overlap. Contains match to Prosite entry PS00893 mutT domain signature. (153 aa)
SCO10852SCG4.01, probable acyltransferase, len: 242 aa; similar to TR:O0780 (EMBL:Z97188) Mycobacterium tuberculosis acyltransferase MTCY409.14, 259 aa; fasta scores: opt: 758 z-score: 928.7 E(): 0; 51.7% identity in 234 aa overlap and to SW:PLSC_LIMDO (EMBL:X83266) Limnanthes douglasii 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) PlsC, 281 aa; fasta scores: opt: 218 z-score: 272.2 E(): 1.1e-07; 31.0% identity in 174 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. (242 aa)
SCO09932SCG2.06, conserved hypothetical protein, len: 412 aa; similar to SW:Y4RH_RHISN (EMBL:AE000094) Rhizobium sp. hypothetical 52.5 kDa protein Y4rH, 478 aa; fasta scores: opt: 348 z-score: 384.2 E(): 7.1e-14; 26.3% identity in 400 aa overlap. (412 aa)
SCO0920SCM10.08c, probable acyltransferase, len: 260 aa; similar to SW:PLSC_NEIGO (EMBL:U21806) Neisseria gonorrhoeae 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)PlsC, 255aa; fasta scores: opt: 384 z-score: 454.1 E(): 6.7e-18; 38.9% identity in 185 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Contains possible hydrophobic membrane spanning region. (275 aa)
SCO0855Putative acetyltransferase; SCM2.08c, possible acetyltransferase, len: 168 aa. Weak similarity to several other putative acetyltransferases e.g. Streptomyces coelicolor TR:CAB51273 (EMBL:AL096872) putative acetyltransferase SC5F7.12C (169 aa), fasta scores opt: 121 z-score: 155.1 E(): 0.29 31.3% identity in 147 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (168 aa)
SCO07823SCF60.14c, prsA, ribose-phosphate pyrophosphokinase, len: 317 aa; similar to SW:KPRS_SYNP7 (EMBL:D14994) Synechococcus sp. ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PrsA, 331 aa; fasta scores: opt: 795 z-score: 931.4 E(): 0; 42.7% identity in 307 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. (317 aa)
SCO07703SCF60.02c, possible membrane protein, len: 185 aa. Contains possible hydrophobic membrane spanning region. (185 aa)
SCO07233SC5B7.01, conserved hypothetical protein (fragment), len: >151 aa; similar to TR:Q9SA67 (EMBL:AC006550) Arabidopsis thaliana F10O3 protein, 270 aa; fasta scores: opt: 219 z-score: 240.7 E(): 7.1e-06; 30.4% identity in 125 aa overlap; SCF42.33, unknown, partial CDS, len: > 117 aa. Similar to a protein of undefined function from Schizosaccharomyces pombe (Fission yeast) TR:CAB61463(EMBL:AL133156) (235 aa), fasta scores opt: 241 z-score: 282.8 E(): 2.3e-08 37.0% identity in 119 aa overlap and Escherichia coli SW:YGGC_ECOLI(EMBL:X14436) (237 aa), fasta scores opt: 184 z-score: 219.2 E(): [...] (229 aa)
SCO0667SCF91.27c, putative secreted protein, len: 293 aa. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53526(EMBL:AL021925) hypothetical 32.8 KD protein (309 aa), fasta scores opt: 441 z-score: 476.5 E(): 3.6e-19 32.8% identity in 299 aa overlap. Contains possible N-terminal region signal peptide sequence. (293 aa)
SCO0603SCF55.27, probable amino transferase, len: 233 aa; similar to TR:P95530 (EMBL:D85415) Pseudomonas putida amino group transfer TdnT, 253 aa; fasta scores: opt: 251 z-score: 300.9 E(): 2.2e-09; 31.9% identity in 160 aa overlap. Contains match to Pfam entry PF00117 GATase, Glutamine amidotransferase class-I and to Prosite entry PS00442 Glutamine amidotransferases class-I active site. (233 aa)
SCO0578SCF55.02c, possible triosephosphate isomerase, len: 259 aa; similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA, 261 aa; fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20; 38.9% identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM, Triosephosphate isomerase. (259 aa)
SCO0549Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (92 aa)
SCO0506NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)
SCO0410Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (416 aa)
SCO0171Conserved hypothetical protein SCJ1.20; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (438 aa)
SCO5628SC6A9.39c, probable integral membrane protein, len: 391 aa; C-terminus is similar to many phosphatidate cytidylyltransferases e.g. SW:CDSA_ECOLI (EMBL:M11330) phosphatidate cytidylyltransferase (249 aa), fasta scores; opt: 379 z-score: 384.3 E(): 3.6e-14, 38.8% identity in 196 aa overlap; Belongs to the CDS family. (391 aa)
SCO56941-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (418 aa)
SCO5696Hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
SCO5711SC9F2.05c, probable riboflavin kinase (FAD synthetase), len: 318 aa; similar to many e.g. SW:RIBF_CORAM riboflavin kinase from Corynebacterium ammoniagenes (338 aa) fasta scores; opt: 801, z-score: 904.5, E(): 0, (45.4% identity in 326 aa overlap). (318 aa)
SCO5743Conserved hypothetical protein SC9A10.07; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
SCO5753SC7C7.08, pgsA, probable phosphatidylglycerophosphate synthase, len: 263 aa; integral membrane protein similar to many e.g. PGSA_BACSU CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (193 aa), fasta scores; opt: 304 z-score: 312.1 E(): 3.8e-10, 38.0% identity in 187 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. FramePlot suggests start site at V40, similarities start downstream of this. Upstream start site chosen by HMM, corroborated by RBS. Contains possible hydrophobic membrane spanning regions; Belongs to the CDP-alcohol phosphatidyl [...] (263 aa)
SCO5754SC7C7.09, unknown, len: 181 aa; similar to competence damage induced proteins of B. subtilis and Streptococcus pneumoniae e.g. CINA_STRPN putative competence-damage protein (418 aa), fasta scores; opt: 304 z-score: 431.6 E(): 8.4e-17, 35.8% identity in 165 aa overlap. Contains probable coiled-coil from 133 to 175; Belongs to the CinA family. (181 aa)
SCO5845SC9B10.12, possible thimidine kinase, len: 216 aa; similar to several eg. KITH_ECOLI P23331 thymidine kinase (ec 2.7.1.21) (205 aa), fasta scores; opt: 404 z-score: 500.0 E(): 1.1e-20, 35.5% identity in 200 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (216 aa)
SCO5868Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (183 aa)
SCO5899Hypothetical protein; SC10A5.04, unknown, len: 295 aa; similar to hypothetical proteins from Mycobacterioum tuberculosis and M. leprae e.g. YV29_MYCTU Q11167 hypothetical 39.3 kd protein CY20G9.29 (358 aa), fasta scores; opt: 1075 z-score: 1514.7 E(): 0, 57.8% identity in 263 aa overlap. (295 aa)
SCO5910SC10A5.15, putative membrane protein, len: 114 aa. Contains possible hydrophobic membrane spanning regions. (114 aa)
SCO5983SCBAC16H6.18c, possible fatty acid-CoA ligase, len: 563 aa: similar to many e.g. TR:Q53005 (EMBL:U02033) 4-hydroxybenzoate-coenzyme A ligase rom Rhodopseudomonas palustris (539 aa) fasta scores; opt: 758, Z-score: 808.8, 33.747% identity (35.667% ungapped) in 483 aa overlap and TR:BAB48174 (EMBL:AP002995) probable acid-CoA ligase from Rhizobium loti (541 aa) fasta scores; opt: 1793, Z-score: 1909.7, 51.866% identity (53.565% ungapped) in 536 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and Prosite match to PS00455 Putative AMP-binding domain signature. (563 aa)
SCO6013Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
SCO6186Putative phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (231 aa)
SCO6195SC2G5.16, probable acetyl-coenzyme A synthetase, len:558 aa; similar to many e.g. SW:ACSA_BACSU from Bacillus subtilis (572 aa) fasta scores; opt: 798, z-score: 878.3,E():0, (31.8% identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. (558 aa)
SCO6325Putative membrane protein; SC10H5.01c, unknown, partial CDS, len >109 aa; possible integral membrane protein; SCIF3.27c, possible membrane protein (fragment), len: >221 aa; similar to TR:Q9ZC02 (EMBL:AL033505) Streptomyces coelicolor hypothetical 52.3 kDa protein SC1E6.20c, 501 aa; fasta scores: opt: 245 z-score: 288.4 E(): 1.6e-08; 36.3% identity in 212 aa overlap. (302 aa)
SCO6415Putative D-hydantoinase; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (467 aa)
SCO6437Hypothetical protein SC9B5.04; SC9B5.04, unknown, len: 424 aa; similar to two hypothetical proteins SW:Y4RH_RHISN from Rhizobium sp. fasta scores; opt: 213, z-score: 366.1, E(): 4.2e-13, (26.3% identity in 335 aa overlap) and SW:YWFE_BACSU from Bacillus subtilis (472 aa) fasta scores; opt: 217, z-score: 289.2, E(): 8.1e-09, (29.4% identity in 364 aa overlap). Also weakly similar to carbomylphosphate synthetases eg. TR:O50302 (EMBL:AJ001805) carbomylphosphate synthetase large subunit from Bacillus subtilis (1064 aa) fasta scores; opt: 150, z-score: 196.8, E(): 0.0011, (25.8% identity in [...] (424 aa)
SCO6467Putative phosphatidylserine synthase; SC9C7.03c, probable integral membrane protein, possible phosphatidylserine synthase, len: 260 aa; similar to many from prokaryotes (all putative) and eukaryotes eg. SW:PSS_YEAST phosphatidylserine synthase from Saccharomyces cerevisiae (275 aa) fasta scores; opt: 187, z-score: 254.6, E(): 6.8e-07, (35.9% identity in 170 aa overlap). Contains possible membrane spanning regions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (260 aa)
SCO6468Conserved hypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (218 aa)
SCO6511SC1E6.20c, unknown, len: 501 aa; similar to two hypothetical proteins from Rhodococcus erythropolis: TR:P72262 (EMBL:Z82004) ORF8 (487 aa), fasta scores; opt: 1098 z-score: 762.9 E(): 0, 45.5% identity in 488 aa overlap, and TR:P72269 (EMBL:Z82005) ORF8 (487 aa), fasta scores; opt: 1060 z-score: 717.1 E(): 1.2e-32, 41.7% identity in 487 aa overlap. Contains Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 31.00, E-value 1.3e-05. (501 aa)
SCO6558Putative protein associated with oxidoreductase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (282 aa)
SCO6573SC3F9.08, probable secreted protein, len: 417 aa; some similarity to many eukaryotic myo-inositol-1-phosphate synthases e.g. INO1_SPIPO (510 aa), fasta scores; opt: 159 z-score: 190.1 E(): 0.0022, 28.1% identity in 423 aa overlap, and to Archaeoglobus fulgidus TR:O28480 (EMBL:AE000979) AF1794 (392 aa), fasta scores; opt: 546 z-score: 713.5 E(): 1.6e-32, 37.0% identity in 397 aa overlap. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (417 aa)
SCO6611Hypothetical protein SC1F2.08c; SC1F2.08c, unknown, len: 186 aa. (186 aa)
SCO6647SC4G2.21c, possible integral membrane protein, len: 264 aa; similar to a hypothetical protein from Rhodobacter sphaeroides TR:O54078 (EMBL:AJ002398) (227 aa), fasta scores; opt: 493 z-score: 616.8 E(): 4.1e-27, 43.6% identity in 220 aa overlap. Also very weak similarity to PGSA_PSEFL (CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) (195 aa) E:0.0018, 30.8% identity in 146 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. (264 aa)
SCO6750Putative IPP isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (197 aa)
SCO6752SC6A5.01, partial CDS, possible integral membrane transferase, len: >490aa; similar to TR:O67379 (EMBL:AE000737) glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 215, z-score: 245.5, E(): 2.2e-06, (26.2% identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature and possible membrane spanning hydrophobic regions; SC5F2A.35, partial CDS, possible transferase, len: >148aa; C-terminal region lies on cosmid 6A5 (EMBL:AL049485). Similar over a defined region to many proposed/hypothetical proteins e [...] (605 aa)
SCO6755Putative transferase; SC6A5.04, possible integral membrane transferase, len: 227aa; similar to many eg. TR:O67379 (EMBL:AE000737) glucose-1-phophate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 206, z-score: 257.3, E(): 5e-07, (28.1% identity in 199 aa overlap). Contains possible membrane spanning hydrophobic region. (227 aa)
SCO6763SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...] (378 aa)
SCO6767GcpE protein homolog, conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
SCO6768Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (656 aa)
SCO6821Putative transferase; SC1A2.30c, possible transferase, len: 240 aa. Weakly similar to the C-terminal glutamine amide transferase domain of several CTP synthases e.g. Escherichia coli SW:PYRG_ECOLI(EMBL:M12843) CTP synthase (EC 6.3.4.2) (544 aa), fasta scores opt: 184 z-score: 227.2 E(): 3e-05 24.4% identity in 225 aa overlap. (240 aa)
SCO6898Putative carboxylase; SC1B2.04, possible carboxylase, len: 405 aa. Weakly similar to several e.g. Anabaena sp. (strain PCC 7120) SW:ACCC_ANASP(EMBL:L14862) biotin carboxylase (EC 6.3.4.14) (447 aa), fasta scores opt: 226 z-score: 262.2 E(): 3.8e-07 28.5% identity in 214 aa overlap. Contains a Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and a Prosite hit to PS00867 Carbamoyl-phosphate synthase subdomain signature 2. (405 aa)
SCO6983Conserved hypothetical protein SC8F11.09; SC8F11.09, unknown, len: 137 aa. Weakly similar to a protein of undefined function from Mycobacterium tuberculosis SW:Y887_MYCTU(EMBL:Z73101) (152 aa), fasta scores opt: 193 z-score: 239.5 E(): 6.6e-06 31.7% identity in 139 aa overlap. (137 aa)
SCO7081Putative phospholipase; SC3A4.07c, possible phospholipase, len: 395 aa. Similar to several including: Bacillus firmus TR:O66043(EMBL:U88888) cardiolipin synthase, ClS (503 aa), fasta scores opt: 605 z-score: 748.2 E():0 31.8% identity in 377 aa overlap. Contains 2xPfam matches to entry PF00614 PLDc, Phospholipase D. Active site motif. (395 aa)
SCO7215SC2H12.14c, hypothetical protein, len: 186 aa. Similar to Deinococcus radiodurans TR:Q9RRF8(EMBL:AE002082) hypothetical protein, GrpB (188 aa), fasta scores opt: 281 z-score: 356.9 E(): 2.1e-12 35.9% identity in 184 aa overlap and to SW:YI88_BACHD (EMBL:AP001513) Bacillus halodurans hypothetical protein BH1888, 195 aa; fasta scores: opt: 471 Z-score: 557.2 E(): 2.1e-23; 41.361% identity in 191 aa overlap; Belongs to the UPF0157 (GrpB) family. (186 aa)
SCO7268SC5H1.24c, add, probable adenosine deaminase, len: 359 aa; similar to many e.g. SW:ADD_ECOLI (EMBL:M59033), Add, Escherichia coli adenosine deaminase (333 aa), fasta scores; opt: 369 z-score: 434.3 E(): 7.2e-17, 32.8% identity in 338 aa overlap. Weakly similar to TR:O86737 (EMBL:AL031035) S.coelicolor possible adenosine deaminase (387 aa) (28.9% identity in 342 aa overlap). Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase, score 220.40, E-value 2.6e-62; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deami [...] (359 aa)
SCO7528Conserved hypothetical protein SC8G12.04; SC8G12.04, unknown, len: 166 aa; similar to TR:Q9KZG9 (EMBL:AL353864) hypothetical protein SC8F11.09 from Streptomyces coelicolor (137 aa) fasta scores; opt: 348, Z-score: 421.0, E(): 8.2e-16, 38.060% identity (38.636% ungapped) in 134 aa overlap. (166 aa)
SCP1.159cSCP1.159c, possible oxidoreductase subunit, len: 90aa; similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. SW:P37606 (GPDA_ECOLI) glycerol-3-phosphate dehydrogenase from Escherichia coli (339 aa) fasta scores; opt: 176, z-score: 239.8 E(): 6.9e-06, 39.5% identity in 76 aa overlap and TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores; opt: 252, z-score: 338.2, E(): 2.3e-11, 53.1% identity in 81 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores; opt: 238, z-score: 294.0, E(): 7.6 [...] (69 aa)
SCP1.162cSCP1.162c, possible oxidoreductase subunit, len: 65aa; similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores; opt: 302, z-score: 432.6, E(): 1.3e-16, 76.9% identity in 65 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores; opt: 238, z-score: 294.0, E(): 7.6e-12, 50.7% identity in 75 aa overlap. (65 aa)
mmyXSCP1.233A, mmyX, possible ATP/GTP-binding protein, len: 234aa; previously sequenced and annotated as TR:Q9JN81 (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.236 MmyK, putative ATP/GTP-binding protein (206 aa)(previously sequenced as TR:Q9JN85 (EMBL:AJ276673) hypothetical protein) fasta scores; opt: 538, z-score: 647.7, E(): 1.3e-28, 42.7% identity in 199 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (234 aa)
mmyKSCP1.236, mmyK, possible ATP/GTP-binding protein, len: 206aa; previously sequenced and annotated as TR:Q9JN85 (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.233A MmyX, putative ATP/GTP-binding protein (234 aa) (previously sequenced as TR:Q9JN81 (EMBL:AJ276673) hypothetical protein) fasta scores; opt: 538, z-score: 647.7, E(): 1.3e-28, 42.7% identity in 199 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (206 aa)
SCO5626Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (253 aa)
SCO5569Hypothetical protein SC7A1.13; SC7A1.13, unknown, len: 379 aa; similar to TR:O69467 (EMBL:AL023635) hypothetical protein from Mycobacterium tuberculosis (245 aa) fasta scores; opt: 254, z-score: 388.8, E(): 2.3e-14, (29.5% identity in 234 aa overlap). Contains probable coiled-coil from 82 to 124 (43 residues) Max score: 1.615 (probability 1.00). (379 aa)
SCO5568Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
SCO5563Phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. (269 aa)
SCO5562Putative thiamine monphosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
SCO5559SC7A1.03, gpsA, glycerol-3-phosphate dehydrogenase, len: 366aa; similar to many eg. SW:GPDA_BACSU glycerol-3-phosphate dehydrogenase from Bacillus subtilis (345 aa) fasta scores; opt: 874, z-score: 1221.4, E(): 0, (41.8% identity in 330 aa overlap). Contains a possible PS00017 ATP /GTP-binding site motif A (P-loop) and Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 295.10, E-value 8.8e-85. (336 aa)
SCO5558SC7A1.02, possible acyltransferase, len: 264aa; similar to several proposed acyltransferases eg. TR:O07809 (EMBL:Z97188) acyltransferase from Mycobacterium tuberculosis (251 aa) fasta scores; opt: 266, z-score: 384.5, E(): 4e-14, (29.7% identity in 229 aa overlap). (264 aa)
SCO5425Phosphate acetyltransferase (fragment); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
SCO5424Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)
SCO5374ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa)
SCO5373ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (478 aa)
SCO5372ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa)
SCO5371ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (529 aa)
SCO5370ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (274 aa)
SCO5369ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (184 aa)
SCO5368ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (76 aa)
SCO5367ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (273 aa)
SCO52502SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa; previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1; Belongs to the FPP/GGPP synthase family. (386 aa)
SCO52412SC7G11.03c, hypothetical protein, len: 322 aa; similar to TR:O05848 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 34.5 kDa protein MTCY07D11.08c, 321 aa; fasta scores: opt: 694 z-score: 788.3 E(): 0; 39.9% identity in 328 aa overlap. Contains Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed). (322 aa)
SCO5225Ribonucleotide-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (343 aa)
SCO52012SC3B6.25, moaE-like protein, len: 152 aa; similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor, subunit 2 MoaE, 149 aa; fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10; 33.3% identity in 129 aa overlap. (152 aa)
SCO5058Hypothetical protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
SCO4980Hypothetical protein 2SCK36.03c; 2SCK36.03c, unknown, len: 316 aa. (316 aa)
SCO4928SCK13.20, cya, adenylate cyclase, len: 381 aa; identical to previously sequenced SW:CYAA_STRCO (EMBL:X74768) Streptomyces coelicolor adenylate cyclase (EC 4.6.1.1) Cya, 381 aa. Contains Pfam match to entry PF00211 guanylate_cyc, Adenylate and Guanylate cyclase catalytic domain; Belongs to the adenylyl cyclase class-3 family. (381 aa)
SCO4909SCK13.01c, possible ATP-binding protein, len: 258 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (258 aa)
SCO49012SCK8.27, probable adenosine deaminase, len: 396 aa; similar to SW:ADD_ECOLI (EMBL:M59033) Escherichia coli adenosine deaminase (EC 3.5.4.4) Add, 333 aa; fasta scores: opt: 421 z-score: 505.2 E(): 1.4e-20; 32.2% identity in 338 aa overlap and to TR:Q9X7T2 (EMBL:AL049863) Streptomyces coelicolor putative adenosine deaminase SC5H1.24c, 359 aa; fasta scores: opt: 1373 z-score: 1637.4 E(): 0; 60.7% identity in 351 aa overlap. Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases famil [...] (396 aa)
SCO4849SC5G8.17, possible integral membrane protein, len: 436 aa; N-terminal region contains possible membrane-spanning hydrophobic regions while the remainder is similar to many hypothetical proteins e.g. TR:Q9ZM43 (EMBL:AE001473) putative from Helicobacter pylori J99 (370 aa) fasta scores; opt: 596, z-score: 590.7, E(): 1.9e-25, 37.4% identity in 273 aa overlap. (436 aa)
SCO4824Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
SCO4814SCD63A.25, purH, bifunctional purine biosynthesis protein, len: 523 aa; highly similar to TR:AAF05727 (EMBL:AF191543) Mycobacterium paratuberculosis phosphoribosylaminoimidazolecarboxamide/formyltransferase, PurH, 527 aa; fasta scores: opt: 2301 z-score: 2632.5 E(): 0; 69.1% identity in 518 aa overlap. Contains Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme. (523 aa)
SCO4813Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
SCO4785GMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
SCO4771SCD63.03, possible inosine-5'-monophosphate dehydrogenase, len: 374 aa; N-terminal region identical to previously sequenced TR:O86845 (EMBL:AJ010601) Streptomyces coelicolor hypothetical 38.9 kD protein (fragment), 84 aa and whole CDS similar to SW:IMDH_ECOLI (EMBL:X02209) Escherichia coli inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) GuaB, 488 aa; fasta scores: opt: 275 z-score: 311.9 E(): 6.1e-10; 29.0% identity in 376 aa overlap. Contains Pfam matches to entries PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C [...] (374 aa)
SCO4770Inosine 5' monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa)
SCO4738SC6G4.16c, coaA, probable pantothenate kinase, len: 329 aa; similar to e.g. COAA_ECOLI pantothenate kinase (EC 2.7.1.33) (316 aa), fasta scores; opt: 1100 z-score: 1601.0 E(): 0, 51.4% identity in 315 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (329 aa)
SCO4723Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
SCO4663Hypothetical protein SCD40A.09c; SCD40A.09c, unknown, len: 117 aa. (117 aa)
SCO4657SCD40A.03c, possible integral membrane protein, len: 434 aa; similar to TR:Q9EWX4 (EMBL:AL445403) Streptomyces coelicolor putative integral membrane protein 2SCI34.05, 396 aa; fasta scores: opt: 678 Z-score: 732.5 E(): 3.6e-33; 37.923% identity in 414 aa overlap. Contains possible hydrophobic membrane spanning regions. (434 aa)
SCO4644Adenosine deaminase; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (343 aa)
SCO4418SC6F11.16c, probable oxidase, len: 222 aa; similar to TR:O88794 (EMBL:U91561) Rattus norvegicus pyridoxine 5'-phosphate oxidase PnpO, 261 aa; fasta scores: opt: 413 z-score: 479.7 E(): 3.2e-19; 38.0% identity in 184 aa overlap. Contains Pfam match to entry PF01243 Pyridox_oxidase, Pyridoxamine 5'-phosphate oxidase. (222 aa)
SCO4403Putative formyltetrahydrofolate deformylase (fragment); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa)
SCO4387Putative pyridoxamine oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (234 aa)
SCO42342C-methyl-D-erythriol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (170 aa)
SCO42334-diphodphocytidyl-2C-methyl-D-erythriol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (270 aa)
SCO4161SCD84.28, possible molybdopterin converting factor, len: 84 aa; similar to TR:O53880 (EMBL:AL022004) Mycobacterium tuberculosis putative molybdopterin converting factor (subunit 1) MoaD-2, 92 aa; fasta scores: opt: 191 z-score: 269.0 E(): 1.6e-07; 45.9% identity in 85 aa overlap. (84 aa)
SCO4087SCD25.23, purM, phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1), len: 355 aa. Identical to Streptomyces lividans TR:Q9ZB03 (EMBL:U64826) phosphoribosyl aminoimidazole synthetase (EC 6.3.3.1) (355 aa), fasta scores opt: 2313 z-score: 2645.5 E(): 0; 100.0% identity in 355 aa overlap and highly similar to many others e.g. Escherichia coli SW:PUR5_ECOLI (EMBL:M13747) phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (phosphoribosyl-aminoimidazole synthetase) (AIR synthase) (344 aa), fasta scores opt: 1018 z-score: 1167.8 E(): 0; 48.4% identity in 343 aa overlap [...] (355 aa)
SCO4086Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (530 aa)
SCO4079Phosphoribosyl formylglycinamidine synthase II (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thou [...] (752 aa)
SCO4078Phosphoribosyl formylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (226 aa)
SCO4077Hypothetical protein SCD25.13; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (90 aa)
SCO4071SCD25.07, purC, phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6), len: 299 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:PUR7_MYCTU (EMBL; Z80226) phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (saicar synthetase) PurC or MTCY369.24 (297 aa), fasta scores: opt: 1085 z-score: 1276.6 E(): 0 58.3% identity in 278 aa overlap. Contains a PS01057 SAICAR synthetase signature 1, PS01058 SAICAR synthetase signature and a Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase. (299 aa)
SCO4068SCD25.04, purD, phosphoribosylamine-glycine ligase (EC 6.3.4.13), len: 416 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:PUR2_MYCTU (EMBL; Z80226) phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) MTCY369.17 (422 aa), fasta scores opt: 957 z-score: 1033.0 E(): 0 58.3% identity in 424 aa overlap. Contains a PS00184 Phosphoribosylglycinamide synthetase signature and a Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). (416 aa)
SCO4041Putative uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (214 aa)
SCO3938SCD78.05, thiC', probable thiamin biosynthesis protein ThiC, partial CDS, len: 43 aa; simlar to the extreme C-terminus of e.g. THIC_ECOLI thiamin biosynthesis protein ThiC (631 aa), fasta scores; opt: 97 z-score: 137.7 E(): 2, 46.2% identity in 39 aa overlap and THIC_MYCTU (547 aa), fasta scores; opt: 143 z-score: 272.4 E(): 6.4e-08, 53.1% identity in 49 aa overlap. Note that this gene appears to have been interrupted by the integration of the upstream element. (43 aa)
SCO3928Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (612 aa)
SCO3899SCH24.21c, conserved hypothetical protein, len: 360 aa; unknown function, similar to e.g. TR:P71703 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical protein (367 aa), fasta scores; opt: 1790 z-score: 2136.2 E(): 0, 78.5% identity in 353 aa overlap. C-terminal half shows weak similarity with a region of SW:INO1_CANAL (EMBL:L22737), Ino1, Candida albicans myo-inositol-1-phosphate synthase (520 aa) (26.3% identity in 251 aa overlap) and with TR:O69948 (EMBL:AL023862) S.coelicolor probable secreted protein (417 aa) (25.2% identity in 226 aa overlap). (360 aa)
SCO3831SCGD3.32c, bkdA2, probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit, partial CDS, len: >179 aa; similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53592 (EMBL:U17169), BkdA, Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (381 aa), fasta scores; opt: 987 z-score: 1131.6 E(): 0, 90.3% identity in 165 aa overlap and SW:ODPA_ACHLA (EMBL:M81753), PdhA, Acholeplasma laidlawii pyruvate dehydrogenase E1 component, alpha subunit (345 aa) (34.6% identity in 162 [...] (388 aa)
SCO3828Putative molybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (303 aa)
SCO3827Putative molybdenum cofactor biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (465 aa)
SCO3817SCGD3.18c, bkdA1, probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit, len: 417 aa; similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53610 (EMBL:U26308) Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (406 aa), fasta scores; opt: 2177 z-score: 2466.3 E(): 0, 80.9% identity in 409 aa overlap and SW:ODPA_BACST (EMBL:X53560), PdhA, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 alpha subunit (368 aa) (39.7% identity in 325 aa overlap). Simil [...] (417 aa)
SCO3726Hypothetical protein SCH22A.04c; SCH22A.04c, unknown, len: 206 aa. (206 aa)
SCO3678Putative deoxynucleotide triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
SCO3677SCH35.47, possible purine phosphoribosyltransferase, len: 165 aa; similar to many eg. TR:P74916 (EMBL:D37928) purine phosphoribosyltransferase from Thermus flavus (154 aa) fasta scores; opt: 222, z-score: 291.9, E(): 6.3e-09, 931.8% identity in 151 aa overlap). (165 aa)
SCO3650Putative uridine 5'-monophosphate synthase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
SCO3645Putative hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (410 aa)
SCO3630SCH10.08, hypothetical protein, len: 301 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains a hydrophobic, possible membrane-spanning region. (301 aa)
SCO3629Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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